Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment by Takayasu Nishimaki, MD, Hitoshi Sasano, MD, PhD, Sonoko Harada, PhD, Tomohito Takeshige, MD, PhD, Yuuki Sandhu, MD, PhD, Yuki Tanabe, MD, Kei Matsuno, MD, PhD, Tetsutaro Nagaoka, MD, PhD, Jun Ito, MD, PhD, Ryo Atsuta, MD, PhD, Mayu Ohuchi, PhD, Shigehiro Yagishita, MD, PhD, Akinobu Hamada, PhD, Kazuhisa Takahashi, MD, PhD, Norihiro Harada, MD, PhD

“…However, patients with severe asthma may require biologics, such as mepolizumab, which targets IL-5 and can manage uncontrolled eosinophilic asthma. Objective: We investigated the relationship between serum mepolizumab concentrations and treatment response in patients with severe asthma. …”
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Usefulness of Mechanical Thrombectomy in Patients with Cancer Who Developed Cerebral Infarction by Sayaka TERAZONO, Yuki SAKAEYAMA, Yutaka FUCHINOUE, Masataka MIKAI, Shuhei KUBOTA, Mitsuyoshi ABE, Kosuke KONDO, Nobuo SUGO, Takaaki NAGAO, Masaaki NEMOTO

“…Aggressive treatment may be recommended to patients with cancer and/or a history of cancer who present with a systemic condition that can be managed with MT.…”
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Increased sensitivity in electron–nuclear double resonance spectroscopy with chirped radiofrequency pulses by J. Stropp, N. Wili, N. C. Nielsen, D. Klose

“…In 2D triple resonance experiments (TRIPLE), the signal increase exceeds 10 times for some lines, thus making chirped 2D TRIPLE experiments feasible even for broad peaks in manageable acquisition times.</p>…”
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Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout by Bin Yang, Bin Yang, Guihu Luo, Tailei Nie, Zhenglan Ban, Quanxin Ning, Jialin Zhang, Xiangru Liu, Yanhua Lin, Xiaochun Xie, Qianyun Chen, Han Zhong, Ying Huang, Pan Liao, Yan Liu, Chenyang Guo, Chuanxu Cheng, Erwei Sun, Erwei Sun

“…IntroductionUricase replacement therapy is a promising approach for managing hyperuricemia and gout but is hindered by challenges such as short blood circulation time, reduced catalytic activity, and excessive hydrogen peroxide (H2O2) production. …”
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Endovascular Treatment of Mirror Aneurysms in Subarachnoid Hemorrhage Patients: Single Stage or Multiple Stage? by Yunfei Song, Guoqiang Song, Guijing Liu, Limei Mao, Xiuhu An, Chao Peng, Jian Li, Yan Chen, Hongwen Li, Changkai Hou, Bangyue Wang, Yan Zhao, Xiangdong Wang, Gangfeng Yin, Xinyu Yang

“…In the single‐stage cohort, all 114 aneurysms in 57 patients were managed during a single session. During the 2‐year follow‐up, it was observed that 49 patients achieved a modified Rankin Scale score ≤2. …”
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Leo Tolstoy’s Principle of Non-Resistance to Evil by Violence and Its Criticism in Ivan Ilyin’s Philosophy by Igor I. Evlampiev, Wang Yue

“…In his later teaching, though, he emphasized the need for people to transition from a lower ‘animalistic’ form of life towards the divine form; his principle of non-resistance to evil by violence could only apply to those who managed such a transition. According to Tolstoy, the divine life means an unmediated spiritual unity of people, enabling them to influence one another directly without any material sources. …”
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Cost-effectiveness analysis of pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in the Chinese healthcare system by Wenwang Lang, Yulong He, Changchun Hou, Hua Li, Qinling Jiang, Liuyong Mei

“…Outcomes measured included quality-adjusted life years (QALYs), incremental cost-effectiveness ratio (ICER), incremental net health benefit (INHB), and incremental net monetary benefit (INMB). To manage the uncertainty in the model, both probabilistic sensitivity analysis (PSA) and one-way sensitivity analysis (OWSA) were used.ResultsIn the base-case analysis, pembrolizumab plus chemotherapy resulted in an incremental gain of 0.23 QALYs at an additional cost of $18,199.63, resulting in an ICER of $80,557.23/QALY. …”
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Efficacy and safety of once-weekly semaglutide monotherapy in a young subject with Prader-Willi syndrome, obesity, and type 2 diabetes: a case report by Elisa Dinoi, Giuseppe Daniele, Giuseppe Daniele, Angela Michelucci, Fulvia Baldinotti, Fabrizio Campi, Piero Marchetti, Stefano Del Prato, Angela Dardano, Angela Dardano

“…The patient was discharged on a basal-bolus insulin therapy managed by his parents due to his cognitive impairment. …”
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The current status and influencing factors of diabetes knowledge among non-endocrinology nurses of tertiary general hospitals: a cross-sectional survey study by Jia Song, Su Li, Chongcai Gu, Shiyan Zhao, Xing Li, Siqin Liu, Jinmei Tuo, Shiming Huang

“…There is a gap between non-endocrinology nurses’ self-perception of diabetes knowledge and their actual knowledge level. Therefore, nursing managers should prioritize diabetes knowledge training for nurses in non-endocrinology departments, develop practical training programs based on nurses’ needs, enhance their diabetes care knowledge, and provide higher quality care services to patients.…”
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Associations between heavy metal exposure and vascular age: a large cross-sectional study by Yuntao Feng, Chengxing Liu, Litang Huang, Jun Qian, Na Li, Hongwei Tan, Xuebo Liu

“…The findings underscore the importance of considering sex-specific responses and interventions measures in cardiovascular risk assessments and managements. Further research is needed to validate these findings and to develop more precise public health strategies targeting environmental risks. …”
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Prevalence and Distribution of Nonsyndromic Dental Anomalies in Children in Eastern Saudi Arabia: A Radiographic Study by Eman A. Bakhurji, Fatima Aldossary, Jood Aljarbo, Fatimah AlMuhammadi, Maysaa Alghamdi, Muhammad Ashraf Nazir

“…The study findings may guide dental practitioners to better diagnose and manage children with dental anomalies in eastern Saudi Arabia.…”
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Electricity Theft Detection Using Machine Learning in Traditional Meter Postpaid Residential Customers: A Case Study on State Electricity Company (PLN) Indonesia by Alief Pascal Taruna, Galih Arisona, Dwi Irwanto, Arif Bijak Bestari, Wildan Juniawan

“…Electricity theft is a major challenge for PT PLN (Persero), particularly in managing 27 million postpaid customers, most of whom still use traditional meters. …”
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Influence of long-term supplementation of a formulated botanical blend on growth performance and carcass traits in feedlot steers by Thiago Lauro Maia Ribeiro, Becca B. Grimes Francis, Erin R. DeHaan, Cassidy R. Ross, Justin J. Delver, Forest L. Francis, Jeff S. Heldt, Emma H. Wall, Warren C. Rusche, Zachary K. Smith

“…Steers were fed twice daily, and bunks were managed according to a slick bunk system. Results There were no differences (p≥0.10) in any growth performance outcomes from d 1 to 35, 36 to 70, or 71 to 98. …”
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Effectiveness of interventions for the prevention of occupational violence against professionals in health services: a protocol for a systematic review by Caroline Vieira Cláudio Okubo, Renata Cristina Campos Pereira Silveira, Maria José Quina Galdino, Daiane Rubinato Fernandes, Aline Aparecida Oliveira Moreira, Júlia Trevisan Martins

“…Statistical analyses will be performed using the software Cochrane Review Manager, and a meta-analysis will be performed if possible for the statistical combination of at least two studies. …”
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Genomic identification, evolutionary analysis, and transcript profiling of protein phosphatase 2C in Solanum lycopersicum by Miah Mohammad Sakib, Md. Sifatul Islam, Asifur Rob Bhuya, Md. Rihan Kabir Shuvo, Mohammad Abdullah-Al-Shoeb, Muhammad Abul Kalam Azad, Ajit Ghosh

“…These findings add to the comprehension of the evolutionary history and significance of tomato PP2C in managing abiotic stress and pave the way for additional verification of the functional aspect of these PP2C genes in tomato.…”
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Study of the Environmental Kuznets Curve in the EU27 Countries Taking into Account Socio-Economic Factors and GHG and PM Emissions by Alicja Kolasa-Więcek, Iveta Šteinberga, Agnieszka A. Pilarska, Dariusz Suszanowicz, Małgorzata Wzorek

“…The EKC approach can be successfully used both in system awareness (qualitative) and quantitative studies to prepare scenarios of changes in greenhouse gas and PM emissions and to create strategic planning, manage resources, promote innovation, and in climate policy.…”
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Signal Processing-Free Intelligent Model for Power Quality Disturbances Identification by Mohammed F. Al-Mashdali, Asif Islam, Abdulbasit Hassan, Md Shafiullah, Mujahed Al-Dhaifallah, Khalid Al Fuwail

“…The results demonstrate that these simple CNN models maintain stable accuracy values in normal and noisy environments, even with increasing classes and noise, the models managed to maintain a high-performance level with up to 99.39% accuracy for 17 classes when the Adam optimizer was used instead of RMSprop. …”
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Legitimate Expectations as an Object of Corporate Legal Relations by S. O. Slipchenko, Yu. M. Zhornokui

“…It is applied both to the violation of the right to manage the corporation (in case of failure to notify about the general meeting of participants) and the refusal to repurchase shares from a shareholder as the exercise of the “right to disagree”. …”
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Efficacy and safety of first-line nivolumab plus ipilimumab treatment in elderly patients (aged ≥ 75 years) with non-small cell lung cancer by Satoshi Endo, Hisao Imai, Atsuto Mouri, Kasumi Tsukamoto, Kenji Masaki, Kosuke Hashimoto, Yu Miura, Ayako Shiono, Ou Yamaguchi, Junichi Nakagawa, Kyoichi Kaira, Kunihiko Kobayashi, Hiroshi Kagamu

“…Although there was an increased incidence of pneumonitis, the treatment was manageable and presented as a viable treatment option. …”
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Comparative study of polymeric nanoparticles and traditional agents in dental implant decontamination by Håvard J Haugen, Jaime Bueno, Badra Hussain, Raquel Osorio, Mariano Sanz

“…This research contributes to developing targeted decontamination protocols to manage peri-implant diseases and improve long-term implant outcomes.…”
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