Impact of the COVID-19 lockdown in the United Kingdom on adolescent's time use (CONTRAST study). by Irina Pokhilenko, Emma Frew, Marie Murphy, Miranda Pallan

“…<h4>Background</h4>The COVID-19 pandemic has led to major changes in everyone's lives, including adolescents. …”
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A Prospective, Multinational Pharmacoepidemiological Study of Clinical Conversion to Sirolimus Immunosuppression after Renal Transplantation by Bertram L. Kasiske, Bjorn Nashan, Maria Del Carmen Rial, Pablo Raffaele, Graeme Russ, Josep Campistol, Mark D. Pescovitz, Paul A. Keown

“…Principal reasons for conversion were declining graft function (146/484, 30%) and side effects of prior therapy (144/484, 30%) and the major treatment combinations after conversion were SRL ± MMF (62%), SRL + TAC (21.5%), SRL + CSA (16.5%). …”
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Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia In Vitro by Ivan Mikhailovich Rashchupkin, Ekaterina Yakovlevna Shevela, Aleksandra Aleksandrovna Maksimova, Marina Aleksandrovna Tikhonova, Aleksandr Anatolevich Ostanin, Elena Removna Chernykh

“…Macrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. …”
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The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary. by Laurence Drouilhet, Camille Mansanet, Julien Sarry, Kamila Tabet, Philippe Bardou, Florent Woloszyn, Jérome Lluch, Grégoire Harichaux, Catherine Viguié, Danielle Monniaux, Loys Bodin, Philippe Mulsant, Stéphane Fabre

“…In the Lacaune sheep breed, large variation in litter size is genetically determined by the segregation of a fecundity major gene influencing ovulation rate, named FecL and its prolific allele FecL(L) . …”
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Imunopatogenesis Treponema pallidum dan Pemeriksaan Serologi by Efrida ., Elvinawaty .

“…The spread of syphilis in the world has become a major health problem and the common, the number of 12 million cases per year. …”
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The European Union’s Policies Towards Iraq (2014–2020) by L. D. Oganisyan

“…The paper consists of three sections: the first one outlines the evolution of the EU strategic priorities in Iraq during 2014–2019, the second covers the major assistance programmes implemented by the European Union, both bilaterally and multilaterally, in Iraq; the third examines the EU reaction to the rising tensions in Iraq at the turn of 2019–2020.The author concludes that the EU’s growing interest in Iraq in recent years stems not only from concerns about transformation of this country into a source of cross-border challenges and threats, but also from the conviction of the EU officials that Iraq might potentially become the cornerstone of a new regional security architecture. …”
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Influence of Messa di Voce speed on vocal stability of untrained, healthy subjects. by Jonas Kirsch, Marie Köberlein, Michael Döllinger, Matthias Echternach

“…<h4>Conclusion</h4>There was no specific effect on stability found corresponding to the task's speed. Also, no major vocal instabilities at a specific sound pressure level were apparent, indicating no transitions as they exist for fo regions with registration events.…”
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Lipid-lowering drug targets and lung related diseases: a Mendelian randomization study by Haifeng Yu, Xiaofei Zhang, Bian Wen, Shuo Hu, Bin Ni

“…METHODS We extracted genetic variations of six drug target genes from a major genome-wide association study of low-density lipoprotein cholesterol (LDL-C) in individuals predominantly of European ancestry to represent the effects of LDL-C-lowering treatment. …”
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Interpretation of Rehabilitation Medicine Specialty Indicators in National Report on the Services， Quality and Safety in Medical Care System by ZHOU Mouwang

“…The quality control index includes structure index, process quality index and result quality index, and consists of 16 major items and 149 sub-items. The report is carried out by the National Clinical Improvement System (NCIS), and the quality, accuracy and completeness of the data report will be used as the reference for hospital evaluation and key specialty setting. …”
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Survey on the development of mimic defense in cyberspace:from mimic concept to “mimic+” ecology by Hailong MA, Liang WANG, Tao HU, Yiming JIANG, Yanze QU

“…Build upon the dynamic-heterogeneous-redundant architecture for multi-body execution, multi-mode ruling and multi-dimension reconstruction, cyberspace mimic defense (CMD) uses uncertain system to deal with the uncertain threat to cyberspace ubiquity.The evolution of CMD over the past 8 years were reviewed systematically from the vertical, horizontal, current, developing and future perspectives.From the vertical perspective, the development process of CMD from concept to theory and practice was summarized.From the horizontal view, it elaborated the core structure DHR (dynamical heterogeneous redundancy) of CMD, the principles based on CMD’s three major theorems, safety gains and performance costs.A comparison was conducted between CMD and five other active defense technologies, namely intrusion tolerance, moving target defense, zero trust architecture, trusted computing and computer immunology.From the current perspective, it reviewed the implementation elements, performance, system architecture, heterogeneous strategies, scheduling strategies, voting strategies and other common technology patterns and characteristics of 11 types of main existing mimic products including mimicry router, mimicry processor, mimicry DNS server and mimicry cloud platform.From the developing perspective, it explored the “mimic+” AICDS (Mimic + AI/IoT/Cloud/Data/SDN) symbiotic ecology with respect to 5 types of new technologies, namely artificial intelligence, Internet of things, cloud computing, big data and software-defined network, and proposed the corresponding technology junctions and cross research value.From the future perspective, it looked into the future mimicry baseline 2.0 product ecology, “mimic +5G/6G”, “mimic + edge computing”,“mimic + cloud” and “mimic + blockchain” application scenarios.Besides, 4 types of challenges faced by CMD in the future were analyzed and summarized, including escape space of multi-mode decision attack, mutual restriction of heterogeneous and synchronous, difficult balance between security and function, and limited transformation space of existing endogenous security components.…”
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Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis by Jie Zhao, Ying-Hui Zhou, Ya-Qiong Zhao, Yao Feng, Fei Yan, Zheng-Rong Gao, Qin Ye, Yun Chen, Qiong Liu, Li Tan, Shao-Hui Zhang, Jing Hu, Marie Aimee Dusenge, Yun-Zhi Feng, Yue Guo

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Regulatory mechanism analysis of signal transduction genes during rapeseed (Brassica napus L.) germination under aluminum stress using WGCNA combination with QTL by Chenyang Li, Ruili Wang, Jiana Li, Qingyuan Zhou, Cui Cui

“…In this study, we focused on one of the major bioenergy crops—rapeseed. Seeds of aluminum-sensitive (S) and aluminum-resistant (R) lines screened from the recombinant inbred lines (RILs) population of rapeseed were treated with 80 µg·ml-1 AlCl3 (ST, RT). …”
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Declining Trend of Transapical Access for Transcatheter Aortic Valve Replacement in Patients with Aortic Stenosis by Sumit Sohal, Harsh Mehta, Krishna Kurpad, Sheetal Vasundara Mathai, Rajiv Tayal, Gautam K. Visveswaran, Najam Wasty, Sergio Waxman, Marc Cohen

“…The last decade has witnessed major evolution and shifts in the use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). …”
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Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid ob... by Pau Soldevila-Matías, Joan Vicent Sánchez-Ortí, Patricia Correa-Ghisays, Vicent Balanzá-Martínez, Gabriel Selva-Vera, Roberto Sanchis-Sanchis, Néstor Iglesias-García, Manuel Monfort-Pañego, Pilar Tomás-Martínez, Víctor M Victor, Benedicto Crespo-Facorro, Constanza San Martin Valenzuela, José Antonio Climent-Sánchez, Rosana Corral-Márquez, Inmaculada Fuentes-Durá, Rafael Tabarés-Seisdedos

“…<h4>Methods</h4>Patients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid obesity (n = 29) were assigned to a 12-week structured physical exercise program. …”
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Development of the adaptive spring bread wheat cultivar ‘Omskaya Yubileynaya’ under the conditions of the Siberian region by N. A. Popolzukhina, P. V. Popolzukhin, A. A. Gaidar, Yu. Yu. Parshutkin, N. A. Yakunina

“…‘Omskaya Yubileynaya’ was characterized by resistance to lodging and to major plant diseases. It exceeded the reference in grain yield both in fallow (+0,50 t/ha) and nonfallow lands (+0,58 t/ha). …”
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Electrocatalytic CO Reduction to Produce Long‐chain Products Through Fischer‐Tropsch Pathway by Bo Cao, Fu‐Zhi Li, Songbai Han, Qiang Xu, Jun Gu

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Visualization of Observational Learning and Peer Influence on Plastic Waste Diversity in the Campus Environment Using ArcGIS by Nüket Sivri, Atilla Aydoğdu, Vildan Zülal Sönmez, Ceyhun Akarsu

“…Plastic pollution has become a major environmental problem affecting ecosystems, wildlife and human health. …”
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Pneumococcal vaccination in elderly care facilities in Japan: A cross-sectional, web-based survey by Youngju Kim, Hironori Taniguchi, Kotoba Okuyama, Junpei Kamimoto, Kenji Kawakami

“…Multivariable analysis showed that major factors associated with a high pneumococcal vaccination rate (≥15%) were “managing director’s willingness to recommend” and “pneumococcal vaccination request from the residents.” …”
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YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders by Aderonke O. Ajongbolo, Aderonke O. Ajongbolo, Sigrid A. Langhans

“…YAP/TAZ (Yes-associated protein/paralog transcriptional co-activator with PDZ-binding domain) are transcriptional cofactors that are the key and major downstream effectors of the Hippo signaling pathway. …”
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Mixed Infant Feeding Practice and Associated Factors among HIV-Positive Women under Care in Gondar City’s Public Health Facilities within Two Years Postpartum: A Cross-Sectional St... by Muhabaw Shumye Mihret, Mengstu Melkamu Asaye, Banchigizie Adane Mengistu, Habte Belete

“…Mixed infant feeding practice remains a major setback for effective prevention of mother to child transmission of HIV program and updated evidences on this issue is essential for better interventions. …”
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