α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach by Aimin Cai, Dingchao Shen, Qiushuang Xiong, Jie Ding, Yang Ding, Xinlu Lin, Lijia Chen, Qing Yao, Qing Yao, Guangyong Lin, Ruijie Chen, Vadivel Ganapathy, Vadivel Ganapathy, Longfa Kou

“…IntroductionDiabetic nephropathy (DN), a major complication of diabetes, presents with poor clinical outcomes and affects patients throughout their lifetime. α-Methyltryptophan (α-MT) is a blocker of the amino acid transporter. …”
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Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice by Luciana Lontro Alves, Priscila Gomes Pereira, Bianca Torres Ciambarella, Miguel Porto Campos, Kíssila Rabelo, Ana Lúcia Rosa Nascimento, Raíssa Leal de Carvalho dos Santos Cunha, Cherley Borba Vieira Andrade, Alan Cesar Nunes Moraes, Andressa Bernardi, Fernanda Verdini Guimarães, Jemima Fuentes Ribeiro da Silva, Jorge José de Carvalho

“…Obesity is a complex chronic disease characterized by excess body fat (adipose) that is harmful to health and has been a major global health problem. It may be associated with several diseases, such as nonalcoholic fatty liver disease (NAFLD). …”
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Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men by Pedro Fernandez, Charnita M. Zeigler-Johnson, Elaine Spangler, André van der Merwe, Mohamed Jalloh, Serigne M. Gueye, Timothy R. Rebbeck

“…African ethnicity is one of the major risk factors for developing prostate cancer. …”
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Radiological Patterns of Lung Involvement in Inflammatory Bowel Disease by Diletta Cozzi, Chiara Moroni, Gloria Addeo, Ginevra Danti, Monica Marina Lanzetta, Edoardo Cavigli, Massimo Falchini, Fabio Marra, Claudia Lucia Piccolo, Luca Brunese, Vittorio Miele

“…Inflammatory bowel disease (IBD) is a form of chronic inflammation of the gastrointestinal tract, including two major entities: ulcerative colitis and Crohn’s disease. …”
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Cytoskeletal Vimentin Directs Cell‐Cell Transmission of Hepatitis C Virus by Yifan Xing, Zeyu Wen, Jie Mei, Xinyi Huang, Shuangshuang Zhao, Jin Zhong, Yaming Jiu

“…Abstract Hepatitis C virus (HCV) is a major human pathogen causing liver diseases. Although direct‐acting antiviral agents effectively inhibit HCV infection, cell–cell transmission remains a critical venue for HCV persistence in vivo. …”
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CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases by Arthur I. Cederbaum, Lili Yang, Xiaodong Wang, Defeng Wu

“…The mechanisms by which alcohol causes cell injury are not clear. A major mechanism is the role of lipid peroxidation and oxidative stress in alcohol toxicity. …”
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Characterization and Etiopathogenic Approach of Pediatric Renal Biopsy Patients in a Colombian Medical Center from 2007-2017 by Mayerly Prada Rico, Carmen Inés Rodríguez Cuellar, Monica Fernandez Hernandez, Luz Stella González Chaparro, Olga Lucía Prado Agredo, Ricardo Gastelbondo Amaya

“…Glomerulonephritis was more frequent in patients older than 10 yrs (65%) and the rate of postbiopsy major complications was low (1.2%). Conclusion. Immune complex glomerulonephritis was the most frequent histological finding, differing from previous reports. …”
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Fusion Features-Based Entity Recognition Method for Safety Knowledge of Non-Coal Open-Pit Mine by Ziji Ma, Rui Zhao, Jianhua Huang, Shicheng Liu, Feilong Wang, Zhikang Shuai

“…However, as a key step in the construction of knowledge graph, it is a major challenge to recognize and extract entities from the complex field of safety production in non-coal open-pit mines. …”
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Comparative transcriptome analysis reveals a serotype-specific immune response in Nile tilapia (Oreochromis niloticus) infected with Streptococcus agalactiae by Renan José Casarotto Appel, Renan José Casarotto Appel, Karine Nicole Siqueira, Ioannis Konstantinidis, Maria Isabel Mello Martins, Rajesh Joshi, Lucienne Garcia Pretto-Giordano, Laurival Antônio Vilas-Boas, Jorge Manuel de Oliveira Fernandes, Jorge Manuel de Oliveira Fernandes

“…Streptococcus agalactiae is a major causative agent of streptococcosis in Nile tilapia (Oreochromis niloticus) and understanding its etiology is important to ensure the sustainable development of global tilapia farming. …”
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Self-Injurious Behavior in Child and Adolescent Psychiatry Inpatient Units: Actual Aspects of the Complex Care Provision by Sigita Lesinskienė, Mariam Afrahi, Kamilė Pociūtė

“… Background: Nonsuicidal self-injurious behavior in children and adolescents is a major concern that requires mental health professionals’ attention. …”
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Improved protocol for metabolite extraction and identification of respiratory quinones in extremophilic Archaea grown on mineral materials by Sebastian V. Gfellner, Sebastian V. Gfellner, Cyril Colas, Cyril Colas, Cyril Colas, Guillaume Gabant, Guillaume Gabant, Janina Groninga, Martine Cadene, Martine Cadene, Tetyana Milojevic, Tetyana Milojevic

“…The extraction of organic materials from these microorganisms is a major challenge because of the tight contact and interaction between cells and mineral materials. …”
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Acute Soft Head Syndrome as the Initial Presentation of Sickle Cell Disease in an Adolescent in Rural Western Uganda: Case Report by Abukar Ali Ahmed, Dalton Kambale Munyambalu, Awil Abdulkadir Abdi, Elias Joseph Xwatsal, Hanan Asad Hassan, Ibrahim Ahmed Nur, Abdikani Ali Hassan, Venance Emmanuel Mswelo

“…In such settings, the pre-existing poor socio-economic background coupled with atypical presentation constitute a major impediment for timely diagnosis.…”
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A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging by Zheyi Dong, Xiaofei Wang, Sai Pan, Taohan Weng, Xiaoniao Chen, Shuangshuang Jiang, Ying Li, Zonghua Wang, Xueying Cao, Qian Wang, Pu Chen, Lai Jiang, Guangyan Cai, Li Zhang, Yong Wang, Jinkui Yang, Yani He, Hongli Lin, Jie Wu, Li Tang, Jianhui Zhou, Shengxi Li, Zhaohui Li, Yibing Fu, Xinyue Yu, Yanqiu Geng, Yingjie Zhang, Liqiang Wang, Mai Xu, Xiangmei Chen

“…Abstract Differentiating between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD) without a kidney biopsy remains a major challenge, often leading to missed opportunities for targeted treatments that could greatly improve NDRD outcomes. …”
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Evaluation of Tinospora cordifolia stem extract bioactive content and anticancer activity against breast cancer cells by Annisa Yuslinda, Rosyadah Nuraini, Kamila Fairuz Sarah, Ulfa Siti Mariyah, Lestari Sri Rahayu, Widodo Nashi

“…Breast cancer remains a major public health challenge, highlighting the importance of finding new therapeutic approaches, including the use of traditional plants with unstudied medicinal properties. …”
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Parameters Estimation of a Microscopic Traffic Flow Sub-Model Within a Multiscale Approach Using Experimental Data by Facundo Storani, Roberta Di Pace, Shi-Teng Zheng, Rui Jiang, Stefano de Luca

“…Simulated Leader – Simulated Follower interaction approach. The major finding of the paper is that the calibrated parameters obtained using the Simulated Leader approach display greater regularity across different cell lengths.…”
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cLegal-QA: a Chinese legal question answering with natural language generation methods by Yizhen Wang, Xueying Shen, Zixian Huang, Lihui Niu, Shiyan Ou

“…This approach improves the efficiency of the judiciary and ensures prompt, professional legal assistance to the public. Currently, a major challenge is the absence of a large-scale dataset tailored for Chinese generative legal question answering. …”
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Vermicompost quality and earthworm reproduction in different organic waste substrates by Saeed Mohammad Alipour, Ebrahim Fataei, Fatemeh Nasehi, Ali Akbar Imani

“…The first two principal components in PCA revealed that the major parameters responsible for the qualitative changes in the produced vermicompost were iron, copper, calcium, magnesium, potassium, phosphorus and nitrogen.Conclusion Current results suggested that the treatment CPVS and the treatment S (sawdust) provided the optimal conditions for the growth and reproduction of earthworms and the production of high-quality vermicompost.…”
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Advancements in Predictive Analytics: Machine Learning Approaches to Estimating Length of Stay and Mortality in Sepsis by Houssem Ben Khalfallah, Mariem Jelassi, Jacques Demongeot, Narjès Bellamine Ben Saoud

“…Sepsis remains a major global health concern, causing high mortality rates, prolonged hospital stays, and substantial economic burdens. …”
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Liquid-based encapsulation for implantable bioelectronics across broad pH environments by He Sun, Xiaoting Xue, Gabriella L. Robilotto, Xincheng Zhang, ChangHee Son, Xingchi Chen, Yue Cao, Kewang Nan, Yiyuan Yang, Gavin Fennell, Jaewook Jung, Yang Song, Huijie Li, Shao-Hao Lu, Yizhou Liu, Yi Li, Weiyi Zhang, Jie He, Xueju Wang, Yan Li, Aaron D. Mickle, Yi Zhang

“…The encapsulation of these systems, however, presents a major challenge, as such devices require superior barrier performance against water and ion penetration in challenging pH environments while also maintaining flexibility and stretchability to match the physical properties of the surrounding tissue. …”
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Phylogenetic Analysis of Dengue Virus in Bangkalan, Madura Island, East Java Province, Indonesia by Teguh Hari Sucipto, Tomohiro Kotaki, Kris Cahyo Mulyatno, Siti Churrotin, Amaliah Labiqah, Soegeng Soegijanto, Masanori Kameoka

“…Dengue virus (DENV) infection is a major health issue in tropical and subtropical areas. …”
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