Efficacy and Safety of Direct-Acting Oral Anticoagulants (DOACs) in the Overweight and Obese by Kimberley Doucette, Hira Latif, Anusha Vakiti, Eshetu Tefera, Bhavisha Patel, Kelly Fitzpatrick

“…Among patients with NVAF and VTE on apixaban, there were no differences in rates of major bleeding (MB) and clinically relevant nonmajor bleeding (CRNMB) in the overweight and obese populations when compared to normal weight and underweight individuals. …”
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Exploring the nexus of migration dynamics and urban expansion: key drivers of horizontal spatial growth in Woldia Township, Ethiopia by Mulu Fasigo Fente, Birhanu Girma Abebe, Mintesnot Gebeyehu Woldeamanuel

“…Woldia has recently faced significant urban challenges due to its expanding horizontal growth. One of the major issues associated with this growth is the increasing demand for land and space, driven by population pressure, largely attributed to migration. …”
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Aqueous extracts from indigenous plant in Burkina Faso with bio-herbicide properties to reduce Striga hermonthica (Del.) Benth propagation by Tinkoudougou Cathérine Sawadogo/Ilboudo, Djibril Yonli, Soumaïla Sourabie, Patrice Zerbo, Hamidou Traoré, Joseph Issaka Boussim

“…Striga hermonthica (Del.) Benth. is a major biotic constraint to the cereal crops production in Africa. …”
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Levels of Urinary Trypsin Inhibitor and Structure of Its Chondroitin Sulphate Moiety in Type 1 and Type 2 Diabetes by Antonio Junior Lepedda, Gabriele Nieddu, Silvia Rocchiccioli, Nadia Ucciferri, Michela Idini, Pierina De Muro, Marilena Formato

“…Diabetes mellitus is a global health problem representing the fifth leading cause of mortality and a major risk factor for cardiovascular diseases. In the last years, we reported an association among urinary trypsin inhibitor (UTI), a small proteoglycan that plays pleiotropic roles in many inflammatory processes, and both type 1 and 2 diabetes and developed a method for its direct quantitation and structural characterization. …”
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Safety Distance of Shotcrete Subjected to Blasting Vibration in Large-Span High-Speed Railway Tunnels by Ao Li, Dingli Zhang, Qian Fang, Jiwei Luo, Liqiang Cao, Zhenyu Sun

“…Unfortunately, blasting vibration can damage newly performed shotcrete layers which are major support structures to stabilize surrounding structures. …”
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Characterization of Triterpene Saponin Composition of White, Yellow and Red Beetroot ( Beta vulgaris L.) by Aneta Spórna-Kucab, Anna Tekieli, Krystyna Skalicka-Woźniak, Agnieszka Grzegorczyk, Tomasz Świergosz, Sławomir Wybraniec

“…Among them, betavulgaroside I, II, III and IV were the major compounds, but the quantitative profile of saponins was found to be dependent on beet cultivar and root part, respectively. …”
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The Role of PDGFs and PDGFRs in Colorectal Cancer by Roberta M. Manzat Saplacan, Loredana Balacescu, Claudia Gherman, Romeo I. Chira, Anca Craiu, Petru A. Mircea, Cosmin Lisencu, Ovidiu Balacescu

“…Tumor microenvironment associated angiogenesis involves a large spectrum of signaling molecules and deciphering their role in colorectal carcinogenesis still represents a major challenge. The aim of our study is to point out the diagnosis and prediction role of PDGF family and their receptors in colorectal carcinogenesis. …”
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Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels by Rahela Zaman, Eugenie Sin Sing Tan, Normina Ahmad Bustami, Farahnaz Amini, Marjan Sadat Seghayat, Yu Bin Ho, Chung Keat Tan

“…Abstract Opuntia ficus-indica (OFi) is a major fruit source prevalent in semiarid and arid regions across various countries worldwide. …”
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Diagnostic accuracy of CCTA-derived versus angiography-derived quantitative flow ratio (CAREER) study: a prospective study protocol by Liang Zhang, Yang Chen, Cheng Li, Ming Li, Shaofeng Guan, Xinkai Qu, Tingwen Weng, Qian Gan, Zehang Li, Wenzheng Han, Xinrong Zhai, Lin Qi, Xifeng Chang, Shengxian Tu

“…The primary endpoint is the diagnostic accuracy of CT-QFR in identifying haemodynamically significant coronary stenosis with FFR as the reference standard. The major secondary endpoint is the non-inferiority of CT-QFR compared with QFR in the patients without extensively calcified lesions.Ethics and dissemination The study was approved by the Ethics Committee of Huadong Hospital Affiliated to Fudan University (2020K192). …”
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Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis by Jun-jie Kuang, Zhi-min Jiang, Yan-xian Chen, Wei-peng Ye, Qiong Yang, Hui-zhong Wang, De-rong Xie

“…Smoking is a well-known major risk factor in development of esophageal cancer, but few studies have reported the association between smoking status and prognosis of these patients. …”
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Optimization of Polysaccharide Extraction Process from Rosa rugosa Residue and Analysis of Its Antioxidant Activity in Vitro by Tingyang ZHANG, Ling ZHANG, Yuqin JIANG, Yang LIU, Xinhui WANG, Xinxin ZHAO, Baohe MIAO

“…Rose flower residue, a major by-product of rose essential oil extraction, was used as the raw material in this study. …”
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Chinese version of the Perth Alexithymia Questionnaire: psychometric properties and clinical applications by Wei Wei, Zhe Zhang, Lin Zhu, Qian Zhang, Xin-Lu Cai, Qingying Ye, Ke Ni, Minmin Yin, David A. Preece, Bao-Ming Li

“…In Study 2, four groups, including a major depressive disorder (MDD) group (n=50), a matched healthy control group for MDD (n=50), a subclinical depression group (n=50) and a matched healthy control group for subclinical depression (n=50), were recruited. …”
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Feasibility and Safety of Bariatric Surgery in High-Risk Patients: A Single-Center Experience by Yusef Moulla, Orestis Lyros, Matthias Blüher, Philipp Simon, Arne Dietrich

“…One patient required an operative revision due to a stapler line leak after sleeve gastrectomy. No other major postoperative complications occurred. Conclusion. …”
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An Assessment of The Effect of The Average Speed Enforcement Systems on Lithuanian Roads by Laura Gavėnienė, Donatas Čygas, Laura Jateikienė Jateikienė, Viktoras Vorobjovas, Vilma Jasiūnienė, Atis Zarinš

“…The speeding is a major road safety problem on the roads of Lithuania and many other countries. …”
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Associations of Sun Exposure with 25-Hydroxyvitamin D and Parathyroid Hormone Levels in a Cohort of Hypertensive Patients: The Graz Endocrine Causes of Hypertension (GECOH) Study by Stefan Pilz, Katharina Kienreich, Daniel Stückler, Andreas Meinitzer, Andreas Tomaschitz

“…Sunlight-induced vitamin D, synthesis in the skin is the major source of vitamin D, but data on the relationship of sun-related behaviour with vitamin D and parathyroid hormone (PTH) levels are relatively sparse. …”
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MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes by Néron, Bertrand, Denise, Rémi, Coluzzi, Charles, Touchon, Marie, Rocha, Eduardo P.C., Abby, Sophie S.

“…This is done by integrating the identification of each individual gene at the level of the molecular system. We hereby present a major release of MacSyFinder (version 2) coded in Python 3. …”
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Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma by Annika L. Gustafson, Annika L. Gustafson, Annika L. Gustafson, Adam D. Durbin, Kristin B. Artinger, Heide L. Ford, Heide L. Ford, Heide L. Ford

“…Rhabdomyosarcoma is a soft-tissue sarcoma that occurs most frequently in pediatric patients and has poor survival rates in patients with recurrent or metastatic disease. There are two major sub-types of RMS: fusion-positive (FP-RMS) and fusion-negative (FN-RMS); with FP-RMS typically containing chromosomal translocations between the PAX3/7-FOXO1 loci. …”
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Western diet promotes the progression of metabolic dysfunction‐associated steatotic liver disease in association with ferroptosis in male mice by Nicole Maddie, Nefia Chacko, David Matatov, Maria Alicia Carrillo‐Sepulveda

“…To date, there are no pharmacological treatments for MASLD. While obesity is a major cause of the development and progression of MASLD, the underlying mechanisms remain unclear. …”
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Influence of endosymbionts on the reproductive fitness of the tick Ornithodoros moubata by Taraveau, Florian, Pollet, Thomas, Duhayon, Maxime, Gardès, Laëtitia, Jourdan-Pineau, Hélène

“…The present study aims to better understand the potential influence of these two major members of the tick microbiota on the reproductive fitness of O. moubata. …”
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Comprehensive chemical and bioactive investigation of Chinese peony flower: a case of valorization of by-products as a new food ingredient from Chinese herb by Meng-ling Peng, Ming-Jiong Gong, Jing Zhang, Anastassiya V. Gadetskaya, Qian-Wen Liang, Pei-Wen He, Xiao-Hui Qiu, Zhi-Hai Huang, Wen Xu, Wen Xu

“…IntroductionIn the present study, the flower of Chinese peony (CPF), major waste by-product of Chinese Herb Radix paeoniae, was comprehensively investigated for the first time.MethodsA validated UHPLC Orbitrap Mass spectrometry combined a three-levels characterization strategy were used to analyze CPF samples from four representative cultivars. …”
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