Mycobacterium bovis BCG Surface Antigens Expressed under the Granuloma-Like Conditions as Potential Inducers of the Protective Immunity by Yingyu Chen, Lia Danelishvili, Sasha J. Rose, Luiz E. Bermudez

“…Significantly high levels of specific IgA and IgG antibodies were observed in recombinant protein immunized groups by both inhalation and intraperitoneal (IP) routes, but only IP delivery induced high total IgA and IgG levels. We did not detect major differences in antibody levels in the M. smegmatis group that overexpressed surface antigens. …”
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Cost-effectiveness and budget impact of Empirical vitamin D therapy on unintentional falls in older adults in the UK by J Smith, J S Davies, C D Poole

“…Objectives To evaluate the health outcomes and economics associated with the current guidance relating to the prevention of falls in the elderly through vitamin D supplementation.Setting UK.Participants UK population aged 60 years and above.Interventions A Markov health state transition model simulated patient transitions between key fall-related outcomes using a 5-year horizon and annual cycles to assess the costs and benefits of empirical treatment with colecalciferol 800 iu daily.Primary and secondary outcome measures Costs and health outcomes attributable to fall prevention following vitamin D supplementation.Results Our model shows that treating the UK population aged 60 years and above with 800 iu colecalciferol would, over a 5-year period: (1) prevent in excess of 430 000 minor falls; (2) avoid 190 000 major falls; (3) prevent 1579 acute deaths; (4) avoid 84 000 person-years of long-term care and (5) prevent 8300 deaths associated with increased mortality in long-term care. …”
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Assessing mechanized, conservation, and small-scale tillage impacts on Alexander wander wheat performance in Bamenda, Cameroon by Engonwie Sharon Mbachan, Ngwa Martin Ngwabie

“…Tillage practices constitute the major initial applications of farm power and machinery during crop cultivation. …”
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Training and education provided to local change champions within implementation trials: a rapid systematic review by Laura Jolliffe, Natasha A. Lannin, Stacy Larcombe, Brendan Major, Tammy Hoffmann, Elizabeth Lynch

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The Study of Mono- and Polysubstance Abuse Effects on Complete Blood Count Parameters in Samples of Iraqi Patients by Athmar Kadhim Gatea, Kareem Nasir Hussien, Mohammed Ali Al-Jabory

“…BACKGROUND: Substance abuse represents a major health problem worldwide. In Iraq, the number of substance abusers increased, both single and polysubstance, alcohol and medications. …”
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La Nòva Cançon occitana : révolution en occitan, révolution dans la chanson occitane ? by Philippe Martel

“…Elle est nouvelle aussi par son mode de diffusion (spectacles-débats, vente militante hors du circuit des « majors » du disque). Mais cette nouveauté n’empêche pas que l’on peut y retrouver, à côté de la rhétorique révolutionnaire du moment la trace de thématiques qui circulaient déjà dans l’occitanisme, voire le Félibrige, bien avant 68. …”
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β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC by Ernst Fredericks, Gill Dealtry, Saartjie Roux

“…Conclusion. β-catenin is confirmed as a major driver of colorectal carcinogenesis but is controlled by many more players other than APC. …”
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What are the perceived needs of people living with chronic pain regarding physiotherapy services? A scoping review protocol. by Jonathan Gervais-Hupé, Arthur Filleul, Kadija Perreault, Isabelle Gaboury, Timothy H Wideman, Céline Charbonneau, Fatiha Loukili, Martine Gagnon, Anne Hudon

“…<h4>Introduction</h4>Chronic pain represents a major health issue, affecting the physical and mental health of approximately one in five people worldwide. …”
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Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke by AbdelRahman Mohamed Hussein, Iman Mohamed Bayoumy, Khaled Ossama Abdulghani, Mona Ali Eissa, Ehab Mostafa Ahmed, Ali Ahmed Abou Elmaaty

“…Abstract Background Stroke stands as a major cause of morbidity and mortality worldwide. …”
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Soviet and British diplomacy at international conferences on the eve of the formation of the USSR by E. Yu. Sergeev

“…The author emphasizes that the Kremlin managed to pave the way for the diplomatic recognition of the Bolshevik regime by the leading powers and to take part in the discussion on Black Sea straits regime, while Whitehall managed to strengthen imperial positions both in Europe and in the Middle East, although the prospects of rapprochement between Moscow and Berlin and Ankara remained a major concern for the Foreign Office. However, these conferences failed to address the issue of Russian debts and it continued to be an obstacle to the normalization of bilateral relations. …”
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Existence of a weak solution to a regularized moving boundary fluid-structure interaction problem with poroelastic media by Kuan, Jeffrey, Čanić, Sunčica, Muha, Boris

“…The nonlinear coupling over the moving interface presents a major difficulty since both the fluid domain and the poroelastic medium domain are functions of time, and the finite energy spaces do not provide sufficient regularity for the corresponding weak formulation to be well-defined. …”
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Review: cell mechanisms in the control of inflammatory foundations of obesity and secondary metabolic disorders by Kristin Goldstone, Keelin Irwin, Ava O' Meara-Cushen, Cathy Brougham

“…Inflammation plays an integral role in disease pathogenesis and is a major hallmark of obesity and obesity-related secondary co-morbidities. …”
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A Comparison of the Celiacomesenteric Trunk in the Caribbean with Global Prevalence Calculated by a Systematic Review by Shamir O. Cawich, Maurice Fortune, Rahul Deshpande, Michael Gardner, Neil Pearce, Peter Johnson, Vijay Naraynsingh

“…In this study, we evaluated all consecutive patients who had multiphase contrast-enhanced CT scans at two major referral centres in the Caribbean from August 30, 2017, to September 1, 2019. …”
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Physicians’ moral distinctions between medical assistance in dying (MAiD) and withdrawing life-sustaining treatment in Canada: a qualitative descriptive study by Midori Matthew, Kieran Bonner, Andrew Stumpf

“…By asking physicians if they perceive the major bioethical accounts as clinically useful, we seek to distinguish between aspects of the contemporary bioethical landscape which are useful at the bedside and those which are divorced from the realities faced by clinicians. …”
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Genetic diversity assessed in Ethiopian highland bamboo [Oldeania alpina (K. Schum) Stapleton] populations revealed by microsatellite markers by Muhamed Adem, Oumer Abdie, Tileye Feyissa, Dereje Beyene

“…Methods The study relied on 150 DNA samples representing 15 O.alpina populations collected across major O.alpina harboring forests of Ethiopia. Following total genomic DNA isolation SSR primer screening was conducted using PCR, gel electrophoreses, gel doc imaging, allele scoring, and statistical analysis. …”
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Efisiensi Big Data Menggunakan Improved Nearest Neighbor by Aditya Hari Bawono, Ahmad Afif Supianto

“…In kNN, the relationships between samples are measured by the degree of similarity represented as distance. In major cases, especially on big data, there will be some samples that have the same distance but may not be selected as neighbors, then the selection of k parameters will greatly affect the results of kNN classification. …”
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A Strategic Management Approach to Reduce Pepper Weevil Damage to Jalapeño Pepper Plants with Conventional and Biorational Insecticides by Naga Mani Kanchupati, Dakshina R. Seal, Bruce Schaffer, Oscar E. Liburd

“…The pepper weevil (<i>Anthonomus eugenii</i>) is a major pest that causes significant economic damage to several species and cultivars of pepper, including jalapeño <i>(Capsicum annuum</i> var. jalapeño). …”
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Exploitation of Unconventional CD8 T-Cell Responses Induced by Engineered Cytomegaloviruses for the Development of an HIV-1 Vaccine by Joseph Bruton, Tomáš Hanke

“…Rhesus macaques vaccinated with molecular clone 68-1 of RhCMV (RhCMV68-1) engineered to express simian immunodeficiency virus (SIV) immunogens elicited an unconventional major histocompatibility complex class Ib allele E (MHC-E)-restricted CD8⁺ T-cell response, which consistently protected over half of the animals against a highly pathogenic SIV challenge. …”
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Hydroxychloroquine Potentiates Apoptosis Induced by PPARα Antagonist in 786-O Clear Cell Renal Cell Carcinoma Cells Associated with Inhibiting Autophagy by Ruizhe Mao, Jian Shi, Xuyi Ma, Haiyan Xu

“…Clear cell renal cell carcinoma (ccRCC) is the major pathological pattern of renal cell carcinoma. …”
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Metastatic papillary thyroid carcinoma with internal jugular vein tumor thrombus - A case report and review of the literature by Zaina Adnan, Edmond Sabo, Sameer Kassem

“…However, although rare, PTC can demonstrate aggressive behaviour, including vascular invasion with extension into major vessels. Intraluminal tumor thrombus involving the great veins, such as the internal jugular vein (IJV), is an uncommon but significant complication. …”
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