miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway by Zhongsheng Zhu, Jinyu Li, Rui Tong, Xiaorong Zhang, Bo Yu

“…The miR-149 level in HUVECs was reduced by ox-LDL (100 μg/mL) incubation in a time-dependent manner. miR-149-mimic transfection markedly protected HUVECs from ox-LDL-induced injury, with increased cell viability and reduced caspase-3 activity. miR-149 mimics enhanced HUVEC autophagy, which was induced initially by ox-LDL. miR-149 mimics also markedly downregulated the expression of Akt, p-Akt, mTOR, and p-mTOR in ox-LDL-treated HUVECs. …”
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Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis by Fujun Yu, Zhongqiu Lu, Bicheng Chen, Peihong Dong, Jianjian Zheng

“…In LX-2 cells, the reduction of lincRNA-p21 induced by TGF-β1 was in a dose- and time-dependent manner. lincRNA-p21 expression was reduced in liver tissues from patients with liver cirrhosis when compared with that of healthy controls. …”
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Postcards from Inside the Practices by Alicia Lazzaroni, Antonio Bernacchi, Enrique Espinosa Pérez, Lydia Maria Arantes, Michele Avis Feder-Nadoff

“…Instead, their panel was designed to explore making-knowledge with others in a manner that is improvisatory, non-authoritative, and open to the silence of gestures and quiet exchange. …”
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Opposing Effects of Omega-3 and Omega-6 Long Chain Polyunsaturated Fatty Acids on the Expression of Lipogenic Genes in Omental and Retroperitoneal Adipose Depots in the Rat by B. S. Muhlhausler, R. Cook-Johnson, M. James, D. Miljkovic, E. Duthoit, R. Gibson

“…Altering red blood cell concentrations of n-3 PUFA is thus associated with altered expression of lipogenic genes in a depot-specific manner and this effect is modulated by prevailing n-6 PUFA concentrations.…”
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Critical analysis of doctrinal approaches to the definition of “biological terrorism” by О. V. Shamsutdinov

“…Terrorism has been defined as socially dangerous criminal acts provided for by international and national law, which consist of demonstrative public violence in a generally dangerous manner or with particular cruelty, as well as threats, organisation, preparation, logistical, financial and other support or incitement to commit such acts aimed at intimidating the population, inducing specific institutions or individuals to commit or refuse to commit certain acts, or with the aim of destabilising or destroying law and order. …”
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Silver Nanoparticles Stabilized by Poly (Vinyl Pyrrolidone) with Potential Anticancer Activity towards Prostate Cancer by Ahmed A. H. Abdellatif, Ahmed Abdelfattah, Abdellatif Bouazzaoui, Shaaban K. Osman, Issa Saad Al-Moraya, Abdulaziz M. Saleh Showail, Mansour Alsharidah, Ashraf Aboelela, Osamah Al Rugaie, Tarek M. Faris, Hesham M. Tawfeek

“…In vitro cytotoxicity testing showed the AgNPs-PVP exhibited antiproliferation properties in PC3 in a dose-dependent manner. In addition, when compared to control cells, AgNPs-PVP has lower TNF-α with a significant value (∗p<0.05); the value reached 16.84 ± 0.71 pg/ml versus 20.81 ± 0.44 pg/ml, respectively. …”
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Expert decision-making in clinicians: An auto-analytic ethnographic study of operational decision-making in urgent care. by Nicola Irvine, Robert Van Der Meer, Itamar Megiddo

“…Expert solutions generated in this manner are pragmatic rather than optimal, context dependent, and seek to achieve goals which vary from moment-moment. …”
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Enhanced Disc Herniation Classification Using Grey Wolf Optimization Based on Hybrid Feature Extraction and Deep Learning Methods by Yasemin Sarı, Nesrin Aydın Atasoy

“…The aim of this study was to classify lumbar disc herniations in a computer-aided, fully automated manner using magnetic resonance images (MRIs). Methods: This study presents a hybrid method integrating residual network (ResNet50), grey wolf optimization (GWO), and machine learning classifiers such as multi-layer perceptron (MLP) and support vector machine (SVM) to improve classification performance. …”
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Knowledge, Attitude and Practice of Medical Students of Sulaimani Regarding Modern Lifestyle and Its Effect on Health by Bushra M. Ali, Saman Mohammed, Shajwan Akram, Saya Salar, Lezan Baxtiar, Lawen Ismail, Shad Nawzad

“…A cross sectional study was conducted among 420 students, in a convenient sampling way, Data collected from 18th to 22nd of September 2019 in a self-administrated manner from four different medical colleges (Medicine, Dentistry, Pharmacy and Veterinary.) in university of Sulaimani. …”
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Functional switching among dynamic neuronal hub-nodes in the brain induces maintenance/transition of cognitive states by Jasleen Gund, Yashaswee Mishra, B. N. Mallick, R. K. Brojen Singh

“…The switching behaviour in the ratio of hub/non-hub nodes between frontal and occipital regions during NREMS-Wake and Wake-NREMS transitions provides support as proof-of-principle of functional regional inactivation or activation of hub-nodes as the gradual switching mechanism towards transitioning of cognitive states in a graded (or non-flipping) manner, wake to sleep or vice versa; the detailed neuro-physio-chemical mechanism needs further study. …”
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Biomarker Profiling for Pyridoxine Dependent Epilepsy in Dried Blood Spots by HILIC-ESI-MS by Elizabeth Mary Mathew, Sudheer Moorkoth, Leslie Lewis, Pragna Rao

“…The newly developed method involves no derivatisation and has a simple sample preparation and a low run time enabling it to be easily automated with a high sample throughput in a cost-effective manner.…”
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Implementation of global health competencies: A scoping review on target audiences, levels, and pedagogy and assessment strategies. by Meike Schleiff, Bhakti Hansoti, Anike Akridge, Caroline Dolive, David Hausner, Anna Kalbarczyk, George Pariyo, Thomas C Quinn, Sharon Rudy, Sara Bennett

“…Further development is needed to understand how to assess competencies in a consistent and relevant manner.…”
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An indole alkaloid from a tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infected mice. by Paromita Bag, Durbadal Ojha, Hemanta Mukherjee, Umesh Chandra Halder, Supriya Mondal, Nidhi S Chandra, Suman Nandi, Ashoke Sharon, Mamta Chawla Sarkar, Sekhar Chakrabarti, Debprasad Chattopadhyay

“…The in vivo studies revealed that HM at its virucidal concentration was nontoxic and reduced virus yield in the brain of HSV-2 infected mice in a concentration dependent manner, compared to vaginal tissues. Thus, our results suggest that HM can serve as a prototype to develop non-nucleotide antiviral lead targeting the viral IE transcription for the management of HSV-2 infections.…”
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Effect of Construction Waste as a Fine Aggregate on Properties of Concrete. by Sempala, Ronald

“…In order to continue all development efforts with the least possible harm to the environment and to obtain all the infrastructure needed to provide services and convenience in an affordable and environmentally friendly manner, research in this sector and successful outcomes are very essential. …”
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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…Implementation of the developed clinical guidelines can help to establish a diagnosis in a timely manner, which will lead to an improvement in the quality of medical care for patients with achalasia.…”
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Clinical Pregnancy and Miscarriage Rates in relation to Vitamin D Supplementation among women with Hyper Androgenic PCOS: A prospective study by Sherif Sobhy Menshawy Khalifa, Wael Gaber Eldamaty, Ahmed Tharwat Abo Dakika, Mohamed Zaeim Hafez Ahmed, Muhammad Abdelbaeth Hassan Elfiky, Ghada Adel Hegazy

“…Our results indicate that women who have enough 25(OH)D are far more likely to get clinically pregnant than those who had deficiency of 25(OH)D.Conclusion More research is necessary to determine whether vitamin D supplementation can increase pregnancy rates in a simple and economical manner. In our study population, there was a significant prevalence of 25(OH)D deficit or insufficiency. …”
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Mechanisms underlying the effects of cyanogenesis on development and reproduction of Tetranychus urticae: Insights from enzyme activity and gene expression aspects by Mufeng Wu, Xiao Liang, Ying Liu, Chunling Wu, Xingkui An, Zihua Zhao, Guifeng Hao, Ijiti Oluwole Gregory, Zhihong Li, Qing Chen

“…Numerous studies have speculated this CNG-mediated toxicity by a plant-pest interaction manner. However, the specific toxic effect of HCN was not well-demonstrated because of the interference of other ingested metabolites. …”
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The Effect of the Glucosinolate Sinigrin on Alterations in Molecular Biomarkers of the Myocardium in Swiss Mice by Nikola Ferara, Vedran Balta, Domagoj Đikić, Dyana Odeh, Ana Mojsović-Ćuić, Lana Feher Turković, Dario Dilber, Anđelo Beletić, Irena Landeka Jurčević, Ivana Šola

“…These results suggest that the hydrolysis products of sinigrin may exert a potentially toxic effect on the myocardial tissue of female mice and possess the capability to modulate transcription factors <i>in vivo</i> in a sex-dependent manner. This observation calls for further investigation into the mechanisms regulating the actions of glucosinolate hydrolysis products, their interactions with sex hormones, and the determination of permissible intake levels associated with both beneficial and adverse outcomes.…”
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Optimising Palm Olein-Based Betamethasone 17-Valerate Emulsions for Scalable Manufacturing and Stability by Thazin Win, Mohd. Rushdi Abu Bakar, Farahidah Mohamed, Muhammad Taher, Md. Zaidul I. Sarker

“…Results: The findings established that the quadratic model was the most suitable model as it could predict the interactions between factors and responses in an accurate manner as well as suggest the optimum operating conditions. …”
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A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Dia... by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Herein, we report that RGI-3100-iB, a novel liposomal formulation carrying both α-galactosylceramide (α-GalCer), which is a representative ligand for invariant natural killer T (iNKT) cells, and insulin B chain 9–23 peptide, which is an epitope for CD4+ T cells, could induce the accumulation of regulatory T cells (Tregs) in islets in a peptide-dependent manner, followed by the remarkable prevention of diabetes onset in nonobese diabetic (NOD) mice. …”
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