Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration by Fan Gong, Thomas Groth, Chenlin Tu, Mingyan Zhao, Xinqia Huang, Jiaqi Chu

“…Therefore, the treatment of bone defects represents a major clinical challenge worldwide. In such situations, the application of biomaterials is necessary for filling defects and promoting bone regeneration. …”
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Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation by L. Caccialupi Da Prato, A. Rezzag Lebza, A. Consumi, M. Tessier, A. Srinivasan, C. Rivera, C. Rivera, J. Laurin, C. Pellegrino

“…BackgroundTraumatic brain injury (TBI) is a major cause of disabilities in industrialized countries. …”
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Octodon degus laboratory colony management principles and methods for behavioral analysis for Alzheimer’s disease neuroscience research by B. Maximiliano Garduño, Todd C. Holmes, Todd C. Holmes, Robert M. J. Deacon, Xiangmin Xu, Xiangmin Xu, Xiangmin Xu, Patricia Cogram, Patricia Cogram

“…Degus require species-specific housing and handling methods that reflect their ecology, life history, and group-living characteristics. Here we introduce major principles and ethological considerations of colony management and husbandry. …”
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Hydrogeological structure of shallow-buried coal seam in wind erosion landform area and water-retaining coal mining method by MENG Fanlin, LI Jiashan, SUN Zhihao, CAI Jin, QIAO Wei, WANG Qiqing, WU Huijie

“…Xinjiang has an arid climate and scarce water resources, thus rendering the protection of water resources a major issue for coal mining. Taking the Yushuquan Coal Mine in Xinjiang as the study area, this study investigated the hydrogeological structure and water circulation patterns of the wind-eroded landform area and proposed the water-retaining coal mining method for the mine. …”
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High-Urgency Renal Transplantation: Indications and Long-Term Outcomes by Lampros Kousoulas, Nikos Emmanouilidis, Wilfried Gwinner, Jürgen Klempnauer, Frank Lehner

“…The clinical course of 33 HU renal transplant recipients operated on at our center between 1995 and 2010 was retrospectively analyzed. The major indication for the HU renal transplantation was the imminent lack of access for either hemodialysis or peritoneal dialysis (67%). …”
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Future Changes in Drought Characteristics under Extreme Climate Change over South Korea by Joo-Heon Lee, Hyun-Han Kwon, Ho-Won Jang, Tae-Woong Kim

“…First, the Mann-Kendall method was adopted to identify drought trends at the five major watersheds. The simulated temporal evolution of SPI (standardized precipitation index) during the winter showed significant drying trends in most parts of the watersheds, while the simulated SPI during the spring showed a somewhat different feature in the GCMs. …”
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Evaluating the Biodeterioration Enzymatic Activities of Fungal Contamination Isolated from Some Ancient Yemeni Mummies Preserved in the National Museum by Khalid Mohammed Naji, Qais Yusuf M. Abdullah, Aida Qaseem M. AL-Zaqri, Saeed M. Alghalibi

“…The higher activities of these fungal hydrolytic enzymes represent the major threats of biodeterioration including deteriorating linen bandages as well as the mummy bodies. …”
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Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery by Chun‐Mei Lai, Wei‐Ji Chen, Yuan Qin, Di Xu, Yue‐Kun Lai, Shao‐Hua He

“…Abstract Despite significant progress in tissue engineering, the full regeneration of chronic wounds persists as a major challenge, with the immune response to tissue damage being a key determinant of the healing process's quality and duration. …”
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Improvement of Renal Function by Long-Term Sustained Eculizumab Treatment in a Patient with Paroxysmal Nocturnal Hemoglobinuria by Haruhiko Ninomiya, Naoshi Obara, Akiko Niiori-Onishi, Yasuhisa Yokoyama, Mamiko Sakata-Yanagimoto, Yuichi Hasegawa, Shigeru Chiba

“…Chronic kidney disease (CKD) is one of the major manifestations of paroxysmal nocturnal hemoglobinuria (PNH). …”
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Experimental Analysis Using IoT-Based Smart Power Quality Analyzer System With Remote Data Access and GSM Alerting Mechanism by Balasubbareddy Mallala, Mohammad Faridun Naim Tajuddin, Sudhakar Babu Thanikanti, Rajasekhar Reddy Manyam

“…The real-time field data is gathered at the ThingSpeak platform for future analysis, while GSM-based design ensures timely alerts to the end users for any major fluctuation in the power supply. The performance of the proposed low-cost system has been compared with the readings obtained from FPGA-based conventional PQA and standard Fluke Meter when connected to different loads. …”
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Peripheral Blood Derived Mononuclear Cells Enhance the Migration and Chondrogenic Differentiation of Multipotent Mesenchymal Stromal Cells by Niina Hopper, John Wardale, Daniel Howard, Roger Brooks, Neil Rushton, Frances Henson

“…A major challenge in cartilage repair is the lack of chondrogenic cells migrating from healthy tissue into damaged areas and strategies to promote this should be developed. …”
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Molecular characterization, DNA fingerprinting and genetic diversity analysis of Nepalese rice landraces using SSR markers by Bal Krishna Joshi, Nancy Shrestha, Rakshya Pokhrel, Raju Chaudhary

“… Rice (Oryza sativa) is the major crop of Nepal. Genetic diversity studies in rice have been conducted extensively with collections from various parts of the world, including Nepal. …”
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Small Cages with Insect Couples Provide a Simple Method for a Preliminary Assessment of Mating Disruption by Françoise Briand, Patrick M. Guerin, Pierre-Joseph Charmillot, Patrik Kehrli

“…We tested the suitability of small insect field cages for a pre-evaluation of the impact of sex pheromones on mating using the grape moths Eupoecilia ambiguella and Lobesia botrana, two major pests in vineyards. Cages consisted of a cubic metal frame of 35 cm sides, which was covered with a mosquito net of 1500 μm mesh size. …”
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Partial AUCs in Long-Acting Injectables: Rationale, Challenges, Variability, Usefulness, and Clinical Relevance by Georgia Tsakiridou, Maria-Faidra-Galini Angelerou, Panagiotis Efentakis, Antonios Margaritis, Antigoni-Maria Papanastasiou, Lida Kalantzi

“…In this communication, authors discuss the usefulness and challenges associated with the estimation of pAUCs in the development of generic LAI products through the review of six case studies under the lens of regulatory requirements from the two major authorities, namely the FDA and EMA.…”
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Extrinsic Factors Influencing Fetal Deformations and Intrauterine Growth Restriction by Wendy Moh, John M. Graham, Isha Wadhawan, Pedro A. Sanchez-Lara

“…The magnitude and direction of force impact the form of the developing fetus, with a specific tissue response depending on its pliability and stage of development. Major uterine constraining factors include primigravida, small maternal size, uterine malformation, uterine fibromata, early pelvic engagement of the fetal head, aberrant fetal position, oligohydramnios, and multifetal gestation. …”
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LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation by Litao Liang, Wenbo Jia, Jinyi Wang, Yanzhi Feng, Deming Zhu, Wenhu Zhao, Chao Xu, Xiangyu Ling, Qingpeng Lv, Xiaoming Ai, Lianbao Kong, Wenzhou Ding

“…Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and a major public health challenge. Lipid metabolism plays a crucial role in the metabolic reprogramming observed in HCC, although the underlying mechanisms are still being elucidated. …”
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“ADAPTING TO A CHANGING WORLD: STRATEGIES FOR MITIGATING THE GLOBAL CONSEQUENCES OF CLIMATE CHANGE” by FRANK FUNKEYE SAPELE, AKUMKA JOSEPH YABAYANZE, KANYINSOLA AZEEZ

“…This research structures its opinions with the human security model as its theoretical framework. Major findings showed that environmental degradation, desertification caused by climate change had greatly stunted agricultural production and government rules universally; climate change has increased food uncertainty, poor statistical analysis and implementation by government. …”
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French Energy Sector in Search for Optimal Model by A. V. Zimakov

“…Clean energy transition is one of major transformation processes in the EU. There are different approaches among EU countries to decarbonization of their energy systems. …”
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Mechanical and Frictional Behavior of Jute-Textile-Reinforced Polymer Composites With Matrix Modification by Farhin Tabassum, M. R. Asekin, M. Salim Kaiser, S. Reaz Ahmed

“…A quantitative comparison of the measured results verifies the relative improvement of the major mechanical and frictional properties of the composites, which, in turn, verifies the effectiveness of the selective matrix modifiers in conjunction with post-thermal treatments.…”
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