The absorption kinetics of Antarctic krill oil phospholipid liposome in blood and the digestive tract of healthy mice by single gavage by Lin Li, Chengcheng Wang, Shan Jiang, Rong Li, Tiantian Zhang, Changhu Xue, Teruyoshi Yanagita, Xiaoming Jiang, Yuming Wang

“…The lipid analysis in serum, small intestinal content and wall was carried out after oral administration of AKOP liposome to illustrate its absorption kinetics in blood and the digestive tract of healthy mice by single gavage. The major type of the obtained AKOP was phosphatidylcholine, and the total contents of the DHA and EPA were 29.31%. …”
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Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome by Bashdar Mahmud Hussen, Bnar Saleh Ismael, Saman S. Abdulla, Noor Haval Jamal, Suhad Asad Mustafa, Zana Baqi Najmalddin, Mohammed Fatih Rasul

“…CRISPR/Cas9 gene editing can overcome BC treatment resistance by identifying crucial genetic variables and revealing new therapeutic targets Despite the advantages, there are limitations in the study on CRISPR/Cas9-based gene editing for BC treatment resistance, for example, off-target effects and the improvement of delivery techniques are still major issues. Successful clinical translation depends on methods to improve the specificity and effectiveness of CRISPR/Cas9 editing and to solve these constraints. …”
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Assessment of High-resolution Local Emissions and Land-use in Air Quality Forecasting at an Urban, Coastal, Desert Environment by Christos Fountoukis, Yasir Mohieldeen, Luis Pomares, Ivan Gladich, Azhar Siddique, Adam Skillern, Mohammed A. Ayoub

“…The footprint of the Doha metropolitan area on the geographical distribution of the anthropogenic emissions is much more realistically represented in the new version of emissions, which includes major differences in the magnitude of emission rates, locally, compared to the base case. …”
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Iris from Iridectomy Used as Spacer underneath the Scleral Flap: The Iridenflip Trabeculectomy Technique by Veva De Groot, Liselotte Aerts, Stefan Kiekens, Tanja Coeckelbergh, Marie-José Tassignon

“…IOP ≤ 16 mmHg was reached in 90% of patients without pressure lowering medication. No major complications were seen; no abnormal inflammatory reaction and no deformation or dislocation of the pupil occurred. …”
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Evaluating the Impact of Flexibilities from Heating and Electromobility in Chile’s Carbon Neutrality Pathway by Abhishake Kundu, Francisco Flores, Carlos A. A. Fernández Vázquez, Humberto Godoy, Sylvain Quoilin, Monica Castaneda, Felipe Feijoo

“…Flexibilities in individual heating, when coupled with more renewable energy capacity, show the potential to decrease reliance on fossil fuels significantly. The evidence of major efficiency gains in Chile’s 2050 energy plan, which is achievable by investing in heating and transportation flexibilities and further augmented by the country’s unique renewable potential, should interest stakeholders. …”
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Decoding substance use disorder severity from clinical notes using a large language model by Maria Mahbub, Gregory M. Dams, Sudarshan Srinivasan, Caitlin Rizy, Ioana Danciu, Jodie Trafton, Kathryn Knight

“…Abstract Substance use disorder (SUD) poses a major concern due to its detrimental effects on health and society. …”
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Fungal and oomycete pathogens and heavy metals: an inglorious couple in the environment by Joanna Gajewska, Jolanta Floryszak-Wieczorek, Ewa Sobieszczuk-Nowicka, Autar Mattoo, Magdalena Arasimowicz-Jelonek

“…Abstract Heavy metal (HM) contamination of the environment is a major problem worldwide. The rate of global deposition of HMs in soil has dramatically increased over the past two centuries and there of facilitated their rapid accumulation also in living systems. …”
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OMP38 of Carbapenem‐Resistant Acinetobacter Baumannii‐Mediated mtDNA Release Activates the cGAS‐STING Signaling to Induce Inflammatory Response by Yang Yang, Yuanyuan Zeng, Jianjie Zhu, Jianjun Li, Lei Gu, Lin Wei, Zeyi Liu, Jian‐an Huang

“…Abstract Carbapenem‐resistant Acinetobacter baumannii (CRAB) has become a major threat in the treatment of bacterial infection, and immunotherapy in a non‐antibiotic‐dependent manner is an effective way to overcome CRAB infection. …”
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Vacuum Assisted Closure Therapy versus Standard Wound Therapy for Open Musculoskeletal Injuries by Kushagra Sinha, Vijendra D. Chauhan, Rajesh Maheshwari, Neena Chauhan, Manu Rajan, Atul Agrawal

“…A free flap was needed to cover exposed bone and tendon in one case in standard wound therapy group. No major complication occurred that was directly attributable to treatment. …”
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Large range sizes link fast life histories with high species richness across wet tropical tree floras by Timothy R. Baker, Stephen Adu-Bredu, Kofi Affum-Baffoe, Shin-ichiro Aiba, Perpetra Akite, Miguel Alexiades, Everton Almeida, Edmar Almeida de Oliveira, Esteban Alvarez Davila, Christian Amani, Ana Andrade, Luiz Aragao, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Peter Ashton, Suspense A. Averti Ifo, Gerardo A. C. Aymard, Michel Baisie, William Balee, Michael Balinga, Lindsay F. Banin, Olaf Banki, Christopher Baraloto, Jorcely Barroso, Jean-Francois Bastin, Hans Beeckman, Serge Begne, Natacha Nssi Bengone, Nicholas Berry, Wemo Betian, Vincent Bezard, Lilian Blanc, Pascal Boeckx, Damien Bonal, Frans Bongers, Francis Q. Brearley, Roel Brienen, Foster Brown, Musalmah Bt. Nasaradin, Benoit Burban, David F. R. P. Burslem, Plinio Camargo, Jose Luis Camargo, Wendeson Castro, Carlos Ceron, Victor Chama Moscoso, Colin Chapman, Jerome Chave, Eric Chezeaux, Murray Collins, James Comiskey, David Coomes, Fernando Cornejo Valverde, Flavia R. C. Costa, Aida Cuni-Sanchez, Lola da Costa, Douglas C. Daly, Martin Dančák, Armandu Daniels, Greta Dargie, Stuart Davies, Charles De Canniere, Thales de Haulleville, Jhon del Aguila Pasquel, Geraldine Derroire, Kyle G. Dexter, Anthony Di Fiore, Marie-Noel K. Djuikouo, Jean-Louis Doucet, Vincent Droissart, Gerald Eilu, Thaise Emillio, Julien Engel, Bocko Yannick Enock, Fidele Evouna Ondo, Corneille Ewango, Sophie Fauset, Ted R. Feldpausch, Muhammad Fitriadi, Gerardo Flores Llampazo, Ernest G. Foli, Gabriella Fredriksson, David R. Galbraith, Martin Gilpin, Emanuel Gloor, Christelle Gonmadje, Rene Guillen Villaroel, Jefferson Hall, Keith C. Hamer, Alan Hamilton, Olivier Hardy, Terese Hart, Radim Hédl, Rafael Herrera, Niro Higuchi, Claude Marcel Hladik, Eurídice Honorio Coronado, Isau Huamantupa-Chuquimaco, Walter Huaraca Huasco, Wannes Hubau, Muhammad Idhamsyah, Sascha A. Ismail, Kath Jeffery, Eliana Jimenez, Tommaso Jucker, Elizabeth Kearsley, Lip Khoon Kho, Timothy Killeen, Kanehiro Kitayama, William Laurance, Susan Laurance, Miguel Leal, Simon L. Lewis, Stanislav Lhota, Jeremy Lindsell, Gabriela Lopez-Gonzalez, Jon Lovett, Richard Lowe, William E. Magnusson, Jean-Remy Makana, Yadvinder Malhi, Beatriz Marimon, Ben Hur Marimon Junior, Andrew Marshall, Colin Maycock, Faustin Mbayu, Casimiro Mendoza, Irina Mendoza Polo, Faizah Metali, Vianet Mihindou, Abel Monteagudo-Mendoza, Sam Moore, Patrick Mucunguzi, Jacques Mukinzi, Pantaleo Munishi, Laszlo Nagy, Petrus Naisso, David Neill, Adriano Nogueira Lima, Percy Nunez Vargas, Lucas Ojo, Walter Palacios, Nadir Pallqui Camacho, Alexander Parada Gutierrez, Julie Peacock, Kelvin S.-H. Peh, Antonio Pena Cruz, Colin Pendry, Toby Pennington, Maria Cristina Penuela-Mora, Pascal Petronelli, Oliver L. Phillips, Georgia Pickavance, G. John Pipoly, Nigel Pitman, Axel Dalberg Poulsen, Ghillean T. Prance, Adriana Prieto, Richard B. Primack, Lan Qie, Simon A. Queenborough, Terry Sunderland, Carlos Quesada, Freddy Ramirez Arevalo, Hirma Ramirez-Angulo, Jan Reitsma, Maxime Réjou-Méchain, Anand Roopsind, Francesco Rovero, Ervan Rutishauser, Kamariah Abu Salim, Rafael Salomao, Ismayadi Samsoedin, Muhd Shahruney Saparudin, Juliana Schietti, Ricardo A. Segovia, Julio Serrano, Rafizah Serudia, Douglas Sheil, Natalino Silva, Javier Silva Espejo, Marcos Silveira, Murielle Simo-Droissart, James Singh, Bonaventure Sonké, Thaise Emilio Lopes De Sousa, Juliana Stropp, Rahayu Sukri, Terry Sunderland, Martin Svátek, Michael Swaine, Hermann Taedoumg, Joey Talbot, Sylvester Tan, James Taplin, David Taylor, Hans ter Steege, John Terborgh, Armando Torres-Lezama, John Tshibamba Mukendi, Darlington Tuagben, Peter van de Meer, Geertje van der Heijden, Peter van der Hout, Mark van Nieuwstadt, Bert van Ulft, Rodolfo Vasquez Martinez, Ronald Vernimmen, Barbara Vinceti, Simone Vieira, Ima Celia Guimaries Vieira, Emilio Vilanova Torre, Jason Vleminckx, Lee White, Simon Willcock, Mathew Williams, John T. Woods, Tze Leong Yao, Ishak Yassir, Roderick Zagt, Lise Zemagho

“…Here, we test whether traits are related to species richness among lineages of trees from all major biogeographical settings of the lowland wet tropics. …”
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Recent Advancements in Robotic-assisted Plastic Surgery Procedures: A Systematic Review by Kazuho Kawashima, MD, Shadi Ghali, MD, FRCS (Plast), Dariush Nikkhah, MD, FRCS (Plast), Ali Esmaeili, MD

“…Searches were conducted across major databases, including MEDLINE, Embase, and Central for published literature from March 2023 to December 2024. …”
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Decoding HIV-associated neurocognitive disorders: a new perspective from multimodal connectomics by Zhongkai Zhou, Wei Wang, Hui Li, Ying Shi, Lingling Zhao, Yibo Lu, Xingchen Wei, Hongjun Li

“…Currently, HIV-associated neurocognitive disorders (HAND) remains one of the major challenges faced by people living with HIV (PLWH). …”
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Comparing Dynamic User Equilibrium and Noniterative Stochastic Route Choice in a Simulation-Based Dynamic Traffic Assignment Model: Practical Considerations for Large-Scale Network... by Mudabber Ashfaq, Ziyuan Gu, S. Travis Waller, Meead Saberi

“…The noniterative stochastic route choice (SRC) model, as a nonequilibrium seeking DTA model, provides an alternative for specific transportation operations applications that may not require equilibrium results after all (e.g., evacuation and major network disruptions) and thus tend to be computationally less expensive, yet may suffer from inconsistent outcomes. …”
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Comprehensive analysis of advanced glycation end-products in commonly consumed foods: presenting a database for dietary AGEs and associated exposure assessment by Qiaozhi Zhang, Huatao Li, Ruixing Zheng, Lili Cao, Shufen Zhang, Shuifeng Zhang, Huadong Sheng, Yuhao Jiang, Yanbo Wang, Linglin Fu

“…In this study, we first established an isotope dilution UHPLC-QqQ-MS/MS-based method for simultaneous quantification of 10 major AGEs in foods. The contents of these AGEs were detected in 334 foods covering all main groups consumed in Western and Chinese populations. …”
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Enterococcus faecium Mediastinitis Complicated by Disseminated Candida parapsilosis Infection after Congenital Heart Surgery in a 4-Week-Old Baby by Hanna Renk, Felix Neunhoeffer, Florian Hölzl, Michael Hofbeck, Matthias Kumpf

“…However, infectious complications still remain a major cause of morbidity and mortality in these patients. …”
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Programmed Cell Death, Proliferating Cell Nuclear Antigen and p53 Expression in Mouse Colon Mucosa during Diet-Induced Tumorigenesis by Mauro Risio, Ivana Sarotto, Francesco Paolo Rossini, Harold Newmark, Kan Yang, Martin Lipkin

“…No changes in PCD were seen in the upper third of the crypt or in surface epithelium throughout the study, indicating that PCD in that colonic crypt segment produces a constant flux of cell loss, uninfluenced by homeostatic fluctuations. A major finding was an irreversible, progressive, age‐related decline of PCD at the crypt base in both control and treated animals that occurred during the second half of the rodents  life span. p53 protein was not immunohistochemically detected, suggesting that neither overexpression of wild‐type nor mutated forms of the protein are involved in the above mentioned changes.…”
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Identification of In Vivo Metabolites of Dictamnine in Mice Using HPLC-LTQ-Orbitrap Mass Spectrometry by Yudong Fu, Yujie Deng, Qing Yu, Xuxia Meng, Dabo Wang, Pei Wang, Ping Wang

“…Nine metabolites were identified in the DIC-treated mouse urine, plasma, and fecal samples, of which two were identified as new metabolites. The major metabolic pathways of DIC in animal and human liver microsomes were confirmed in the present study, including o-demethylation, monohydroxylation, N-oxidation, and 2,3-olefinic epoxidation pathways. …”
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The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation? by Catherine Gebhard, Catherine Gebhard, Susan Bengs, Susan Bengs, Achi Haider, Achi Haider, Michael Fiechter, Michael Fiechter, Michael Fiechter

“…Interestingly, amygdalar metabolic activity, a central neural structure involved in emotional stress processing, has proven to be an independent predictor of major adverse cardiovascular events (MACE). Moreover, upregulated amygdalar metabolism was directly linked to myocardial injury in women, but not in men. …”
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Nutrition before and during Surgery and the Inflammatory Response of the Heart: A Randomized Controlled Trial by Marlieke Visser, Hans W. M. Niessen, Wouter E. M. Kok, Riccardo Cocchieri, Willem Wisselink, Paul A. M. van Leeuwen, Bas A. J. M. de Mol

“…Major surgery induces a long fasting time and provokes an inflammatory response which increases the risk of infections. …”
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Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice by Alessandro Ieraci, Alessandra Mallei, Maurizio Popoli

“…Stress is a major risk factor in the onset of several neuropsychiatric disorders including anxiety and depression. …”
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