The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development by Baimei Zhao, Eugenie Nepovimova, Qinghua Wu

“…PER1 orchestrates the cooperation of the enzyme GPX1, modulating mitochondrial dynamics in sync with daily rhythms and oxidative stress, thus regulating the mechanisms managing energy substrates. PERs in innate immune cells modulate the temporal patterns of NF-κB and TNF-α activities, as well as the response to LPS-induced toxic shock, initiating inflammatory responses that escalate into chronic inflammatory conditions. …”
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Health-economic evaluation of the outpatient, inpatient, and public health sector in Germany: Insights from the first three COVID-19 waves. by Afschin Gandjour

“…<h4>Aim</h4>The aim of this study is to quantify the effectiveness and cost-effectiveness of the outpatient and inpatient sectors (specifically intensive care units, ICUs) and local health departments in managing the first three waves of the COVID-19 pandemic in Germany.…”
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Stroke in the newborn. Clinical report and literature review by R. Jakuškienė, V. Joneliūnaitė, U. Jucevičiūtė

“…Clinical practice reveals that there are no common guidelines to diagnose and manage perinatal stroke as an extremely urgent pathology which has a significant impact on a child’s further mental development. …”
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Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study by Juan Antonio Carrillo-Norte, Guillermo Gervasini-Rodríguez, María Ángeles Santiago-Triviño, Virginio García-López, Rafael Guerrero-Bonmatty

“…This study provides valuable insights into the efficacy and safety of collagen peptides in managing knee OA symptoms.…”
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Early Refractive and Clinical Outcomes of High-Myopic Photorefractive Keratectomy as an Alternative to LASIK Surgery in Eyes with High Preoperative Percentage of Tissue Altered by Nir Sorkin, Amir Rosenblatt, David Smadja, Eyal Cohen, Marcony R. Santhiago, David Varssano, Yossi Yatziv

“…The rate of stromal haze, managed successfully with topical steroids only, was 4.8%. …”
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Decanoic acid-enriched ketogenic diet in refractory epilepsy by Hui Jin Shin, Seonae Ryu, NaRae Lee, Eunjoo Lee, Ara Ko, Hoon-Chul Kang, Joon Soo Lee, Se Hee Kim, Heung Dong Kim, Heung Dong Kim

“…Adverse effects included transient hypoglycemia, metabolic acidosis, hypercalciuria, and gastrointestinal symptoms, all of which were manageable.DiscussionThe C10-enriched KD demonstrated comparable efficacy and tolerability to the classic KD, offering a promising option for patients with refractory epilepsy who do not respond adequately to the classic KD alone. …”
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Long-term Breast Shape Analysis After Short-scar Reduction Mammaplasty: A Critical View by Daniel Hilewitz, MD, Oren Ganor, MD, Neta Adler, MD, Asaf Olshinka, MD, Dafna Shilo Yaacobi, MD, Lior Har-Shai, MD, Tamir Shay, MD, Michael Icekson, MD, Dean Ad-El, MD, Sagit Meshulam-Derazon, MD

“…However, many surgeons are still hesitant to use it routinely because of the uncertainty of the effectiveness of vertical scar techniques in managing lower pole skin excess. We aimed to test its efficacy by using objective anthropometric measurements to evaluate long-term breast shape and lower pole stability. …”
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Resistance of potato cultivars and hybrid clones from the VIR collection to the northwestern population of <i>Phytophthora infestans</i> by N. M. Zoteyeva, O. S. Kosareva, E. V. Rogozina, N. A. Chalaya

“…Due to the changes in the pathogen population, the late blight disease caused by P. infestans is still difficult to manage. Economic losses are caused by the susceptibility of potato foliage or tubers to late blight, and both expressions of susceptibility are often not interconnected. …”
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Short-term and long-term revision rates after lumbar spine discectomy versus laminectomy: a population-based cohort study by Yao-Chun Hsu, Feng-Chen Kao, Chang-Bi Wang, Yuan-Kun Tu, Pao-Hsin Liu

“…Background/objective Degenerative diseases of the lumbar spine were managed with discectomy or laminectomy. This study aimed to compare these two surgical treatments in the postoperative revision rates.Design A population-based cohort study from analysis of a healthcare database.Setting Data were gathered from the Taiwan National Health Insurance Research Database (NHIRD).Participants We enrolled 16 048 patients (4450 women and 11 598 men) with a mean age of 40.34 years who underwent lumbar discectomy or laminectomy for the first time between 1 January 1997 and 31 December 2007. …”
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Reinforcement Learning-Based Sequential Control Policy for Multiple Peg-in-Hole Assembly by Xinyu Liu, Chao Zeng, Chenguang Yang, Jianwei Zhang

“…This approach introduces human knowledge to manage intermediate states, such as lifting height and aligning direction, thereby enabling flexible deployment across various scenarios. …”
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“Rat race” or “lying flat”? The influence of performance pressure on employees' work behavior by Qianyi Liao, Jinsong Zhang, Fangfang Li, Shiyuan Yang, Zhen Li, Longhua Yue, Cunfang Dou

“…These insights provide practical guidance for managing performance pressure and minimizing associated risks in the workplace.…”
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Human Strategy Learning-Based Multi-Agent Deep Reinforcement Learning for Online Team Sports Game by Seongbeen Lee, Gyuhyuk Lee, Wongyeom Kim, Junoh Kim, Jisun Park, Kyungeun Cho

“…Nevertheless, applying multi-agent reinforcement learning-based AI in commercial online basketball games presents significant challenges, particularly in ensuring real-time processing, which requires efficient methods for managing observational data. In addition, the stochastic nature of action selection in reinforcement learning complicates the accurate learning of behaviors through explicit decision data. …”
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Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review by Dan Wang, Yu Chen, Hua Duan, Shu-Yue Zheng, Chufan Luo, Xueni Fang, Haoyue Pang, Man Wang, Tian Zhou, Quanwang Li, Kaiwen Hu

“…The strength of evidences will be evaluated according to the Grading of Recommendations Assessment, Development and Evaluation approach. Review Manager V.5.3 software will be used for data analyses. …”
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Long-Term Stability and Osteogenic Activity of Recycled Polysulfone-Calcium Silicate Bone Implants In Vitro by Chi-Nan Chang, Yun-Ru Huang, Shinn-Jyh Ding

“…Our findings revealed that, while the bending strength of PSF-based composites declined with prolonged exposure to SBF, the dissolution of CaSi particles led to a manageable weight loss of about 4% after 12 months, regardless of pH 7.4 or 5.0. …”
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The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease by Shiyuan Wang, Yan Huang, Cili Zhou, Huangan Wu, Jimeng Zhao, Luyi Wu, Min Zhao, Fang Zhang, Huirong Liu

“…Accumulating evidence demonstrates that microRNA- (miR-) mediated posttranscriptional regulation plays an important role in autophagy in inflammatory bowel disease (IBD), a disease that is difficult to manage clinically because of the associated chronic recurrent nonspecific inflammation. …”
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Evaluation of Toxicological Risks and Effects of Microplastics on Nile Tilapia (Oreochromisniloticus) under in Vitro Laboratory Conditions by Macarius Pancras Mtega, Matobola Joel Mihale, Kessy Fidel Kilulya

“…Knowing the effects of microplastics to fresh water fish which are kept in ponds helps in managing fish keeping practice. The objective of research was to determine the toxicity of microplastics to Nile tilapia (Oreochromis niloticus). …”
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Protocol to assess bottlenecks inhibiting the scaling up of evidence-based family planning practices in low-income and middle-income countries using mixed methods by James Kiarie, Moazzam Ali, Rita Kabra, Komal Preet Allagh, Kathryn Church, Abdulmumin Saad, Petrus Steyn

“…To gain a better understanding of the factors that may be hindering the sustained scale-up of these interventions, WHO has developed an assessment protocol to systematically identify the health systems’ ‘bottlenecks’ to implementation and to then identify solutions and develop strategies to address them.Methods and analysis A mixed method approach that includes document review, secondary data analysis (from surveys, service delivery data and case studies) and key informant interviews with policymakers, programme managers, health providers and community groups will be used to identify bottlenecks. …”
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“Does the Response to Morning Medication Predict the ADL-Level of the Day in Parkinson’s Disease?” by Trine Hørmann Thomsen, Troels Wesenberg Kjær, Lene Bastrup Jørgensen, Anita Haahr, Kristian Winge

“…Individuals with Parkinson’s Disease (PD) have bradykinesia during mobility tasks in the morning before intake of dopaminergic treatment and have difficulties managing Activities of Daily Living (ADLs). Early morning off (EMO) refers to off-states in the morning where the severity of bradykinesia is increased and causes a decrease in mobility related to wearing off of effects of medication. …”
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Numerical Modeling and Structure Optimization for Magnetic Levitation Planar Machine Using PCB Coils by Han Zhang, Jiawen He, Xianze Xu, Rui Wang, Manman Xu, Fengqiu Xu

“…However, due to the high resistance of PCB coils, managing heat generation has become a significant area of study. …”
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Striving for consistency in a national lake assessment: Defining reference status and littoral macroinvertebrate condition in lakes across the conterminous United States by Richard M. Mitchell, Alan T. Herlihy, Robert M. Hughes

“…Using these five MMIs with the 2022 survey data, an estimated 44% of the lakes were in good condition, whereas 27% were in poor condition. Our MMIs offer managers valuable tools for assessing lakes at large ecoregional and continental extents.…”
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