Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

“…The TME of RCC brain metastases, a major cause of morbidity, also remains largely uncharacterized.Methods We performed digital spatial profiling on the NanoString GeoMx platform using 52 validated immuno-oncology markers on RCC tissue microarrays representing progressive stages of RCC, including brain metastases. …”
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Nutrition and Antioxidant Potential of Three Cauliflower (Brassica oleracea L. Var. Botrytis) Cultivars Cultivated in Southern Part of Bangladesh by Mousumi Jahan Sumi, Sharmin Akter Serity, Tusar Kanti Roy, Keya Akter, Shishir Rasul, Mostofa Jaman Depro, Md. Masum Abdullah, Md. Nesar Uddin

“…Linear discriminant analysis identified lycopene, chlorophyll b, and β-carotene as major differentiators, highlighting the diverse nutritional and antioxidant properties of these cauliflower varieties. …”
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Impacts of Chemical Initial Conditions in the WRF-CMAQ Model on the Ozone Forecasts in Eastern China by Tangyan Hou, Shaocai Yu, Yaping Jiang, Xue Chen, Yibo Zhang, Mengying Li, Zhen Li, Zhe Song, Pengfei Li, Jianmin Chen, Xiaoye Zhang

“…Abstract Ozone (O3) has become the major factor for exceeding air pollution standards in many Chinese cities, especially in the more economically developed and densely populated regions, such as eastern China. …”
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Is there a mental health diagnostic crisis in primary care? Current research practices in global mental health cannot answer that question by Brandon A. Kohrt, Dristy Gurung, Ritika Singh, Sauharda Rai, Mani Neupane, Elizabeth L. Turner, Alyssa Platt, Shifeng Sun, Kamal Gautam, Nagendra P. Luitel, Mark J.D. Jordans

“…The lack of accurate diagnoses is a major bottleneck to reducing the global mental health treatment gap. …”
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Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility by Rosalyn W Sayaman, Masaru Miyano, Eric G Carlson, Parijat Senapati, Arrianna Zirbes, Sundus F Shalabi, Michael E Todhunter, Victoria E Seewaldt, Susan L Neuhausen, Martha R Stampfer, Dustin E Schones, Mark A LaBarge

“…The mammary epithelium is a bilayer of two major phenotypically and functionally distinct cell lineages: luminal epithelial and myoepithelial cells. …”
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Insulin-Attenuated Inflammatory Response of Dendritic Cells in Diabetes by Regulating RAGE-PKCβ1-IRS1-NF-κB Signal Pathway: A Study on the Anti-Inflammatory Mechanism of Insulin in... by Liding Zhao, Ya Li, Qingbo Lv, Min Wang, Yi Luan, Jiale Song, Guosheng Fu, Junbo Ge, Yunzeng Zou, Wenbin Zhang

“…CD83, CD86, and type II major histocompatibility complex (MHC-II) of BMDCs were measured by flow cytometry. …”
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Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails by Yiyue Zhang, Hong-Zhe Li, Martin Breed, Zhonghui Tang, Li Cui, Yong-Guan Zhu, Xin Sun

“…Abstract Background Global warming is redrawing the map for invasive species, spotlighting the globally harmful giant African snail as a major ecological disruptor and public health threat. …”
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A Study on the Induction of Multi-Type Immune Responses in Mice via an mRNA Vaccine Based on Hemagglutinin and Neuraminidase Antigen by Mengyuan Liu, Yixuan Liu, Shaohui Song, Qiurong Qiao, Jing Liu, Yun Xie, Jian Zhou, Guoyang Liao

“…Background: The Influenza A virus (IAV), a pathogen affecting the respiratory system, represents a major risk to public health worldwide. Immunization remains the foremost strategy to control the transmission of IAV. …”
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Effects of high-intensity interval and moderate-intensity continuous training on ambulatory blood pressure and cardiovascular outcomes in older adults with hypertension (HEXA Study... by Francisco Dalton-Alves, Maria Beatriz F Araújo, Bruno Erick B Lucena, Gabriel C Souto, Daniele Samara D Lopes, Maria Isabel S Lucena, Raíssa de Melo Silva, Ludmila L P Cabral, Yuri A Freire, Fabíola L Golveia, Telma Maria Araújo Lemos, Rodrigo A V Browne, Eduardo Caldas Costa

“…The trial is conducted with blinded outcome assessors and statistical analysts. 66 inactive older adults with hypertension aged 60–80 years without a history of major adverse cardiovascular events will be randomly assigned to one of the following groups: (1) HIIT (3 months; 3× week); (2) MICT (3 months; 3× week); (3) health education programme (control; 3 months; 1× week). …”
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Screening of <em>FecLL</em> prolific allele of the <em>B4GALNT2</em> gene in Algerian sheep populations by Assia Hadjazi, Fatima Zahra Belharfi, Fatima Zohra Mahammi, Stéphane Fabre, Semir Bechir Suheil Gaouar, Nacera Tabet-Aoul

“…However, their action differs from that of other major genes discovered previously, such as: FecX/BMP15 (bone morphogenetic protein 15); FecG/GDF9 (growth differentiation factor 9); and FecB/BMPR1B (bone morphogenetic protein receptor type 1B). …”
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Peroral endoscopic myotomy with fundoplication (POEM-F) for achalasia: Systematic review and meta-analysis by Harishankar Gopakumar, Eugene Annor, Ishaan Vohra, Iman Andalib, Amy Tyberg, Avik Sarkar, Haroon Shahid, Mine Carames, Juan Carlos Carames, Giovanna Porfilio Gularte, Abed Al-Lehibi, Resheed Alkhiari, Amol Bapaye, Carlos Robles-Medranda, Michel Kahaleh

“…Mean total procedure duration and fundoplication time was 115.74 minutes; 95% CI 103.53-126.96 and 55.28 minutes; 95% CI 47.35-63.20, respectively. The overall pooled major adverse events (AE) rate was 3.60%; 95% CI 1.40-9.40. …”
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Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery by Michal Holub, Eva Bartáková, Alžběta Stráníková, Eva Koblihová, Simona Arientová, Marie Blahutová, Jan Máca, Miroslav Ryska

“…Because calprotectin and calgranulin C serum levels have been demonstrated to be potential biomarkers of certain cancers and complications of major surgery, the levels of both proteins were tested in the current study in patients with benign and malignant pancreatic tumors that were surgically removed. …”
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The First Ground‐Level Enhancement of Solar Cycle 25 as Seen by the High‐Energy Particle Detector (HEPD‐01) on Board the CSES‐01 Satellite by Matteo Martucci, Monica Laurenza, Simone Benella, Francesco Berrilli, Dario DelMoro, Luca Giovannelli, Alexandra Parmentier, Mirko Piersanti, Gabor Albrecht, Simona Bartocci, Roberto Battiston, William J. Burger, Donatella Campana, Luca Carfora, Giuseppe Consolini, Livio Conti, Andrea Contin, Cinzia De Donato, Cristian De Santis, Francesco Maria Follega, Roberto Iuppa, Alessandro Lega, Nadir Marcelli, Giuseppe Masciantonio, Matteo Mergé, Marco Mese, Alberto Oliva, Giuseppe Osteria, Francesco Palma, Beatrice Panico, Francesco Perfetto, Piergiorgio Picozza, Michele Pozzato, Ester Ricci, Marco Ricci, Sergio Bruno Ricciarini, Zouleikha Sahnoun, Valentina Scotti, Alessandro Sotgiu, Roberta Sparvoli, Vincenzo Vitale, Simona Zoffoli, Paolo Zuccon

“…The event was associated with the major, long‐duration X1‐class flare and the concomitant coronal mass ejection (CME) that erupted from the Active Region 12887. …”
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Stage deformation characteristics of natural and saturated crushed gangue with large particle size by LU Wei, LU Yao, LIAO Changlong, LI Qinghai, LI Weiyu, JIANG Ning, MU Wenqiang, WANG Changxiang

“…The load gradient significantly affects the displacement deformation in the early stage, and the water also exerts major influence on the displacement deformation in the creep stage. 2) Under natural and saturated conditions, about 1/3 of the work is consumed by friction, while 2/3 by crushing; 3) Compared with the natural state, energy consumption and its variation rate are reduced in the full stage of saturated crushed gangue. …”
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Changes in Phenylacetylglutamine Levels Provide Add-On Value in Risk Stratification of Hypertensive Patients: A Longitudinal Cohort Study by Xuan Xu, Lixin Jia, Bokang Qiao, Yanyan Gong, Shan Gao, Yuan Wang, Jie Du

“…Background: Despite antihypertensive treatment, some high-risk hypertensive patients still experience major adverse cardiovascular events (MACEs). Current risk stratification tools may underestimate the presence of metabolites in hypertension and thereby risk of MACEs. …”
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Characteristics and Outcomes of 79 Patients with an Insulinoma: A Nationwide Retrospective Study in Finland by Elina Peltola, Päivi Hannula, Heini Huhtala, Saara Metso, Ulla Kiviniemi, Martine Vornanen, Juhani Sand, Johanna Laukkarinen, Mirja Tiikkainen, Camilla Schalin-Jäntti, Johanna Arola, Jukka Sirén, Antti Piiroinen, Minna Soinio, Pirjo Nuutila, Mirva Söderström, Hanna Hämäläinen, Leena Moilanen, David Laaksonen, Elina Pirinen, Fia Sundelin, Tapani Ebeling, Pasi Salmela, Markus J. Mäkinen, Pia Jaatinen

“…Developing the surgical treatment is another major target, in order to lower the overall complication rate, without compromising the high cure rate of insulinomas.…”
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Clinical impact of proteinuria on renal function and treatment outcomes in patients with radioiodine-refractory thyroid cancer treated with lenvatinib by Naoki Fukuda, Kazuhisa Toda, Hirotaka Suto, Ryosuke Oki, Xiaofei Wang, Tetsuya Urasaki, Yasuyoshi Sato, Kenji Nakano, Makiko Ono, Junichi Tomomatsu, Hiroki Mitani, Shunji Takahashi

“…Proteinuria has been described as a major on-target adverse event of lenvatinib, although its long-term impact on renal function and clinical outcomes remains unclear. …”
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Sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes and myocardial infarction undergoing percutaneous coronary intervention: A systematic review and meta-ana... by Huzaifa Ul Haq Ansari, Muhammad Ammar Samad, Eman Mahboob, Eeshal Zulfiqar, Shurjeel Uddin Qazi, Areeba Ahsan, Mushood Ahmed, Faizan Ahmed, Raheel Ahmed, Shafaqat Ali, Mahboob Alam, Jamal S. Rana, Gregg C. Fonarow

“…The results indicated that SGLT2i with PCI was associated with a significantly reduced risk of all-cause death (RR=0.61; 95 % CI=0.54 to 0.68), CV death (RR=0.46; 95 % CI=0.22 to 0.94), major adverse cardiovascular events (RR=0.80;95 % CI: 0.66 to 0.96), HF-related hospitalizations (RR=0.63; 95 % CI=0.44 to 0.90), stroke (RR=0.77; 95 % CI: 0.62 to 0.96) and acute kidney injury (RR=0.46; 95 % CI: 0.25 to 0.84) compared to PCI without SGLT2i use. …”
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Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats by Michael J. Butler, Stephanie M. Muscat, Maria Elisa Caetano-Silva, Akriti Shrestha, Brigitte M. González Olmo, Sabrina E. Mackey-Alfonso, Nashali Massa, Bryan D. Alvarez, Jade A. Blackwell, Menaz N. Bettes, James W. DeMarsh, Robert H. McCusker, Jacob M. Allen, Ruth M. Barrientos

“…Abstract Background Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. …”
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Short-term Outcomes of Pancreatoduodenectomy in Patients with Liver Cirrhosis: A Systematic Review and Meta-analysis by Shahab Hajibandeh, MRCS, Shahin Hajibandeh, FRCS, Alwin Puthiyakunnel Saji, Ayman Ashabi, MRCS, Christopher Brown, FRCS, Nicholas G Mowbray, FRCS, Matthew Mortimer, FRCS, Guy Shingler, FRCS, Amir Kambal, FRCS, Bilal Al-Sarireh, FRCS, PhD

“…Analysis of 18,184 patients from 11 studies suggested LC increased the risk of postoperative mortality (odds ratio [OR]: 3.94, P < 0.00001), major complications (OR: 2.25, P = 0.0002), and pancreatic fistula (OR: 1.73, P = 0.03); it resulted in more blood loss (mean difference [MD]: 204.74 ml, P = 0.0003) and longer hospital stay (MD: 2.05 days, P < 0.00001). …”
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