Antibody and serum bactericidal response to Burkholderia pseudomallei in acute localized and septicemic melioidosis cases with diabetes mellitus by Sraboni Mazumder, Md. Shariful Alam Jilani, Lovely Barai, KM Shahidul Islam

“…Background and objectives: Melioidosis, caused by the gram-negative bacillus Burkholderia pseudomallei, is a major cause of fatal community acquired infection in diabetic patients. …”
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Seasonal Changes in the Elemental Composition of Five Valuable Fish Species (<i>Sparidae</i>) from Bozcaada, North Aegean Sea: A Health Risk and Nutritional Benefit Assessment by İlknur Yuvka, Ali Rıza Kosker, Mustafa Durmus, Yılmaz Ucar, Yesim Ozogul

“…This study investigates the seasonal variations in the elemental composition of five economically valuable <i>Sparidae</i> fish species from Bozcaada, North Aegean: red seabream (<i>Pagrus major</i>), gilthead seabream (<i>Sparus aurata</i>), saddled seabream (<i>Oblada melanura</i>), white seabream (<i>Diplodus sargus</i>), and common dentex (<i>Dentex dentex</i>), with a focus on both essential minerals and toxic metals. …”
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The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment by Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He

“…Formaldehyde (FA) has been found to induce major Alzheimer’s disease (AD)-like features including cognitive impairment, Aβ deposition, and Tau hyperphosphorylation, suggesting that it may play a significant role in the initiation and progression of AD. …”
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Appropriateness of Antiplatelet Therapy and Proton Pump Inhibitor Prescribing in End-Stage Kidney Disease: A Retrospective Quality Investigation Study by Michael Che, Sumaiya Ahmed, Ryan Chan, Ayub Akbari, Deborah Zimmerman

“…Overall, it appears that prescribing patterns of DAPT and PPI at our center are unlikely to be a major contributor to the known increased risk of gastrointestinal bleeding in patients treated with hemodialysis. …”
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READMISSIONS TO ADOLESCENT PSYCHIATRIC INPATIENT CARE: A REGISTER STUDY by VISA VADÉN, RIITTAKERTTU KALTIALA, TIMO HOLTTINEN

“…This suggests that illness-related factors play a major role. However, female gender predicted readmissions in general and within 30 days when disorder-related factors were accounted for. …”
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Co-occurrence of direct and indirect extracellular electron transfer mechanisms during electroactive respiration in a dissimilatory sulfate reducing bacterium by Liyuan Hou, Rebecca Cortez, Michael Hagerman, Zhiqiang Hu, Erica L.-W. Majumder

“…The mutant with a deletion of the major pilus-producing gene yielded less voltage and far less attachment to both anodic and catholic electrodes, suggesting the importance of pili in extracellular electron transfer. …”
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Pirfenidone Alleviates Choroidal Neovascular Fibrosis through TGF-β/Smad Signaling Pathway by Chuang Gao, Xin Cao, Lili Huang, Yueqi Bao, Tao Li, Yue Di, Liucheng Wu, Yu Song

“…Transforming growth factor-β (TGF-β) plays a major role in CNV. However, the mechanism is unclear. …”
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Systematic review of the impact of non-alcoholic fatty liver disease on mortality and adverse clinical outcomes for individuals with chronic kidney disease by Paul Roderick, Julie Parkes, Theresa Hydes, Ryan Buchanan, Oliver J Kennedy, Simon Fraser

“…Two studies examined CKD progression; in one adjusted rate of percentage decline in estimated glomerular filtration rate per year was found to be increased in those with NAFLD (p=0.002), whereas the other found no significant difference.Conclusions Few studies have examined the influence of NAFLD on prognosis and major adverse clinical outcomes within the CKD population. …”
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The developing speciality coffee businesses of Bangkok, Thailand and Penang, Malaysia. A story of entrepreneurial passion and creativity? by Mark Azavedo, Art Gogatz

“…Implications for theory and practice: It presents a potential view of entrepreneurship at major variance with the views of classical economics. …”
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The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride—A Systematic Review and Meta-Analysis by Mubara Azhar, Mohammed S. Alasmari, Ammara Zamir, Hamid Saeed, Faleh Alqahtani, Tanveer Ahmad, Muhammad Fawad Rasool

“…<b>Methods:</b> A systematic search of the peer-reviewed literature was combined using major databases—Google Scholar, PubMed, Cochrane, and ScienceDirect, to identify studies reporting the PK of GLM. …”
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A survey on the Epidemiology of Acute Poisoning in Adults Referring to Imam Khomeini Hospital in Ardabil during 2017-2020 by Roksana Farabi, Aylin Javan-Molaei, Esmaeil Farzaneh, Saeid Sadeghieh Ahari, Sara Mostafalou

“…Conclusion: Acute poisoning is a major health problem in Ardabil province. The results show that the three agents of drug poisoning, opium and pesticides are the main means of poisoning in adults. …”
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Dexmedetomidine Attenuates Myocardial Ischemia-Reperfusion Injury in Diabetes Mellitus by Inhibiting Endoplasmic Reticulum Stress by Jinjie Li, Ying Zhao, Nan Zhou, Longyun Li, Kai Li

“…With the increasing incidence of diabetes mellitus (DM) combined with myocardial ischemia, how to reduce myocardial ischemia-reperfusion injury in DM patients has become a major problem faced by clinicians. We investigated the therapeutic effects of dexmedetomidine (DEX) on myocardial ischemia-reperfusion injury in DM rats and its effect on endoplasmic reticulum stress. …”
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Influence of malting and fermentation on the nutritional composition, thermal stability, structural and physicochemical properties of a gluten-free flour blend of Digitaria exilis... by Oluwatobi Victoria Obayomi, Abiola Folakemi Olaniran, Stephen Olugbemiga Owa

“…Childhood malnutrition is one of the major public health challenges in low- and middle-income countries. …”
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Comparative analysis of phytonutrients of Moringa oleifera leaves from South Africa and Nigeria, and their antimicrobial and antioxidant potentials by UPLC-ESI-QToF-MS and OPLS-DA... by Jonathan Kayembe, Cosa Sekelwa, Kokoette Bassey

“…In addition, kaempferol, quercetin, luteolin, tangutorid E, and podophyllotoxin, among others were annotated as the major phytonutrients in the samples. The antioxidant assays unveiled concentration-dependent trends with scavenging activity of up to 98% (half-maximal inhibitory concentration [IC50] = 0.14 mg/mL) for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 87% (IC50 = 0.28 mg/mL) for hydrogen peroxide assay. …”
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Assessing equity in preventing central line-associated bloodstream infections and surgical site infections in pediatric patients by Xiaoyan Song, Deena Levey, Jenhao Jacob Cheng, Monica Monteon, Annette Lee, Nada Harik, Denice Cora-Bramble, Rahul K. Shah

“… Abstract Background: Central line-associated bloodstream infections (CLABSIs) and surgical site infections (SSIs) are major healthcare-associated infections that can be prevented by consistently applying evidence-based infection prevention practices. …”
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Characterization of the First Marine Pestivirus, Phocoena Pestivirus (PhoPeV) by Lars Söder, Denise Meyer, Olaf Isken, Norbert Tautz, Matthias König, Alexander Postel, Paul Becher

“…Infection of a CD46-deficient porcine cell line suggested that CD46, which is implicated in the viral entry of several pestiviruses, is not a major factor for the viral entry of PhoPeV. Moreover, the results of this study confirmed that the cellular factor DNAJC14 plays a crucial role in viral RNA replication of non-cytopathic pestiviruses, including PhoPeV.…”
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Prophylactic and therapeutic effects of EsV3 on atherosclerotic lesions in ApoE−/− mice by Yaze Wang, Hifumi Ohishi, Rongji Wu, Hui Liu, Rong Xu

“…Abstract Background Atherosclerosis (AS) is a major contributor to vascular disorders and represents a significant risk to human health. …”
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A Study of the Solid-Liquid-Gas Three-Phase Coupling Relationship of Coal, Water and Gas by Anying Yuan, Chunhui Huang, Junling Hou, Zhaomin Zhang, Weihui Pan, Lei Duan, Quansen Wu

“…At the present time, it is of major significance to study the solid-liquid-gas three-phase coupling relationship of coal, water, and gas in deep-mining stopes in order to prevent and control coal and gas outbursts in high-gas mines. …”
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Human and Nature Effects Detection on the Environmental Properties of Archaeological Historic Cairo City in Egypt Based on Space and Ground Remote Sensing Data by Abdelaziz Elfadaly, Osama Wafa, Ahmed Gad, Hossam Khedr, Ghada Atta

“…These factors played a major role in increasing the groundwater level beneath these sites, causing serious damage to them. …”
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An Exploration of Students’ Misconceptions about the Concept ‘Classification of Animals’ at Secondary Level and Effectiveness of Inquiry Method for Conceptual Change by Anjum NAZ, Abida NASREEN

“…The responses of students were divided into major and minor categories. The frequencies and percentages of responses given by students in pre and post session interviews were calculated and compared. …”
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