Safety profile of EZH2 inhibitors for cancer: a systematic review and meta-analysis by Zhou Zhao, Xiufeng Chen, Huayang Pang, Yan Shi, Hao Sun

“…Conclusion EZH2 inhibitors demonstrate a manageable safety profile with a low incidence of severe TRAEs, emphasizing their potential as safe therapeutic options in cancer treatment. …”
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Factors associated with recognition at work among nurses and the impact of recognition at work on health-related quality of life, job satisfaction and psychological health: a singl... by Latifa Alahiane, Youssef Zaam, Redouane Abouqal, Jihane Belayachi

“…The trajectory analysis model found that supervisor recognition had the best impact on anxiety, job satisfaction and HRQOL.Conclusions Recognition from superiors is important in maintaining nurses’ psychological health, HRQOL and job satisfaction. Therefore, managers in hospitals should address the issue of recognition at work as a potential personal, professional and organisational lever.…”
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Investigation of Potential Profiles and Influencing Factors of Voice Behavior among Chinese Nurses by Shuangying Huang, Hanwen Chen, Liyan Zhang, Xianming Weng, Lingming Zhou, Xiaoqin Ma, Weiyi Wang

“…Heterogeneity was observed in the voice behavior of nurses, suggesting variations among individuals. The focus of nurse managers should be on nurses belonging to the C1 and C2 group, enabling them to implement early targeted prevention and care based on the distinctive characteristics and influencing factors associated with each latent profile.…”
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Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults by Florence Ader, Jean-François Timsit, Yazdan Yazdanpanah, François-Xavier Lescure, Laetitia Moinot, Christelle Delmas, Hélène Espérou, Laurent Abel, Benjamin Leveau, Vinca Icard, Toni Alfaiate, Linda Wittkop, Charles Burdet, France Mentré, Marion Schneider, Nathan Peiffer-Smadja, Julien Poissy, Lila Bouadma, Bruno Lina, Florence Morfin-Sherpa, Maude Bouscambert, Alexandre Gaymard, Gilles Peytavin, Jeremie Guedj, Claire Andrejak, Cedric Laouenan, Drifa Belhadi, Axelle Dupont, Basma Basli, Anissa Chair, Samira Laribi, Julie Level, Marie-Capucine Tellier, Aline Dechanet, Dominique Costagliola, Sandrine Couffin-Cadiergues, Juliette Saillard, Claire Fougerou, Carole Cagnot, Soizic Le Mestre, Delphine Lebrasseur-Longuet, Ventzislava Petrov-Sanchez, Alpha Diallo, NoéMie Mercier, Sarah Tubiana, Benjamin Hamze, Ambre Gelley, Marion Noret, Eric D’Ortenzio, Oriane Puechal, Caroline Semaille

“…The objective of the trial is to evaluate the clinical efficacy and safety of different investigational re-purposed therapeutics relative to Standard of Care (SoC) in patients hospitalised with COVID-19.Methods and analysis DisCoVeRy is a phase III, open-label, adaptive, controlled, multicentre clinical trial in which hospitalised patients with COVID-19 in need of oxygen therapy are randomised between five arms: (1) a control group managed with SoC and four therapeutic arms with re-purposed antiviral agents: (2) remdesivir + SoC, (3) lopinavir/ritonavir + SoC, (4) lopinavir/ritonavir associated with interferon (IFN)-β−1a + SoC and (5) hydroxychloroquine + SoC. …”
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Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts by Arbi Guetat, Slimen Selmi, Abdelrhman T. Abdelwahab, Marwa A. Abdelfattah, Abd Ealrhman M. Elhaj, Roaa T. Mogharbel, M. J. A. Abualreish, Abdullah F. Alanazi, Karim Hosni, Naceur Mejri, Abdennacer Boulila

“…The presence of several phenolic compounds (derivatives of ferulic, coumaric, and caffeic acids, among other derivatives) could at least in part explain the obtained data and empower the use of S. deserti as a source of bioactive ingredients with antioxidant, antidiabetic and antihyperlipidemic properties.DiscussionOur research has unveiled S. deserti as a source of potential to effectively manage diabetes and its associated dyslipidemia by improving antioxidant status, recovery of the liver and kidney functions and presumably by increasing insulin secretion and sensitivity of peripheral tissues to insulin.…”
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Effect of a nutritional immunomodulator in dry cows heat stressed with an electric blanket model by L.T. Casarotto, L. Cattaneo, K.M. Glosson, B.D. Humphrey, J.D. Chapman, G.E. Dahl

“…After calving, all the cows were cooled and managed identically, and milk yield and composition were measured at each milking. …”
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Treatment of neovascular age-related macular degeneration: one year real-life results with intravitreal Brolucizumab by Settimio Rossi, Carlo Gesualdo, Ernesto Marano, Raffaele Perrotta, Maria Consiglia Trotta, Antonio Del Giudice, Francesca Simonelli

“…Finally, the presence of subretinal hyperreflective material correlates with lower visual recovery.DiscussionOur findings highlight the efficacy of Brolucizumab in managing wet-AMD and suggest its role for long-term efficacy in stabilizing retinal exudation and fluid accumulation, resulting in improved visual prognosis.…”
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The burden and outcomes of firearm injuries at two district-level emergency centres in Cape Town, South Africa: A descriptive analysis by L Bush, C Hendrikse, C Van Koningsbruggen, K Evans

“…Firearm injuries represent a substantial proportion of the trauma burden at district emergency centres in the Western Cape Province. Managing patients with firearm injuries is resource intensive, as evident by their high acuity, the need for operative care, the long length of stay, the high burden on emergency medical services with interfacility transfers and the high demand for tertiary care. …”
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Evaluation and diagnostic approach in patient with Perrault Syndrome by Rachael Christin Nathania, Steven Yulius Usman, Ekarini Aryasatiani

“…Avoiding aminoglycosides and excessive noise is crucial for managing hearing loss.…”
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Characteristics of the smallest brucellaphage with strong lytic ability by Hongbaiyu Liu, Hongbaiyu Liu, Youhong Zhong, Zhihong Zhang, Kehong Xu, Kehong Xu, Chunpeng Mao, Chunpeng Mao, Qiuju Yang, Lihua Yang, Binbin Yu, Ying Long, Ying Long, Xinyu Qin, Xinyu Qin, Liyuan Shi, Sheng Chang, Yuanying Shen, Peng Wang

“…This study significantly enriches the brucellaphage database and highlights the potential of Y17 as a biocontrol agent for managing brucellosis in endemic regions.…”
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Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review by Giulia Negro, Giulia Negro, Michele Rossi, Camillo Imbimbo, Alberto Gatti, Andrea Magi, Andrea Magi, Ildebrando Marco Appollonio, Ildebrando Marco Appollonio, Alfredo Costa, Alfredo Costa, Tino Emanuele Poloni, Tino Emanuele Poloni

“…Among these, the Hyperactivity–Impulsivity–Irritiability–Disinhibition–Aggression–Agitation (HIDA) and Psychosis (P) domains are particularly challenging to manage. Despite their prevalence, their underlying mechanisms and neuropathological correlates, remain poorly understood. …”
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An updated network meta-analysis of non-pharmacological interventions for primary hypertension in adults: insights from recent studies by Ziwen Chen, Qifu Li, Tao Xu, Xueli Zhou, Yunjie Shu, Taipin Guo, Fanrong Liang

“…The study reinforces the role of NPIs in managing primary hypertension, providing a foundation for future hypertension research.…”
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Exploration of key genes and pathways in response to submergence stress in red clover (Trifolium pratense L.) by WGCNA by Panpan Shang, Lei Bi, Wenwen Li, Xiaoli Zhou, Yanlong Feng, Jiahai Wu, Bing Zeng

“…Research on plant submergence stress tolerance has been essential in managing plant production under excessive rainfall. …”
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Data-driven insights into pre-slaughter mortality: Machine learning for predicting high dead on arrival in meat-type ducks by Chalita Jainonthee, Phutsadee Sanwisate, Panneepa Sivapirunthep, Chanporn Chaosap, Raktham Mektrirat, Sudarat Chadsuthi, Veerasak Punyapornwithaya

“…Additionally, considering these factors when managing transportation can help create conditions that reduce duck deaths.…”
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What activities do patients hope to perform following anatomic total shoulder arthroplasty but are unable to? Looking beyond patient-reported outcome measures by Alexander E. White, MD, Nicolas Pascual-Leone, MD, Anthony Finocchiaro, BS, Christopher M. Brusalis, MD, David M. Dines, MD, Joshua S. Dines, MD, Andreas Kontaxis, PhD, Samuel A. Taylor, MD, Lawrence V. Gulotta, MD, Michael C. Fu, MD, MHS

“…The majority of patients had no difficulty managing toileting (93.7%), driving a car (92.4%), washing their hair (91.9%), and putting on a seatbelt (90.7%). …”
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Durvalumab and tremelimumab in combination with metronomic oral vinorelbine for recurrent advanced cervical cancer: an open-label phase I/II study by Pernelle Lavaud, Esma Saada-Bouzid, Renaud Sabatier, Olivia Le Saux, Thibault de la Motte Rouge, Anthony Gonçalves, Elodie Coquan, Jean-Sébastien Frenel, Marta Jiménez, Alice Hervieu, Laurent Mathiot, François Legrand, Claire Cropet, Edith Borcoman, Emmanuelle Charafe

“…Toxicity was significant but manageable.…”
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The Role of Cardiac Resynchronization Therapy in Heart Failure: A Narrative Review by Olivier Uwishema, Ece Karabulut, Dalal Sheikhah, Burhan Kantawala, Misgana Gallo, Fatima Soufan, Magda Wojtara

“…Mendeley was used as a reference manager for formatting. Results Functional improvements and an enhanced quality of life across a diverse range of patients have been demonstrated using CRT. …”
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Temporal backscatter characterisation of ratoon rice crops based on Sentinel-1 intensity data by Vidya Nahdhiyatul Fikriyah, Roshanak Darvishzadeh, Alice Laborte, Jitender Rathore, Andrew Nelson

“…We also found no significant backscatter difference in ratoon crops across different water managements throughout all growth phases. This study demonstrates the potential of SAR Sentinel-1 time series data to determine periods and SAR features for optimal main and ratoon rice discrimination, which offers advantages for future remote sensing-based rice ratooning mapping and rice production estimation.…”
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The effects of mother-infant bonding on children's strengths and difficulties by Tomoko Kawasaki, Yoshikazu Noda, Yoshiyuki Hirano, Akiko Kawanami, Kenichi Sakurai, Chisato Mori, Eiji Shimizu

“…These findings can help parents better understand and manage these issues in their children for prevention and intervention.…”
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Snake-DETR: a lightweight and efficient model for fine-grained snake detection in complex natural environments by Heng Wang, Shuai Zhang, Cong Zhang, Zheng Liu, Qiuxian Huang, Xinyi Ma, Yiming Jiang

“…Additionally, we introduced the Enhanced Feature Extraction Backbone Network Based on Context Anchor Attention, which manages input information using multiple Enhanced Generalized Efficient Layer Aggregation Networks to retain essential spatial and semantic information. …”
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