Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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What do ultrasound vocalizations really mean in rats with different origins of pain? by Yang Yu, Chun-Li Li, Rui Du, Xiao-Liang Wang, Jun Chen

“…The effects of local lidocaine blockade of the injection site and intraperitoneal administration of antidepressant (amitriptyline) and anticonvulsant (gabapentin) were examined as well in typical inflammatory and neuropathic pain models, respectively. Results:. The major new gains were as follows: (1) naive rats staying alone and engaging dyadic social interaction with a naive or a conspecific in pain emitted similar power and amounts of both 22 kHz and 50 kHz spontaneous USV calls; however, rats suffering from various origins of pain emitted significantly less USV calls of both 22 kHz and 50 kHz in terms of both number and time. (2) Local blockade of the injury sites of inflammatory pain could reverse the impaired emission of both 22 kHz and 50 kHz spontaneous calls, so did the treatment of the rats with neuropathic pain by amitriptyline and gabapentin. …”
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Improved Neutral Density Predictions Through Machine Learning Enabled Exospheric Temperature Model by Richard J. Licata, Piyush M. Mehta, Daniel R. Weimer, W. Kent Tobiska

“…We conducted 10 case studies where we compare the accelerometer‐derived temperature and density estimates from four satellites to NRLMSISE‐00, EXTEMPLAR, and EXTEMPALR‐ML during major storm periods. These comparisons show that EXTEMPLAR‐ML generally has the best performance of the three models during storms. …”
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Relationship between Learning Styles and Academic Performance in Medical Students at Jazan University, Kingdom of Saudi Arabia: A Cross-sectional Study by Mai Mohamed Elhassan Mustafa, Sami Alhazmi, Raum Abdu Hasan Ayoub, Sarah Jaber Mobarki, Reham Mousa Aljudayba, Imtenan Ali Oberi, Sarah Hassan Moafa, Yara Ajeebi, Lamyaa Ahmed Mohamed El Hassan, Salaheldin Elamin Abdalla Terair

“…Our results showed that high achievers differ in their perceived learning preferences from low achievers, and they tend to have more than one major learning preference; however, demographic data did not correlate with learning style preferences.…”
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Increasing extreme hourly precipitation risk for New York City after Hurricane Ida by Carolien Mossel, Spencer A. Hill, Nihar R. Samal, James F. Booth, Naresh Devineni

“…Abstract The remnants of Hurricane Ida caused major damage and death in the United States on September 1st, 2021, and 11 people drowned in flooded basement apartments within New York City (NYC). …”
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PreMevE Update: Forecasting Ultra‐Relativistic Electrons Inside Earth's Outer Radiation Belt by Saurabh Sinha, Yue Chen, Youzuo Lin, Rafael Pires de Lima

“…Abstract Energetic electrons inside Earth's Van Allen belts pose a major radiation threat to space‐borne electronics that often play vital roles in modern society. …”
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Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method by Cassandra Yun, Kazuki Fukami, Raku Shinkyo, Rongrong (Rosa) Jiang

“…To further characterize the interaction between ASOs and plasma proteins, individual binding measurements were taken for five major proteins in human plasma: human serum albumin, α1-acid glycoprotein, human γ-globulin, low-density lipoprotein, and high-density lipoprotein.ResultsThe results showed a notable difference in plasma protein binding between the two types of ASOs, with MOE/PS-modified ASOs exhibiting significantly higher binding compared to PMOs. …”
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Hip and Trunk Variables in University Students with and without Recurrent Low Back Pain by BJ Lehecka, Jordin Burleson, Paige Diederich, Morgan Salem, Rachel Schoonover, Jason Tejano

“…This study also suggests that hip strength and endurance may not play a major role in the development or treatment of rLBP.\ \ **Level of Evidence:** 3…”
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Pesticide pollution status in cocoa plantation soil by E. Atuanya, W. Aborisade

“…Young and old cocoa plantation fields from 4 major cocoa producing States in Nigeria were selected as the study area. …”
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A comparative study evaluating three line immunoassays available for serodiagnosis of equine Lyme borreliosis: Detection of Borrelia burgdorferi sensu lato-specific antibodies in s... by Cornelia V Broeckl, Stephanie Hiereth, Reinhard K Straubinger

“…Depending on LIA used, deficiencies were observed in the form of non-sufficient sensitivity of antigen signals on the LIA strips (especially for outer surface protein A (OspA) or variable major protein like sequence expressed (VlsE)) or as an inappropriate test interpretation of the OspA signal. …”
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Mental health literacy among primary care providers in Hungary: a vignette-based survey by Valerie S. Swisher, Dorottya Őri, Zoltán Rihmer, Róbert Wernigg

“…Participants read six vignettes describing obsessive-compulsive disorder (OCD) harm/aggression subtype (OCD-Aggression), OCD order/symmetry subtype (OCD-Order), generalized anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder (PD), and major depressive disorder (MDD) and were asked to identify each condition, perceived disorder causes, and provide treatment referrals. …”
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Electron injection and acceleration in a twisted laser driven by the light fan by Xiang Tang, Juexuan Hao, Yin Shi

“…A routine and reliable way to obtain high-intensity LG lasers in experiments remains a major challenge. One approach involves utilizing a solid plasma with a ‘light fan’ structure to reflect the Gaussian laser and obtain a relativistic intense LG laser. …”
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Exploring the quality of end-of-life care in the intensive care unit: a qualitative multiple case study approach with family members of Muslim patients by Robert Fowler, Craig Dale, Ayah Nayfeh, Lesley Gotlib Conn

“…Culture, religion and religiosity did not appear to have a major influence on the medical decision-making process. …”
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Measurement and Numerical Simulation of Ground and Subgrade Vibrations of Beijing Urban Rail Line 13 by Futong Wang, Leilei Yan, Qi Jiang, Xiaxin Tao

“…Urban rail transit is an effective way to deal with the problem of traffic congestion in major cities. Trains travel through dense residential and commercial areas, providing convenient transportation while also result in vibration problems in the surrounding environment. …”
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Cost-effectiveness analysis of deep brain stimulation for the treatment of alcohol use disorder and alcoholic liver disease by Oluwatofunmi A. Abiola, Collin M. Lehmann, Khaled Moussawi, Hawre Jalal

“…Background: Alcohol use disorder (AUD) is a major public health concern and cause of mortality and morbidity. …”
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Dynamic relationships between environment-related technologies, agricultural value added, transport infrastructure and environmental emissions in the five most populous countries by Yinuo Wang, Arshad Ali, Zhaojie Chen

“…Abstract Densely populated countries have higher demand for agricultural products and greater use of fuel and vehicles, resulting in higher environmental emissions, so this study considers transportation infrastructure and the agricultural sector as the two major drivers of environmental degradation in the top five densely populated countries. …”
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Plio–Quaternary Tectonic Activity in the Northern Nubian Belts: The Main Driving Forces by Enzo Mantovani, Marcello Viti, Daniele Babbucci, Caterina Tamburelli

“…Since then, the consumption of the residual low-buoyancy domains in the Mediterranean area was allowed by a major change in the plate mosaic and the related kinematics. …”
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Propolis as an Adjuvant in the Healing of Human Diabetic Foot Wounds Receiving Care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca by Verónica Mujica, Roxana Orrego, Roberto Fuentealba, Elba Leiva, Jessica Zúñiga-Hernández

“…Diabetic foot wounds are a relevant diabetes complication and a major health problem. It has been described that propolis has health benefits due to its anti-inflammatory, antioxidant, and support in the healing process. …”
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Beta Blocker Therapy in Heart Failure Patients with Active Cocaine Use: A Systematic Review by Baldeep K. Mann, Janpreet S. Bhandohal, Mohammad Saeed, Gerald Pekler

“…The main primary outcomes included readmission rates, mortality, left ventricular ejection fraction (LVEF) improvement, New York Heart Association (NYHA) functional class, and major adverse cardiovascular events (MACEs). In the studies analyzed, beta blockers were found to have either a beneficial or a neutral effect on primary outcomes in heart failure patients with active cocaine use. …”
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Statistical analysis and characteristics of hospital medical waste under novel Coronavirus outbreak by H.A. Abu-Qdais, M.A. Al-Ghazo, E.M. Al-Ghazo

“…The main objective of the present study is to carry out statistical analysis and assess the generation rates and the composition of the medical waste generated during the treatment of coronavirus pandemic with reference to a major tertiary care hospital in Jordan. Data onthe daily generated waste, number of the admitted patients and on the amounts of consumables like various personal protective equipment, testing kits, and disinfectant used during the treatment of coronavirus disease was obtained. …”
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