Anthelmintic Activity of Crude Extract and Essential Oil of Tanacetum vulgare (Asteraceae) against Adult Worms of Schistosoma mansoni by Loyana Silva Godinho, Lara Soares Aleixo de Carvalho, Clarissa Campos Barbosa de Castro, Mirna Meana Dias, Priscila de Faria Pinto, Antônio Eduardo Miller Crotti, Pedro Luiz Silva Pinto, Josué de Moraes, Ademar A. Da Silva Filho

“…TV-EO was obtained by hydrodistillation and analyzed by GC/MS, which allowed the identification of β-thujone (84.13%) as the major constituent. TV and TV-EO, at 200 μg/mL, decreased motor activity and caused 100% mortality of all adult worms. …”
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Thyme Essential Oil as a Potential Tool Against Common and Re-Emerging Foodborne Pathogens: Biocidal Effect on Bacterial Membrane Permeability by Martina Di Rosario, Leonardo Continisio, Giuseppe Mantova, Francesca Carraturo, Elena Scaglione, Daniela Sateriale, Giuseppina Forgione, Chiara Pagliuca, Caterina Pagliarulo, Roberta Colicchio, Mariateresa Vitiello, Paola Salvatore

“…Over the past decade, foodborne diseases have become a significant public health concern, affecting millions of people globally. Major pathogens like <i>Salmonella</i> spp., <i>Escherichia coli</i>, <i>Listeria monocytogenes</i>, and <i>Staphylococcus aureus</i> contaminate food and cause several infections. …”
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Connexin-Based Therapeutics and Tissue Engineering Approaches to the Amelioration of Chronic Pancreatitis and Type I Diabetes: Construction and Characterization of a Novel Prevascu... by J. Matthew Rhett, Hongjun Wang, Heather Bainbridge, Lili Song, Michael J. Yost

“…Total pancreatectomy and islet autotransplantation is a cutting-edge technique to treat chronic pancreatitis and postoperative diabetes. A major obstacle has been low islet cell survival due largely to the innate inflammatory response. …”
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Role of Transforming Growth Factor-β1 and Smads Signaling Pathway in Intrauterine Adhesion by Umme Salma, Min Xue, Md Sayed Ali Sheikh, Xiaoming Guan, Bin Xu, Aiqian Zhang, Lihua Huang, Dabao Xu

“…Our study suggested that TGF-β1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.…”
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Diagnostic Performance of Positron Emission Tomography/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Ca... by Carmelo Caldarella, Salvatore Annunziata, Giorgio Treglia, Ramin Sadeghi, Narjes Ayati, Luca Giovanella

“…Our meta-analysis demonstrates that FDG-PET is a specific diagnostic tool in detecting locoregional lymph node involvement in patients with ACC. Low sensitivity is a major concern; however, higher sensitivity could be reached combining FDG-PET with MR scan.…”
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Systemic Comorbidity in Children with Cataracts in Nigeria: Advocacy for Rubella Immunization by Roseline Duke, Sidney Oparah, Adedayo Adio, Okon Eyo, Friday Odey

“…They may be associated with systemic diseases including congenital heart diseases which are among the major causes of morbidity and mortality in childhood. …”
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Microencapsulation, Chemical Characterization, and Antimicrobial Activity of Mexican (Lippia graveolens H.B.K.) and European (Origanum vulgare L.) Oregano Essential Oils by Elvia Hernández-Hernández, Carlos Regalado-González, Pedro Vázquez-Landaverde, Isabel Guerrero-Legarreta, Blanca E. García-Almendárez

“…EUO showed α-pinene (methanol) and γ-terpinene (pentane) as major constituents, the latter being the main component of the volatile fraction. …”
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Physicochemical properties and drug likeness of hydroxycinnamic acids and their molecular docking with caffeine and amoxicillin: Potential anticancer drugs by Umer Sherefedin, Abebe Belay, Kusse Gudishe, Alemu Kebede, Alemayehu Getahun Kumela, Tesfaye Feyisa, Jebel Haji Mahamud, Shallo Fekadu

“…Cancer is a major global health challenge, with traditional therapies often yielding limited success and significant side effects. …”
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Local Ecological Knowledge on Climate Change and Ecosystem-Based Adaptation Strategies Promote Resilience in the Middle Zambezi Biosphere Reserve, Zimbabwe by Olga Laiza Kupika, Edson Gandiwa, Godwell Nhamo, Shakkie Kativu

“…Local communities observed water scarcity, changes in vegetation phenology, livestock and wildlife mortalities, and food shortages due to drought as the major impacts on their livelihoods. LEK can contribute to adaptive management strategies that enhance resilience of socioecological systems (SES) in the face of climate change by providing information on the status and use of biophysical components of the environment and by highlighting potential local adaptation strategies that can sustain key livelihood practices.…”
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Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo by Marjan Nokhbehsaim, Anna Damanaki, Andressa Vilas Boas Nogueira, Sigrun Eick, Svenja Memmert, Xiaoyan Zhou, Shanika Nanayakkara, Werner Götz, Joni Augusto Cirelli, Andreas Jäger, James Deschner

“…Ghrelin plays a major role in obesity-related diseases which have been shown to be associated with periodontitis. …”
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Fluoxetine for reducing postoperative cognitive dysfunction in elderly patients after total knee replacement: study protocol for a single-centre, double-blind, randomised, parallel... by Yusheng Yao, Hong Ye, Yushan Wu, Daoyi Lin, Lulu Yu, Jiaxin Chen

“…Introduction Postoperative cognitive dysfunction (POCD) is a common complication following major surgical procedures. The underlying pathophysiology is poorly understood, but the role of neuroinflammation is strongly implicated. …”
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Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat by Quynh Vo, Timothy P. Gilmour, Kala Venkiteswaran, Jidong Fang, Thyagarajan Subramanian

“…Sleep pattern disruption, specifically REM sleep behavior disorder (RBD), is a major nonmotor cause of disability in PD. Understanding the pathophysiology of these sleep pattern disturbances is critical to find effective treatments. 24-hour polysomnography (PSG), the gold standard for sleep studies, has never been used to test sleep dysfunction in the standard 6-OHDA lesioned hemiparkinsonian (HP) rat PD model. …”
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Volume-regulated anion channels conduct ATP in undifferentiated mammary cells and promote tumorigenesis in xenograft nude mouse by Kishio Furuya, Kishio Furuya, Hiroaki Hirata, Hiroaki Hirata, Takeshi Kobayashi, Hiroshi Ishiguro, Masahiro Sokabe, Masahiro Sokabe

“…The high interstitial ATP concentration in the cancer microenvironment is a major source of adenosine, which acts as a strong immune suppressor. …”
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Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes by Maima Matin, Natalia Ksepka, Kamil Wysocki, Michel-Edwar Mickael, Alpana Pande, Jarosław Olav Horbańczuk, Artur Jóźwik, Olga Adamska, Artur Stolarczyk, Laszlo Barna Iantovics, Yordanka Ilieva, Pencho Penchev, Atanas G. Atanasov

“…Curcumin, the major bioactive compound found in turmeric (Curcuma longa) is a subject of intensive research, due to its multiple bioactivities. …”
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Scope of work and contributions of female community health volunteers in Nepal’s healthcare sector: a qualitative study by Archana Shrestha, Biraj Man Karmacharya, Surakshya Kunwar, Sudim Sharma, Sabina Marasini, Anjali Joshi, Bandana Paneru, Akina Shrestha

“…All the interviews were conducted through telephone.Setting Six municipalities in Kavre district, Nepal.Participants 16 FCHVs participated in IDIs and 12 local stakeholders involving members of mother’s group, health workers and local ward representatives of the selected municipalities were involved in KIIs from May to August 2021.Results The FCHVs perceived a sense of workload because of their wide scope of work. The major challenges faced by FCHVs were limited allowances and incentives for their contribution, negative and judgemental attitudes, geographical challenges, multitasking, inadequate supply of health commodities and limited infrastructures for service delivery. …”
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Optimization Analysis Method of New Orthotropic Steel Deck Based on Backpropagation Neural Network-Simulated Annealing Algorithm by Xiuli Xu, Kewei Shi, Xuehong Li, Zhijun Li, Rengui Wang, Yuwen Chen

“…To study the effects of the fatigue performance due to the major design parameter of the orthotropic steel deck and to obtain a better design parameter, a construction parameter optimization method based on a backpropagation neural network (BPNN) and simulated annealing (SA) algorithm was proposed. …”
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Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function by A. J. Theron, H. C. Steel, G. R. Tintinger, C. M. Gravett, R. Anderson, C. Feldman

“…These and other secondary anti-inflammatory mechanisms of the commonly used cysLTR1 antagonists are the major focus of the current review, which also includes a comparison of the anti-inflammatory effects of montelukast, pranlukast, and zafirlukast on human neutrophils in vitro, as well as an overview of both the current clinical applications of these agents and potential future applications based on preclinical and early clinical studies.…”
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Socioeconomic disparities in childhood vaccine hesitancy among parents in China: The mediating role of social support and health literacy by Xuelin Yao, Mao Fu, Jin Peng, Da Feng, Yue Ma, Yifan Wu, Liuxin Feng, Yu Fang, Minghuan Jiang

“…Parental vaccine hesitancy is a major obstacle to childhood vaccination. We examined parental socioeconomic status (SES) disparities in vaccine hesitancy, and the potential mediating roles of perceived social support and health literacy. …”
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Chaos Game Optimization with stacked LSTM sequence to sequence autoencoder for malware detection in IoT cloud environment by Moneerah Alotaibi, Ghadah Aldehim, Mashael Maashi, Mashael M. Asiri, Faheed A.F. Alrslani, Sultan Refa Alotaibi, Ayman Yafoz, Raed Alsini

“…The proposed CGOIDL-MD technique majorly concentrates on the automated detection and classification of malware in the IoT cloud framework. …”
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Research progress on geogenic-contaminated high ammonium groundwater by Yao DU, Yaojin XIONG, Yamin DENG, Yanxin WANG

“…Based on two typical case studies, it is clarified that the evolution of macroscopic depositional environments controls the abundance/bio-availability of buried organic matter and thus results in the formation of high-ammonium groundwater through mineralization, whereas the molecular composition of natural organic matter and its degradation pathway at the microscale play a major role in controlling the transport and enrichment of ammonium in groundwater. …”
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