Impact of shear wave elastography and attenuation imaging for predicting life-threatening event in patients with metabolic dysfunction-associated steatotic liver disease by Yudai Fujiwara, Hidekatsu Kuroda, Tamami Abe, Tomoaki Nagasawa, Ippeki Nakaya, Asami Ito, Takuya Watanabe, Kenji Yusa, Hiroki Sato, Akiko Suzuki, Kei Endo, Yuichi Yoshida, Takayoshi Oikawa, Keisuke Kakisaka, Kei Sawara, Toshifumi Tada, Akio Miyasaka, Takuma Oguri, Naohisa Kamiyama, Takayuki Matsumoto

“…Abstract We aimed to elucidate the value of ultrasound-based biomarkers for predicting the major life-threatening events in metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Shared perceptions of flavored cigarette pack design among young adults who smoke in Mexico and the Philippines by Graziele Grilo⁺, Jennifer L. Brown⁺, Joanna E. Cohen, Katherine Clegg Smith

“…Transcribed and translated data were thematically analyzed and compared between countries. Results Three major themes were identified: 1) Flavor capsules cigarettes are recognizable via pack design through imagery on the pack that is understood to signify capsules; 2) Colors signal flavor and make the pack attractive; and 3) Young adults who smoke identify the target audience for these products as young people and those who are beginning to smoke. …”
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Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers by Weiping Ji, Ye Fang, Liwei Chen, Yitong Zheng, Yifei Pei, Changqiu Mei, Meng Zhou

“…T cell exhaustion (TEX) is a major barrier to effective immunotherapy. The role of N6-methyladenosine (m6A) modification in regulating immune cell function has been recognized, but its impact on TEX dynamics across cancer types and clinical outcomes remains unclear. …”
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Testing Multi-Theory Model (MTM) in Predicting Physical Activity Behavior Among Upper Elementary School Children in Northern India by Poonam KHANNA, Tejinder Pal SINGH, Tarundeep SINGH, Rekha KAUSHIK, Manoj SHARMA

“…Introduction: Physical inactivity in children is a precursor to childhood obesity, which is a major public health concern due to its increasing prevalence over the years. …”
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Effects of Biostabilization on Engineering Properties of Geomaterials by Shengting Li, Chenyi Luo, Yi Yang, Lvzhen Yang, Lijian Wu, Tuo Huang, Zhuangji Wang

“…EDS and XRD results indicated that calcite, dolomite, and albite were the major precipitates produced during biostabilization treatments. …”
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Prevalence of Chronic Complications, Their Risk Factors, and the Cardiovascular Risk Factors among Patients with Type 2 Diabetes Attending the Diabetic Clinic at a Tertiary Care Ho... by Maulee Hiromi Arambewela, Noel P. Somasundaram, Hettiarachchige Buddhi Pradeep Ranjan Jayasekara, Mahesh P. Kumbukage, Pulukkutti Mudiyanselage Sarath Jayasena, Chandrasekara Mudalige Priyanka Hemanthi Chandrasekara, Kurukulasuriya Ravindra Alexis Sudath Fernando, Divadalage Priyantha Kusumsiri

“…This study highlights the major burden of chronic complications and high prevalence of CAD risk factors in this population.…”
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FreshWater Watch: Investigating the Health of Freshwater Ecosystems, from the Bottom Up by Isabel Bishop, Amedeo Boldrini, Wim Clymans, Charlotte Hall, Heather Moorhouse, Stephen Parkinson, Kesella Scott-Somme, Ian Thornhill, Steven Loiselle

“…Freshwater ecosystems are increasingly facing major global and local stressors, while monitoring surface water status by regulatory agencies is often limited by financial and political constraints. …”
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An Efflux Pumps Inhibitor Significantly Improved the Antibacterial Activity of Botanicals from Plectranthus glandulosus towards MDR Phenotypes by Gravalain Nanmeni, Alex T. Tedonkeu, Aimé G. Fankam, Armelle T. Mbaveng, Brice E. N. Wamba, Paul Nayim, Gabin T. M. Bitchagno, Raïssa T. Nzogong, Maurice D. Awouafack, Mathieu Tene, Veronique P. Beng, Victor Kuete

“…The phytochemical study of P. glandulosus plant extract afforded seven major fractions (A–G) which lead to the isolation of seventeen known compounds. …”
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Recommendations for developing, documenting, and distributing data products derived from NEON data by Jeff W. Atkins, Kelly S. Aho, Xuan Chen, Andrew J. Elmore, Rich Fiorella, Wenqi Luo, Danica Lombardozzi, Claire Lunch, Leah Manak, Luis X. dePablo, Allison N. Myers‐Pigg, Sydne Record, Tong Qiu, Samuel Reed, Benjamin Ruddell, Brandon Strange, Christa L. Torrens, Kelsey Yule, Andrew D. Richardson

“…Here we provide an overview of the process of creating derived data products while outlining the advantages, challenges, and major considerations.…”
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Evaluation of Antibiotic Resistance and Biofilm Production among Clinical Strain Isolated from Medical Devices by Veronica Folliero, Gianluigi Franci, Federica Dell’Annunziata, Rosa Giugliano, Francesco Foglia, Rossella Sperlongano, Anna De Filippis, Emiliana Finamore, Massimiliano Galdiero

“…Our results highlighted that Sulfamides and Glycopeptides for the major Gram-positive strains and Fluoroquinolones, Carbapenems, and Aminoglycosides for the most represented Gram-negative isolates could be the most suitable therapeutic choice for most biofilm-DRIs.…”
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Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro by Wen Tang, Fangwei Liu, Ying Chen, Laiyu Song, Wujing Dai, Chao Li, Dong Weng, Jie Chen

“…Blocking the function of IL-1 signal pathway could suppress the level of IL-17A, which played the major role in modulating silica-induced Th responses in vitro.…”
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L-Cysteine Treatment Delays Leaf Senescence in Chinese Flowering Cabbage by Regulating ROS Metabolism and Stimulating Endogenous H₂S Production by Linzhi Gan, Zhenliang Mou, Jianye Chen, Wei Shan, Jianfei Kuang, Wangjin Lu, Yating Zhao, Wei Wei

“…Leaf senescence is a major concern for postharvest leafy vegetables, as leaves are highly prone to yellowing and nutrient loss, resulting in reduced commercial value and limited shelf-life. …”
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The availability of drugs for stable COPD treatment in China: a cross-sectional survey by Dongru Du, Xueru Hu, Qiunan Zuo, Dan Xu, Tao Zhu, Tao Fan, Jiao Yang, Weiguo Xu, Hailong Wei, Kangzhuo Baima, Ying Zhang, Yanhui Gu, Lei Chen, Fengming Luo, Yongchun Shen, Fuqiang Wen

“…Insufficient drug supply and imbalanced drug availability among different hospitals are major barriers that warrant further improvements.…”
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Microstructure modulation of hard carbon derived from long-flame coal to improve electrochemical sodium storage performances by Hai-Tao Zeng, Wei-Wei Kang, Bao-Lin Xing, Guang-Xu Huang, Qiang Li, Han Hu, Fang-Le Su, Jian-Bo Jia, Chuan-Xiang Zhang

“…Widely sourced precursors for hard carbon with high performances are still a major challenge for industrializing sodium-ion batteries. …”
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Safety and performance of oropharyngeal muscle strength training in the treatment of post-stroke dysphagia during oral feeding: protocol for a systematic review and meta-analysis by Xin Wang, Ying Wang, Fenghua Zhou, Minxing Gao, Lingyuan Xu, Heying Wang, Jinan Song, Xiaoqiu Yang

“…Oropharyngeal muscle strength training is a major method of swallowing training, and recent studies have focused on healthy adults, elderly persons, and patients with head and neck cancer or neurodegenerative diseases; but there have been few studies on such training in patients with post-stroke dysphagia. …”
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Efficacy of Amblyseius swirskii (Athias-Henriot) (Acari: Phytoseiidae) and Alternaria destruens (Ascomycota: Pleosporaceae) for managing Phenacoccus solenopsis Tinsley (Hemiptera:... by Mohamed El Aalaoui, Said Rammali, Fatima Zahra Kamal, Alin Ciobică, Bouchaib Bencharki, Abdellatif Rahim, Luminita Diana Hritcu, Laura Romila, Vasile Burlui, Mohamed Sbaghi

“…Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae) is a major pest of potatoes and other crops, highlighting the need for effective management strategies. …”
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Recovering Pulsar Periodicity from Time-of-arrival Data by Finding the Shortest Vector in a Lattice by Dotan Gazith, Aaron B. Pearlman, Barak Zackay

“…Such a detection would be a major breakthrough, providing us with the FRB source’s age, magnetic field, and binary orbit. …”
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Enrichment features, ecological risks assessment and quantitative sources appointment of sediment heavy metals: An example of the urbanized Xizhi River catchment, South China by Chao Yan, Qirui Wu, Rui Li, Zuobing Liang, Zaizhi Yang, Aiping Zhu, Lei Gao

“…Sediment Cd was identified as the major contributor to the potential ecological risks posed to aquatic species. …”
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Enhanced UV-B photoprotection activity of carotenoids from the novel Arthrobacter sp. strain LAPM80 isolated from King George Island, Antarctica by Beatriz Vivian Paredes Contreras, Alane Beatriz Vermelho, Livia Casanova, Claudia de Alencar Santos Lage, Caren Leite Spindola Vilela, Veronica da Silva Cardoso, Luis William Pacheco Arge, Janine Simas Cardoso-Rurr, Sulamita Santos Correa, Felipe Raposo Passos De Mansoldo, Maria Cristina Pinheiro Pereira Reis-Mansur, Eikon Alves da Silva, Júnia Schultz, Alexandre Soares Rosado

“…Chemical characterization of the carotenoid extract identified major components as C50 carotenoids, probably decaprenoxanthin and/or sarcinaxanthin. …”
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Non-small cell lung cancer and the tumor microenvironment: making headway from targeted therapies to advanced immunotherapy by Anna De Lucia, Lucia Mazzotti, Lucia Mazzotti, Anna Gaimari, Anna Gaimari, Matteo Zurlo, Roberta Maltoni, Claudio Cerchione, Sara Bravaccini, Angelo Delmonte, Lucio Crinò, Patricia Borges de Souza, Luigi Pasini, Fabio Nicolini, Fabrizio Bianchi, Manel Juan, Hugo Calderon, Chiara Magnoni, Chiara Magnoni, Luca Gazzola, Luca Gazzola, Paola Ulivi, Massimiliano Mazza

“…In this review, we discuss how the understanding of this intricate relationship is crucial for the success of immunotherapy and survey the current state of immunotherapy intervention, with a focus on forthcoming and promising chimeric antigen receptor (CAR) T cell therapies in NSCLC. The TME sets major obstacles for CAR-T therapies, creating conditions that suppress the immune response, inducing T cell exhaustion. …”
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