Clinical Outcomes and Patient Experience of Biosimilar to Biosimilar Infliximab Switching in Patients with Inflammatory Bowel Disease: A Prospective, Single-Centre, Phase IV Interv... by Clare Harris, Richard James Harris, David Young, Martin McDonnell, Bridget Clancy, Justin Harvey, Carlos Araujo, Ines Iria, Joao Goncalves, Susan Latter, J. R. Fraser Cummings

“…Thematic analysis identified six major themes that reflected the patient experience—trust, clinical status at the point of switching, past experience, general disposition, information provision, and concerns/anxiety. …”
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Uso e ocupação do solo em São Paulo, alterações climáticas e os riscos ambientais contemporâneos by Jane Zilda dos Santos Ramires, Neli Aparecida de Mello-Théry

“…This phenomenon is exacerbated in major cities of less developed countries, where we see the increasing number of people living in extreme poverty surviving in areas of risk, such as hillsides and areas prone to flooding. …”
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Exposure to needlestick injury among healthcare support staff in Greater Accra, Ghana: a cross-sectional study by Mary Eyram Ashinyo, Philip Apraku Tawiah, Emmanuel Appiah-Brempong, Paul Okyere

“…Objectives This study aims to determine the prevalence and predisposing factors of a needlestick injury (NSI) among healthcare support staff in the Greater Accra region, Ghana.Methods An analytical cross-sectional survey was carried out from 30 January 2023 to 31 May 2023, involving 10 major health facilities. A multistage sampling method was adopted. …”
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Hypotony maculopathy after glaucoma surgery: pathogenic mechanisms, diagnostic tools, and treatment modalites by V.P. Erichev, S.Yu. Petrov, N.A. Orekhova, L.Kh. El’murzaeva

“…Risk factors for hypotony maculopathy are younger age, male sex, myopia, and primary glaucoma surgery using antimetabolites.</i> </p> <p> <i>Major diagnostic tools for hypotony maculopathy to assess the abnormalities and their changes over time are ultrasound (to provide differential diagnosis in poor fundus visualization), fluorescent angiography (to identify choroidal folds and to differentiate between choroidal and retinal folds), and optical coherence tomography.…”
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Seasonal coastal residency and large-scale migration of two grey mullet species in temperate European waters by Jena E. Edwards, Anthonie D. Buijse, Hendrik V. Winter, Allert I. Bijleveld

“…Both species showed an affinity for receivers near major harbours, with thinlip mullet more often detected near fresh water outflows. …”
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Prevalence of Hepatitis C Virus Infection in Cancer Patients: A Cross-sectional Study from Regional Cancer Care Centre, Gujarat, India by Hirenkumar Ashokbhai Patel, Foram Maulin Patel

“…Introduction: Hepatitis C infection is a liver disease caused by the Hepatitis C Virus (HCV). It is one of the major risk factors for acute to chronic liver diseases, such as altered liver functions, chronic hepatitis, cirrhosis, hepatocellular carcinoma and liver failure. …”
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Semen extender triggers a mild physiological inflammatory response in the uterus without disrupting sperm-uterine immune crosstalk in vitro in cattle by Malinda HULUGALLA, Alireza MANSOURI, Elham WAEHAMA, Ihshan AKTHAR, Akio MIYAMOTO

“…This study investigated the impact of the major component of the insemination dose, egg yolk-based SE, on the uterine immune response in vitro. …”
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Prevalence of depression among medical students in Africa: Systematic review and meta-analysis. by Chilot Kassa Mekonnen, Hailemichael Kindie Abate, Zerko Wako Beko, Alebachew Ferede Zegeye, Abere Woretaw Azagew

“…<h4>Introduction</h4>Depression has become a major health problem that students in a University encounter during their study life. …”
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Point Prevalence Survey of Antimicrobial Use among Hospitalized Patients in a Referral Hospital in Northwest Ethiopia: A Hospital-Based Cross-Sectional Study by Mengistie Yirsaw Gobezie, Minimize Hassen, Nuhamin Alemayehu Tesfaye, Mulat Belete Demessie, Tewodros Solomon, Ermiyas Alemayehu

“…This study aimed to examine the prevalence of antimicrobial use, common antimicrobial drug types, and indications for antimicrobial use in a major public hospital. Methodology. A cross-sectional PPS study design conducted in a hospital setting was utilized to explore the usage of antimicrobials in the adult wards of Felege Hiwot Comprehensive Specialized Hospital (FHCSH), employing the WHO-PPS methodology. …”
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Correlation of Platelet Indices with Severity of Gastroesophageal Varices in Patients of Liver Cirrhosis: A Research Protocol by Parav Tantia, Sourya Acharya

“…Gastroesophageal varices are major contributors to both mortality and morbidity on a global scale. …”
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Combining machine learning algorithms for bridging gaps in GRACE and GRACE Follow-On missions using ERA5-Land reanalysis by Jaydeo K. Dharpure, Ian M. Howat, Saurabh Kaushik, Bryan G. Mark

“…The model's performance was further compared across five climatic zones, with two previously reconstructed products (Li and Humphrey methods) at 26 major river basins, during flood/drought events, and for sea-level rise. …”
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Fluidization of fine coal particles in an ultrasound enhanced gas-solid fluidized bed by Sayuri Naicker, Neeraj Kuarsingh, Milan Carsky, David Lokhat

“…Coal continues to be one of the most important primary energy sources and is a major contributor to economic growth, especially in the developing world. …”
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Association between risk of ischemic stroke and liver enzymes levels: a systematic review and meta-analysis by Omnia Samy El-Sayed, Asmaa Zakria Alnajjar, Abdelfattah Arafa, Hazem E. Mohammed, Abdelrahman M. Elettreby, Safiya Ibraheem, Dalia Esam Tawfik, Menna Allah Ashraf Abdullah, Mohamed Ahmed Tolba

“…Abstract Background Ischemic stroke is a major public health concern, contributing significantly to global morbidity and mortality. …”
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Identifying the snake: First scoping review on practices of communities and healthcare providers confronted with snakebite across the world. by Isabelle Bolon, Andrew M Durso, Sara Botero Mesa, Nicolas Ray, Gabriel Alcoba, François Chappuis, Rafael Ruiz de Castañeda

“…<h4>Background</h4>Snakebite envenoming is a major global health problem that kills or disables half a million people in the world's poorest countries. …”
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Analysis and Evaluation of Quality Indicators and Volatile Compounds of Different Rice Cultivars with Geographical Indication by WANG Qin, ZHOU Changyan, ZHAO Xiaoyan, LI Xiaobei, LI Xujiao, JIANG Zhenghui, ZHANG Yanmei

“…Using headspace solid-phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC-MS) followed by odor activity value (OAV) analysis, the major odor-active compounds of rice were identified as 2-acetyl-1-pyrroline, hexanal, heptanal, octanal, nonanal, trans-2-octenal, hexanol, 1-octen-3-ol, and heptanol. …”
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Efficient task scheduling and computational offloading optimization with federated learning and blockchain in mobile cloud computing by Matheen Fathima G, Shakkeera L

“…Resource matching, task sequencing, and task scheduling are major steps of Optimization Task Scheduling based Computational Offloading (OTSCO) framework. …”
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Efficacy of an Emergency Cervical Cerclage Using Absorbable Monofilament Sutures by Yuka Sato, Nobuhiro Hidaka, Takahiro Nakano, Saki Kido, Masahiro Hachisuga, Yasuyuki Fujita, Kiyoko Kato

“…Although nonabsorbable woven tape has been widely used for cervical cerclage, technical difficulties that can occur with an effaced cervix because of the thickness of the tape, and the risks of local infection are two major concerns. This study investigated perinatal outcomes of pregnancies involving an emergency cervical cerclage using absorbable monofilament polydioxanone sutures, which is a narrow thread and protects against bacterial infection. …”
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Comparison of the extraction efficiencies of four different solvents used in trace metal digestion of selected soils within Abakaliki, Nigeria by NO Omaka, IF Offor, ER Chukwu, U Ewuzie

“…Soil pollution by trace metals is one of the major global environmental challenges facing us today. …”
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Anaemia Associated with Trypanosomes Infections in Cattle of West Gojjam Zone, Northwest Ethiopia by Kumela Lelisa, Behablom Meharenet

“…African animal trypanosomosis is a major veterinary problem over a large area of the tsetse belt region of Africa. …”
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Investigation of intracellular signals generated by γ-interferon and IL-4 leading to the induction of class II antigen expression by S. Vassiliadis, N. Kyrpides, D. Stravopodis, M. Grigoriou, I. Athanassakis, J. Papamatheakis

“…This diversity of activation reveals the existence of a previously unknown complicated network of intracellular interactions able to regulate the same phenotype or cellular event. As major histocompatibility complex antigens (MHC) or human leukocyte antigens (HLA), are important in immune recognition and response, the results show that for human cells a more coherent method of HLA-DR antigen induction is followed after γ-IFN administration, as calcium participation seems to be the first step in signal transduction. …”
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