Process Optimization and Antioxidant Activity of Pine Needle Essential Oil Extracted by Microwave-assisted Extraction by Suyuan LÜ, Bingqing SHANG, Luyan SUN, Guolong LIU, Fa ZHAO, Xiuqing LIANG, Qiu WU, Yue GENG

“…A total of 104 candidate components were obtained from the essential oil, with major components including thunbergol (3.938%), and verticillol (3.597%), and so on. …”
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Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells by Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu

“…Moreover, CPT1C was shown to be regulated at the post-translational level and an E3-ubiquitin ligase, NEDD4L, was shown to be a major regulator of CPT1C stability and activity. …”
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Efficacy and safety of left bundle branch area pacing versus biventricular pacing in heart failure patients with left bundle branch block: study protocol for a randomised controlle... by Lin Zhao, Liting Cheng, Junmeng Zhang, Zefeng Wang, Mengge Zhou, Zhuo Liang, Jieruo Chen, Yongquan Wu

“…The secondary outcomes are NT-proBNP, duration of the QRS complex, end systolic volume, end diastolic volume, the 6-minute walking test and quality of life (SF-36 scale), all causes of mortality, cardiovascular death, rehospitalisation rate of heart failure, other rehospitalisation rates, major complication rates, procedure costs and hospitalised dates.Ethics and dissemination This study has been approved by the Beijing Anzhen Hospital Medical Ethics Committee (No. ks201932). …”
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Out-of-phase relationship of Holocene moisture variations between the northeastern and southeastern Tibetan plateau and its societal impacts by Duo Wu, Minmin Ma, Yongxiu Lu, Shilong Guo, Tao Wang, Xuyi Ma, Guanghui Dong

“…It is widely accepted that Holocene climatic and environmental changes had major impacts on socioeconomic development and the evolution of civilization. …”
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Computed tomography-guided microwave ablation for right middle lobe pulmonary nodules: a retrospective, single-center, case-control study by Yanting Hu, Guoliang Xue, Xinyu Liang, Zhichao Li, Nan Wang, Pikun Cao, Gang Wang, Haitao Zhang, Xiaohuan Zheng, Aiguang Wang, Wenhua Zhao, Cuiping Han, Zhigang Wei, Xin Ye

“…There were no significant differences in technique efficacy rates between the RML and non-RML groups (97.2% vs. 95.1%, p = 0.721). However, both major (47.9% vs. 19.7%, p < 0.001) and minor (26.8% vs. 11.3%, p = 0.004) pneumothorax were more common in the RML group than non-RML group. …”
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Risk factors for Clostridioides difficile infection among patients diagnosed with inflammatory intestinal and rheumatological diseases in the biologic era by Helena Martínez-Lozano, Paula Saralegui-Gonzalez, Elena Reigadas, Pablo Ramón Fueyo-Peláez, Aurea García-García, José Miranda-Bautista, Luis Alcalá, Juan Carlos Nieto, María Elena Lobato-Matilla, Ignacio Marín-Jiménez, Patricia Muñoz, Luis Menchén

“…The diagnosis of IBD was the major risk factor for developing CDI in the overall population (OR: 18.29, CI 95%: 5.59–59.80, p < 0.001). …”
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Multicenter Study of the Hemorrhage Risk after Endoscopic Mucosal Resection Associated with Direct Oral Anticoagulants by Ritsu Yasuda, Naohisa Yoshida, Takaaki Murakami, Ryohei Hirose, Ken Inoue, Osamu Dohi, Yuji Naito, Yutaka Inada, Takashi Okuda, Daisuke Hasegawa, Kotaro Okuda, Kiyoshi Ogiso, Yoshikazu Inagaki, Koichi Soga, Akira Tomie, Yoshito Itoh

“…However, postoperative hemorrhage (POH) is a major complication associated with endoscopic mucosal resection (EMR) for colorectal lesions. …”
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Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study by Zhang-Yang Xu, Hong Zheng, Zi-Jun Pan, Shou-Yi Hu, Yun-Xia Wang, Wen-Jun Su

“… Insulin resistance has been proposed as a contributing factor to major depressive disorder (MDD), with previous studies reporting a positive correlation between triglyceride-glucose (TyG) a proxy indicator of insulin resistance and MDD. …”
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Foliar spraying with zinc oxide nanoparticles enhances the anti-osteoporotic efficacy of the fruit extracts of Silybum marianum L. by stimulating silybin production by Bedoor Fahad Almulhim, Fadia El Sherif, Fadia El Sherif, Nancy S. Younis, Yamen Safwat, Salah Khattab, Salah Khattab

“…Silybin (A+B) are two major hepatoprotective flavonolignans produced predominantly in S. marianum fruits. …”
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Contemporary Management of Patients With Chagas Cardiomyopathy in Bolivia by Evan Czulada, BS, Sascha Bercovitch, BA, Yazan Alshawkani, MD, Natalia Noya Weise, MD, Adriana E. Hernani Rodrigo, BS, Ronald Gustavo Durán Saucedo, MD, Marcelo Buhezo Chamón, MD, Robert H. Gilman, MD, David T. Martin, MD

“…Responses were collected from every major Bolivian city. More than 70% of cardiologists cared for CCM patients daily or weekly. …”
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Prepregnancy Depression and Breastfeeding Duration: A Look at Maternal Age by Jordyn T. Wallenborn, Anny-Claude Joseph, Whitney C. Graves, Saba W. Masho

“…In the United States, major depressive disorder affects one in five women aged 20-40 years. …”
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Fabry cardiomyopathy: Gb3‐induced auto‐reactive panmyocarditis requiring heart transplantation by Andrea Frustaci, Maurizio Scarpa, Rosalia Maria da Riol, Chiara Agrati, Nicoletta Finato, Romina Verardo, Claudia Grande, Cristina Chimenti, Concetta Di Nora, Matteo Antonio Russo, Ugolini Livi

“…Abstract Resistance to enzyme replacement therapy (ERT) is a major therapeutic challenge in Fabry disease (FD). …”
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Effect of custom-designed transfection buffer on delivery of genome modification components into primary cells of buffalo, cattle, goats, and sheep by Shreya Malhotra, Priyanka Singh, Aseem Tara, Bosco Jose, Devika Gautam, Ram Prasad, Gaurav Tripathi, Sacchinandan De, Naresh L. Selokar

“…Electroporation efficiency depends on various physical parameters, of which cell type is considered a major factor for transfection efficiency. Primary cells are generally less susceptible to transfection than other cell types due to their finite lifespan and limited expansion capacity. …”
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Cognitive control in individuals with heroin use disorder after prolonged methadone maintenance treatment by Wei Zhao, Fan Duan, Xiangyu Li, Junda Li, Lingling Xia, Zixuan Ren, Yegang Li, Li Song, Peipei Song, Linlin Mu, Lijin Wang, Jing Zhang, Xun Song, Ze Wang, Jinxuan Chen, Xiaochu Zhang, Dongliang Jiao

“…Abstract Background Although impaired cognitive control is common during the acute detoxification phase of substance use disorders (SUD) and is considered a major cause of relapse, it remains unclear after prolonged methadone maintenance treatment (MMT). …”
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Cerebellar lipid dysregulation in SCA3: A comparative study in patients and mice by Alexandra F. Putka, Varshasnata Mohanty, Stephanie M. Cologna, Hayley S. McLoughlin

“…Recent studies demonstrate prominent white matter atrophy and microstructural alterations in disease-vulnerable brain regions of SCA3 patients and mouse models. However, the major constituent of white matter – lipids – remains understudied in SCA3.In this study, we conducted the first unbiased investigation of brain lipids in SCA3, focusing on the disease-vulnerable cerebellum of SCA3 postmortem patients and mouse models. …”
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Laparoscopic Versus Robotic Ventral Hernia Repair With Intraperitoneal Mesh: A Systematic Review and Meta-Analysis Comparing the Perioperative Outcomes Randomised Controlled Trials by Anurag Singh, Wei H. Toh, Nada Elzahed, Goldie Khera, Mirza K. Baig, Andrei Mihailescu, Muhammad S. Sajid

“…Due to the paucity of the RCTs and significant heterogeneity among the compared variables, a major multi-centre RCT is needed to validate these findings.…”
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2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project by Lucia Billeci, Valentina Riva, Elena Capelli, Serena Grumi, Miriam Paola Pili, Maddalena Cassa, Eleonora Siri, Elisa Roberti, Renato Borgatti, Renato Borgatti, Livio Provenzi, Livio Provenzi

“…IntroductionVery preterm (VPT) birth is a major risk condition for child development and parental wellbeing, mainly due to multiple sources of stress (e.g., separation and pain exposure) during the neonatal intensive care unit (NICU) stay. …”
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Abnormal characteristics of inferior vena cava and abdominal aorta among neonates with early onset septic shock by Lanlan Mi, Yiman Liu, Fei Bei, Jianhua Sun, Jun Bu, Yuqi Zhang, Weiwei Guo

“…Abstract Background The variety of shocks in neonates, if not recognized and treated immediately, is a major cause for fatality. The use of echocardiography may improve assessment and treatment, but its reference values across gestational age (GA) and birth weight (BW) are lacking. …”
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Moving from monitoring to real-time interventions for air quality: are low-cost sensor networks ready to support urban digital twins? by Nicole Hannah Cowell, Nicole Hannah Cowell, Lee Chapman, David Topping, Philip James, Daniel Bell, Thomas Bannan, Ettore Murabito, James Evans, Mark Birkin

“…However, the availability and standardization of live streams of big data is a major challenge and there are issues with interoperability, metadata management, communicating uncertainty, network longevity, data ownership and transparency. …”
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Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events by Takahiro Nishihara, MD, PhD, Toru Miyoshi, MD, PhD, Kentaro Ejiri, MD, PhD, Kazuhiro Osawa, MD, PhD, Soichiro Fuke, MD, PhD, Kousuke Seiyama, MD, Masayuki Doi, MD, PhD, Mitsutaka Nakashima, MD, PhD, Takashi Miki, MD, PhD, Shinsuke Yuasa, MD, PhD

“…PCATA was evaluated using coronary CTA to measure pericoronary adipose tissue density surrounding the 3 major coronary arteries. The outcomes were composite cardiovascular events, including cardiovascular death and acute coronary syndrome; 33 cardiovascular events observed during a median follow-up of 6.0 years (Q1-Q3: 3.6-8.2 years). …”
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