Efficacy and Safety of Different Acupuncture Treatments for Cancer-Related Pain: A Systematic Review and Network Meta-Analysis by Tianle Xie MD, Can Liu MD, Yudi Wu MD, Xiuxiu Li MD, Qianyun Yang PhD, Jing Tan PhD

“…Background: Cancer pain is a prevalent and persistent issue, and while there have been some observations of the possible benefits of acupuncture in managing cancer pain, there is still debate regarding its safety and effectiveness. …”
Get full text

Outcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study by Yan Sun, Xiaoli Zhu, Jaime Lin, John Abisheganaden, Zhiwen Joseph Lo, Lixia Ge, Joseph Molina, Elaine Tan, Huiling Liew, Jeremy Hoe, Gary Ang, Kai Qiang Low, Theophilus Yap, Nur Aberleen Syafirah Binte Azmi, Enming Yong, Tiffany Chew, Hui Yan Koo, Chelsea Law, Dexter Yak Seng Chan, Claris Shi, Julia Choo, Wai Han Hoi, Sadhana Chandraskear, Jo Ann Lim, Jemes Siow, Sabariah Binte Kaspon, Subramaniam Tavintharan, Daniel Chew

“…Probabilistic sensitivity analysis supported these findings.Conclusions The integrated multidisciplinary DEFINITE Care program improved LEA-free survival, reduced inpatient admissions and length of stay within 1 year and demonstrated long-term cost-effectiveness managing DFUs.…”
Get full text

The potential use of brewers' spent grain-based substrates as horticultural bio-fertilizers by Angela Bianco, Angela Bianco, Sara Melito, Matteo Garau, Vittoria Giannini, Giacomo Zara, Giacomo Zara, Davide Assandri, Safa Oufensou, Safa Oufensou, Roberta Coronas, Niccolò Pampuro, Marilena Budroni, Marilena Budroni

“…Nonetheless, composting, vermicomposting, and biochar production pathways offer promising alternatives for managing this organic byproduct.MethodsBSG-based substrates were evaluated as bio-fertilizers for use during the transplantation of Lactuca sativa L. and without additional fertilization at the end of the crop cycle. …”
Get full text

Comparison of robotic-assisted and laparoscopic partial nephrectomy based on the PADUA score and the predictive value of the PADUA score and the Mayo Adhesive Probability score for... by Shuo Liu, Bowen Zhang, Bowen Weng, Xiangqiang Liu, Sichuan Hou

“…Conclusion RAPN provides significant advantages over LPN in managing complex renal tumors (PADUA score ≥ 10), significantly in reducing OT, WIT, EBL, and absolute eGFR change at three months post-surgery, while minimizing postoperative stay. …”
Get full text

Leveraging Smart Telemedicine Technology to Enhance Nursing Care Satisfaction and Revolutionize COVID-19 Care: Prospective Cohort Study by You-Lung Chang, Chi-Ying Lin, Jiun Hsu, Sui-Ling Liao, Chun-Ti Yu, Hung-Chueh Peng, Chung-Yu Chen, Matthew Huei-Ming Ma, Juey-Jen Hwang

“…The QOCA remote care system monitored isolated cases through remote care packages and a 4G tablet. Case managers and physicians provided telemedicine appointments and medications. …”
Get full text

A phase II trial of anlotinib plus EGFR-TKIs in advanced non-small cell lung cancer with gradual, oligo, or potential progression after EGFR-TKIs treatment (CTONG-1803/ALTER-L001) by Hua-Jun Chen, Hai-Yan Tu, Yanping Hu, Yun Fan, Guowu Wu, Shundong Cang, Yi Yang, Nong Yang, Rui Ma, Gaowa Jin, Ximing Xu, Anwen Liu, Shubin Tang, Ying Cheng, Yan Yu, Chong-Rui Xu, Qing Zhou, Yi-Long Wu

“…Conclusion Anlotinib in combination with continuation of EGFR-TKIs prolonged the clinical benefit of EGFR-TKIs, demonstrating favorable survival outcomes and manageable toxicity in NSCLC treated with EGFR-TKIs and had specific progression modes, such as gradual progression. …”
Get full text

Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies by Amani M. El Sisi, Essam M. Eissa, Ahmed H. E. Hassan, Marina A. Bekhet, Fatma I. Abo El-Ela, Eun Joo Roh, Rasha M. Kharshoum, Adel A. Ali

“…<b>Background/Objectives</b>: Mirtazapine (MRZ) is a psychotropic drug prescribed to manage serious sorts of depression. By virtue of its extensive initial-pass metabolic process with poor water solubility, the ultimate bioavailability when taken orally is a mere 50%, necessitating repeated administration. …”
Get full text

Development and pilot testing of INTERVENER, a web-based tool to match barriers to the cancer continuum organization to evidence-based interventions by Isabel Mosquera, Hannah Theriault, Dominique Meunier, Partha Basu, Andre L. Carvalho

“…This tool can support governments, policymakers, managers, and healthcare providers to make better informed decisions to improve their cancer screening programmes.…”
Get full text

The analgesic effectiveness of auriculotherapy for acute postoperative pain: A systematic review and meta-analysis by Guilin Zhang, Guixing Xu, Yao Tang, Lingxue Zhang, Xi Chen, Xingyu Liang, Ling Zhao, Dehua Li

“…Background: Postoperative pain is a significant yet inadequately managed complication following surgery, and auriculotherapy to alleviate acute postoperative pain (APP) and reduce the use of opioids remains controversial. …”
Get full text

Foot screening and customized health education program for patients with diabetic peripheral neuropathy: A nurse-led, real-world observational study by Shuhong Liu, Hexiao Ding, Dandan Li, Fen Lu, Gumei Luo, Yujin He, Hui Li, Xiuhong Zeng, Kaixin Li, Dong-E Gong, Xiling Hu, Yanming Chen, Xubin Yang

“…Conclusions: In this observational study conducted among Chinese patients with diabetes, it was found that the nurse-led FSCHE program effectively manages DPN and its associated risk factors. These results highlight the importance of employing objective screening tools to detect DPN at an early stage, as well as the significance of nurse-led interventions in promoting healthy behaviors and preventing the development and progression of DPN.…”
Get full text

Qualitative Insights on Barriers to Receiving a Second Dose of Measles-Containing Vaccine (MCV2), Oromia Region of Ethiopia by Kalkidan Solomon, Brooke N. Aksnes, Abyot Bekele Woyessa, Chala Gari Sadi, Almea M. Matanock, Monica P. Shah, Paulos Samuel, Bekana Tolera, Birhanu Kenate, Abebe Bekele, Tesfaye Deti, Getachew Wako, Amsalu Shiferaw, Yohannes Lakew Tefera, Melkamu Ayalew Kokebie, Tatek Bogale Anbessie, Habtamu Teklie Wubie, Aaron Wallace, Ciara E. Sugerman, Mirgissa Kaba

“…Strategies to address these barriers include tools to help caretakers track appointments, enhanced community engagement, HCW training to improve provider–client interactions and MCV2 knowledge, and efforts to manage HCW workload.…”
Get full text

Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in pat... by Christy Ralph, Sumati Gupta, Matthew Zibelman, Brendan D Curti, Kevin J Harrington, Steven J O'Day, Andrew G Hill, David C Campbell, Gavin M Wright, David E Gerber, Jonathan E Rosenberg, Jaime R Merchan, Charles M Rudin, Hardev S Pandha, Wallace L Akerley, Daphne Day, Timothy D Clay, Ross R Jennens, Yixin Ren, Emmett V Schmidt, Lisa Guttman

“…Objective response rates were 6% (part A), 9% in the NSCLC dose-expansion cohort (n=43), and 20% in the urothelial cancer dose-expansion cohort (n=35).Conclusions Intravenous V937+pembrolizumab had a manageable safety profile. Although V937 was detected in tumor tissue, in NSCLC and urothelial cancer, efficacy was not greater than that observed in previous studies with pembrolizumab monotherapy.Trial registration number NCT02043665.…”
Get full text

Characterization of food wastes from the hotel industry as a potential feedstock for energy production by Emily Machuma Muchele, Booker Osodo, Isaiah Omosa, Emmanuel Yeri Kombe

“…Therefore, there is a need for efficient ways to manage the generated waste. Developed countries have embraced Waste-to-Energy technologies, minimizing waste generation and converting generated waste into energy and other resources. …”
Get full text

Factors protecting against progression of myopia in school students exposed to societal change in Vietnam: a 3-year cohort study by Kyoko Ohno-Matsui, Keiko Nakamura, Kaoruko Seino, Xuan Minh Tri Tran, Hoang Thuy Linh Nguyen, Thao Vi Tran, Tae Igarashi-Yokoi, Thang Van Vo

“…The results highlight the high prevalence and considerable incidence of myopia, and the need for further effective strategies to reduce the risk of myopia by managing computer time and increasing outdoor time.…”
Get full text

Family planning and preimplantation testing: family experiences in congenital adrenal hyperplasia by Jessica L. Sandy, Jessica L. Sandy, Jessica L. Sandy, Grant Betts, Jessica L. Harper, Suzanne M. Nevin, Suzanne M. Nevin, Suzanne M. Nevin, Rebecca Deans, Rebecca Deans, Rebecca Deans, Kristen A. Neville, Kristen A. Neville

“…A better healthcare professional understanding of these experiences may subsequently help guide clinicians to better manage and support families of children with CAH and other autosomal recessive conditions.MethodsAll parents of current children of a tertiary service in 2020 with 21-hydroxylase deficient CAH who made an active decision regarding family planning after diagnosis of their index child were invited to participate in a semi-structured interview. …”
Get full text

Spatiotemporal dynamics and prevention strategies of cervical cancer incidence in Addis Ababa, Ethiopia: an ecological study by Mathewos Assefa, Eva Johanna Kantelhardt, Teferi Gedif Fenta, Tariku Shimels

“…Techniques such as Bayesian empirical testing with a block weighting matrix for hotspot identification, Global Moran’s I for spatial autocorrelation, nearest neighbour imputation and universal Kriging interpolation were used to manage data gaps. Joinpoint trend analysis and direct age-standardised incidence rate (ASIR) using the Segi’s World standard population was applied to compare trends across subcities. …”
Get full text

Early Palliative Care Following Aborted Cancer Surgery: Results of a Prospective Feasibility Trial by Jordan M. Cloyd, MD, Rakhsha Khatri, BA, Angela Sarna, BS, Lena Stevens, PhD, Victor Heh, PhD, Mary Dillhoff, MD, Alex Kim, MD, Timothy M. Pawlik, MD, PhD, MPH, Aslam Ejaz, MD, Sharla Wells-Di Gregorio, PhD, Erin Scott, MD, Sachin S. Kale, MD

“…Following aborted cancer surgery, patients have unique care needs that specialized palliative care (PC) providers may be best equipped to manage. We hypothesized that early ambulatory PC referral following aborted cancer surgery would be feasible and acceptable. …”
Get full text

Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants by Shujun Lin, Wenshan Lin, Chunling Liao, Tianbiao Zhou

“…The Cochrane Library, Embase, ISI Web of Science, and PubMed databases were searched up to December 31, 2019, to identify studies and extract data to assess the efficacy of MSCs treatment of kidney disease induced by toxicants using Cochrane Review Manager Version 5.3. A total of 27 studies were eligible and selected for this meta-analysis. …”
Get full text

Specific plasma metabolite profile in intestinal Behçet’s syndrome by Cheng-cheng Hou, Hua-fang Bao, Chun-hui She, Hua-yu Chen, Guan-xing Pan, Hua-ning Chen, Hong-bing Rui

“…These findings might provide potential valuable insights for developing therapeutic strategies to manage IBS in the future.…”
Get full text

Place-based household vouchers for locally supplied fruit and vegetables: the Fresh Street pilot cluster randomised controlled trial by C. Relton, M. K. Blake, G. Bridge, D. Umney, S. J. C. Taylor, J. Adams, B. Mihaylova, C. Griffiths, R. Hooper, R. Phillips, L. Palmer, A. Gamston, K. Williamson

“…Methods The pilot cluster RCT took place in three inner city areas of high socioeconomic deprivation in England (Tower Hamlets, Bradford, and Doncaster). New systems for managing vouchers and doorstep delivering weekly envelopes to households were developed. …”
Get full text