Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway by Weiwei Tang, Xiaomin Huang, Yun-Di Yi, Fan Cao, Manli Deng, Jiawei Fan, Zheng-Xuan Jiang, Li-Ming Tao, Xianwen Wang, Lei Shi

“…Excessive autoimmune inflammation and oxidative stress are major drivers that contribute to the initiation and progression of uveitis. …”
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INTERNATIONAL NORMALIZED RATIO AND ACTIVATED PARTIAL THROMBOPLASTIN TIME DO NOT PREDICT PLASMA TRANSFUSION IN LIVER TRANSPLANTATION by David Silveira MARINHO, Joel Avancini ROCHA FILHO, Estela Regina Ramos FIGUEIRA, Claudia Regina FERNANDES, Rui Carlos DETSCH JUNIOR, José Huygens Parente GARCIA, Wellington ANDRAUS, Luiz Augusto Carneiro D’ALBUQUERQUE

“…ABSTRACT BACKGROUND: Blood loss during liver transplantation (LT) remains a major concern associated with increased morbidity and reduced patient and graft survival. …”
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Impact of hydroxyurea on clinical and biological parameters of sickle cell anemia in children in Abidjan by MIREILLE YAYO- AYE, Adia Eusèbe Adjambri, Boidy Kouakou, Rebecca N'guessan-Blao, Louis Missa Adjé, Taïratou Kamagaté, Vincent Yapo, Duni Sawadogo

“…More than 75% of patients were  homozygous SSFA2 major sickle cell individuals. After 6 months on hydroxyurea, our study observed rates of 84.4%, 100%, and 97.8%, respectively, for the absence of vaso-occlusive crises, hospitalization, and transfusion. …”
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Fates of nutrient elements and heavy metals during thermal conversion of cattle slurry-derived anaerobic digestates by Daniel J. Lane, Olli Sippula, Jorma Jokiniemi, Mikko Heimonen, Niko M. Kinnunen, Perttu Virkajärvi, Narasinha Shurpali

“…Volatilisation of P was low (< 20%) when the digestates were heated in inert and oxidising atmospheres, whereas a reducing atmosphere volatilized P to a major extent (~ 60% at 1000 °C). Oxidising atmospheres increased volatilisation of N but suppressed volatilisation of K, Na, and Zn. …”
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mTOR downregulation promotes anti-inflammatory responses via the CCL3-CCR5 axis in hypoxic retinopathy by Tae Kwon Moon, Im Kyeung Kang, Kyoung Jin Lee, Ji Hyun Kim, Hee Jong Kim, A. Reum Han, Ha-Na Woo, Joo Yong Lee, Jun-Sub Choi, Keerang Park, Heuiran Lee

“…Hypoxic retinopathies, including diabetic retinopathy, are major contributors to vision impairment, mainly due to accelerated angiogenesis and inflammation. …”
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Harnessing the potential of chloroplast-derived expression elements for enhanced production of cellulases in Escherichia coli by Ayesha Siddiqui, Muhammad Mudassar Iqbal, Asad Ali, Iqra Fatima, Hazrat Ali, Aamir Shehzad, Sameer H. Qari, Ghulam Raza, Muhammad Aamer Mehmood, Peter J. Nixon, Niaz Ahmad

“…Thermophilic cellulases can play a crucial part in the efficient breakdown of cellulose—a major component of lignocellulosic plant biomass, however, their commercial production needs simple and robust biomanufacturing biosystems. …”
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Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease by Maria Galluzzo, Elisa Ciraolo, Monica Lucattelli, Eriola Hoxha, Martina Ulrich, Carlo Cosimo Campa, Giuseppe Lungarella, Gerd Doring, Zhe Zhou-Suckow, Marcus Mall, Emilio Hirsch, Virginia De Rose

“…Thus, reducing airway inflammation is a major goal to prevent lung damage in CF. However, current anti-inflammatory drugs have shown several limits. …”
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Parental Attitudes, Motivators and Barriers Toward Children’s Vaccination in Poland: A Scoping Review by Krystyna Szalast, Grzegorz Józef Nowicki, Mariola Pietrzak, Agnieszka Mastalerz-Migas, Aleksander Biesiada, Elżbieta Grochans, Barbara Ślusarska

“…Moreover, parental primary motivators for vaccinating their children were prevention against infectious diseases, the opinion that vaccines are safe, and the belief that childhood vaccination is right and effective. The major barriers to vaccination were fear of vaccine side effects and the belief that vaccines are ineffective. …”
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Detection and quantification of pathogens in saliva of adolescents with cerebral palsy: a cross-sectional study by Rosemeire Arai Yoshida, Tiago Bertola Lobato, Renata Gorjão, Lucas Santiago França, Lívia Araujo Alves, Maria Teresa Botti Rodrigues Santos

“…A significant contrast was observed for the pathogen P. intermedia when comparing the difference in the control group (p = 0.0396). No major differences were detected in the quantification of periodontopathogens evaluated between the control group and CP.ConclusionAdolescents with CP showed variability in the detection of DNA of periodontopathogens, especially a great variation in the detection of P gingivalis in saliva of CP with gingivitis.…”
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The Impact of Bar-induced Noncircular Motions on the Measurement of Galactic Rotation Curves by Jie Liu, Zhi Li, Juntai Shen

“…The shape of the derived RC depends on the difference in position angle (Δ ϕ ) between the major axes of the bar and the disk in the face-on plane. …”
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An Evaluation of the Responsiveness and Discriminant Validity of Shoulder Questionnaires among Patients Receiving Surgical Correction of Shoulder Instability by Kyle A. R. Kemp, David M. Sheps, Lauren A. Beaupre, Fiona Styles-Tripp, Charlene Luciak-Corea, Robert Balyk

“…Responsiveness and discriminant validity was assessed between those with a satisfactory outcome and those with (1) a major recurrence of instability, (2) a single episode of subluxation, (3) any postoperative episode of instability. …”
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Cost-effectiveness of the addition of sintilimab as a first-line therapy for locally advanced or metastatic oesophageal squamous cell carcinoma: a Chinese healthcare system perspec... by Cuicui Yu, Yingqi Wu, Yadi Geng, Hui Yan, Pengli Zhu, Peng Ji, Fei Wu, Lijuan Ning, Yubin Feng, Aizong Shen

“…Sensitivity analysis demonstrated that the PFS and cost of sintilimab were the major influencing factors affecting the results. …”
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LOW POWER BRACHYTHERAPY IN COMBINED TREATMENT IN PATIENTS WITH INTERMEDIATE RISK OF LOCALIZED PROST ATE CANCER by V. A. Biryukov, O. B. Karyakin, O. V. Morov, O. G. Lepilina, D. V. Neledov, D. B. Sanin, G. N. Grishin, M. S. Kalinina

“…Tumor-specific and overall survival in bothgroups was 100%. The major complications of treatment in both groups were radiation urethritis 1 to 2 degrees in 9.5% of cases (12 patients), urethral stricture in 5 patients (3.9% of cases), acute urinary retention in 1 patient (0.8% of cases) and late radiation rectitis of 2 degree in 1.58% of cases (2 patients).Conclusions. …”
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The Ischial Spine in Developmental Hip Dysplasia: Unraveling the Role of Acetabular Retroversion in Periacetabular Osteotomy by Gerard El-Hajj, Hicham Abdel-Nour, Rami Ayoubi, Joseph Maalouly, Fouad Jabbour, Raja Ashou, Alexandre Nehme

“…In a previous paper, we reported the classic coxometric measurements of 178 patients with symptomatic hip dysplasia undergoing PAO where retroversion was noted in 42% of the cases and was not found to be a major factor in the appearance of symptoms. In the current study, we have added the retroversion signs PRISS and PWS to our analysis. …”
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Retrieval of NO2 Columns by Exploiting MAX-DOAS Observations and Comparison with OMI and TROPOMI Data during the Time Period of 2015–2019 by Ahmad Iqbal, Naveed Ahmad, Hassan Mohy ud Din, Michel Van Roozendael, Muhammad Shehzaib Anjum, Muhammad Zeeshan Ali Khan, Muhammad Fahim Khokhar

“…Abstract Nitrogen dioxide (NO2)—a criteria major air pollutant, is of paramount importance due to its role in atmospheric chemistry and tropospheric ozone formation. …”
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Development of the novel gene chip and restriction fragment length polymorphism (RFLP) methods for rapid detection of Mycobacterium tuberculosis complex in broth culture by Wen-Hung Wang, Chun-Yu Lin, Shu-Huei Jain, Po-Liang Lu, Yen-Hsu Chen

“…Background: Tuberculosis (TB) is a major global public health issue. Prompt and accurate TB diagnosis is crucial for starting appropriate treatments and preventing the disease's spread. …”
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NIR‐II AIEgens nanosystem for fluorescence and chemiluminescence synergistic imaging‐guided precise resection in osteosarcoma surgery by Ruotong Li, Kaiyuan Liu, Qian Hu, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Xingjun Zhu, Wei Sun

“…Abstract Osteosarcoma (OS) is characterized by an unfavorable prognosis and high mortality rates, with the local recurrence attributed to residual lesions post‐surgery being a major reason for treatment failure. Precise and tumor‐specific resection guidance to minimize recurrence remains a significant challenge. …”
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Enabling smart parking for smart cities using Internet of Things (IoT) and machine learning by Mofadal Alymani, Lenah Abdulaziz Almoqhem, Dhuha Ahmed Alabdulwahab, Abdulrahman Abdullah Alghamdi, Hussain Alshahrani, Khalid Raza

“…With the escalating number of vehicles and the lack of parking spaces, the issue of parking has become a significant problem in major cities as it is a daily occurrence for educational institutions, companies, and government facilities, resulting in fuel wastage and time inefficiencies. …”
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Asymptomatic infection and antibody prevalence to co-occurring avian influenza viruses vary substantially between sympatric seabird species following H5N1 outbreaks by Fiona Greco, Hannah M. Ravenswater, Francisco Ruiz-Raya, Chiara D’Avino, Mark A. Newell, Josie Hewitt, Erin Taylor, Ella Benninghaus, Francis Daunt, Gidona Goodman, David Steel, Jenny Park, Emma Philip, Saumya S. Thomas, Marek J. Slomka, Marco Falchieri, Scott M. Reid, Joe James, Ashley C. Banyard, Sarah J. Burthe, Emma J. A. Cunningham

“…Abstract Emerging infectious diseases are of major concern to animal and human health. Recent emergence of high pathogenicity avian influenza virus (HPAIV) (H5N1 clade 2.3.4.4b) led to substantial global mortality across a range of host species. …”
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Impact of antibiotic prophylaxis on gut microbiota in colorectal surgery: insights from an Eastern European stewardship study by Irina Cezara Văcărean-Trandafir, Roxana-Maria Amărandi, Iuliu Cristian Ivanov, Loredana Mihaiela Dragoș, Mihaela Mențel, Ştefan Iacob, Ştefan Iacob, Ana-Maria Muşină, Ana-Maria Muşină, Elena-Roxana Bărgăoanu, Cristian Ene Roată, Cristian Ene Roată, Ștefan Morărașu, Ștefan Morărașu, Valeri Țuțuianu, Marcel Ciobanu, Mihail-Gabriel Dimofte, Mihail-Gabriel Dimofte

“…Romania's stricter healthcare regulations result in more standardized antibiotic protocols, whereas Moldova's limited healthcare funding leads to less consistent practices and greater variability in treatment outcomes.MethodsThis study presents the results of a prospective cross-border investigation involving 86 colorectal cancer patients from major oncological hospitals in Romania and Moldova. …”
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