Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level by Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang

“…Objective. To compare major clinical outcomes after successful percutaneous coronary intervention (PCI) with first-generation (1G) drug-eluting stents (DES) and second-generation (2G) DES in patients with acute myocardial infarction (AMI) and prediabetes. …”
Get full text

Network pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease by Yuyan Li, Yueming Luo, Yilan Hu, Siting Li, Guandong Li, Wanyangchuan Zhang, Xiufen Gu, Jianting Wang, Shunmin Li, Hong Cheng

“…ObjectiveChronic kidney disease (CKD) is a major global health problem. In clinical practice, the Chinese patent herbal medicine Jianpi-Yishen (JPYS) formula is commonly used to treat CKD. …”
Get full text

Protocol, rationale and design of DAbigatran for Stroke PreVention In Atrial Fibrillation in MoDerate or Severe Mitral Stenosis (DAVID-MS): a randomised, open-label study by Andrew Ng, Esther W Chan, Duo Huang, Cheung Chi Lam, Ning Tan, Chung Wah Siu, Jo Jo Hai, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Yuk Ming LAU, Chor Cheung Frankie Tam, Yiu Tung Anthony Wong, See Yue Arthur Yung, Ki Wan Kelvin Chan, Yingqing Feng, Chi Yui Yung, Kwok Lun Lee, Chun Wai Choi, Ho Lam, Katherine Fan, Man Hong Jim, Kai Hang Yiu, Bryan P. Yan

“…Secondary outcomes are ischaemic stroke, systemic embolism, haemorrhagic stroke, intracranial haemorrhage, major bleeding and death. The estimated required sample size is approximately 686 participants.Ethics and dissemination The study protocol has been approved by the Institutional Review Board of the University of Hong Kong and Hong Kong West Cluster, Hospital Authority, Hong Kong for Fung Yiu King Hospital, Grantham Hospital, Queen Mary Hospital and Tung Wah Hospital in Hong Kong. …”
Get full text

A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway by Pengdi Yang, Meiling Fan, Ying Chen, Dan Yang, Lu Zhai, Baoyu Fu, Lili Zhang, Yanping Wang, Rui Ma, Liwei Sun

“…Context The decline in ovarian reserve is a major concern in female reproductive health, often associated with oxidative stress and mitochondrial dysfunction. …”
Get full text

Pathogen community composition and co-infection patterns in a wild community of rodents by Abbate, Jessica L., Galan, Maxime, Razzauti, Maria, Sironen, Tarja, Voutilainen, Liina, Henttonen, Heikki, Gasqui, Patrick, Cosson, Jean-François, Charbonnel, Nathalie

“…Rodents are major reservoirs of pathogens that can cause disease in humans and livestock. …”
Get full text

Emerging malaria in Indonesia: An overview of Plasmodium knowlesi infections by Nisa Fauziah, Karomahul Malaya Jati, Fedri Ruluwedrata Rinawan, Naufal Fakhri Nugraha, Bachti Alisjahbana, Jontari Hutagalung

“…The origin of the sample was found to be the most significant factor (p-value <0.001), with individuals from Kalimantan having the highest risk for malaria caused by P. knowlesi (OR = 3.97, 95 % CI: 2.10–7.49). Conclusions: Two major Indonesian islands of Sumatra and Kalimantan, which reported malaria cases during the period studied, exhibit a potential risk for P. knowlesi infections that is influenced by factors beyond natural hosts and vectors, such as sex, age, and occupation. …”
Get full text

Rockfish abundance, recruitment, and community structure trends in the western Strait of Juan de Fuca, Washington, 2005-2023 by Shawn E. Larson, Katie Shelledy, Daniela Escontrela Dieguez, Jeff Christiansen, Amy Y. Olsen, Zachary Randell, Megan H. Williams, Chris VanDamme, Dayv Lowry, William Jasper

“…We documented low levels of young-of-the-year (YOY) rockfish recruitment over the years with one major recruitment event in 2016. Despite an increase in abundance across eight rockfish species, recruitment events remained infrequent. …”
Get full text

Balance and Gait Improvements of Postoperative Rehabilitation in Patients with Parkinson’s Disease Treated with Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) by Kazunori Sato, Noriaki Aita, Yoshihide Hokari, Eriko Kitahara, Mami Tani, Nana Izawa, Kozo Hatori, Ryota Nakamura, Fuyuko Sasaki, Satoko Sekimoto, Takayuki Jo, Genko Oyama, Taku Hatano, Yasushi Shimo, Hirokazu Iwamuro, Atsushi Umemura, Nobutaka Hattori, Toshiyuki Fujiwara

“…Postural instability is one of the major impairments, which induces disabilities of activities of daily living (ADLs). …”
Get full text

Evaluation of outcome relevance of quality indicators in the emergency department (ENQuIRE): study protocol for a prospective multicentre cohort study by Anna Slagman, Felix Greiner, Martin Möckel, Rainer Röhrig, Susanne Drynda, Wencke Schindler, Johannes Pollmanns, Dirk Horenkamp-Sonntag, Wiebke Schirrmeister, Ronny Otto, Jonas Bienzeisler, Saskia Drösler, Rolf Lefering, Jennifer Hitzek, Enno Swart, Felix Walcher

“…Quality indicators (QIs) for ED care are a major challenge due to the heterogeneity of patient populations, health care structures and processes in Germany. …”
Get full text

Severe pneumonia due to concurrent Legionella pneumophila and Acinetobacter baumannii infections: a case report by Xiaoming Yang, Zhongda Liu, Xiaojing Liu, Quan Li, Hui Huang, Yibo Wei, Tao Sun

“…Acinetobacter baumannii is a major pathogen responsible for hospital-acquired pneumonia, but it rarely causes serious infections in a community setting. …”
Get full text

Comparative Analysis of Five Moroccan Thyme Species: Insights into Chemical Composition, Antioxidant Potential, Anti-Enzymatic Properties, and Insecticidal Effects by Mohamed Ouknin, Hassan Alahyane, Naima Ait Aabd, Sara Elgadi, Youssef Lghazi, Lhou Majidi

“…Gas chromatography–mass spectrometry (GC-MS) identified thymol, <i>p</i>-cymene, borneol, γ-terpinene, carvacrol, α-pinene, and camphene as major constituents, with variations across species. …”
Get full text

A real-world analysis of antidepressant medications in US veterans aged 60 years and older: a comparative analysis by Ryan D Pittman, S Scott Sutton, Joseph Magagnoli, Tammy H Cummings

“…Aim: To compare the safety and efficacy of antidepressants (AD) among older adults with major depressive disorder (MDD) by assessing treatment change, augmentation and hospitalization rates. …”

Nasal microbial diversity is associated with survival in piglets infected by a highly virulent PRRSV-1 strain by Pau Obregon-Gutierrez, Martí Cortey, Gerard E. Martín-Valls, Hepzibar Clilverd, Florencia Correa-Fiz, Virginia Aragón, Enric Mateu

“…Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine industry worldwide, especially virulent variants arising during the last years, such as Spanish PRRSV-1 Rosalia strain. …”
Get full text

Neoadjuvant adebrelimab combined with chemotherapy (cisplatin/carboplatin and etoposide) for limited-stage small-cell lung cancer: a study protocol of phase 2 trial (NIUS) by Yan Zhang, Qian Huang, Mengxia Li, Xi Zheng, Yanyang Liu, Long Tian, Guizhi Chen, Hongyu Xu, Daxing Zhu

“…The secondary endpoints will be a major pathological response, objective response rate, event-free survival, OS, R0 resection rate, safety and potential predictive biomarker parameters related to efficacy in peripheral blood samples, including minimal residual disease, circulating tumour cells and cluster of differentiation (CD) 4/CD8. …”
Get full text

Migrant Health Country Profile tool (MHCP-t) for transforming health data collection and surveillance in the Middle East and North African (MENA) region: tool development protocol... by Farah Seedat, Bouchra Assarag, Kolitha Wickramage, Sally Hargreaves, Ana Requena-Mendez, Dominik Zenner, Anna Deal, Stella Evangelidou, Oumnia Bouaddi, Moudrick Abdellatifi, Hassan Edries, Eman Elafef, Taha Maatoug, Anissa Ouahchi, Sara Arias, Adel Abdelkhalek, Ibrahim Ahmed Bani, Kenza Hassouni, Mahmoud Hilali, Mohamed Khalis, Wejdene Mansour, Ali Mtiraoui, Hassan Chrifi, Mohamed Douagi, Abdedayem Khelifi

“…Introduction The Middle East and North Africa (MENA) region is characterised by major health disparities and complex migration flows. …”
Get full text

Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 days by Shuanglian Li, Shuanglian Li, Chenghao Mei, Chenghao Mei, Sainan Chen, Chenglin Wang, Chenglin Wang, Yelei Gao, Yelei Gao, Jinhua Ma, Jinhua Ma, Li Zhong, Li Zhong, Tingting Luo, Tingting Luo, Xin Zhao, Xin Zhao, Huaqin Bu, Huaqin Bu, Ying Lyu, Ying Lyu, Xiaohu Kuang, Zhenxing Jia, Xiaoli Wang, Yuqing Wang, Daiyin Tian, Daiyin Tian, Daiyin Tian

“…BackgroundRespiratory syncytial virus (RSV) is a major cause of severe health problems in newborns and young children. …”
Get full text

PneumoniaCheck, a novel aerosol collection device, permits capture of airborne Mycobacterium tuberculosis and characterisation of the cough aeromicrobiome in people with tuberculos... by Tinaye L. Chiyaka, Georgina R. Nyawo, Charissa C. Naidoo, Suventha Moodley, Jose C. Clemente, Stephanus T. Malherbe, Robin M. Warren, David N. Ku, Leopoldo N. Segal, Grant Theron

“…Abstract Background Tuberculosis (TB), a major cause of disease and antimicrobial resistance, is spread via aerosols. …”
Get full text

Bridging the gap: challenges and adoption of climate-resilient agriculture technologies in agricultural landscapes across agro-climatic zones of Bihar, India by Raj Kumar Jat, Vijay Singh Meena, Vijay Singh Meena, Shubham Durgude, Ravindra Kumar Sohane, Ratnesh Kumar Jha, Abhay Kumar, Ujjwal Kumar, Anjani Kumar, Raj Narain Singh, Suneel Kumar, Illathur R. Reddy, S. Pazhanisamy, Rakesh Kumar, Sunita Kumari Meena, Ved Prakash, Sanjay Kumar, Anirban Mukherjee, Brijendu Kumar, Umesh Narayan Umesh, Ranjan Kumar Singh, Ranjan Kumar Singh, Ravikant Chaubey, Vikash Kumar, Mukesh Kumar, Vinod Kumar, Kumari Sharda, Susheel Singh, Rama Kant Singh, Rama Kant Singh, Seema Kumari, Kamleshwari Prasad Singh, Govind Kumar, Ravindra Kumar Tiwari, Vineeta Kashyap, Suneeta Kushwaha, Sripriya Das, Prem Prakash Gautam, Nurnabi Meherul Alam, Shailesh Kumar, Sanjay Kumar, Sanjay Kumar, Bharati Upadhaya, Sumit Kumar Singh, Sanchita Ghosh, Shubham Bhagat, Shubham Bhagat, Amit Kumar Lenka

“…Logistic regression results highlighted that technology awareness significantly influences the adoption of DSR (coefficient = 0.400, p = 0.253), while initial investment costs are major barriers for ZT/MT and LLL (coefficient = 0.400, p = 0.267). …”
Get full text

Novel role of FTO in regulation of gut–brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure by Ruonan Chen, Xiaoqin Chai, Yunxiao Zhang, Tianxiu Zhou, Yinyin Xia, Xuejun Jiang, Bo Lv, Jun Zhang, Lixiao Zhou, Xin Tian, Ruonan Wang, Lejiao Mao, Feng Zhao, Hongyang Zhang, Jun Hu, Jingfu Qiu, Zhen Zou, Chengzhi Chen

“…We also firstly identified a dominant gut microbial species, Desulfovibrio fairfieldensis, which was sharply reduced in arsenic-exposed mice, was able to proceed arsenic-induced neurobehavioral impairments by declining the levels of its major metabolite hydrogen sulfide. Administration of Desulfovibrio fairfieldensis could significantly alleviate the neurotoxicity of arsenic. …”
Get full text

Intraoperative Electrical Nerve Stimulation as a Prognostic Tool in Patients Undergoing Peripheral Nerve Neurolysis by Christoph A. Schroen, BS, Yufan Yan, MD, Christian E. Awah, MD, Unwana Abasi, MD, Paul J. Cagle, MD, Michael R. Hausman, MD, Steven M. Koehler, MD

“…Purpose: Functional recovery from peripheral nerve injuries remains unpredictable and continues to pose a major clinical challenge to surgeons. This study sought to investigate the utility of intraoperative nerve stimulation following neurolysis surgery as a prognostic indicator of functional recovery. …”
Get full text