Challenges and opportunities for assessing trends of amphibians with heterogeneous data – a call for better metadata reporting by Klaus Henle, Reinhard A. Klenke, M. Benjamin Barth, Annegret Grimm-Seyfarth, Diana E. Bowler

“…Over the last decades, the worldwide decline of amphibian populations has become a major concern of researchers and conservationists. …”
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Water Quality Assessment of Rivers in Aquatic Eco-environmental Function Regions in Changzhou City by WANG Xuesong, ZHANG Ge, LI Ying, XU Jinqian, CAI Yongjiu

“…In 2018,57 monitoring sections were arranged for a quarterly water quality survey in Changzhou,which can help grasp the water quality of 13 aquatic eco-environmental function regions.The current situation,characteristics of spatial heterogeneity,and seasonal changing laws of main water quality indicators are evaluated by multiple methods such as the water quality grade analysis,comprehensive water quality identification index (WQII) method,redundancy analysis,and principal component analysis.In this way,we can explore the major influencing factors of water quality.The results are as follows:① In 2018,the water quality of rivers in Changzhou City was mainly classified as Grade IV according to the Environmental Quality Standards for Surface Water (GB 3838—2002),which indicates the poor water quality.② The results show significant spatio-temporal difference in the concentration of main water quality indicators,and the water quality in the western hills is better than that in the eastern plains.The grade of water quality is higher in summer and autumn than in spring and winter.③ From the perspective of aquatic eco-environmental function regions,the water quality of III-09 (ecologically Grade III), IV-02 (ecologically Grade IV),and IV-03 (ecologically Grade IV) regions in the eastern urban area is poor,while the water quality of I-02 (ecologically Grade I), II-01 (ecologically Grade II),III-08 (ecologically Grade III) regions in the west is good.The grades of aquatic eco-environmental function regions are highly consistent with the water quality,which proves that the function regions can provide scientific reference for the monitoring, assessment,and environmental management of water quality.④ The redundancy analysis shows that the land for construction is the main influencing factor in the deterioration of water quality.The increase in the relative proportion of arable land and the decrease in the aquatic area closely correlate with the deterioration of water quality when the scale is over 2,000 m.⑤ The principal component analysis indicates that the five-day biochemical oxygen demand,COD,and permanganate index have high interpretation rates.This shows that the water quality of rivers in Changzhou City is mainly affected by organic pollution and eutrophication. …”
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Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing by Gulam Altab, Brian J. Merry, Charles W. Beckett, Priyanka Raina, Inês Lopes, Katarzyna Goljanek-Whysall, João Pedro de Magalhães

“…Abstract Age-related muscle wasting, sarcopenia is an extensive loss of muscle mass and strength with age and a major cause of disability and accidents in the elderly. …”
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Egfr Amplification Specific Gene Expression in Phyllodes Tumours of the Breast by Konstantin Agelopoulos, Christian Kersting, Eberhard Korsching, Hartmut Schmidt, Arno Kuijper, Christian August, Pia Wülfing, Joke Tio, Werner Boecker, Paul J. van Diest, Burkhard Brandt, Horst Buerger

“…The interplay between EGFR and caveolin-1, eps15, pAkt, mdm2 and pERK therefore seems to present a major molecular pathway in carcinogenesis and progression of breast phyllodes tumours.…”
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Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation by Md Ruhul Amin, Lakhan Khara, Joshua Szaszkiewicz, Andrew M. Kim, Trevor J. Hamilton, Declan W. Ali

“…Medicinal and recreational use of cannabis has increased in the last decade with a concomitant increase in use by pregnant women. The major psychoactive compound in cannabis, Δ9-tetrahydrocannabinol (THC), exists in different isomers, with the (-) trans isomer most common. …”
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<i>Lomatium</i> Species of the Intermountain Western United States: A Chemotaxonomic Investigation Based on Essential Oil Compositions by William N. Setzer, Ambika Poudel, Prabodh Satyal, Kathy Swor, Clinton C. Shock

“…<i>triternatum</i> were too variable to confidently assign a chemical type. The major components in the <i>L. nudicaule</i> essential oils were β-phellandrene (16.0–45.7%), (<i>Z</i>)-ligustilide (5.6–47.1%), (<i>E</i>)-β-ocimene (3.3–9.9%), and δ-3-carene (0.2–12.6%). …”
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Comparing the cost-benefit of breast cancer screening programs in rural and urban areas across four economic zones in China: a Markov modeling analysis by Dachuang Zhou, Kejia Zhou, Wenjuan Wang, Hanqiao Shao, Hongliu Zhang, Wenxi Tang

“…Conclusion Our study identified cost-effective breast cancer screening strategies suitable for the rural and urban areas in China’s four major economic zones. These findings highlight the necessity of universal screening and the importance of optimizing strategies based on regional economic development and epidemiological characteristics. …”
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Bark water affects the isotopic composition of xylem water in tropical rainforest trees by Adriana Vega Grau, John Herbohn, Susanne Schmidt, Jeffrey McDonnell, Jeffrey McDonnell, Jeffrey McDonnell

“…Understanding these possible effects is a major challenge for the identification of tree water sources and the interpretation of water use patterns using isotopes. …”
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Basal metabolic rate correlates with excess postexercise oxygen consumption across different intensities by Shu-Chun Huang, Kuan-Hung Chen, Watson Hua-Sheng Tseng, Lan-Yan Yang, Ching-Chung Hsiao, Yi-Chung Fang, Chen-Hung Lee

“…Conclusions The BMR is a major predictor of EPOC/OC and demonstrates a negative linear correlation across various CWR intensities. …”
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Predictive Clinical Factors of Pain-Related Quality of Recovery Following Elective Gastrointestinal and Hepato-Pancreato-Biliary Surgery: An Observational Study in Norway by Bergestuen L, Hagen M, Kisa S

“…Younger patients, compared to older patients (b=0.23, 95% CI: [0.03, 0.41]), female patients (b=− 0.61, 95% CI: [− 1.19, − 0.04]), patients undergoing minor and intermediate surgeries compared to major surgeries (b=0.96, 95% CI: [0.00, 1.92]) all reported higher levels of postoperative pain. …”
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Factors determining primary or delayed surgery for unilateral, non-metastatic Wilms tumor: a multicentric Egyptian study by Ahmed Elgendy, Amr Abdelhamid AbouZeid, Mohamed El-Debeiky, Shaimaa Abdelsattar Mohammad, Marwa Romeih, Ahmed Ebeed, Mohamed Abouheba, Mohammed Hamada Takrouney, Mahmoud Mostafa, Ahmed Khairi, Osama El-Naggar, Sameh Shehata

“…A retrospective analysis was conducted on all patients with unilateral, non-metastatic WT treated at four major Egyptian institutions from January 2019 to January 2024. …”
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MUNet: a novel framework for accurate brain tumor segmentation combining UNet and mamba networks by Lijuan Yang, Lijuan Yang, Qiumei Dong, Da Lin, Chunfang Tian, Xinliang Lü

“…Brain tumors are one of the major health threats to humans, and their complex pathological features and anatomical structures make accurate segmentation and detection crucial. …”
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Psilocybin-assisted therapy for reducing alcohol intake in patients with alcohol use disorder: protocol for a randomised, double-blinded, placebo-controlled 12-week clinical trial... by Claus Thorn Ekstrøm, Patrick MacDonald Fisher, Gitte Moos Knudsen, Dea Siggaard Stenbæk, Anders Fink-Jensen, Mathias Ebbesen Jensen, Tobias Søgaard Juul

“…Introduction Alcohol use disorder is a difficult-to-treat psychiatric disorder and a major burden on public health. Existing treatment efficacy is moderate, and relapse rates are high. …”
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Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves&rsquo; Disease and Graves&rsquo; Ophthalmopathy by Ke C, Yu Y, Li J, Yu Y, Sun Y, Wang Y, Wang B, Lu Y, Tang M, Wang N, Chen Y

“…Chenxin Ke,1,&ast; Yuefeng Yu,1,&ast; Jiang Li,1 Yuetian Yu,1 Ying Sun,1 Yuying Wang,1 Bin Wang,1 Yingli Lu,1 Mengjun Tang,2 Ningjian Wang,1 Yi Chen1 1Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 2Orthopedic Department, Taizhou Hospital of Zhejiang Province, Zhejiang University, Taizhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yi Chen, Email chenyi9h@126.com; Ningjian Wang, Email wnj486@126.comBackground: The blood proteome is a major source of biomarkers and therapeutic targets. …”
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Non-inferiority study to compare the efficacy of relugolix with dienogest for endometriosis-associated pain and usefulness of administering relugolix prior to dienogest (READY stud... by Fuminori Taniguchi, Motoko Fukui, Yutaka Osuga, Tasuku Harada, Jo Kitawaki

“…Abstract Background Endometriosis presents as endometrial tissue growths outside the uterine cavity with its major symptoms including dysmenorrhea and infertility. …”
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Protective Effect of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) against Vascular Dysfunction in Hyperglycemic Rats by Nurul Paramita, Brilliant C. Puspasari, Randika Arrody, Neng T. Kartinah, Trinovita Andraini, Julfiana Mardatillah, Hardiyanti Rusli, Dewi I. S. Santoso

“…Background. Hyperglycemia is a major risk factor for endothelial dysfunction. Endothelial dysfunction is associated with the inability of endothelial cells to maintain homeostasis of the cardiovascular system. …”
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Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats by Yunlong Xing, Kai Li, Yuan Jiao, Zinan Li

“…The nucleus basalis (NB) acts as a major relay between the reticular activating system and the frontal cortex (FC). …”
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Moderate-severe aortic arch calcification and high serum alkaline phosphatase co-modify the risk of cardiovascular events and mortality among chronic hemodialysis patients by Cheng-Hao Chang, Hung-Hsiang Liou, Chung-Kuan Wu

“…The Cox proportional hazard model and Kaplan–Meier analysis were used to evaluate the risks of major adverse cardiovascular effects (MACEs) and cardiovascular and all-cause mortality after multivariate adjustment.Results Among 376 chronic HD patients recruited, 125 (33%) had non-to-mild AoAC/low Alk-P, 76 (20%) had non-to-mild AoAC/high Alk-P, 89 (24%) had moderate-to-severe AoAC/low Alk-P, and 86 (23%) had moderate-to-severe AoAC/high Alk-P. …”
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The impact of delay in HIV diagnosis on patient survival: analysis of HIV infection trends from 2007 to 2023 by Riyaz A. Shaik, Sharan K. Holyachi, Mohammad S. Ahmad, Mohammed Miraj, Syed Yousaf Kazmi, Mohammad Rehan Asad, Ali Faraz, Mirwais Ramozi, Ritu Kumar Ahmad

“…Abstract Background and purpose HIV disease is one of the major public health challenges and its early diagnosis and timely management play a vital role in reducing mortality. …”
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The use of veno-arterial extra corporeal membrane oxygenation for hemodynamics support during high-risk percutaneous coronary intervention by Wael Samy, Helmy Elghawaby, Akram Abdelbary, Hany Zakaria Mohamed, Alia Hassan Abdel Fattah

“…Abstract Background Complex coronary artery disease still a major health problem, whether high-risk PCI on V-A ECMO or not is a better choice. …”
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