Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway by Baolong Li, Kaiming Yu, Xiongyao Zhou, Jialu Sun, Le Qi, Weiye Li, Tuo Yang, Weizhen Li, Ningning Wang, Xiaosong Gu, Shusen Cui, Rangjuan Cao

“…In summary, this study enhances our understanding of the molecular interplay between TSPO, mitochondrial health, and neuropathic pain, highlighting TSPO as a potential therapeutic target for pain management. Graphical Abstract…”
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Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…Conclusion Overall, our study demonstrated that sorafenib enhanced the function of MDSCs by facilitating PPARα-mediated FAO and further augmenting sorafenib resistance, which sheds light on dietary management and improves the therapeutic response in HCC.…”
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ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk by Fredrik Ildstad, Hanne Ellekjær, Torgeir Wethal, Stian Lydersen, Hild Fjærtoft, Bent Indredavik

“…Since there is a generally lower stroke risk after TIA during the last years, the benefit of these clinical risk scores and their role in TIA management seems limited. Clinical Trial Registration. …”
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Impact of Prone Position on 12-Lead Electrocardiogram in Healthy Adults: A Comparison Study with Standard Electrocardiogram by Yunis Daralammouri, Murad Azamtta, Hamza Hamayel, Amro Adas, Osama Sawalmeh, Yahia Ismail, Saed H. Zyoud

“…Prone position ECG resulted in significant changes in healthy adults that should be aware of this as this can affect diagnosis and management strategies. Further studies are needed to investigate the impact of prone position on ECG recording in patients with cardiovascular diseases.…”
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Improving the physiological status of broiler chickens using rosemary leaf meal and sodium bentonite as ammonia gas control agents by Mercy Chisara Ogwuegbu, Fredrick Ugochukwu Udeh, Josephine Chinenye Ugwuozor, Precious Ezinne Okoye, Joy Chimela Kalu, Emmanuel Chinonso Arum, Doctor Mziwenkosi Nhlanhla Mthiyane

“…As the poultry industry shifts towards natural antibiotic-free alternatives, rosemary leaf meal (RLM) and sodium bentonite (SB) have emerged as promising dietary supplements for enhancing broiler physiological status, meat quality, and environmental management. This study evaluated the effects of RLM and SB inclusion on broiler physiological status, meat quality and litter ammonia levels. …”
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Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography by Ching-Yi Lee, Ching-Hsin Lee, Sze-Yuen Yau, Hung-Yi Lai, Po-Jui Chen, Mi-Mi Chen

“…Results Thematic analysis revealed seven key themes in CCR: information sharing, active verbal and behavioral information gathering, information processing and recall, modification and discussion, short-term indications, and management plans and goals. Information sharing was fundamental, with team members frequently exchanging patient data to ensure a common understanding. …”
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Barriers and Facilitators to Collecting Surgical Outcome Data in Low- and Middle-Income Countries: An International Survey by Thomas Diehl, MD, Taylor J. Jaraczewski, MD, MS, Kaleem Sohail Ahmed, MBBS, MSAI, Muhammad Rizwan Khan, MBBS, FCPS, FRCS, FACS, MHPE, Ewen M. Harrison, MB, ChB, MSc, PhD, FRCS, Belay Mellese Abebe, MD, Asad Latif, MD, MPH, Nabiha Mughal, MD, Sadaf Khan, MBBS, FACS, FACRS, K. A. Kelly McQueen, MD, MPH, FASA, Girma Tefera, MD, Syed Nabeel Zafar, MBBS, MPH, FACS

“…The Performance of Routine Information Systems Management framework was used to explore the frequency and relative importance of organizational, technical, and behavioral barriers. …”
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Tetramethylpyrazine and paeoniflorin combination (TMP-PF) alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathw... by Rong Yuan, Qiqi Xin, Weili Shi, Yu Miao, Zhengchuan Zhu, Yahui Yuan, Ying Chen, Xiaoning Chen, Sean Xiao Leng, Keji Chen, Weihong Cong

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Malignant transformation of proliferative Verrucous Leukoplakia—systematic review & meta-analysis by Khadijah Mohideen, Snehashish Ghosh, Chandrasekaran Krithika, Mutaz Ali-Hassan, Revant Chole, Safal Dhungel

“…Understanding its etiology could aid early detection and management.…”
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Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer by Zhe Chen, Gaoming Wang, Nan Wang, Jiangjiang Liu, Yu Yao, Haitao Ma, Haitao Ma, Jing Luo, Kai Xie

“…While SPLC chemotherapy enhanced OS for patients who did not receive FPLC chemotherapy, it was associated with reduced CSS for those who had.ConclusionsOverall, FPLC chemoradiotherapy influences SPLC prognosis and influences sensitivity to treatment. Tailoring SPLC management to FPLC treatment regimens may improve survival outcomes.…”
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Accounting for differences between crops and regions reduces estimates of nitrate leaching from nitrogen-fertilized soils by Yan Wang, Yihong Liu, Longlong Xia, Hiroko Akiyama, Xinli Chen, Ji Chen, Yunying Fang, Tony Vancov, Yongfu Li, YuanZhi Yao, Dianming Wu, Bing Yu, Scott X. Chang, Yanjiang Cai

“…Here we synthesize 2500 field observations worldwide and show that LFs vary by an order of magnitude across regions and crops, primarily driven by hydroclimatic and edaphic conditions rather than N fertilizer management. Global cropland NO3 − leaching from synthetic N fertilization, calculated through spatially explicit (15.4, 14.8–16.1 Tg N yr–1) and crop-specific (12.9, 11.0–14.8 Tg N yr–1) LFs, is 41% lower than the Intergovernmental Panel on Climate Change Tier 1 global inventory. …”
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SDG11-Based Sustainability Assessment of Urban Communities: A Case Study of Changsha by Qin Shuqian, Zhang Nan, Zhu Peijuan, Zhang Yong, Zhang Chen

“…It is found that: (1) During the period 2010-2020, the degree of achievement of community SDG in Changsha falls in the "relative closeness" range, with a "core-periphery" spatial distribution from the high sections to the low ones. (2) Of the 7 goals, housing guarantee, disaster prevention and relief, and environmental governance are progressing well; public transportation and heritage protection are improving significantly; public space is rising slowly; however, planning management is less than ideal. (3) Based on the assessment results of the coupling coordination degree of the communities' economic-social-environmental systems, the sample communities are classified into three types: coordinated development, transitional development, and dysfunctional decline communities. …”
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Deep learning radiomics nomogram for preoperatively identifying moderate-to-severe chronic cholangitis in children with pancreaticobiliary maljunction: a multicenter study by Hui-min Mao, Kai-ge Chen, Bin Zhu, Wan-liang Guo, San-li Shi

“…Conclusions The integrated DLRN can be a useful and non-invasive tool for preoperatively identifying moderate-to-severe chronic cholangitis in children with PBM, potentially enhancing clinical decision-making and personalized management strategies.…”
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Evaluation of the Psychiatric Disorders among Amphetamine Addicts in Rehabilitation Centers: A Cross-Sectional Analysis by Saud D. AlOtaibi, Hossam A. Elsisi, Mohammed J. AlShammary, Saud A. AlQader, Hejab A. AlHarbi, Bayan R. AlOlaiyan, Ahmad O. Alanazi, Firas S. AlMendeel, Yazeed N. AlHarbi, Ibrahim AlKhalaf, Ahmad H. Alhowail, Abdelhamid Mohamed Elwy, Ashraf M. Emara

“…The assessment of the Work and Social Adjustment Scale (WSAS) reflected a higher impairment that minimized their ability to perform the work requirements, home management, social leisure, and relationships. Conclusions. …”
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Сontrolled breeding of the psychrophilic strain G-034 VIZR of Trichoderma asperellum for fast crop residues’ polymers utilization and soil enhancement by I. I. Novikova, J. A. Titova, I. V. Boykova, I. L. Krasnobaeva

“…The methods for inoculum cultivation, sporulation capacity determination, modified wet chamber, estimating antagonistic activity and biologics’ quality, field small-plot trials management, quantitative estimates of biomass losses, cellulose and lignin content were used in the work. …”
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The effect of political will, information technology, and the quality of financial reporting information on fraud prevention by Haliah, Hasnawiya Hasan, Syamsuddin, Fatmawati, Andi Ratna Sari Dewi, Muhammad Alief Fahdal Imran Oemar, Linda Arisanty Razak

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Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma by Jin-Xing Wang, Ling Zhang, Peng-Wei Zhang, Luo-Wei Yuan, Jian Jiang, Xiao-Hui Cheng, Wei Zhu, Yong Lei, Fa-Qing Tian

“…Despite advancements in therapeutic strategies, resistance to proteasome inhibitors, particularly bortezomib (BTZ), poses a substantial challenge to disease management. This study aimed to explore the efficacy of boanmycin, a novel antitumor antibiotic, in overcoming resistance to BTZ in MM. …”
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Primary Neuroendocrine Carcinoma of Ocular Adnexa by Daisuke Yamanouchi, Toshiyuki Oshitari, Yosuke Nakamura, Jiro Yotsukura, Kaoru Asanagi, Takayuki Baba, Tomohiro Nizawa, Takashi Kishimoto, Yoko Yonemori, Satoshi Ota, Shuichi Yamamoto

“…Thus, combined therapy including surgery, radiotherapy, and/or chemotherapy is needed for complete management of NEC.…”
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Hybrid Harmony Search Algorithm Integrating Differential Evolution and Lévy Flight for Engineering Optimization by Feng Qin, Azlan Mohd Zain, Kai-Qing Zhou, Norfadzlan Bin Yusup, Didik Dwi Prasetya, Rozita Abdul Jalil, Zaheera Zainal Abidin, Mahadi Bahari, Yusri Kamin, Mazlina Abdul Majid

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Nonimmune Hydrops Fetalis and Early Skeletal Changes in Congenital Syphilis: Case Series and Review of Literature by Kruti N Shah, Shwetal Bhatt, Vaishali Chanpura

“…Some cases also present with early skeletal changes, and hence, skeletal radiographs expedite the clinical decision-making process and direct further management of neonates. The signs of neonatal syphilis, including hepatic and bone dysfunction, and fetal hemolytic anemia, do follow complete recovery with penicillin treatment. …”
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