Peripheral signaling pathways contributing to non-histaminergic itch in humans by Andrea Fiebig, Victoria Leibl, David Oostendorf, Saskia Lukaschek, Jens Frömbgen, Maral Masoudi, Andreas E. Kremer, Marion Strupf, Peter Reeh, Miriam Düll, Barbara Namer

“…Abstract Background Chronic itch (chronic pruritus) is a major therapeutic challenge that remains poorly understood despite the extensive recent analysis of human pruriceptors. …”
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Inactivation of the TIM complex components leads to a decrease in the level of DNA import into Arabidopsis mitochondria by T. A. Tarasenko, K. D. Elizova, V. I. Tarasenko, M. V. Koulintchenko, Yu. M. Konstantinov

“…The phenomenon of DNA import into mitochondria has been shown for all major groups of eukaryotes. In plants and animals, DNA import seems to occur in different ways. …”
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Real-World Parkinson’s Hand Tremor Detection Using Ensemble Learning Techniques by Sungwook Hur, Jieming Zhang, Moon-Hyun Kim, Tai-Myoung Chung

“…Hand tremor is a major motor symptom of Parkinson’s disease (PD) that seriously affects the life quality of patients. …”
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Integration of a specialist pharmacist-led multidisciplinary team in primary care: preventing strokes in people with atrial fibrillation across North East London by Riyaz Patel, Sotiris Antoniou, Shabana Ali, Mital Patel, Matt Kearney, Jagjot Kaur Chahal, John Robson, Paul Wright, Afzal Sohaib, Richard Clements, Angela Theodoulou

“…There was a 52% reduction in dual antithrombotic therapy, preventing an estimated three major bleeds.Improvements were achieved through a combination of specialist pharmacist reviews, GP and practice-based pharmacist training and virtual multidisciplinary reviews supporting the integration of specialists into a primary care setting to enable joined-up pathways for effective stroke prevention.…”
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SOCIAL AND ECONOMIC DEVELOPMENT OF MAGADAN: FROM A PLANNED ECONOMY TO A MARKET ECONOMY (1960–2020) by Natalya V. Galtseva, Oksana S. Favstritskaya, Olga A. Sharypova

“…The findings reveal that during the planned economy era, Magadan experienced major growth, with integrated development across industries, population increase, and economic appeal driven by northern benefits provided by the government. …”

Experiences of Māori and Pacific women recruited into a pregnancy clinical trial in Aotearoa, New Zealand: a Kaupapa Māori qualitative study by Matire Harwood, Benjamin B Albert, Rachel Roskvist, Jamie-Lee Rahiri, Richard Enright, Tania Mullane, Vidit Vinod Satokar

“…The desire to create a better future for participants’ babies and to give back to Māori and Pacific communities through participating in a clinical trial were also key drivers of successful recruitment. In contrast, the major barriers described were time pressures and the distance to the research facility.Conclusions Sixteen Māori and Pacific women who participated in a double-blinded randomised controlled trial shared that successful recruitment of Māori and Pacific women into clinical trials can be promoted by research flexibility participants’ whānau/family responsibilities, effective and culturally safe communication, and research teams striving to build and maintain relationships with participants throughout the trial.Trial registeration number Australian New Zealand Clinical Trials Registry, ACTRN12617001078347p. …”
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Antimicrobial resistance, virulence gene profiling, and genetic diversity of multidrug-resistant Pseudomonas aeruginosa isolates in Mazandaran, Iran by Ghazaleh Elahi, Hamid Reza Goli, Morvarid Shafiei, Vajihe Sadat Nikbin, Mehrdad Gholami

“…Abstract Background Pseudomonas aeruginosa is a major cause of healthcare-associated infections (HAIs), particularly in immunocompromised patients, leading to high morbidity and mortality rates. …”
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Pengaruh Inisiasi Menyusu Dini (IMD) terhadap Suhu dan Kehilangan Panas pada Bayi Baru Lahir by Hotma Sauhur Hutagaol, Eryati Darwin, Eny Yantri

“…Kehilangan panas kering lebih rendah pada kelompok IMD walau tidak bermakna secara statistik<br />Kata kunci: IMD, suhu aksila, kehilangan panas kering<br />Abstract<br />Hypothermia is a major cause of morbidity and mortality in neonatal period. …”
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Prevalence and influencing factors of non-suicidal self-injurious behaviour among Chinese college students: a Meta-analysis by TAO Silu, MAO Guoju, XIONG Yi, GUO Mengjia, WU Dongmei

“…Freshman year [OR=1.55, 95%CI(1.22, 1.97)], sophomore year [OR=1.74, 95%CI(1.36, 2.23)], bornin urban or town [OR=1.44, 95%CI(1.26, 1.64)], non-medical colleges or majors [OR=1.50, 95%CI(1.39, 1.61)], negative life events [OR=1.02, 95%CI(1.01, 1.04)], sexual abuse in primary school or earlier [OR=3.14, 95%CI(1.97, 5.02)], depression [OR=1.47, 95%CI(1.33, 1.63)], anxiety [OR=2.20, 95%CI(1.25, 3.87)], fantasies [OR=1.18, 95%CI(1.03, 1.35)], alcohol consumption [OR=1.60, 95%CI(1.40, 1.83)], and feelings of sadness and despair [OR=6.32, 95%CI(2.96, 13.51)] were the risk factors for prevalence of NSSI in Chinese college students.Conclusion The prevalence of NSSI among Chinese college students is high and closely related to a variety of factors. …”
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Obesity-induced mesenteric PVAT remodelling is sexually dimorphic, but not driven by ovarian hormones by Lisa Ivatt, Mhairi Paul, Allende Miguelez-Crespo, Patrick W. F. Hadoke, Matthew A. Bailey, Ruth A. Morgan, Mark Nixon

“…Abstract Background Obesity, a major risk factor for cardiovascular disease (CVD), is associated with hypertension and vascular dysfunction. …”
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Effects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure by Le Zhou, Mingyuan Niu, Wei Chen, Qian Hu, Yi Chen, Xiaohong Geng, Jiani Gu

“…Additionally, echocardiographic parameters, including EF, LVESD, LVEDD, IVST, LVMI, and E/e’, showed greater improvement in the observation group (P &lt; 0.05). The incidence of major adverse cardiovascular events was lower in the observation group (P &lt; 0.05). …”
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Clinical Predictors of Aspirin Resistance in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis by Fan Zhang, Hongyan Zheng

“…Methods: We conducted a systematic search of three major medical databases (PubMed, Embase, and Cochrane Library) to identify relevant articles up to September 17, 2024. …”
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Development and Validation of a Nomogram to Predict Type 2 Diabetes Mellitus in Overweight and Obese Adults: A Prospective Cohort Study from 82938 Adults in China by Qingqing Liu, Jie Yuan, Maerjiaen Bakeyi, Jie Li, Zilong Zhang, Xiaohong Yang, Fangming Gao

“…The twin epidemic of overweight/obesity and type 2 diabetes mellitus (T2DM) is a major public health problem globally, especially in China. …”
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Prevalence and determinants of early childhood caries among preschool children in district Shimla, North India: a cross -sectional study by Seema Thakur, Reetica Sharma, Parul Singhal, Deepak Chauhan

“…Abstract Background A high prevalence of early childhood caries (ECC) has been reported in children over the past few decades making it a major health burden. The study investigated the prevalence of ECC and associated factors among the preschool children of Shimla district. …”
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Impact of Oseltamivir and Diabetes Development by Bor-Show Tzang, Chih-Chen Tzang, Pei-Hua Chuang, I-Ying Kuo, Yu-Chun Pan, Pei-Hsun Wu, Tsai-Ching Hsu

“…<b>Background/Objectives</b>: Influenza is a major global health challenge, causing thousands of deaths annually. …”
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The effect of fecal bile acids on the incidence and risk-stratification of colorectal cancer: an updated systematic review and meta-analysis by Shaohui Yang, Yu Wang, Lijuan Sheng, Wei Cui, Chenyang Ma

“…We searched online to identify relevant cross-sectional and case-control studies published online in the major English language databases (Medline, Embase, Web of Science, AMED, and CINAHL) up to January 1, 2024. …”
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Knowledge, Attitudes, Motivations, Expectations, and Systemic Factors Regarding Antimicrobial Use Amongst Community Members Seeking Care at the Primary Healthcare Level: A Scoping... by Nishana Ramdas, Johanna C. Meyer, Natalie Schellack, Brian Godman, Eunice Turawa, Stephen M. Campbell

“…Background/Objectives: Antimicrobial resistance (AMR) is a major global health challenge, particularly in low- and middle-income countries (LMICs). …”
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Disease burden of tuberculosis in China from 1990 to 2021 and its prediction to 2036 by Rong Sun, Liang Wang, Hongfang Xia

“…BackgroundTuberculosis (TB) is one of the oldest infectious diseases and continues to be a major killer of human beings. This paper was designed to provide insights into the disease burden of TB.MethodsThe data was retrieved and downloaded from the latest GBD database. …”
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Relevance of tumor boards for the inclusion of patients in oncological clinical trials by Hendrik Dapper, Maurice Dantes, Peter Herschbach, Hana Algül, Volker Heinemann

“…Abstract Introduction Major national and international oncological societies generally recommend treating a significant proportion of oncological patients in clinical trials to improve therapy strategies for cancer patients. …”
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Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers by Bill Liao, Christine Tumanut, Lin Li, Adam Corper, Dilip Challa, Alex Chang, Hydari Begum, Elinaz Farokhi, Catherine Woods, Xiaomin Fan

“…CD16a, a Fc gamma III receptor, is the major component that is responsible for the ADCC activity of NK cells. …”
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