Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans by Fengqing Shao, Xiaoqi Liu, Xianzhi Zhang, Qi Wang, Wencai Wang

“…Cancer and aging, two distinct processes of cell development, are two major problems threatening our human health and life in current days. …”
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Pangenome mining of the Streptomyces genus redefines species’ biosynthetic potential by Omkar S. Mohite, Tue S. Jørgensen, Thomas J. Booth, Pep Charusanti, Patrick V. Phaneuf, Tilmann Weber, Bernhard O. Palsson

“…This synteny suggests that vertical inheritance is a major factor in the diversification of BGCs. Conclusions Our analysis of a genomic dataset at a scale of thousands of genomes refines predictions of BGC diversity using Mash-clusters as a basis for pangenome analysis. …”
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Recanalization of atherosclerotic stenosis and occlusion of intracranial vertebrobasilar artery by Zhi-Long Zhou, Liang-Fu Zhu, Tian-Xiao Li, Bu-Lang Gao

“…Intracranial vertebrobasilar atherosclerosis is one of the major causes of posterior circulation ischemic strokes and may result in a high risk of recurrent stroke. …”
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The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue by Angelica Johansson, Eirini Kalliara, Emma Belfrage, Teodor Alling, Paul Theodor Pyl, Anna Sandström Gerdtsson, Urban Gullberg, Anna Porwit, Kristina Drott, Sara Ek

“…<b>Background/objectives:</b> Mycosis fungoides (MF) is a rare malignancy, with an indolent course in the early stages of the disease. However, due to major molecular and clinical heterogeneity, patients at an advanced stage of the disease have variable responses to treatment and considerably reduced life expectancy. …”
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The Effect of Land Cover Change on Soil Properties around Kibale National Park in South Western Uganda by J. G. M. Majaliwa, R. Twongyirwe, R. Nyenje, M. Oluka, B. Ongom, J. Sirike, D. Mfitumukiza, E. Azanga, R. Natumanya, R. Mwerera, B. Barasa

“…Focused group discussions and key informant interviews were used for land-use/cover reconstruction. Three major land uses were included; woodlot (Eucalyptus grandis; 5 years old) ), tea (57 years old) and natural forest used as a control. …”
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Prognostic significance of pathological response and lymph node status in neoadjuvant immunotherapy for potentially resectable non-small cell lung cancer by Yuan Xu, Dongjie Ma, Yingzhi Qin, Hongsheng Liu

“…Pathological response, lymph node involvement, and clinical outcomes were comprehensively assessed using Kaplan-Meier analysis and Cox regression.Results Both major pathological response (MPR) and complete pathological response (CPR) significantly correlated with improved PFS (p < .01), with no statistically significant difference between them (p = .15). …”
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Modelling Seismically Induced Mesothermal Goldfields along the Deep-Rooted Cadillac-Larder Lake Fault, Abitibi, Canada by Pierre Bedeaux, Silvain Rafini, Pierre Pilote, Réal Daigneault

“…Gold deposits are not uniformly distributed along major faults due to complex (and long-debated) interactions between seismicity, hydrothermalism, and structural heterogeneities. …”
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Mitigative Effect of Erythromycin on PMMA Challenged Preosteoblastic MC3T3-E1 Cells by Yi Shen, Weili Wang, Xiaomiao Li, David C. Markel, Weiping Ren

“…Aseptic loosening (AL) is a major complication of total joint replacement. Recent approaches to limiting AL have focused on inhibiting periprosthetic inflammation and osteoclastogenesis. …”
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3D printing driving innovations in extreme low-temperature energy storage by Shutong Qin, Jiao Dai, Haoran Tian, Hanyuan Zhang, Jingru Huang, Tianqi Guan, Weilin Xu, Jun Wan

“…Conventional technologies face major limitations under these conditions, including electrolyte freezing, restricted interfacial reaction kinetics, and microstructural instability. …”
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Chlorhexidine cytotoxicity on oral Behaviors: Last 20 Years systematic review by Luca Fiorillo, Cesare D'Amico, Vini Mehta, Marco Cicciù, Gabriele Cervino

“…All manuscripts according that cytotoxic effect in vitro is present at a concentration major than 0.001%. Conclusion: In conclusion, the cytotoxicity of chlorhexidine on oral cells and tissues is a complex issue that requires further investigation. …”
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The Enigmatic Upper Ordovician of the Naturtejo UNESCO Global Geopark (Portugal) by Sofia Pereira, Jorge Colmenar, Cristiana Esteves, Ícaro Dias da Silva, Miguel Pires, Carlos Neto de Carvalho

“…Despite its limited exposure area in major Variscan folded structures, the Ordovician series hosts some of its most famous geological heritage features, such as the Penha Garcia Ichnological Park.  …”
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Endoscopic ultrasound-guided hepaticogastrostomy and endoscopic retrograde cholangiopancreatography-guided biliary drainage for distal malignant biliary obstruction due to pancreat... by Naminatsu Takahara, Yousuke Nakai, Kensaku Noguchi, Tatsunori Suzuki, Tatsuya Sato, Ryunosuke Hakuta, Kazunaga Ishigaki, Tomotaka Saito, Tsuyoshi Hamada, Mitsuhiro Fujishiro

“…While the median TRBO was comparable (5.7 vs. 8.8 months, p=0.60), EUS-HGS was associated with a lower incidence of early RBO compared to ERCP-BD (8% vs. 29%, p=0.09). The major causes of early RBO in ERCP-BD were sludge and food impaction, rarely occurring in EUS-HGS. …”
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Diversity and Conservation of Carnivores in Saudi Arabia by Ali Al Ahmari, Farah Neyaz, Faisal Shuraim, Abdul Rahman Al Ghamdi, Ahmad Al Boug, Mesfer Alhlafi, Sharif Al Jbour, Francesco M. Angelici, Saleh Alaamri, Khalid Al Masabi, Zuhair Sami Amr

“…The southwestern corner of Saudi Arabia covering the Asir, Jazan, and Najran Plateaus extending further into the Al Sarawat Mountains hosts the highest number of carnivore species. Major threats affecting carnivores include killing and animal trade. …”
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Dynamic Changes in Parameters of Complete Blood Count Predict Disease Severity and Prognosis in Patients with COVID-19; A Prospective Study by Toktam Alirezaei, Mahdi Baratnia, Rama Bozorgmehr, Yasamansadat Keshmiri, Faezeh Ebrahimpour, Maryam Arefnia, Mohammadali Ghodsirad

“…Background: The pandemic of the coronavirus disease 2019 (COVID-19) is a major cause of death worldwide; thus, disease prediction is important. …”
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5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity by Thomas Stübig, Anita Badbaran, Tim Luetkens, York Hildebrandt, Djordje Atanackovic, Thomas M. C. Binder, Boris Fehse, Nicolaus Kröger

“…In vivo data confirm the increase of Treg compartment, while CD8+ T-effector cell numbers were reduced. 5-Aza treatment results in a shift from cytotoxic to regulatory T-cells with a functional phenotype and a major reduction in proinflammatory Th1-cells, indicating a strong inhibition of tumor-specific T-cell immunity by 5-Aza.…”
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Impetus of US hospital leaders to invest in patient-reported outcome measures (PROMs): a qualitative study by Andrea L Pusic, Marilyn Heng, Danny Mou, Rachel C Sisodia, Meredith B Rosenthal, Barbara Bokhour, Christer Mjåset, Claire M Sokas, Azan Virji

“…Understanding why leaders of major healthcare institutions invest in PROMs is critical to understanding the role that PROMs play in the US healthcare system.…”
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Comprehensive Analysis of Word Embedding Models and Design of Effective Feature Vector for Classification of Amazon Product Reviews by B. Priya Kamath, M. Geetha, U. Dinesh Acharya, Dipesh Singh, Ayush Rao, Shwetha Rai, Roopashri Shetty

“…Feature engineering is considered to be one of the major steps in the Machine Learning (ML) pipeline with effective feature extraction playing a vital role in improving the performance of the SA tasks. …”
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Structural Characterizations and Biological Evaluation of a Natural Polysaccharide from Branches of <i>Camellia oleifera</i> Abel by Shengjia Lu, Yali Zhang, Yanghui Ou, Jianghui Xin, Hongliang Yao, Litao Guan

“…After purification, the major monosaccharides of branches of <i>C. oleifera’s</i> polysaccharide (CBP) were disclosed as glucose and galactose. …”
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Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians by Larisa Geskin, Christiane Querfeld, Emmilia Hodak, Neda Nikbakht, Evangelia Papadavid, Marco Ardigò, Ulrike Wehkamp, Martine Bagot

“…Chlormethine gel is recommended by major treatment guidelines as a first-line option for stage IA–IIA disease, and, on the basis of these guidelines, used in combination with other therapies in patients with advanced-stage MF in clinical practice. …”
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Blood transcriptome resources of chinstrap () and gentoo () penguins from the South Shetland Islands, Antarctica by Bo-Mi Kim, Jihye Jeong, Euna Jo, Do-Hwan Ahn, Jeong-Hoon Kim, Jae-Sung Rhee, Hyun Park

“…In the blood transcriptomes, KEGG analyses detected many essential genes involved in the major innate immunity pathways, which are key metabolic pathways for maintaining homeostasis against exogenous infections or toxins. …”
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