Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation by Daniel Czyzyk, Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji, Mitsuhiro Yamaguchi, Shinji Furuzono, David M. Turner, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu

“…Abstract Mutations in RAS and PI3Kα are major drivers of human cancer. Their interaction plays a crucial role in activating PI3Kα and amplifying the PI3K-AKT-mTOR pathway. …”
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The Effect of Galaxy Interactions on Starbursts in Milky Way-mass Galaxies in FIRE Simulations by Fei Li, Mubdi Rahman, Norman Murray, Dušan Kereš, Andrew Wetzel, Claude-André Faucher-Giguère, Philip F. Hopkins, Jorge Moreno

“…Our analysis shows that some, but not all, major interactions cause starbursts in the simulated Milky Way-mass galaxies, and that most starbursts are not caused by galaxy interactions. …”
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Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes by J. R. Thiele, J. Zeller, H. Bannasch, G. B. Stark, K. Peter, S. U. Eisenhardt

“…In this respect, the development of clinically applicable derivatives of the palindromic compound 1,6-bis(phosphocholine)-hexane (1,6-bis PC) should be a major focus of future CRP research.…”
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Rethinking Assessment Concepts in Dental Education by Mohamed El-Kishawi, Khaled Khalaf, Dana Al-Najjar, Zahra Seraj, Sausan Al Kawas

“…A search strategy was implemented using electronic search in major databases. The following key terms, clinical skills, preclinical, dental students, and assessment, were included in the search. …”
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Removal of Toxic Metal Ions from Aqueous Solutions in Integrated Clay Adsorption and Electroflotation by Raimundo Nonato Pereira Teixeira, Vicente Oliveira Sousa Neto, Juliene Tomé Oliveira, Lucas Fontenele Amorim, Eliezer Fares Abdala Neto, Diego de Quadros Melo, Henrique Douglas Melo Coutinho, Bonglee Kim, Jorge Marcell Coelho Menezes, Ronaldo Ferreira do Nascimento

“…Such a method produces an amount of galvanic sludge that is often disposed of inappropriately to the environment, causing major environmental damage. These rejects present high concentrations of toxic metallic ions, such as copper (Cu(II)), lead (Pb(II)), nickel (Ni(II)), and cadmium (Cd(II)). …”
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Serum Lipids Alterations in Patients Under Systemic JAK Inhibitors Treatments in Dermatology: Clinical Aspects and Management by Giovanni Paolino, Mario Valenti, Andrea Carugno, Matteo Bianco, Dario Didona, Matteo Riccardo Di Nicola, Pier Luigi Acutis, Carmen Cantisani, Vittoria Giulia Bianchi, Nicola Zerbinati, Alessandra Narcisi, Antonio Costanzo, Santo Raffaele Mercuri

“…Despite these changes, there is no clear evidence linking these alterations to an increased risk of major adverse cardiovascular events (MACE), indicating a complex interaction between lipid metabolism and JAK-STAT signalling. …”
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Influence of the housing system on carcass composition and meat quality of laying hens after the laying period by Marcin Wegner, Dariusz Kokoszyński, Joanna Żochowska-Kujawska, Marek Kotowicz, Joanna Frischke-Krajewska

“…The texture, rheological properties, and microstructure of the pectoralis major muscle were analyzed. The housing system affected the percentage of abdominal fat (SW - 2.10% vs. …”
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Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract by S. Anbazhagi, A. Murugesan, M. Paramanantham, K. Chinnaiah, Karthik Kannan, Nadezhda Palko, K. Gurushankar

“…Hence, this study explores the antimicrobial and Vitro studies green-synthesized CuS–ZnO nanocomposite and examined the responsible major biocompound for activity through the theoretical study. …”
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Microscale Research on Effective Geosequestration of CO2 in Coal Reservoir: A Natural Analogue Study in Haishiwan Coalfield, China by Kaizhong Zhang, Wei Li, Yuanping Cheng, Jun Dong, Qingyi Tu, Rong Zhang

“…The sealing capacity of cap rock (oil shale) and geological tectonism (F19 fault), as the major contributors to CO2 enrichment and accumulation, provides insights into the suitable selection of CCGS site for long geological time.…”
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Enhanced As (V) Removal from Aqueous Solution by Biochar Prepared from Iron-Impregnated Corn Straw by Jiaming Fan, Xin Xu, Qunli Ni, Qi Lin, Jing Fang, Qian Chen, Xiaodong Shen, Liping Lou

“…Fe oxide constituted a major As-adsorbing sink. Based on the X-ray diffraction spectra, saturation indices, and selective chemical extraction, the data suggested three main mechanisms for arsenate removal: sorption of arsenate, strong inner-sphere surface complexes with amorphous iron oxyhydroxide, and partial occlusion of arsenate into the crystalline Fe oxides or carbonized phase. …”
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Association between the Time of Length since Smoking Cessation and Insulin Resistance in Asymptomatic Korean Male Ex-Smokers by Ko-Woon Kim, Sung-Goo Kang, Sang-Wook Song, Na-Rae Kim, Jun-Seung Rho, Yun-Ah Lee

“…Aim. Smoking is a major risk factor for diabetes mellitus, mainly due to decreased insulin secretion and increased insulin resistance. …”
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Evaluating the Contribution of Nocardia spp. and Mycobacterium tuberculosis to Pulmonary Infections among HIV and Non-HIV Patients at the Komfo Anokye Teaching Hospital, Ghana by Samuel Asamoah Sakyi, Kwabena Owusu Danquah, Richard Dadzie Ephraim, Anthony Enimil, Venus Frimpong, Linda Ahenkorah Fondjo, Esther Love Darkoh

“…Tuberculosis (TB) is a major cause of human mortality particularly in association with the human immunodeficiency virus (HIV). …”
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7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents by Shuke Nie, Kai Ma, Mingkuan Sun, Matthew Lee, Yang Tan, Guiqin Chen, Zhentao Zhang, Zhaohui Zhang, Xuebing Cao

“…7,8-Dihydroxyflavone (7,8-DHF) is thought to be a promising therapeutic agent for various neurodegenerative diseases. The major purpose of this study was to investigate the neuroprotective effects of 7,8-DHF on the rotenone-induced motor deficit of Parkinson’s disease. …”
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Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection by Nadeem Ullah, Ling Hao, Yaqi Wu, Yandi Zhang, Qing Lei, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin, Xionglin Fan

“…Tuberculosis (TB) remains a major and global problem of public health. An effective TB subunit vaccine is urgently needed. …”
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CONSTRUCTION PROFESSIONALS’ PERCEPTION OF THE MARKETING STRATEGIES EMPLOYED BY CONSTRUCTION FIRMS IN ABUJA, NIGERIA by Emmanuel Chidiebere EZE, Onyinye SOFOLAHAN, Onyealilam Peter ONYEAGAM, Usman MUHAMMED

“…The study revealed that maintaining a strong pool of professionals to boost the company image, developing non-economic or social bonds with clients, including ‘political’ offers in bids, having a project signboard, developing a marketable name as well as equipment branding, claim aversion, and free design contribution are the specific marketing strategies employed by construction firms. The major marketing strategies for improving the performance of construction firms are third-party-based strategies, project performance-based strategies, and client-based strategies. …”
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ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure by Xiuru Cui, Yawei Wang, Hanlin Lu, Lei Wang, Xianwei Xie, Shenghao Zhang, Pavel Kovarik, Shuijie Li, Shanshan Liu, Qunye Zhang, Jianmin Yang, Cheng Zhang, Jinwei Tian, Yan Liu, Wencheng Zhang

“…Abstract Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. …”
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Antimicrobial Efficacy and Cell Adhesion Inhibition of In Situ Synthesized ZnO Nanoparticles/Polyvinyl Alcohol Nanofibrous Membranes by Jian Li, Qun Zhang, Minjing Xu, Changzhu Wu, Ping Li

“…Our data revealed that the major antimicrobial mechanism could be attributed to cell membrane damage and cellular internalization of ZnO NPs, while the hydrophobic surface of the membrane primarily contributed to the cell adhesion inhibition. …”
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Parametric Study Of Friction Stir Spot Welding (FSSW) For Polymer Materials Case Of High Density Polyethylene Sheets: Experimental And Numerical Study by Djilali Benyerou, El Bahri Ould Chikh, Habib Khellafi, Hadj Miloud Meddah, Ali Benhamena, Kaddour Hachelaf, Abdellah Lounis

“…The parameters and mechanical properties of the welds are the major problems in the welding processes. In this paper, we have presented a contribution in finite element modeling of the friction stir spot welding process (FSSW) using Abaqus as a finite element solver. …”
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Generating a Full Cycle of Alternative Current Using a Triboelectric Nanogenerator for Energy Harvesting by Aso Ali Abdalmohammed Shateri, Fengling Zhuo, Nazifi Sani Shuaibu, Rui Wan, Liangquan Xu, Dinku Hazarika, Bikash Gyawali, Xiaozhi Wang

“…The DHLR-TENG’s versatility and efficiency mark it as a major advancement in energy harvesting, with broad implications for powering portable electronic devices in a wide range of environments.…”
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Reservoir characteristics and distribution of the Majiagou Formation in the Fuxian area of Ordos Basin, China by Ning Gu, Juntao Zhang, Xiaohui Jin, Jiaqi Yang, Fei Yang, Lu Liu

“…Through analyses of mineralogy, petrology, and reservoir geology, three major types of dolomite reservoirs with different genetic mechanisms, including anhydritic moldic-dissolved pore type, dolomitic intercrystalline-pore type, and fractured type were identified, and their formation mechanisms and distribution patterns were examined. …”
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