Unveiling the biological activities of Heliotropium indicum L. plant extracts: anti-inflammatory activities, GC–MS analysis, and in-silico molecular docking by Mst. Sadia Afroz Shoily, Md. Ekramul Islam, Nur Mohammad Rasel, Shahnaz Parvin, Jaytirmoy Barmon, Aqibul Hasan Aqib, Debendra Nath Roy, Mst. Shahnaj Parvin

“…EAF demonstrated significant anti-inflammatory activity, inhibiting heat-induced hemolysis (71.90%), hypotonicity-induced hemolysis (67.18%), and AAPH-induced hemolysis (72.52%) at 400 μg/ml. Six major phytoconstituents in EAF, identified by GC–MS, were docked with COX-2. …”
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Analysis of oral cancer carcinogens in repeatedly heated cooking oils by Vidhant Krishna Nambiar, Vidya Mudliar, Inosi Salababa

“…The incidence of oral cancer in recent years has been on the rise; ninety percent of the cancers present in the oral cavity are squamous cell carcinoma with multiple major contributing lifestyle factors such well as the presence of the human papilloma virus. …”
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Atherogenic index of plasma and cardiovascular disease risk in cardiovascular-kidney-metabolic syndrome stage 1 to 3: a longitudinal study by Yu Zhang, Yue Song, Yinfei Lu, Tao Liu, Ping Yin

“…BackgroundCardiovascular disease (CVD) remains a major contributor to the global disease burden. Previous studies have established a link between the atherogenic index of plasma (AIP) and CVD. …”
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Using waist circumference as a predictor of hypertension in Manzese, Dar es Salaam: a community-based cross-sectional study, 2023 by Godbless Henry Mfuru, James N. Allan, Agnes Njau, Omary Ubuguyu, Khadija Y. Malima

“…This study aimed to determine the role of waist circumference in screening for hypertension, a major risk for CVD. Methods An analytical cross-sectional study was conducted in Manzese ward, Dar es Salaam, from August to September 2023. …”
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Real-world clinical experience with secukinumab in psoriatic arthritis: an observational study and a literature review by Eleonora Celletti, Giulio Gualdi, Emanuela Sabatini, Francesco Cipollone, Fabio Lobefaro, Paolo Amerio

“…Fifteen patients completed 6 months of follow-up, eleven patients completed 9 months, and six patients were followed for 12 months. The major comorbidities recorded were fibromyalgia (33% of patients), recurrent bilateral anterior uveitis, and autoimmune thyroiditis with hypothyroidism (both 13% of the patients). …”
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Environmental risk factors for self-harm during imprisonment: A pilot prospective cohort study. by Thomas Stephenson, Imogen Harris, Charlotte Armstrong, Seena Fazel, Roxanna Short, Nigel Blackwood

“…<h4>Introduction</h4>Self-harm is a major public health issue in the imprisoned population. …”
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A critical review of data mining in education on the levels and aspects of education by Inusah Fuseini, Yaw Marfo Missah

“…Design/methodology/approach – This paper reviews 113 conference and research papers from well-known publishers of educational data mining (EDM) and learning analytics-related research using a recognized literature review in computer science by Carrera-Rivera et al. (2022a). Two major stages, planning and conducting the review, were used. …”
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Towards a conceptual framework of the working alliance in a blended low-intensity cognitive behavioural therapy intervention for depression in primary mental health care: a qualita... by Sarah Smith, Caroline Free, Daniel Michelson, Jesus Montero-Marin, Ricardo Araya, Asmae Doukani, Arlinda Cerga-Pashoja, Ritsuko Kakuma

“…A thematic analysis was conducted using a constant comparative method informed by grounded theory.Setting Recruitment was carried out in four psychological primary care services across the UK.Participants Nineteen trial participants with major depressive disorder who completed at least one computerised program and face-to-face session with a PWP in the b-CBT arm were recruited to the study.Results Qualitative interviews that were guided by WA theory and patient involvement, revealed four themes: (1) a healthcare provider (PWP and computerised program) with good interpersonal competencies for building a working relationship with the client (‘bond’); (2) collaborative efforts between the client and the provider to appropriately identify what the client hopes to achieve through therapy (‘goals’); (3) the selection of acceptable therapeutic activities that address client goals and the availability of responsive support (‘task’) and (4) the promotion of active engagement and autonomous problem solving (‘usability heuristics’). …”
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Long-term trends in the burden of multiple myeloma in China: a Joinpoint regression and age-period-cohort analysis based on GBD 2021 by Yanyu Zhang, Quanxin Su, Jiawen Yu, Xiuli Sun

“…The incidence risk increased with age, but the mortality risk showed fluctuations.ConclusionThe trends of MM disease burden in China continued to increase from 1990 to 2021. MM will be a major challenge for the future healthcare sector in China, where the population base is large and gradually aging.…”
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A Seventeen Multilevel High-Power Application Inverter with Low Total Harmonic Distortion by Ajmal Farooq, Shanshan Tu, Fiaz Ahmad, Muhammad Zeeshan Malik, Obaid U. Rehman, Ghulam Hafeez, Sadaqat ur Rehman

“…Thus, achieving a pure sinusoidal AC at the output and to maintain a low THD level is a major issue in conventional MLIs. The proposed MLI has the advantage of decreasing the output THD by using a modified form of the cascaded H-Bridge structure and sine pulse width modulation technique. …”
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Development and validation of a nomogram-based risk prediction model for carbapenem-resistant Klebsiella pneumoniae in hospitalized patients by Tingting Xu, Yuxin Shi, Xiongjing Cao, Lijuan Xiong

“…ABSTRACT Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses one of the major challenges in clinical anti-infective therapy worldwide. …”
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Computation and Visualization of Regional-Scale Forest Disturbance and Associated Dissolved Nitrogen Export from Shenandoah National Park, Virginia by Keith N. Eshleman, Daniel A. Fiscus, Nancy M. Castro, James R. Webb, J Jr. Deviney

“…Vegetation disturbances can apparently cause major changes in N input-output balances with potentially important ramifications for low-order forest streams and downstream receiving waters.…”
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Organic-Inorganic Geochemical Characteristics of the Upper Permian Pusige Formation in a High-Saline Lake Basin, Tarim Basin: Implications for Provenance, Paleoenvironments, and Or... by Jingbin Wang, Zhiliang He, Dongya Zhu, Zhiqian Gao, Xiaowei Huang, Quanyou Liu

“…The third member (M3) of the Upper Permian Pusige Formation is a prominent organic-rich lacustrine mudstone sequence within the Yecheng-Hetian Sag, Tarim Basin, hosting major petroleum resources. However, its depositional history and organic matter (OM) enrichment mechanism have received little attention. …”
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Classification and functional repair and reconstruction of lip and perilabial defects following oncosurgery by CHEN Weiliang

“…Large perilabial defects such as total labial and chin defects or total labial and nasal defects require repair using pectoralis major muscle flaps, trapezius muscle flaps, free tissue flaps, or even a combination of multiple flaps. …”
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Combatting Salmonella: a focus on antimicrobial resistance and the need for effective vaccination by Junaid Nazir, Tasaduq Manzoor, Afnan Saleem, Ubaid Gani, Sahar Saleem Bhat, Shabir Khan, Zulfqarul Haq, Priyanka Jha, Syed Mudasir Ahmad

“…Abstract Background Salmonella infections represent a major global public health concern due to their widespread zoonotic transmission, antimicrobial resistance, and associated morbidity and mortality. …”
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The Impact of Truck Proportion on Traffic Safety Using Surrogate Safety Measures in China by Shengdi Chen, Shiwen Zhang, Yingying Xing, Jian Lu, Yichuan Peng, H. Michael Zhang

“…The k-means algorithm and the support vector machine were employed to evaluate traffic status on a freeway under different truck proportions in different periods. The major results are that the relationship between truck proportion and the value of 85%V–15%V and the speed variation coefficient is consistent in different aggregation periods. …”
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The linkage between economic literacy and students’ intention of starting business: The mediating role of entrepreneurial alertness by Agus Wibowo, Bagus Shandy Narmaditya, Ratieh Widhiastuti, Ari Saptono

“…PURPOSE: Enhancing the number of entrepreneurs is a major study to combat economic and social problems. …”
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Global analysis of influenza epidemic characteristics in the first two seasons after lifting the nonpharmaceutical interventions for COVID-19 by Xiaowei Chen, Honghong Chen, Fangfang Tao, Yinzi Chen, Ying Zhou, Jian Cheng, Xiling Wang

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Patient–specific hemodynamic modeling to optimize LVAD speed and right heart health by Mustafa M. Ahmed, Holly Grant, Jasmine Martinez, Joshua Thomas, Mohammad Al-Ani, Alex Parker, Juan Vilaro, Juan Aranda, Venkat Keshav Chivukula

“…Background: Left ventricular assist device (LVAD) speed optimization and right heart failure post device implantation are major clinical challenges. Right heart catheterization (RHC)–guided speed titration studies are often performed to optimize LVAD settings, which are unknown and must be optimized for each patient. …”
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Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs by Jost Klawitter, Mckay Easton, Alexander Karpeisky, Kristen B. Farrell, Douglas H. Thamm, Touraj Shokati, Uwe Christians, Shawn Patrick Zinnen

“…We validated analytical platforms to analyze GEM-IB and five of its major metabolites IB, gemcitabine-5′-phosphate (GEMMP), gemcitabine (GEM), 2′,2′-difluoro-2′-deoxyuridine-5′-phosphate (dFdUMP), and 2′,2′-difluoro-2′-deoxyuridine (dFdU) and performed proof-of-concept pharmacokinetic studies in mice (5 mg/kg i.p.) and dogs (5 mg/kg i.v.). …”
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