The current and future cancer burden in the Gulf Cooperation Council (GCC) countries by Saleh A. Alessy, Saleh A. Alqahtani, Jerome Vignat, Amid Abuhmaidan, Amani E. L. Basmi, Najla Al Lawati, Ameera Ali A‐Nooh, Wael Shelpai, Samar Alhomoud, Ali Al‐Zahrani, Freddie Bray, Ariana Znaor

“…Colorectal (14%) followed by breast cancer (9%) were the leading causes of cancer death, though the magnitude of rates of the major cancer types varied substantially across the GCC countries. …”
Get full text

Peptide platform for 3D-printed Ti implants with synergistic antibacterial and osteogenic functions to enhance osseointegration by Chenying Cui, Yifan Zhao, Jingyu Yan, Ziyang Bai, Guning Wang, Yingyu Liu, Yurong Xu, Lihong Zhou, Kaifang Zhang, Yanling Mi, Binbin Zhang, Xiuping Wu, Bing Li

“…Bone defects caused by trauma, infection, or tumors present a major clinical challenge. Titanium (Ti) implants are widely used due to their excellent mechanical properties and biocompatibility; however, their high elastic modulus, low surface bioactivity, and susceptibility to infection hinder osseointegration and increase failure rates. …”
Get full text

Validation of ACC/AHA and ESC Sudden Cardiac Death Risk Guidelines in Diverse Hypertrophic Cardiomyopathy Cohort: Stratification HCM Study by Murillo Oliveira Antunes, Fabio Fernandes, Edmundo Arteaga-Fernandez, Félix José Alvarez Ramires, Vinicius Machado Correia, Juliano Novaes Cardoso, Cristhian Espinoza Romero, Henrique Martins Sousa, Marília Taily Soliani, Matheus Ramos Ramos Dal Piaz, Anna Danielle Rodrigues Gandarella, Ruiza Gonçalves Rocha Teixeira, Charles Mady, Caio Assis Moura Tavares, Patricia O. Guimarães, Vagner Madrini Junior

“…Background: Sudden cardiac death (SCD) is a major concern in patients with hypertrophic cardiomyopathy (HCM). …”
Get full text

Approximate solution of plastic zone in surrounding rock under three-dimensional stress field based on Drucker-Prager strength criterion by LIU Hongtao, LIANG Jialu, HAN Zijun, LIU Qinyu, QIAO Zhongjin

“…Results show that ① Variations in horizontal stress exerts significant impact on the plastic zone morphology of roadway surrounding rock: too high or too low horizontal stress will lead to a butterfly-shaped expansion in the roadway surrounding rock. ② Variations in axial pressure has little effect on the plastic zone shape of roadway surrounding rock, yet exerts major influence on the plastic zone size of surrounding rock: under the same horizontal stress, different axial stress will lead to a bowl-shaped development in the plastic zone size of surrounding rock. …”
Get full text

Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…Heart diseases remain the major cause of death worldwide. Advances in pharmacological and biomedical management have resulted in an increasing proportion of patients surviving acute heart failure (HF). …”
Get full text

Safety and efficacy of indocyanine green fluorescence imaging for real-time guidance of laparoscopic thermal ablation in patients with liver cancer by Qitao Hu, Zhou Tian, Yongji Sun, Bo Zhang, Zhe Tang

“…During the follow-up period, no major complications were observed.Conclusion ICG-fluorescence imaging guided laparoscopic thermal ablation was feasible, safe and effective.…”
Get full text

Modern modes of chronic hepatitis B treatment in daily clinical practice by M. V. Mayevskaya, M. A. Morozova, S. A. Ondos, V. T. Ivashkin

“…The modern modes of AVT have several variants: treatment for the limited term by interferon-alpha or nucleotides/ nucleosides analogues and long-term treatment by nucleotides/nucleosides analogues. The major factor decreasing nucleotides/nucleosides AVT efficacy is virus resistance development. …”
Get full text

Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment by Christine McInnis, Lakshmi Srinivasan, Anthony J Coyle, Shilpa Bhatia, Glenn J Hanna, Ann Marie Egloff, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Daniel C Pregibon

“…We used single-cell analysis with encoded peptide-human leukocyte antigen (HLA) tetramers to analyze HPV16+ and HPV33+ OPSCC tumors, characterizing the ex vivo cellular responses to HPV-derived antigens presented in major Class I and Class II HLA alleles.Results We identified robust cytotoxic T-cell responses to HPV16 proteins E1 and E2 that were shared across multiple patients, particularly in HLA-A*01:01 and HLA-B*08:01. …”
Get full text

Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials by George A Wells, Kevin Emery Boczar, Sheojung Shin, Kathryn A Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A Fehlmann, Sarah Visintini, Rob Beanlands

“…The primary outcomes will include major adverse cardiac events (MACE), and each individual component of MACE (myocardial infarction, stroke and cardiovascular death). …”
Get full text

Antifungal Activity of Essential Oil Isolated from Pelargonium roseum against Grey Mould (Botrytis cinerea) of Cherry Tomato by Fuyan LIU, Runxia YANG, Yangcuiji ZHENG, Chongjun ZHAO, Liming FAN, Fawu SU, Min YE

“…Results showed that the extraction rate of P. roseum EO was 0.43%, and 19 compounds were identified in the EO. The major constituent was citronellol (52.16%) followed by nerol (21.93%), citronellyl formate (9.87%), and isomenthol (5.18%). …”
Get full text

The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients by Chunyu Lu, Shuiqin Cheng, Wenjing Fan, Zhihong Zhang, Jinquan Wang

“…Background Cardiovascular disease (CVD) is a major complication in peritoneal dialysis (PD) patients. …”
Get full text

An algorithm for identifying causes of reoperations after orthopedic fracture surgery in health administrative data: a diagnostic accuracy study using the Danish National Patient R... by Signe S Jensen, Anders B Rønnegaard, Per H Gundtoft, Søren Kold, Bjarke Viberg

“…Our algorithm identified major reoperations with a sensitivity/PPV of 89/77%, minor reoperations 99%/89%, infections 77/85%, nonunion 82/56%, early re-osteosynthesis 90/75%, and secondary arthroplasties 95/87%. …”
Get full text

Chatting your way to quitting: A longitudinal exploration of smokers' interaction with a cessation chatbot by Linwei He, Erkan Basar, Reinout W. Wiers, Marjolijn L. Antheunis, Emiel Krahmer

“…Background: Cigarette smoking poses a major public health risk, requiring scalable and accessible interventions. …”
Get full text

Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-κB Signaling by Xiaokang Zeng, Kai Xu, Ji Wang, Yunqi Xu, Shaogang Qu

“…Astrocytes are a major constituent of the central nervous system (CNS). …”
Get full text

Epidemiological and molecular characteristics of extraintestinal pathogenic escherichia coli isolated from diseased cattle and sheep in Xinjiang, China from 2015 to 2019 by Xiaoxiao Gu, Qin Wu, Yingjin Chai, Xin Huang, Xia Zhou, Mengli Han, Tongzhong Wu, Xingxing Zhang, Fagang Zhong

“…Escherichia coli infection is common and tends to be complex in Xinjiang, a major region of cattle and sheep breeding in China. …”
Get full text

Prognostic Value of Atherosclerotic Extent in Diabetic Patients with Nonobstructive Coronary Artery Disease by Yipu Ding, Zinuan Liu, Guanhua Dou, Xia Yang, Xi Wang, Dongkai Shan, Bai He, Jing Jing, Yundai Chen, Junjie Yang

“…During a median follow-up of 31.77 months, 50 major adverse cardiovascular events (MACEs) (6.15%) were experienced, including 2 cardiovascular deaths, 14 nonfatal myocardial infarctions, 27 unstable anginas requiring hospitalization, and 7 strokes. …”
Get full text

Temporal segmentation method for 30-meter long-term mapping of abandoned and reclaimed croplands in Inner Mongolia, China by Deji Wuyun, Liang Sun, Zhongxin Chen, Luís Guilherme Teixeira Crusiol, Jinwei Dong, Nitu Wu, Junwei Bao, Ruiqing Chen, Zheng Sun, Hasituya, Hongwei Zhao

“…The method integrates ground sample collection of major crops and inactive cropland with Normalized Difference Vegetation Index (NDVI) analysis during key growth stages, enabling precise classification of cultivation status. …”
Get full text

Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level by Xiaowen Jia, Rong Zhang, Jinzhu Guo, Hua Yue, Qiuxia Liu, Lipei Guo, Qunchang Zhang

“…Pregnancy-induced hypertension (PIH) remains a major cause of morbidity and mortality in pregnancy worldwide. …”
Get full text

Rifampicin-induced Stevens-Johnson Syndrome: A Rare Case Report by Bhaveshkumar Manilal Patel, Mugdha Manaji Kadam, Arti Dhawal Shah, Chirag Chakravarti, Virenkumar Jayendrakumar Patel

“…Tuberculosis (TB) continues to be a major global health issue, necessitating effective treatment regimens primarily involving antitubercular drugs. …”
Get full text

Profiling the diversity of the village chicken faecal microbiota using 16S rRNA gene and metagenomic sequencing data to reveal patterns of gut microbiome signatures by Mxolisi Nene, Mxolisi Nene, Nokuthula Winfred Kunene, Rian Pierneef, Rian Pierneef, Rian Pierneef, Khanyisile Hadebe

“…At the genus level, Escherichia and Shigella were prevalent, with Escherichia coli and Shigella dysenteriae identified as major contributors to the gut microbiome. ARGs were identified, with MarA, PmrF, and AcrE detected in KwaZulu-Natal, and cpxA, mdtG, and TolA in Limpopo. …”
Get full text