Cost savings of reducing opioid prescribing for the treatment of people with low back pain in general practice: a modelling studyResearch in context by Anagha Killedar, Romi Haas, Alexandra Gorelik, Sean Docking, Rachelle Buchbinder, Chris G. Maher, Chung-Wei Christine Lin, Alison Hayes

“…Contrary to clinical guidelines, opioids are frequently prescribed early in the management of LBP in primary care, leading to potential harm and downstream healthcare costs. …”
Get full text

Evaluating NfL and NTproBNP as predictive biomarkers of intracranial injuries after mild traumatic brain injury in children presenting to emergency departments by Anne-Cécile Chiollaz, Virginie Pouillard, Michelle Seiler, Céline Habre, Fabrizio Romano, Céline Ritter Schenck, Fabian Spigariol, Christian Korff, Fabienne Maréchal, Verena Wyss, Lyssia Gruaz, Joan Montaner, Jean-Charles Sanchez, Sergio Manzano

“…ObjectiveBlood-biomarkers have the potential to aid clinicians in pediatric emergency departments (PED) in managing children with mild traumatic brain injury (mTBI) acutely. …”
Get full text

Predictive nomograms of repeat intrahepatic recurrence and overall survival after radiofrequency ablation of recurrent colorectal liver metastases by Ji-Chen Wang, Bin-Bin Jiang, Zhong-Yi Zhang, Yu-Hui Liu, Li-Jin Shao, Song Wang, Wei Yang, Wei Wu, Kun Yan

“…In both cohorts, the nomogram demonstrated good discrimination and calibration.Conclusions The established nomograms can predict individual risk of rIHR and OS after RFA for recurrent CLMs and contribute to improving individualized management.…”
Get full text

Modeling Lake Titicaca's water balance: the dominant roles of precipitation and evaporation by N. Lima-Quispe, D. Ruelland, A. Rabatel, W. Lavado-Casimiro, T. Condom

“…These results will be useful for supporting decision-making in water resource management. We demonstrate that a simple representation of hydrological processes and irrigation enables accurate simulation of water levels. …”
Get full text

Antioomycete Nanoformulation for Biocontrol of English Walnut Crown and Root Rot Caused by <i>Phytophthora cinnamomi</i> by Aldo Salinas, Iván Montenegro, Yusser Olguín, Natalia Riquelme, Diyanira Castillo-Novales, Alejandra Larach, Laureano Alvarado, Guillermo Bravo, Alejandro Madrid, Juan E. Álvaro, Ximena Besoain

“…This research is the first to study the use of nanoemulsions from native Chilean plants to control <i>P. cinnamomi</i>, showing potential to reduce the use of synthetic fungicides, contributing to safer and more ecological phytosanitary management.…”
Get full text

Survey on the presence of floating microplastics, trace metals and metalloids in seawater from Southern Italy to the United States of America by Elisabetta Morici, Gaetano Cammilleri, Sergio Scirè, Francesco Paolo Bonomo, Luigi Tranchina, Francesca Terracina, Paola Galluzzo, Vincenzo Ferrantelli, Vincenzo Paolo Monteverde, Francesco Giuseppe Galluzzo, Sergio Davì, Mariano Licciardi, Salvatore Dara

“…Here, we emphasize the need for sustainable environmental management actions and policies in a global context to monitoring the growing problem of pollutants in our oceans.…”
Get full text

Composition and the predicted functions of fungal communities and the key drivers in acidic soils of Jiaodong Peninsula, China by Jing Liu, Zafran Gul Wazir, Guoqin Hou, Guizhen Wang, Fangxu Rong, Yuzhi Xu, Kai Liu, Mingyue Li, Aiju Liu, Hongliang Liu, Hongwen Sun

“…As being more tolerant than bacteria to soil acidification, so it would be more meaningful for agricultural management and crop yield to characterize fungal community in acidic soils and manifest its key drivers.MethodThis study investigated the composition and diversity of fungal communities and its key driving factors by collecting 90 soil samples from the acidic region of Jiaodong Peninsula China, spanning 3 × 104 km2.ResultsThe results indicated that most soil pH values ranged from 5.01 to 6.42, and the exchangeable acidity (EA) content raised significantly (p &lt; 0.01) along with soil acidic degree increasing. …”
Get full text

PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response by Tian L, Wang Z, Lei T, Feng L, Li Y, Wang K, Zhang Y, Zhang C, Liu J, Xing H, Ren W

“…Compared to the control group, treatment with PLL-g-HPA hydrogel in conjunction with hUC-MSCs significantly enhanced wound healing, modulated inflammatory responses, and promoted angiogenesis as well as re-epithelialization in rat models.Conclusion: The PLL-g-HPA hydrogel in conjunction with hUC-MSCs represents a promising therapeutic approach for the management of burn wounds.Keywords: rat burn model, wound healing, human umbilical cord mesenchymal stem cells, p-hydroxyphenylacetic acid grafted poly-l-ysine hydrogel…”
Get full text

Unpacking the benefits of black soldier fly frass fertilizer towards nematode suppression and potato production by Emmanuel O. Anedo, Emmanuel O. Anedo, Emmanuel O. Anedo, Dennis Beesigamukama, Benson Mochoge, Nicholas K. Korir, Solveig Haukeland, Solveig Haukeland, Xavier Cheseto, Moses Nyongesa, Patrick Pwaipwai, Sevgan Subramanian, Abdou Tenkouano, Betty Kibaara, Chrysantus M. Tanga

“…Mineral fertilizers and synthetic nematicides are costly and cause negative impacts on humans and the environment, while organic fertilizers are less effective for soil health and nematode management. This study demonstrates the contribution of black soldier fly frass fertilizer (BSFFF) in nematode suppression and potato productivity when compared to commercial mineral fertilizer, organic fertilizer (SAFI), and nematicide. …”
Get full text

Ciphertext policy hidden access control scheme based on blockchain and supporting data sharing by Ruizhong DU, Tianhe ZHANG, Pengliang SHI

“…Secondly, the distributed management of ciphertext is realized by using Ethereum and Interstellar file system.Afterwards,the use of prime order bilinear groups improves the pairing efficiency of bilinear pairs and realizes data sharing by combining proxy re-encryption technology.…”
Get full text

The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis by Heba E. Hashem, Rania M. Abdel Halim, Sherin A. El Masry, Amira M. Mokhtar, Noureldin M. Abdelaal

“…For this purpose, last decades have witnessed a challenge between the battery of sepsis biomarkers including many leukocyte surface antigens, not only for early diagnostic purposes but also for better follow-up and good management of sepsis patients. Aim. To evaluate the diagnostic, prognostic, and monitoring performance of both neutrophil CD64 (nCD64) and presepsin as sepsis biomarkers compared to each other and to the conventional laboratory sepsis parameters aiming to decide which is the best fitting for routine daily use in neonatal intensive care units (NICUs). …”
Get full text

Helping people with psychosis with a low-cost intervention DIALOG+: protocol for the economic evaluation in a randomised control trial in India and Pakistan by Victoria Jane Bird, Sara Evans-Lacko, Lakshmi Venkatraman, Padmavati Ramachandran, Ashar Muhammad Malik, Renata Peppl, Sana Zehra Zehra Sajun, Onaiza Qureshi, Krishna Priya, Hufsa Sarwar

“…The economic evaluation will support efforts to scale up low-cost healthcare interventions such as DIALOG+ to rural and unserved areas, which is otherwise challenging in the resource-constrained health systems in many LMICs.Conclusion The evidence on the cost-effectiveness of DIALOG+ will contribute to efforts to improve community-based care and the quality of life for millions of people suffering from mental health problems in India and Pakistan who experience psychosis.Ethics and dissemination This study is approved by the Queen Mary Ethics of Research Committee (UK), Institutional Ethics Committee of SCARF (India), IRD’s Independent Institutional Review Board (IRD_IRB_2021_01_005) (Pakistan), Karawan-e-Hayat Management Committee (Institutional Approval) (Pakistan), Jinnah Postgraduate Medical Centre Research Committee (NO.F.2-81/2021-GENL/60224/JPMC) (Pakistan), Aga Khan’s Ethics Research Committee (2021-5933-17533) (Pakistan) and National Bio-Ethics Committee, Pakistan (Ref: No.4–87/NBC-774/22/2037 Date: 17 May 2022).The findings of this research will be widely disseminated through research publications and engagement with the communities and the healthcare providers in the public and not-for-profit sectors.Trial registration number ISRCTN13022816.…”
Get full text

Liver Radioembolization: a New Chapter in Russian Oncology by A. D. Kaprin, S. A. Ivanov, V. V. Kucherov, A. P. Petrosyan, K. V. Mayorov, N. V. Markov, L. O. Petrov, G. A. Davydov, M. A. Sigov, N. K. Silantieva, T. P. Berezovskaya, A. Yu. Usacheva, D. B. Sanin

“…The production of microspheres containing 90Y in Russia, as well as a technical improvement of the procedure, will facilitate the introduction of liver radioembolization into the routine management of patients with malignant liver tumours.…”
Get full text

Nationwide cervical precancer screening in Ghana: concurrent HPV DNA testing and visual inspection under an expanded hub-and-spoke model by Kofi Effah, John Allotey, Ethel Tekpor, Comfort Mawusi Wormenor, Joseph Emmanuel Amuah, Ernest Antwi-Boasiako, Erasmus Nikoi Kotey, Seyram Kemawor, Isaac Gedzah, Helena Maame Ama Frempong, Stephen Danyo, Edna Sesenu, Bernard Hayford Atuguba, Nana Owusu Mensah Essel, Patrick Kafui Akakpo

“…This approach, combined with concurrent testing (hr-HPV DNA testing and visual inspection), holds promise for mitigating loss to follow-up among women requiring additional evaluation and lesion management.…”
Get full text

Determinants of healthcare utilization under the Indonesian national health insurance system – a cross-sectional study by Qinglu Cheng, Rifqi Abdul Fattah, Dwidjo Susilo, Aryana Satrya, Manon Haemmerli, Soewarta Kosen, Danty Novitasari, Gemala Chairunnisa Puteri, Eviati Adawiyah, Andrew Hayen, Anne Mills, Viroj Tangcharoensathien, Stephen Jan, Hasbullah Thabrany, Augustine Asante, Virginia Wiseman

Get full text

Evaluation of a content-based image retrieval system for radiologists in high-resolution CT of interstitial lung diseases by Benjamin Böttcher, Marly van Assen, Roberto Fari, Philipp L. von Knebel Doeberitz, Eun Young Kim, Eugene A. Berkowitz, Felix G. Meinel, Carlo N. De Cecco

“…This can provide educational benefits and more time-efficient management of complex cases. Key Points A content-based image retrieval (CBIR) software improves diagnostic accuracy and confidence for in-training radiologists for interstitial lung disease (ILD) assessment on computed tomography (CT). …”
Get full text

Temporal segmentation method for 30-meter long-term mapping of abandoned and reclaimed croplands in Inner Mongolia, China by Deji Wuyun, Liang Sun, Zhongxin Chen, Luís Guilherme Teixeira Crusiol, Jinwei Dong, Nitu Wu, Junwei Bao, Ruiqing Chen, Zheng Sun, Hasituya, Hongwei Zhao

“…The proposed remote sensing methodology reveals spatiotemporal trends in abandonment rates across arid and semi-humid regions, offering valuable insights for agricultural and environmental management in Inner Mongolia. Considering regional climatic, hydrological, and phenological conditions improves sample collection efficiency and cropland status monitoring. …”
Get full text

Un ensemble funéraire de l’Antiquité tardive à dépôt atypique d’âne à Woippy (Moselle) by Gaël Brkojewitsch, Olivier Putelat

“…The rows run parallel to the Roman roadway, which suggests a general management of the area. Additionally, the absence of overlapping burial implantation is an indication of the existence of topographical markings made of organic material. …”
Get full text

Evaluation of outcome relevance of quality indicators in the emergency department (ENQuIRE): study protocol for a prospective multicentre cohort study by Anna Slagman, Felix Greiner, Martin Möckel, Rainer Röhrig, Susanne Drynda, Wencke Schindler, Johannes Pollmanns, Dirk Horenkamp-Sonntag, Wiebke Schirrmeister, Ronny Otto, Jonas Bienzeisler, Saskia Drösler, Rolf Lefering, Jennifer Hitzek, Enno Swart, Felix Walcher

“…The data collected for this purpose comprise medical records from the ED treatment, discharge (claims) data from hospitalised patients, a patient questionnaire to be answered 6–8 weeks after emergency admission, and outcome measures in a 12-month follow-up obtained as claims data from the SHI.Descriptive and analytical statistics will be applied to provide summaries about the characteristics of QIs and associations between quality measures and patient outcomes.Ethics and dissemination Approval of the leading ethics committee at the Medical Faculty of the University of Magdeburg (reference number 163/18 from 19 November 2018) has been obtained and adapted by responsible local ethics committees.The findings of this work will be disseminated by publication of peer-reviewed manuscripts and presentations as conference contributions (abstracts, poster or oral presentations).Moreover, results will be discussed with clinical experts and medical associations before being proposed for implementation into the quality management of EDs.Trial registration number German Clinical Trials Registry (DRKS00015203); Pre-results.…”
Get full text

Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study by Mark Monane, Demetrius M. Maraganore, Robert M. Carlile, Kim G. Johnson, David A. Merrill, Darren R. Gitelman, Kenneth S. Sharlin, Lawren A. VandeVrede, Kristi K. George, Jimin Wang, Tim West, Leslie Jacobs, Philip B. Verghese, Joel B. Braunstein

“…After receiving the BBM test results, clinicians completed surveys on management strategies for each patient. <b>Results</b>: Patients had a median age of 74, 53% were female, and 28% were traditionally under-represented in Black, Hispanic, and Asian groups. …”
Get full text