Application of alternative <i>de novo</i> motif recognition models for analysis of structural heterogeneity of transcription factor binding sites: a case study of FOXA2 binding sit... by A. V. Tsukanov, V. G. Levitsky, T. I. Merkulova

“…The BaMM model provided the main contribution to the recognition of sites. Although the major fraction of predicted peaks contained TFBS of different models with coincided positions, the medians of the fraction of peaks containing the predictions of sole models were 1.08, 0.49, 4.15 and 1.73 % for PWM, diPWM, BaMM and InMoDe, respectively. …”
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Perinatal consequences of a category 1 caesarean section at term by Sailesh Kumar, Leah Grace, Ristan M Greer

“…Objective To characterise maternal demographics, obstetric risk factors and neonatal outcomes associated with term category 1 caesarean sections (CS).Design and setting and main outcome measures Retrospective study of term singleton pregnancies delivering at a major tertiary unit in Brisbane, Australia. Category 1 CS were defined as one that required a decision-to-delivery time interval of &lt;30 min when there was an immediate threat to the life of a woman or fetus. …”
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Tetrahydrobiopterin as a rheostat of cell resistance to oxidant injury by R. Steven Traeger, James Woodcock, Sidhartha Tan, Zhongjie Shi, Jeannette Vasquez-Vivar

“…We showed that BH2 is not a major product of treatments with hydrogen peroxide or RSL3, as indicated by the moderate effect of dihydrofolate reductase-inhibitor methotrexate on the accumulation of BH2. …”
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Self-reported illnesses in Thatta: Evidence from a rural and underdeveloped district in Sindh province, Pakistan. by Muhammad Ashar Malik, Rahat Batool, Muhammad Ahmed, Imran Naeem Abbasi, Zafar Ahmed Fatmi, Sarah Saleem, Sameen Siddiqui

“…Prevalence was estimated for all SRIs categorized into six major and 16 minor illnesses. The influence of important socio-demographic covariates on the illnesses and multiple comorbidities was explored by estimating prevalence ratios with a Generalized Linear Model of the Poisson family and by Zero-Inflated Poison Distribution respectively.…”
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Model systems of human immunodef iciency virus (HIV-1) for in vitro eff icacy assessment of candidate vaccines and drugs against HIV-1 by N. B. Rudometova, D. N. Shcherbakov, A. P. Rudometov, A. A. Ilyichev, L. I. Karpenko

“…HIV infection still remains a major challenge for healthcare systems of the world. …”
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Immunizing adult female mice with a TcpA-A2-CTB chimera provides a high level of protection for their pups in the infant mouse model of cholera. by Gregory A Price, Randall K Holmes

“…CT causes profuse watery diarrhea, and TCP (composed of repeating copies of the major pilin TcpA) is required for intestinal colonization by V. cholerae. …”
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From fragmented to integrated healthcare managing hypertension post-stroke: a qualitative study by Hala F. Azhari, Jonathan Hewitt, Martin O'Neill, Alexander Smith, Terence Quinn, Jesse Dawson

“…Data were analyzed thematically to identify barriers and facilitators in hypertension management post-stroke.ResultsKey findings identified four major themes: the need for improved cooperation among multidisciplinary teams, knowledge gaps in stroke survivors regarding hypertension's role in stroke risk, the complexities of polypharmacy, and the potential benefits of ABPM for individualized care. …”
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Cytotoxic and Apoptosis-Inducing Activity of Plants from the Family Asparagaceae in Relation to Human Alveolar Adenocarcinoma Cells by Y.N. Kamalova, V.V. Shtyreva, Essam Abdul-Hafeez, Omer H.M. Ibrahim, P.V. Zelenikhin, N.S. Karamova, O.N. Ilinskaya

“…Cancer is known as the second major mortality cause. The number of new cases is increasing every year. …”
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Study on Visual Quality After Cataract Surgery and Goniosynechialysis in Patients with Primary Angle-Closure Glaucoma and Cataracts by Chen M, Li J, Chen Q, Zhao Y

“…Correlations: Pupil size was positively correlated with higher-order aberrations and negatively correlated with contrast sensitivity.Conclusion: Pupil dilation is a major factor affecting postoperative visual quality in PACG patients, even after surgery. …”
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Nutrient inputs shape ecosystem functioning gradients along the pristine, upper Neretva River, Bosnia and Herzegovina by Rubén Del Campo, Barbara Jechsmayr, Veronika Settles, Melanie Ströder, Gabriel Singer

“…Our results emphasize the great sensitivity of ecosystem functioning in the Neretva to nutrient inputs and environmental discontinuities, either natural or human-made. Potential major, long-term impacts in the area might alter existing environmental gradients and thus ecosystem functioning in rivers at local and regional scale. …”
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Mathematical modelling and optimization of cutting conditions in turning operation on MDN 350 steel with carbide inserts by Syed Adil, A. Krishnaiah, D. Srinivas Rao

“…Improvement of tool life, enhancement of rate of production, reduction in cost of production and closeness of surface finish to that of grinding are the major goals of the work. The experimental work is divided into two sets wherein in the first set, the cutting inputs are speed and tool feed rate and the experimental output is flank-wear. …”
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A CRITIC-BPNN APPROACH TO FRICTION STIR WELDING PARAMETRIC SELECTION AND PREDICTION USING AA6082-T6 MATERIAL by Mufutau Adeniyi Abolarin, Adeyinka Oluwo, John Rajan, Swaminathan Jose, Sunday Ayoola Oke |, Alexander Iwodi Agada, Ayomide Sunday Ibitoye

“…This paper fills the gap by introducing an integrated CRITIC-BPNN (CRiteria Importance Through Intercriteria Correlation-Back Propagation Neural Network) method to investigate the selection and optimisation characteristics of the friction stir welding process for AA6082-T6 material. In this study, two major performance characteristics i.e. ultimate tensile strength (UTS) and percentage elongation (%EL), were chosen for analysis. …”
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A reproducible representation of healthy tibiofemoral kinematics during stair descent using REFRAME – part I: REFRAME foundations and validation by Ariana Ortigas-Vásquez, William R. Taylor, Barbara Postolka, Pascal Schütz, Allan Maas, Matthias Woiczinski, Thomas M. Grupp, Adrian Sauer

“…Exacerbated by numerous difficulties to consistently define joint coordinate frames, the influence of local frame orientation and position on the characteristics of the resultant kinematic signals has been previously proven to be a major limitation. Consequently, for consistent interpretation of joint motion (especially direct comparison) to be possible, differences in local frame position and orientation must first be addressed. …”
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The relationship between intimate partner violence reported at the first antenatal booking visit and obstetric and perinatal outcomes in an ethnically diverse group of Australian p... by Charlene Thornton, Virginia Schmied, Ana María Muñoz, Hannah Grace Dahlen

“…We analysed routinely collected data (2006–2016) from the ObstetriX system on a cohort of pregnant women.Setting and participants 33 542 women giving birth in a major health facility in Western Sydney.Primary outcomes Incidence of IPV, association with IPV and other psychosocial variables and maternal and perinatal outcomes.Result 4.3% of pregnant women reported a history of IPV when asked during the routine psychosocial assessment. …”
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5-year outcomes of salvage endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma by Andrew Thamboo, Vishal S. Patel, Peter H. Hwang

“…The minor complication rate was 52.6%, major operative complication rate was 0.0%, and late complication rate was 23.1%. …”
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Do meteorological variables impact air quality differently across urbanization gradients? A case study of Kaohsiung, Taiwan, China by Bohan Wu, Shuang Zhao, Yuxiang Liu, Chunyan Zhang

“…Air pollution has become a major challenge to global urban sustainable development, necessitating urgent solutions. …”
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The Use of Trichostatin A during Pluripotent Stem Cell Generation Does Not Affect MHC Expression Level by Sara Farahi, Sara Hosseini, Hossein Ghanbarian, Seyed Mahmoud Hashemi, Mohammad Salehi, Samaneh Hosseini

“…The efficiency of PSC generation and their immunogenicity is major obstacles for clinical use. Hence, we aim to investigate whether the use of TSA during PSC generation affects MHC expression level. …”
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The Recent Progress and Applications of Digital Technologies in Healthcare: A Review by Maksut Senbekov, Timur Saliev, Zhanar Bukeyeva, Aigul Almabayeva, Marina Zhanaliyeva, Nazym Aitenova, Yerzhan Toishibekov, Ildar Fakhradiyev

“…The review highlights the applications of artificial intelligence, “big data,” telemedicine and block-chain technologies, and smart devices (internet of things) for solving the real problems in healthcare and medical education. Major Findings. We identified 252 papers related to the digital health area. …”
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Time dependence effect of metal toxicology and application in WQC derivation of main water basins in China by Tianxin Li, Yao Wang, Ning Qin, Wenjing Zhao, He Huang

“…Finally, the dynamic ecological risks of heavy metals in major Chinese water basins were evaluated. The results indicated a linear negative correlation between the acute toxicity data of heavy metals and exposure time, and a decrease in derived HC5 values as exposure time increased. …”
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Elevated levels of serum alpha-2-macroglobulin associate with diabetes status and incident CVD in type 1 diabetes by Baohai Shao, Janet K. Snell-Bergeon, Ian H. de Boer, W. Sean Davidson, Karin E. Bornfeldt, Jay W. Heinecke

“…Atherosclerotic CVD is a major cause of death in individuals with type 1 diabetes mellitus (T1DM). …”
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