Epidemiologic characteristics of infectious disease-related public health emergencies in Guangdong province, 2014 – 2023: a surveillance data analysis by Weiyi CHEN, Runing GUO, Yun HUANG, Jianhua HUANG, Meiling YANG, Jiya DAI, Fengxiang SHI, Wenjia LIANG

“…Among the events reported in the the Eastern Wing region, 66.09% were caused by vector-borne and zoonotic diseases and the proportion was significantly different from those in other regions. Among the four major categories of infectious diseases causing these events, vector-borne and zoonotic diseases had the highest proportion (33.10%). …”
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The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism by Xue Wang, Chunyou Ning, Xingyi Cheng, Zhengzhong Wu, Dongbo Wu, Xuemei Ding, Cunxiang Ju, Zhihang Zhou, Lingfeng Wan, Wei Zhao, Peiliang Shi

“…Abstract Background The emerging incidence of pathogenic liver conditions is turning into a major concern for global health. Induction of pyroptosis in hepatocytes instigates cellular disintegration, which in turn liberates substantial quantities of pro‐inflammatory intracellular substances, thereby accelerating the advancement of liver fibrosis. …”
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Influence of ecologically relevant urea fertilizer concentrations on nematodes: A microcosm experiment by Rowena B. Caro-Benavides, Ma. Reina Suzette B. Madamba, Nanette Hope N. Sumaya, Ruben F. Amparado, Jr, Joey Genevieve T. Martinez

“… Aim of study: Urea remains one of the most widely used chemical fertilisers in the world and is used extensively in the Philippines as a major source of nitrogen for crops. However, we have a very limited understanding of its impact on soil fauna such as nematodes. …”
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A strain of Talaromyces assiutensis provides multiple protection effects against insect pests and a fungal pathogen after endophytic settlement in soybean plants by Li Sui, Yang Lu, Ke Cheng, Yifan Tian, Zhiming Liu, Zhao Xie, Zhengkun Zhang, Qiyun Li

“…In addition, its control efficiency against major soybean insect pests and phytopathogenicity were also evaluated after plant colonization. …”
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Evaluation of the transmission-blocking potential of Plasmodium vivax antigen Pvg37 using transgenic rodent parasites and clinical isolates by Di Zhang, Yan Zhao, Dongyan Liu, Fei Liu, Pengbo Liu, Biying Zhang, Zifang Wu, Wanlapa Roobsoong, Sirasate Bantuchai, Sataporn Thongpoon, Piyarat Sripoorote, Meilian Wang, Liwang Cui, Yaming Cao

“…BackgroundPlasmodium vivax is a major cause of malaria, particularly outside Africa, necessitating effective strategies for public health management. …”
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Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep by Beaumelle, Camille, Toïgo, Carole, Papet, Rodolphe, Benabed, Slimania, Beurier, Mathieu, Bordes, Léa, Brignone, Anaïs, Curt-Grand-Gaudin, Nadine, Garel, Mathieu, Ginot, Justine, Jacquiet, Philippe, Miquel, Christian, Poirel, Marie-Thérèse, Serafino, Anna, Vannard, Eric, Bourgoin, Gilles, Yannic, Glenn

“…In addition, gastrointestinal nematodes have developed resistance to anthelmintics which is now considered a major problem for the livestock sector. In a context where wild and domestic ungulates share the same pastures, the maintenance and circulation of resistant gastrointestinal nematodes between species have rarely been explored. …”
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Prevalence, risk factors and management of common mental health disorders in Cameroon: a systematic review by Emmanuel Kah, Che Henry Ngwa, John Njuma Libwea, Marion Keinamma, Frankline Sevidzem Wirsiy, Limkile Mpofu, Tchokokam Patricia, Rejoice Uche Obiora, Danga Aloleko Ines, Ngo Valery Ngo, Egbe Henrieta Oneke, Crayton E Bessong, Ngozi Margaret Oguguah, Eman Sobh

“…Objectives This review aimed to synthesise evidence on (1) the prevalence of common mental health disorders (MHDs) in Cameroon; (2) the effectiveness of mental health management interventions; (3) the risk factors for common MHDs in Cameroon and (4) map the state of research on common mental disorders in Cameroon.Design A systematic review.Data sources We performed a comprehensive search for articles in major public health databases including PubMed, Scopus, Medline, CINAHL, PsycINFO, Web of Science, Embase, CINAHL from inception of each database to June 2022.Eligibility criteria Published articles on the prevalence, risk factors or intervention for management of common MHDs in Cameroon met the inclusion criteria for this systematic review.Data extraction and synthesis The abstract and full-text screening, and data extraction were performed independently by at least two researchers. …”
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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

“…Abstract Cytochrome P450 (CYP) 3A4 plays a major role in drug metabolism. Its activity could be determined by non-invasive and cost-effective assays, such as breath analysis, for the personalised monitoring of drug response. …”
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Pollen contamination and mating structure in maritime pine (Pinus pinaster Ait.) clonal seed orchards revealed by SNP markers by Bouffier, Laurent, Debille, Sandrine, Alazard, Pierre, Raffin, Annie, Pastuszka, Patrick, Trontin, Jean-François

“…Maritime pine (Pinus pinaster Ait.) is a major forest tree species in south-western Europe. …”
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Biodegradation of Azo and disperse dyes by Trametes versicolor: Process optimization and MnP enzyme dynamics by Isma Fayyaz, Salina Saddick, Raja Tahir Mahmood, Muhammad Javaid Asad, Muhammad Altaf Hussain, Jiandong Hu, Muhammad Awais, M. Ijaz Khan, Shaxnoza Saydaxmetova

“…Textile industries are the major source of environmental pollution in the world because they release dyes, chemical and pigments in wastewater which are produced during dying process. …”
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Incremental cost of treating antimicrobial-resistant infections among hospitalised patients in India: a cohort study by Sanjay M Mehendale, Kamini Walia, Pallab Ray, Nusrat Shafiq, Shankar Prinja, Sagar Khadanga, Susmita Chatterjee, Raman Gangakhedkar, Samiran Panda, Sanjay Bhattacharya, Megha Mamulwar, Abhijit Kadam, Gayatri Bhambure, Shilpa Bembalkar, Shraddha Bapat, Arati Mane, Shobha Rajure, Jayanthi Mathaiyan, Yamunadevi Ramanathan, Vijayshri Suresh Deotale, Gourangie Gogoi, Ruchita Attal, Jharna Mandal, Venkateswaran Ramanathan

“…Pharmaceutical cost was the major contributor to IC at GHs (61.5%) and PHs (27.1%). …”
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The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) by Wei Xiong, Qinghan Liang, Xiaojie Han, Qiaolu Cheng, Qihang Liu, Xifang Zuo, Huiyu Wang, Huijing He, Guangliang Shan

“…Introduction Infertility has become a major global issue due to the trend of delaying marriage and advanced maternal age. …”
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Increased rate of multidrug-resistant gram-negative bacterial infections in hospitalized immunocompromised pediatric patients by Sarah Khafaja, Sarah Khafaja, Yara Salameh, Celina F. Boutros, Cherine Awad, Kawthar Faour, Nadim Tfaily, Sarah Merhi, Zeinab El Zein, Zeinab El Zein, Samer Bou Karroum, Dana Oweini, Danielle Fayad, George F. Araj, George F. Araj, George F. Araj, Ramia Zakhour, Ghassan S. Dbaibo, Ghassan S. Dbaibo

“…IntroductionMultidrug resistant Gram-negative bacterial infections are considered a major public health threat. Immunocompromised pediatric patients are at a great risk of severe or overwhelming infections. …”
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Characterization of patients with clonal mast cells in the bone marrow with clinical significance not otherwise specifiedResearch in context by Thomas Ballul, Vito Sabato, Peter Valent, Olivier Hermine, Olivier Lortholary, Julien Rossignol, Thomas Ballul, Vito Sabato, Cristina Bulai Livideanu, Antoine Neuraz, Julie Agopian, Fabienne Brenet, Patrice Dubreuil, Didier G. Ebo, Michiel Beyens, Richard Lemal, Olivier Tournilhac, Louis Terriou, David Launay, Laurence Bouillet, Catharina Chatain, Clément Gourguechon, Gandhi Damaj, Stéphane Durupt, Celine Greco, Laurent Frenzel, Christine Bodemer-Skandalis, Laura Polivka, Marine Madrange, Cécile Meni, Hassiba Bouktit, Anne Florence Bellais, Jean-Marc Durand, Marie Gousseff, Edwige Le Mouel, Mohamed Hamidou, Antoine Neel, Dana Ranta, Mathilde Niault, Aurélie Schiffmann, Stéphane Barete, Michel Arock, Danielle Canioni, Thierry Jo Molina, Julie Bruneau, Mélanie Vaes, Violaine Havelange, Hassan Faour, Nicolas Garcelon, Rose-Marie Javier, Fabien Pelletier, Florence Castelain, Denis Vincent, Frédérique Retornaz, Quentin Cabrera, Patricia Zunic, Philippe Guilpain, Marie Pierre Gourin, Ewa Wierzbicka–Hainaut, Jean François Viallard, Christian Lavigne, Cyrille Hoarau, Ludovic Lhermitte, Maël Heiblig, Roland Jaussaud, Peter Valent, Olivier Hermine, Olivier Lortholary, Julien Rossignol

“…Summary: Background: Systemic mastocytosis (SM) diagnosis requires the presence of 3 minor criteria or 1 major and 1 minor criterion according to the WHO 2016 classification. …”
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A cross-sectional study of the current status of psychological health and its correlation with academic performance in medical students: taking medical students in a medical univer... by Han Chunhong, Han Chunhong, Ding Jingjing, He Huan, Zheng Peiyao, Zhang Xiaona, Yang Xiaowen, Zheng Aiming

“…However, no correlation was found between the GAD-7 values and the GPA. The PHQ-9 scores and major categories were identified as independent factors influencing the average GPA.ConclusionThe undergraduates face significant challenges in depression, anxiety, insomnia, and perceived stress, and these have negative effects on their academic performances; in particular, the depressive symptoms and perceived stress can significantly reduce their academic performances. …”
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FOSL2 activates TGF‐β1‐mediated GLUT1/mTOR signaling to promote diabetic kidney disease by Xuelin He, Min Xia, Guanghui Ying, Qien He, Zhaogui Chen, Li Liu, Qiao Zhang, Jianxin Cai

“…ABSTRACT Aims/Introduction Diabetic kidney disease (DKD) is a major cause of kidney failure. FOS‐like antigen 2 (FOSL2) has been revealed to be increased in kidney biopsies of patients with lupus nephritis, while its association with DKD remains unsolved. …”
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Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis by Fang-Chen Gong, Ran Ji, Yu-Ming Wang, Zhi-Tao Yang, Ying Chen, En-Qiang Mao, Er-Zhen Chen

“…Sepsis remains a major global concern and is associated with high mortality and morbidity despite improvements in its management. …”
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Exploring the Impact of Citric Acid on Mitigating Sweet Potato Soft Rot and Enhancing Postharvest Quality by Yixi Chen, Linjiang Pang, Jiacheng Bai, Wenbao Yu, Yueming Zhu, Melvin Sidikie George, Zunfu Lv, Guoquan Lu

“…Soft rot, caused by the pathogen <i>Rhizopus stolonifer</i>, is a major postharvest disease affecting sweet potato (<i>Ipomoea batatas</i> (L.) …”
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Genetic variability and heritability estimates among nutritional traits of groundnut breeding lines by Richard Adu Amoah, James Yaw Asibuo, Richard Akromah, Kwabena Asare Bediako, Maxwell Lamptey, Collins Yeboah Osei, Samuel Awuah, Richard Boampong

“…However, low genetic variability has been a major bottleneck in genetic enhancement of these characters in breeding varieties. …”
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The lysosome-related characteristics affects the prognosis and tumor microenvironment of lung adenocarcinoma by Wuguang Chang, Wuyou Gao, Yawei Wu, Bin Luo, Lekai Zhong, Leqi Zhong, Wenqian Lin, Zhesheng Wen, Youfang Chen

“…BackgroundThe lysosome plays a vitally crucial role in tumor development and is a major participant in the cell death process, involving aberrant functional and structural changes. …”
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