New insights into microbial bile salt hydrolases: from physiological roles to potential applications by Zixing Dong, Shuangshuang Yang, Cunduo Tang, Dandan Li, Dandan Li, Yunchao Kan, Yunchao Kan, Lunguang Yao, Lunguang Yao

“…Bile acids (BAs), the major components of bile, are bidirectionally linked to intestinal microbiota, also known as the gut microbiome-BA metabolic axis. …”
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Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti, Tatiana Armeni

“…This review aims to consolidate current data on the diverse epigenetic effects of the six major flavonoid subclasses, as well as other natural compounds, in the context of cancer. …”
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A metagenomic catalogue of the ruminant gut archaeome by Jiandui Mi, Xiaoping Jing, Chouxian Ma, Fuyu Shi, Ze Cao, Xin Yang, Yiwen Yang, Apurva Kakade, Weiwei Wang, Ruijun Long

“…Abstract While the ruminant gut archaeome regulates the gut microbiota and hydrogen balance, it is also a major producer of the greenhouse gas methane. However, ruminant gut archaeome diversity within the gastrointestinal tract (GIT) of ruminant animals worldwide remains largely underexplored. …”
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Determinants of Youth Participation in Rice Cultivation in South-Eastern Nigeria by Izuogu Chibuzo, Daniel Adu Ankrah, Umeh Ngozi E, Ebenehi Ojomugbokenyode, Musaaab Ibrahim, Iroegbu Susan, Ekweanya Ndidiamaka, Okorie Amah David

“…The respondents cultivated FARO 44 (84.6%), practiced early planting (2.9), and cultivated improved varieties (2.7) as utilised rice improved technologies. The major challenges of youth participation in rice cultivation were inadequate agricultural credit (89.4%) and poor access to improved seeds (86.7%) among others. …”
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Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection by Jianping Wu, David Cui, Xianzhi Yang, Jianzhou Lou, Jie Lin, Xianfei Ye, Zhimei Qin, Li Huang, Dejian Zhao, Zhaoxia Huo, Guoliang Xie, Shufa Zheng, Fei Yu, Liwei Lu, Yu Chen

“…Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) in children. …”
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Comparative Exploration of Antioxidant Properties of Alcalase- and Trypsin-Hydrolyzed Porcine By-Products and Their Classification for Industrial Use by Jun Hwang, Woo-Young Son, Eun Ju Jeong, Kyeong-Soo Kim, Eui-Cheol Shin, Dong-Heon Song, Kyung-Woo Lee, Hyun-Wook Kim

“…In this study, we compared the antioxidant properties of protein hydrolyzates derived from major porcine organs (heart, kidney, spleen, liver, and lung) and performed classification based on their antioxidative potential. …”
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The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class? by Ricardo Godinho, Cristina Mega, Edite Teixeira-de-Lemos, Eugénia Carvalho, Frederico Teixeira, Rosa Fernandes, Flávio Reis

“…This review outlines the therapeutic potential of DPP-4 inhibitors for the treatment of T2DM, focusing on their main features, clinical applications, and risks, and discusses the major challenges for the future, in particular the possibility of becoming the preferred therapy for T2DM due to their ability to modify the natural history of the disease and ameliorate nephropathy, retinopathy, and cardiovascular complications.…”
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Unlocking the secrets of the immunopeptidome: MHC molecules, ncRNA peptides, and vesicles in immune response by Arpita Balakrishnan, Arpita Balakrishnan, Gabriela Winiarek, Olga Hołówka, Jakub Godlewski, Agnieszka Bronisz

“…The immunopeptidome, a diverse set of peptides presented by Major Histocompatibility Complex (MHC) molecules, is a critical component of immune recognition and response. …”
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Traumatic Brain Injury Promotes Neurogenesis and Oligodendrogenesis in Subcortical Brain Regions of Mice by Olga Astakhova, Anna Ivanova, Ilia Komoltsev, Natalia Gulyaeva, Grigori Enikolopov, Alexander Lazutkin

“…Traumatic brain injury (TBI) is one of the major causes of severe neurological disorders and long-term dysfunction in the nervous system. …”
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Application of Liquid Chromatography-Tandem Mass Spectrometry for the Detection of Paralytic Shellfish Poison in Bivalve Shellfish and Its Influencing Factors by DENG Yuxiang, WU Haiyan, XU Xizhen, ZHAO Huihui, TAN Zhijun, ZHENG Guanchao

“…Graphitized carbon black (GCB) packing and hydrophilic interaction liquid chromatography (HILIC) are more suitable for the purification and separation of PSP extracts from bivalve shellfish, respectively. The major factors affecting matrix effects includes endogenous interferences such as phospholipids and proteins and exogenous interferences such as organic substances and polymer residues in the detection methods. …”
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Conformational diversity in class C GPCR positive allosteric modulation by Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon

“…Abstract The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate. The architecture of mGlu receptor comprises an extracellular Venus-Fly Trap domain (VFT) connected to the transmembrane domain (7TM) through a Cysteine-Rich Domain (CRD). …”
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Development and Treatments of Inflammatory Cells and Cytokines in Spinal Cord Ischemia-Reperfusion Injury by Ping Zhu, Jia-xin Li, Masayuki Fujino, Jian Zhuang, Xiao-Kang Li

“…Inflammation is a subsequent event of spinal cord ischemia and possibly a major contributor to spinal cord IRI. However, the development of inflammatory mediators is incompletely demonstrated. …”
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OLED-on-silicon (OLEDoS) microdisplays: Technology challenges, design considerations, and adaptation in eXtended Reality (XR) ecosystem – Review by Rifat Kaçar, Ramis Berkay Seri̇n, Esin Uçar, Murat Artuç, Alper Ülkü, Barış Kınacı

“…The review also examines the commercial landscape of OLEDoS, covering market trends, major industry players, and the adoption of these technologies across the industry. …”
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Islet organoids: a new hope for islet transplantation in diabetes by Xuemei Yu, Chengkong Liu, Zheng Kuang, Siyuan Song, Limin Tian, Yi Wang, Yi Wang

“…Diabetes mellitus, including Type 1 diabetes (T1D) and advanced Type 2 diabetes (T2D), remains a major global health challenge due to the destruction or dysfunction of insulin-producing β-cells. …”
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Cardiovascular Disease Risk Factor Patterns and Their Implications for Intervention Strategies in Vietnam by Quang Ngoc Nguyen, Son Thai Pham, Loi Doan Do, Viet Lan Nguyen, Stig Wall, Lars Weinehall, Ruth Bonita, Peter Byass

“…The age-standardised prevalence of having at least 2/4 metabolic, 2/5 behavioural, or 4/9 major CVDRF was 28%, 27%, 13% in women and 32%, 62%, 34% in men. …”
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Pigmented Maize (Zea mays L.) Contains Anthocyanins with Potential Therapeutic Action Against Oxidative Stress - A Review by Jesús Miguel Magaña Cerino, Héctor Arturo Peniche Pavía, Axel Tiessen, Carmen Magdalena Gurrola Díaz

“…Bioactive compounds, like anthocyanins, contained in dietary plants exert a major activity against oxidative stress. Could the maize anthocyanins play a curative, preventive or complementary role in the treatment of chronic diseases? …”
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Clinical efficacy and safety of first‐line nilotinib or imatinib therapy in patients with chronic myeloid leukemia—Nationwide real life data by Petra Belohlavkova, Daniela Zackova, Hana Klamova, Edgar Faber, Michal Karas, Lukas Stejskal, Eduard Cmunt, Olga Cerna, Ivana Jeziskova, Katerina Machova Polakova, Pavel Zak, Tereza Jurkova, Marika Chrapava, Jiri Mayer

“…Results Nilotinib‐treated patients achieved complete cytogenetic response (CCyR) and major molecular response more rapidly than imatinib‐treated patients. …”
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High-efficiency biodegradation of crude oil and p-hydroxybenzoic acid by Acinetobacter haemolyticus JS-1: Integrated characterization and genomic analysis by Weiyi Tao, Jijie Lu, Junzhang Lin, Mingshan Ding, Weidong Wang, Shuang Li

“…Crude oil contamination is a major threat to both the environment and human health. …”
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Basel III Liquidity Risk Measures and Bank Failure by L. N. P. Hlatshwayo, M. A. Petersen, J. Mukuddem-Petersen, C. Meniago

“…We also find that market-wide liquidity risk (proxied by LIBOR-OISS) was the major predictor of bank failures in 2009 and 2010 while idiosyncratic liquidity risk (proxied by other liquidity risk measures) was less. …”
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CONSUMPTION OF EDIBLE-INSECTS: THE CHALLENGES AND THE PROSPECTS by Nura Abdullahi, Enerst Chukwusoro Igwe, Munir Abba Dandago, Alkasim Kabiru Yunusa

“…Disgust, food neophobia, lack of awareness, unavailability, and personality traits are the major barriers to edible-insect acceptance among consumers. …”
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