Genomic insights into population dynamics and adaptive strategies of the endangered dipterocarp, Hopea chinensis by Wei-Min Xiang, Yu-Ting Jiang, Jie Zou, Yan Deng, Kai Jiang, Kai-Jian Zhang, Xin-Yu Zhou, Kai-Xi Quan, Zi-Wen Han, Wei-Chao Liu, Liang Tang, Yuan-Yuan Li, Simon T. Segar, Yuan-Ye Zhang, Xing-Hua Hu, Rong Wang, Xiao-Yong Chen

“…Despite high levels of inbreeding, we detected only 441 derived deleterious and 337 derived major-effect mutations, which were not significantly enriched in any KEGG pathway, providing evidence of low genetic loads. …”
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Effect of soil-groundwater system on migration and transformation of organochlorine pesticides: A review by Haohao Li, Lin Huo, Rui Zhang, Xuefan Gu, Gang Chen, Ying Yuan, Wenbing Tan, Kunlong Hui, Yu Jiang

“…This paper focuses on two major sources of OCPs in soil and groundwater environments, compiles and summarizes the effects of environmental factors such as pH, microbial communities and enzyme activities on the transport and transformation of OCPs in soil and groundwater systems, discusses the synergistic effects of individual environmental factors and others, and comprehensively analyses the effects of synergistic effects of various environmental factors on the transport and transformation of OCPs. …”
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Prehospital triage of patients with acute cardiac complaints: study protocol of HART-c, a multicentre prospective study by Jan Bosch, Charles JHJ Kirchhof, Mark J Boogers, Enrico de Koning, Tom E Biersteker, Saskia Beeres, Barbra E Backus, Reza Alizadeh Dehnavi, Helen AM Silvius, Martin Schalij

“…Introduction Emergency department (ED) overcrowding is a major healthcare problem associated with worse patient outcomes and increased costs. …”
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Phytochemical Screening and Cytotoxic Properties of Ethanolic Extract of Young and Mature Khat Leaves by Rashad Alsanosy, Hassan A. Alhazmi, Shahnaz Sultana, Ashraf N. Abdalla, Yassin Ibrahim, Mohammed Al Bratty, David Banji, Ibrahim Khardali, Asaad Khalid

“…Hierarchical cluster analysis revealed the existence of two major clusters. The extracts of young leaves were found to contain the maximum content of cathinone; however, methoxyamphetamine was found in only one extract of young leaves. …”
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Peripheral neuropathy in the phase 3 ASPEN study of Bruton tyrosine kinase inhibitors for Waldenström macroglobulinemia by Benjamin M. Heyman, Stephen S. Opat, Björn E. Wahlin, Meletios-Athanasios C. Dimopoulos, Jorge J. Castillo, Alessandra Tedeschi, Constantine S. Tam, Christian Buske, Roger G. Owen, Véronique Leblond, Judith Trotman, Gisoo Barnes, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cohen, Jeffrey V. Matous

“…Logistic regression demonstrated a significant relationship between PN symptom resolution and both major response and lower baseline anti–myelin-associated glycoprotein antibody levels. …”
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Effects of Different River Crab <i>Eriocheir sinensis</i> Polyculture Practices on Bacterial, Fungal and Protist Communities in Pond Water by Yun Bao, Bing Li, Rui Jia, Linjun Zhou, Yiran Hou, Jian Zhu

“…Environmental factors, especially dissolved oxygen (DO), were significantly associated with the communities of bacteria, fungi, and protists, with DO being the major contributor to changes in the microbial communities. …”
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A broad spectrum Shigella vaccine based on VirG53 – 353 multiepitope region produced in a cell-free system by Girmay Desalegn, Charlotte Abrahamson, K. Ross Turbyfill, Lucy Pill-Pepe, Leslie Bautista, Chitradevi S. Tamilselvi, Dylan Dunn, Neeraj Kapoor, Barbara Sullinger, Matheo Herrera, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti

“…Abstract Dysentery caused by Shigella species remains a major health threat to children in low- and middle-income countries. …”
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Serum Magnesium Level among Acute Myocardial Infarction Patients and Its Correlation with Intra-hospital Complications: A Cross-sectional Single-center Study among Sudanese Patient... by Mohammed Taha, Ayman Azhary, Nooh Mohamed Hajhamed, Waleed Azhary Sir Alkhatim, Salahdeen Ismail Mohammed, Abdullah M Bakheit, Abdallah Elssir Ahmed, Abubakar Abdelbagi

“…Chest pain (n = 92; 92%) was the major presenting complaint. Moreover, the most prevalent heart disease determinants among patients were diabetes mellitus (n = 50; 50%) and hypertension (n = 50; 50%). …”
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Improving Fugitive Dust Emission Inventory from Construction Sector Using UAV Images Recognition by Yuyao He, Jicheng Jang, Yun Zhu, Pen-Chi Chiang, Jia Xing, Shuxiao Wang, Bin Zhao, Shicheng Long, Yingzhi Yuan

“…This improved PM emission inventory appeared to precisely identify major emission hotspots and enhanced performance of the Community Multi-scale Air Quality (CMAQ) model, and the correlation coefficient (R-value) is 0.08 ± 0.02 higher than that of the traditional emission inventory. …”
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Exploring the application of knowledge transfer to sports video data by Shahrokh Heidari, Gibran Zazueta, Riki Mitchell, David Arturo Soriano Valdez, Mitchell Rogers, Mitchell Rogers, Jiaxuan Wang, Ruigeng Wang, Marcel Noronha, Alfonso Gastelum Strozzi, Mengjie Zhang, Patrice Jean Delmas, Patrice Jean Delmas

“…However, more efficient methods are needed that can be applied across different sports without incurring high data annotation or model training costs. A major limitation of training deep learning models on large datasets is the significant resource requirement for reproducing results. …”
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Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease by Yanan Sun, Cao Ma, Hui Sun, Huan Wang, Wei Peng, Zibo Zhou, Hongwei Wang, Chenchen Pi, Yingai Shi, Xu He

“…Alzheimer’s disease (AD) is the most frequent cause of dementia and leads to major progressive deficits in memory and cognitive function. …”
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Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics by N. Vila-Chã, S. Cavaco, A. Mendes, A. Gonçalves, I. Moreira, J. Fernandes, J. Damásio, L. F. Azevedo, J. M. Castro-Lopes

“…Introduction. Pain is a major nonmotor symptom of Parkinson’s disease (PD), and central parkinsonian pain is the core feature of the putative Park pain subtype of PD. …”
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Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…Platelet activation has been reported to play a major role in arterial thrombosis, cancer metastasis, and progression. …”
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Induced Defense in Ryegrass–Epichloë Symbiosis Against <i>Listronotus bonariensis</i>: Impact on Peramine Levels and Pest Performance by Manuel Chacón-Fuentes, Gunnary León-Finalé, Marcelo Lizama, Gastón Gutiérrez-Gamboa, Daniel Martínez-Cisterna, Andrés Quiroz, Leonardo Bardehle

“…The Argentine stem weevil (ASW), a major pest in ryegrass pastures, causes significant agricultural losses. …”
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Clinical Differences between Eosinophilic and Noneosinophilic Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study by Guangming Dai, Yajuan Ran, Jiajia Wang, Xingru Chen, Junnan Peng, Xinglong Li, Huojin Deng, Min Xiao, Tao Zhu

“…Our results indicate that viral-dominant infections are the probable major etiologies of eosinophilic AECOPD. Noneosinophilic AECOPD is more likely associated with bacterial-dominant infections. …”
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Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention by Jianmei Zheng, Cen Chen, Zhongcai Fan, Qiang Ye, Yi Zhong, Jinsong Li, Hao Huang, Jianping Deng, Jinghong Zhao, Tinglin Xiong, Wenjie Tian, Xuemei Zhang

“…Heart rate (HR) has been proved to be associated with major adverse cardiovascular events (MACE) in Acute coronary syndrome patients. …”
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Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites by Thomas Kayser, MD, BS, Ronald Smulders, MD, PhD, Tomohiro Kusawake, PhD, Erik Wambre, PhD, Gurunadh R. Chichili, PhD, Mary B. Blauwet, DrPH, Anna Spence, MS, Melanie Patton, BS, Rima Tabash, PhD, Hannah A. DeBerg, PhD, Sugandhika Khosa, MS, Philipp Badorrek, MD, Jens M. Hohlfeld, MD, Brian C. Ferslew, PharmD, PhD

“…The novel LAMP (lysosomal-associated membrane protein)-based DNA vaccine ASP2390 targets major HDM allergens, potentially shifting immune responses toward nonallergic pathways and minimizing the risk of atopy, with positive safety and efficacy signals in preclinical models. …”
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Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

“…BackgroundConducting clinical drug trials (CTs) with children presents several challenges. A major challenge is the need to enroll participants at multiple sites across different jurisdictions. …”
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Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis by Ganesh Bushi, Ashok Kumar Balaraman, Shilpa Gaidhane, Suhas Ballal, Sanjay Kumar, Mahakshit Bhat, Shilpa Sharma, M Ravi Kumar, Aashna Sinha, Mahalaqua Nazli Khatib, Nishant Rai, Sanjit Sah, Ambanna Yappalparvi, Shailesh Kumar Samal, Doddolla Lingamaiah, Muhammed Shabil

“…Background and objective: Lyme disease, caused by Borrelia burgdorferi, presents major health challenges worldwide, leading to serious neurological and musculoskeletal issues that impact patients' lives and healthcare systems. …”
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Assisted Egg White Biogenic Synthesis for Elaboration of ZnO Nanoparticles by Elena Andreea Vijan, Ecaterina Magdalena Modan, Sorin Georgian Moga, Denis Aurelian Negrea, Adriana-Gabriela Schiopu, Mihai Oproescu, Daniela Istrate

“…This study explores the potential of ovalbumin, the major protein in egg white, as a template for the synthesis of nanostructured ZnO. …”
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