Association between osteoarthritis and cognitive function: results from the NHANES 2011–2014 and Mendelian randomization study by Kun Zhao, Liuyan Nie, Jingting Zhao, Yankai Dong, Kaixiu Jin, Song Wang, Xiangming Ye

“…Genetically predicted specific-site OA was not significantly associated with the risk of dementia (OR = 1.12; 95% CI: 0.96–1.32; p = 0.16), Alzheimer’s disease (OR = 0.95, 95% CI: 0.68–1.31, p = 0.74), vascular dementia (OR = 1.32, 95% CI: 0.82–2.13, p = 0.25) with accepted heterogeneity and no evidence of directional pleiotropy. Furthermore, major depression was found to mediate the pathway between OA and vascular dementia (β = 0.044, 95% CI: −0.391 to 0.479, p < 0.05). …”
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Technical considerations towards commercialization of porcine respiratory and reproductive syndrome (PRRS) virus resistant pigs by A. Mark Cigan, Pieter W. Knap

“…While this achievement represents a major step towards solving an important disease in livestock, to realize the positive impact on animal health while benefiting the pork industry and consumers, it is necessary to introduce this recessive disease resistance allele into commercial breeding populations. …”
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Diversity of avenanthramide content in wild and cultivated oats by S. Leonova, A. Gnutikov, I. Loskutov, E. Blinova, K.-E. Gustafsson, O. Olsson

“…Accessions were identified where AVAs A, B and C, which are generally considered as major AVA, had a low percentage, and instead other AVAs prevailed. …”
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Saintes/Mediolanum, cité des Santons et Bordeaux/Burdigala, cité des Bituriges Vivisques : destins croisés by Louis Maurin, Alain Bouet, Eneko Hiriart, Guilhem Landreau, Christophe Sireix, Dominique Tardy

“…AD this city benefited from a properly Roman suite of major architectural embellishments which gave it a glamour unrivalled by its neighbour or by the other civitates of the new province of Aquitania.…”
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Fetal medicine and current practice of prenatal screening by Akshatha Prabhu

“…Prenatal screening has come a long way from the discovery of fetal ultrasound markers for Down syndrome followed by improved ultrasound skills where genetic syndromes and major congenital malformations can be diagnosed right in the first trimester itself. …”
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Predicting noncoding RNA and disease associations using multigraph contrastive learning by Si-Lin Sun, Yue-Yi Jiang, Jun-Ping Yang, Yu-Han Xiu, Anas Bilal, Hai-Xia Long

“…Nevertheless, most existing methods face two major issues: low prediction accuracy and the limitation of only being able to predict a single type of noncoding RNA-disease association. …”
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Mesenchymal Stromal Cells Mediate Clinically Unpromising but Favourable Immune Responses in Kidney Transplant Patients by Urvashi Kaundal, Raja Ramachandran, Amit Arora, Deepesh B. Kenwar, Ratti Ram Sharma, Ritambhra Nada, Mukut Minz, Vivekanand Jha, Aruna Rakha

“…Allograft rejection postkidney transplantation (KTx) is a major clinical challenge despite increased access to a healthcare system and improvement in immunosuppressive (IS) drugs. …”
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A cognitive-stylistic study of deixis and deictic shifting in Iris Murdoch’s The Bell by Mohammad Ghaffary, Seyed Mohammad Hosseini, Mohadesse Khosravi

“…To achieve this goal, this qualitative study draws upon the cognitive deixis theory to examine selected extracts from Dora Greenfield’s and Toby Gashe’s discourses in this novel, as two of the major character-focalizers. The findings suggest that deictic expressions serve a significant function in appreciating the characterization of the fictional personages, their relations, and consequently the narrative’s overall theme, thereby affecting and somehow directing the reading process. …”
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Vaccine-induced reduction of COVID-19 clusters in school settings in Japan during the epidemic wave caused by B.1.1.529 (Omicron) BA.2, 2022 by Yuta Okada, Hiroshi Nishiura

“…Clusters of COVID-19 in high-risk settings, such as schools, have been deemed a critical driving force of the major epidemic waves at the societal level. In Japan, the vaccination coverage among students remained low up to early 2022, especially for 5–11-year-olds. …”
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Higher Levels of Income and Education are Associated with More Specialized Sport Participation Behaviors: Results from a Representative Sample of Youth Sport Parents from the Unite... by Eric G Post, Matthew J. Rivera, Darleesa Doss, Lindsey E. Eberman

“… # Conclusions Thes results suggest that in the modern youth sport culture, family resources may serve as a major determining factor in the type of experiences available for a youth athlete…”
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Adapting and deploying a digital program for training non-specialist providers on a brief psychological intervention for depression in rural Gujarat, India. by Aakrushi Brahmbhatt, Darshana Rathod, Udita Joshi, Azaz Khan, G Sai Teja, Shrey Desai, Ajay Chauhan, Shobha Shah, Deepti Bhatt, Sethuraman Venkatraman, Deepak Tugnawat, Satchit Balsari, Vikram Patel, Anant Bhan, John A Naslund

“…Workforce shortages represent a major bottleneck to delivering depression care, particularly in lower resource settings. …”
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Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells by Ihraiz Worood G., Ahram Mamoun, Bardaweel Sanaa K.

“…Despite the availability of numerous therapeutics for breast cancer management, cytotoxicity and emergence of drug resistance are major challenges that limit their benefits. The acidic microenvironment surrounding tumor cells is a common feature inducing cancer cell invasiveness and chemoresistance. …”
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Perceptions of cervical screening uptake amongst South Asian women in Ontario, Canada: a concept mapping study by Kimberly Devotta, Aisha Lofters, Jacqueline Bender, Patricia O’Campo

“…In Ontario, Canada, South Asian women have the lowest rates of cervical cancer screening among major ethnic groups in the province. Methods Using an innovative and participant-driven method called Concept Mapping (CM), we set out to understand how the lives and experiences of South Asian women living in Ontario shape their decisions around getting screened for cervical cancer. …”
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Proposals by the Ministry of Internal Affairs Commission Headed by F. K. Girs to Subordinate the Kirghiz Inner Horde under Astrakhan Governorate: Administrative Structure and Judic... by Evgeniy A. Gunaev

“…The paper discusses a number of issues pertaining to the Inner Horde’s administrative restructuring project, relocation of its headquarters from Naryn-Peski, centralized localities for uyezd-level authorities, and its judicial system. Conclusions. The major criteria for the Inner Horde’s resubordination to Astrakhan Governorate included geographical, political, and socioeconomic ones. …”
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Feasibility and Safety of Perilla Seed Oil as an Additional Antioxidative Therapy in Patients with Mild to Moderate Dementia by Chuntida Kamalashiran, Junya Pattaraarchachai, Sombat Muengtaweepongsa

“…Oxidative stress plays a major role in the neurodegenerative cascade, leading to the irreversible mechanism in dementia. …”
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Understanding transmission pathways and integrated digital surveillance potential of antimicrobial resistance in Ethiopia in a One Health approach: a mixed-method study protocol by Muhammad Asaduzzaman, Christoph Gradmann, Andrea Sylvia Winkler, Zeleke Mekonnen, Ernst Kristian Rodland

“…Introduction Antimicrobial resistance (AMR) has a critical global impact, mostly affecting low- and middle-income countries. A major knowledge gap exists in understanding the transmission pathway of the gut colonisation with AMR bacteria between healthy humans and their animals in addition to the presence of those AMR bacteria in the surrounding environment. …”
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Assessment of Malaysia-wide PM2.5 Forecasts from a Global Model by Zhixian Tan, Mohd Talib Latif, Matthew J. Ashfold

“…Abstract Airborne particulate matter with an aerodynamic diameter of less than 2.5 µm (PM2.5) is a major air pollutant worldwide. In Malaysia, transboundary ‘haze’ episodes with elevated PM2.5 concentrations linked to fires are common, causing health and economic harms. …”
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Chemical composition by PTP 1B inhibitory activity guided analysis of a plant- based antidiabetic polyherbal drug used in ethnomedical systems by Pardon Mugari, Pamhidzai Dzomba, Stephen Nyoni

“…Results Results showed that the polyherbal drug consisted of two alkaloids and three anthocyanins as the major active components. PTP 1B inhibition of alkaloids was not significantly different from that of metformin with percentage inhibition of 78.6 ± 3.2 and 79.6 ± 2.3%. …”
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The influence of patriarchal cultural factors on pregnancy complications (antepartum hemorrhage) at Mitra Medika General Hospital, Bandar Klippa, Indonesia by Liyana Simamora, Zata Ismah, Susilawati

“…Antepartum hemorrhage stands as one of the major contributors to maternal mortality globally. 2. …”
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The Impact of C-Peptide and Diabetes Mellitus on Coronary Ectasia and Effect of Coronary Ectasia and C-Peptide on Long-Term Outcomes: A Retrospective Cohort Study by Kenan Toprak, Mustafa Kaplangoray, Ali Palice

“…A total of 6611 patients who underwent coronary angiography were followed up retrospectively, and their major adverse cardiovascular event (MACE) status of an average of sixty months was recorded. …”
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