Laboratory and field efficacy of natural products against the invasive pest Halyomorpha halys and side effects on the biocontrol agent Trissolcus japonicus by Elena Chierici, Elisa Marchetti, Adriana Poccia, Antonio Russo, Vito Antonio Giannuzzi, Lorenzo Governatori, Luca Zucchi, Gabriele Rondoni, Eric Conti

“…Abstract The brown marmorated stink bug, Halyomorpha halys (Hemiptera: Pentatomidae), is an invasive pest causing major economic losses to crops. Since its outbreaks in North America and Europe, H. halys has been controlled with synthetic pesticides. …”
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Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis by Aldo Bonaventura, François Mach, Aline Roth, Sébastien Lenglet, Fabienne Burger, Karim J. Brandt, Aldo Pende, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Franco Dallegri, Michele Cea, Nicolas Vuilleumier, Fabrizio Montecucco, Federico Carbone

“…Here, systemic or intraplaque CRP levels were investigated as predictors of major adverse cardiovascular events (MACEs) in patients with severe carotid stenosis. …”
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Retinitis Pigmentosa with EYS Mutations Is the Most Prevalent Inherited Retinal Dystrophy in Japanese Populations by Yuuki Arai, Akiko Maeda, Yasuhiko Hirami, Chie Ishigami, Shinji Kosugi, Michiko Mandai, Yasuo Kurimoto, Masayo Takahashi

“…EYS mutations had the highest prevalence at 23.5%. c.4957_4958insA and c.8868C>A were the two major EYS mutations identified in this cohort. EYS mutations are the most prevalent among Japanese patients with IRD.…”
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Factors Associated with Poor Asthma Control among Sudanese Patients Attending Atbara Teaching Hospital in Sudan by Hadeel Kareem Aladdin, Sufian Khalid Mohammed Noor, Amro Mohamed Fagir Farah, Sara Elamin Bushara

“…Conclusion: Asthma is a major problem in Atbara City. Improper inhaler use, the presence of triggers at home or work, and passive smoking were significantly associated with hospital admission. …”
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Risk-Stratified Cardiovascular Screening Including Angiographic and Procedural Outcomes of Percutaneous Coronary Interventions in Renal Transplant Candidates by Julian König, Martin Möckel, Eda Mueller, Wolfgang Bocksch, Seema Baid-Agrawal, Nina Babel, Ralf Schindler, Petra Reinke, Peter Nickel

“…In 267 patients evaluated 2003 to 2006, screening tests performed were reviewed and PCI characteristics correlated with major adverse cardiovascular events (MACE) during a follow-up of 55 months. …”
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Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China by Chao Yang, Xiaowei Chen, Min Li, Wenchang Yuan, Shunguang Li, Dexing Han, Junhui Feng, Haimin Luo, Minling Zheng, Jiaqi Liang, Cha Chen, Pinghua Qu, Song Li

“…Sequence type (ST) 7, ST15 and ST188 were the major lineages in China. Genes esaC, esxB, and sea were only detected in ST7, potentially contributing to its prevalence in AD. …”
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Identification and pharmacokinetics of saponins in Rhizoma Anemarrhenae after oral administration to rats by HPLC-Q-TOF/MS and HPLC-MS/MS by Wang Hai-Qiao, Lan Fen, Zhang Yi-Han, Xia Jin-Er, Gong Xiao-Mei, Liu Min

“…Rhizoma Anemarrhenae is a well-known herbal medicine with saponins as its commonly regarded major bioactive components. It is essential to classify the properties of saponins which are associated with their toxicity and efficacy. …”
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Tracking Progress of National Health Summit Declarations - Health Policy Analysis: A Qualitative Study by Ashis Shrestha, Lisasha Poudel, Dipesh Tikhatri, Sushant Regmi, Jay Bhushan Jha, Shreya Baniya, Mandish Prasad Phuyal, Akanshya Prasai, Sunil Kunwar, Amit Chand, Prakriti Karki, Nurusha Tamrakar, Ritu Sapkota, Raman Yadav

“…Conclusions: Implementation of declaration is challenging, with fragmentation as major health issues, however, continuous advocacy has had a synergistic effect in implementation and prioritization of the policy. …”
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Triptolide suppresses IL-1β-induced expression of interleukin-8 by inhibiting ROS-Mediated ERK, AP-1, and NF-κB molecules in human gastric cancer AGS cells by Shinan Li, Shinan Li, Dhiraj Kumar Sah, Archana Arjunan, Mohamed Yazeer Ameer, Bora Lee, Young-Do Jung

“…Triptolide, the major component of Chinese herbal medicine Tripterygium wilfordii Hook F, possesses potent anticancer and anti-inflammatory effects. …”
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The landscape of nucleotide diversity in Drosophila melanogaster is shaped by mutation rate variation by Barroso, Gustavo V, Dutheil, Julien Y

“…Our analyses reclaim the well-established signature of linked selection in Drosophila melanogaster, but we estimate that the mutation landscape is the major driver of the genome-wide distribution of diversity in this species. …”
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USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1 by Wensun Chen, Siqi Wu, Yifan Chen, Weijian Li, Yiqing Cao, Yingchun Liang, Xiyu Dai, Xinan Chen, Yilin Chen, Tian Chen, Shenghua Liu, Chen Yang, Haowen Jiang

“…The Hippo-YAP1 axis is inhibited in bladder cancer (BC), which is a major driver of BC progression and oncogenesis. Hippo pathway activity is controlled by the phosphorylation cascade in the MST1/2-LATS1/2-YAP1 axis, in addition to other modifications such as ubiquitination of the Hippo pathway proteins through the co-regulation of E3 ligases and deubiquitinases. …”
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A Global Survey of Self-Reported Cancer Screening Practices by Health Professionals for Kidney Transplant Candidates and Recipients by Nida Saleem, Nida Saleem, Nida Saleem, Wai H. Lim, Wai H. Lim, Jacqueline H. Stephens, Jacqueline H. Stephens, Annabelle Wilson, Billie Bonevski, Allison Jaure, Allison Jaure, Armando Teixeira-Pinto, Armando Teixeira-Pinto, Eleonora Dal Grande, Eleonora Dal Grande, Martin Howell, Martin Howell, Farzaneh Boroumand, Farzaneh Boroumand, Anita van Zwieten, Anita van Zwieten, Chandana Guha, Chandana Guha, Nicole Scholes-Robertson, Nicole Scholes-Robertson, Steven J. Chadban, Steven J. Chadban, Carmel M. Hawley, Carmel M. Hawley, Jonathan C. Craig, Jeremy R. Chapman, Danyal Hassan, Greg Knoll, Greg Knoll, Naoka Murakami, Germaine Wong, Germaine Wong, Germaine Wong

“…Cancer is a major cause of morbidity and mortality in kidney transplant recipients. …”
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Exploring the Circumstellar Environment of Tycho’s Supernova Remnant. II. Impact on the Broadband Nonthermal Emission by Ryosuke Kobashi, Shiu-Hang Lee, Takaaki Tanaka, Keiichi Maeda

“…While the environment around Tycho's supernova remnant has long been believed to be close to homogeneous, the latest analysis of Chandra data has identified a substantial deceleration of the forward shock, which poses a major challenge to this picture. R. Kobashi et al. showed that the existence of dense molecular cloud (MC) surrounding a rarefied wind-like circumstellar matter (CSM) can explain this observational finding in terms of the shock-expansion dynamics, supporting the so-called single-degenerate scenario for the progenitor system. …”
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Microgrid Islanding Detection Using D-PMU and Phase Angle Analysis of Negative Sequence Impedance by Asim Chaulagain, Ramakrishna Gokaraju, Nurul Chowdhury, Krish Narendra

“…Unintentional islanding detection is a major challenge during the operation of a microgrid. …”
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Exploring the potentialities and challenges of deep learning for simulation and prediction of urban sprawl features by Ange Gabriel Belinga, Stéphane Cedric Tékouabou Koumetio, Mohamed El Haziti

“…Of course, this is not without major challenges, both in terms of data and models and in terms of strategic city planning policies.…”
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Transfer learning for multi-material classification of transition metal dichalcogenides with atomic force microscopy by Isaiah A Moses, Wesley F Reinhart

“…However, the limited and imbalanced data of experimental materials that are typically available is a major challenge. Also important is the need to interpret trained models, which are normally complex enough to be uninterpretable by humans. …”
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Holographic inspired high-performance circular polarized spoof surface plasmon polariton leaky-wave antenna excited by a novel launcher by Sajjad Zohrevand, Mohammad Amin Chaychi Zadeh, Ehsan Farokhipour, Daniel Erni, Nader Komjani

“…The anisotropy of each unit cell is achieved by combining the transformation optic method and the particle swarm optimization algorithm. A major challenge of the SSPP LWA based on modulated impedance surfaces is to find a suitable excitation technique. …”
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Structure and function of a β-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium by Yutaka Nakazawa, Masumi Kageyama, Tomohiko Matsuzawa, Ziqin Liang, Kaito Kobayashi, Hisaka Shimizu, Kazuki Maeda, Miho Masuhiro, Sei Motouchi, Saika Kumano, Nobukiyo Tanaka, Kouji Kuramochi, Hiroyuki Nakai, Hayao Taguchi, Masahiro Nakajima

“…Abstract Galactosides are major carbohydrates that are found in plant cell walls and various prebiotic oligosaccharides. …”
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2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis by Fernanda Rosa, Johan S. Osorio, Erminio Trevisi, Francisco Yanqui-Rivera, Charles T. Estill, Massimo Bionaz

“…Mastitis is a major disease in dairy cows resulting in significant economic losses. …”
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Randomized Controlled Pilot Study Testing Use of Smartphone Technology for Obesity Treatment by Jerilyn K. Allen, Janna Stephens, Cheryl R. Dennison Himmelfarb, Kerry J. Stewart, Sara Hauck

“…The established interventions for weight loss are resource intensive which can create barriers for full participation and ultimate translation. The major goal of this pilot study was to evaluate the feasibility, acceptability, and preliminary efficacy of theoretically based behavioral interventions delivered by smartphone technology. …”
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