What is the NCD service capacity and disruptions due to COVID-19? Results from the WHO non-communicable disease country capacity survey in the Americas region by Anselm Hennis, Silvana Luciani, Roberta Caixeta, Carolina Chavez, Dolores Ondarsuhu

“…Objective This article presents the Americas regional results of the WHO non-communicable diseases (NCDs) Country Capacity Survey from 2019 to 2021, on NCD service capacity and disruptions from the COVID-19 pandemic.Setting Information on public sector primary care services for NCDs, and related technical inputs from 35 countries in the Americas region are provided.Participants All Ministry of Health officials managing a national NCD programme, from a WHO Member State in the Americas region, were included throughout this study. …”
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Melatonin induces drought stress tolerance by regulating the physiological mechanisms, antioxidant enzymes, and leaf structural modifications in Rosa centifolia L by Muhammad Ahsan, Adnan Younis, Aftab Jamal, Mohammed O. Alshaharni, Uthman Balgith Algopishi, Abeer Al-Andal, Mateen Sajid, Muhammad Naeem, Jawad Ahmad Khan, Emanuele Radicetti, Mohammad Valipour, Gulzar Akhtar

“…Melatonin is considered an effective bio-stimulant that is crucial in managing several abiotic stresses including drought. …”
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Efficacy and safety of pembrolizumab in patients with advanced endometrial cancer: a systematic review and meta-analysis by Biqiong Pan, Xiaojun Lai, Jiefang Lu, Xiaoyan Bao, Zengke Fan, Jie Sun

“…Two randomized controlled trials (RCTs) found that the pembrolizumab group had a higher incidence of grade 3 or 4 AEs compared to the control group (OR: 2.23; 95% CI: 1.23, 4.04; p = 0.008).ConclusionPembrolizumab monotherapy or combination significantly improves survival in recurrent or advanced EC and has manageable toxicity albeit with a relatively high incidence of treatment-related AEs.…”
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Two-Dimensional Shear-Wave Elastography: Accuracy in Liver Fibrosis Staging Using Magnetic Resonance Elastography as the Reference Standard by Puwitch Charoenchue, Jiraporn Khorana, Taned Chitapanarux, Nakarin Inmutto, Wittanee Na Chiangmai, Amonlaya Amantakul, Suwalee Pojchamarnwiputh, Apichat Tantraworasin

“…<b>Background:</b> The accurate staging of liver fibrosis is crucial for managing chronic liver disease (CLD). Although magnetic resonance elastography (MRE) is the reference standard for noninvasive fibrosis assessment, its cost, specialized hardware, and operational demands restrict accessibility. …”
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Can integrated care interventions strengthen primary care and improve outcomes for patients with chronic diseases? A systematic review and meta-analysis by Yuqi Zhang, Jonathan Stokes, Laura Anselmi, Peter Bower, Jin Xu

“…Although primary care has a central role in managing chronic disease, and integration may be important in strengthening this role, previous research has shown insufficient attention to the relationships between primary care and integration. …”
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Shattering the Amyloid Illusion: The Microbial Enigma of Alzheimer’s Disease Pathogenesis—From Gut Microbiota and Viruses to Brain Biofilms by Anna Onisiforou, Eleftheria G. Charalambous, Panos Zanos

“…We discuss potential microbiome-based therapies as promising strategies for managing and potentially preventing AD progression. …”
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Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis by Jinhui Li, Simiao Chen, Lan He, Yangni Li, Weinan Yang, Yishu Zhang, Lincheng Zhang, Yuyan Zhang

“…The relevant data were extracted in order to conduct the meta-analysis. Review Manager V.5.2 was used to pool data and calculate the mean difference (MD) and its 95% CI. …”
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Comparative Evaluation of Functional Outcomes in High Condylar Fractures Treated with Closed Methods with and without Temporomandibular Joint Arthrocentesis: A Research Protocol fo... by Sachindra Dubey, Nitin Bhola, Anchal Agarwal

“…It has emerged as a valuable tool in the multidisciplinary approach to managing TMDs, offering patients a minimally invasive option to relieve their symptoms and restore jaw function. …”
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“It's a good idea, but…”: a qualitative evaluation of the GoldiCare intervention in Norwegian home care services by Heike Fischer, Fredrik Klæboe Lohne, Fredrik Klæboe Lohne, Marius Steiro Fimland, Skender Elez Redzovic

“…The objective of this qualitative process evaluation study was to gain insights into how the implementation outcomes of acceptability, appropriateness, feasibility, adoption and fidelity, respectively, impacted the implementation of the GoldiCare intervention.MethodsWe conducted ten individual interviews with operations managers and five focus group interviews with home care workers from the intervention units. …”
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Evaluating the Effectiveness of Parent Training Pamphlets: An Intervention Study Among Parents at Child Health Checkups by Kazuko Akutsu, Aya Goto, Fareeda Abo-Rass, Hiroyuki Yokoyama

“…In Japan, these programs are increasingly implemented to help parents manage behavioral issues in children. This study evaluated the effectiveness of PT pamphlets designed and distributed in Shioya Town, Japan, by comparing outcomes between the intervention and control groups and within subgroups of parents, categorized based on their children’s need for follow-up health checkups. …”
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Efficacy and safety of acupuncture for postoperative gastroparesis syndrome: a systematic review and meta-analysis by Yichuan Xv, Yiyi Feng, Jiang Lin

“…After study selection and data extraction, a meta-analysis was performed using Review Manager 5.4.1. Study quality was assessed with the Cochrane risk of bias tool, and publication bias was quantitatively evaluated using Egger’s test and was corrected using the trimming and filling method.ResultsA total of 12 RCTs involving 709 participants (363 in the acupuncture group and 346 in the control group) were included. …”
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Optimizing the selection of quantitative traits in plant breeding using simulation by Rafael Augusto Vieira, Ana Paula Oliveira Nogueira, Roberto Fritsche-Neto

“…Using markers accelerates breeding cycles when marker placement is precise, foreground and background selection are balanced, and QTL are effectively managed. Genomic selection increases genetic gains by shortening breeding cycles and improving parent selection, especially for low heritability traits and complex genetic architectures. …”
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Prevalence of sudden unexpected death of infants and its subcategories in low- or middle-income countries: a systematic review protocol by Liesl Zühlke, David Coetzee, Mark Engel, Natasha R Rhoda, Eunice Turawa, Imen Ayouni, Shanaaz Mathews

“…We will use the tool developed by the South African Medical Research Council—Burden of Disease Review Manager (BODRevMan)—to assess the risk of bias for each included study. …”
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Inverted Internal Limiting Membrane Flap Technique versus Internal Limiting Membrane Peeling for Vitrectomy in Highly Myopic Eyes with Macular Hole-Induced Retinal Detachment: An U... by Ling Ling, Yao Liu, Baixing Zhou, Feifei Gao, Zhe Hu, Man Tian, Yiqiao Xing, Kaibao Ji, Tao Sun, Wentian Zhou

“…The outcomes in the collected articles included the postoperative MH closure rate, retinal reattachment rate, and best-corrected visual acuity (BCVA). Review Manager (version 5.3) was used for analyses. Results. …”
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Clinical and Biological Characteristics of Severe Malaria in Children under 5 Years Old in Benin by Xiao Ma, Xin Fan, Kora Chabi Youssaou, Junfei Zhang, Xingyi Wang, Guoqiang Zheng, Shuping Tian, Yujing Gao

“…We analyzed the clinical characteristics and laboratory indicators of children with severe malaria in Benin to provide important information for designing effective prevention and treatment strategies to manage pediatric cases. Methods. Clinical characteristics of pediatric patients with severe malaria admitted to two hospitals in Benin (Central Hospital of Lokossa and Regional Hospital of Natitingou, located ∼650 kilometers apart) were collected from January to December 2020. …”
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Mechanistic insights into Y-Box binding protein-1 mediated regulation of lipid metabolism and oxidative stress in NAFLD via INHBE/TNF-β pathway by Zhi Ren, Rui Wang, Jun Wei, Zhenzeng Ma, Xiquan Ke

“…These findings provide valuable insights into novel therapeutic strategies for managing NAFLD. …”
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Usefulness of a TDM-Guided Approach for Optimizing Teicoplanin Exposure in the Treatment of Secondary Bloodstream Infections Caused by Glycopeptide-Susceptible <i>Enterococcus faec... by Milo Gatti, Matteo Rinaldi, Maddalena Giannella, Pierluigi Viale, Federico Pea

“…Targeted TDM-guided teicoplanin therapy, coupled with effective source control of the primary infection site by granting microbiological eradication in the vast majority of cases, may be considered a reasonable strategy for managing glycopeptide-susceptible <i>Enterococcus faecium</i> secondary BSIs.…”
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Study protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv): a multicentre phase II randomised controlled trial to evaluate the efficacy of adaptive therapy (AT) with carbo... by Michelle Lockley, Kathy Robinson, Rowan Miller, Charlie Gourley, Nicholas Counsell, Iain Mcneish, Trevor Graham, Uma Anne Mukherjee, Helen Hockings, Apini Patel, Priya Narayanan, Katie Wilkinson, Harjot Dhanda, Alexander R A Anderson

“…ACTOv is open to National Health Service hospitals throughout the UK, recruitment is anticipated to take 36 months across 10 sites and will be managed by the Cancer Research UK and University College London Cancer Trials Centre.Ethics and dissemination The trial has been reviewed and received approval from the London—Dulwich Research Ethics Committee (REC). …”
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Anti-inflammatory effects of Andrographis paniculata (Fah Talai Jone) via TNFα-JNK pathway and bioactive compound identification by Praphat Manuelo Ruengthanoo, Areeya Changthong, Pranee Sriraj, Jatuporn Prathumtet, Nutchapon Laikaew, Ratchadawan Aukkanimart

“…These findings support its potential as a natural therapeutic agent for managing inflammation.…”
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Prehospital video triage of suspected stroke patients in Greater Manchester: pilot project report by Christopher Ashton, Adrian R Parry-Jones, Lisa Brunton, Ibrahim Alghamdi, David A Jenkins

“…Paramedics found PHVT improved confidence in managing stroke patients. Hospital clinicians believed it provided valuable prearrival patient information, enhancing preparation. …”
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