Study on Molecular Recognition between Euphorbia Factor L713283 and β-Tubulin via Molecular Simulation Methods by Shan Chang, Hong-qiu He, Ren Kong, Zhen-jian Xie, Jian-ping Hu

“…It was found that nonpolar interactions made the major contributions for the binding. In addition, we compared the binding pocket and motion modes of L713283-free and L713283-bound β-tubulin systems. …”
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Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice by Peter C. Cook, Sheila L. Brown, Emma L. Houlder, Julio Furlong-Silva, Daniel P. Conn, Stefano A. P. Colombo, Syed Baker, Freya R. Svedberg, Gareth Howell, Margherita Bertuzzi, Louis Boon, Joanne E. Konkel, Christopher R. Thornton, Judith E. Allen, Andrew S. MacDonald

“…Abstract Fungal spores are abundant in the environment and a major cause of asthma. Originally characterised as a type 2 inflammatory disease, allergic airway inflammation that underpins asthma can also involve type 17 inflammation, which can exacerbate disease causing failure of treatments tailored to inhibit type 2 factors. …”
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Projecting the Burden of Chronic Kidney Disease in a Developed Country and Its Implications on Public Health by L. Y. Wong, A. S. T. Liew, W. T. Weng, C. K. Lim, A. Vathsala, M. P. H. S. Toh

“…Chronic Kidney Disease (CKD) is a major public health problem worldwide. There is limited literature on a model to project the number of people with CKD. …”
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Insights from in vivo preclinical cancer studies with histotripsy by Tejaswi Worlikar, Timothy Hall, Man Zhang, Mishal Mendiratta-Lala, Michael Green, Clifford S. Cho, Zhen Xu

“…This review highlights key learnings from in vivo shock-scattering histotripsy, intrinsic threshold histotripsy, and boiling histotripsy cancer studies treating cancers of different anatomic locations and discusses the major considerations in planning in vivo histotripsy studies regarding instrumentation, tumor model, study design, treatment dose, and post-treatment tumor monitoring.…”
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Environmental Influence of Gas Flaring: Perspective from the Niger Delta Region of Nigeria by Kingsley Eghonghon Ukhurebor, Uyiosa Osagie Aigbe, Robert Birundu Onyancha, Hussain Athar, Benedict Okundaye, Paul Atagamen Aidonojie, Benita Ebindu Siloko, Ismail Hossain, Heri Septya Kusuma, Handoko Darmokoesoemo

“…It is also one of the major sources of greenhouse gas emissions which cause climate change (CMC). …”
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Current status and advances in zinc anodes for rechargeable aqueous zinc-air batteries by Muhammad Afiq Irfan Mohd Shumiri, Abdillah Sani Mohd Najib, Nor Akmal Fadil

“…We begin by highlighting the major challenges and underlying mechanisms associated with zinc anodes including issues such as uneven zinc deposition, dendrite growth and hydrogen evolution reaction. …”
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The Role of Open Lung Biopsy in Critically Ill Patients with Hypoxic Respiratory Failure: A Retrospective Cohort Study by Abdullah Almotairi, Sharmistha Biswas, Jason Shahin

“…Open lung biopsy had significant diagnostic yield and led to major changes in management and aided in end-of-life decision-making in the ICU. …”
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A Human/Murine Chimeric Fab Antibody Neutralizes Anthrax Lethal Toxin In Vitro by Guipeng Ding, Ximin Chen, Jin Zhu, Nicholas S. Duesbery, Xunjia Cheng, Brian Cao

“…Lethal factor (LF) is a component of lethal toxin (LeTx), which is the major virulence of anthrax toxin. A murine IgG monoclonal antibody (mAb) against LF with blocking activity (coded LF8) was produced in a previous study. …”
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Virus-Mimicking Polymer Nanocomplexes Co-Assembling HCV E1E2 and Core Proteins with TLR 7/8 Agonist—Synthesis, Characterization, and In Vivo Activity by Thomas R. Fuerst, Alexander Marin, Sarah Jeong, Liudmila Kulakova, Raman Hlushko, Katrina Gorga, Eric A. Toth, Nevil J. Singh, Alexander K. Andrianov

“…Hepatitis C virus (HCV) is a major public health concern, and the development of an effective HCV vaccine plays an important role in the effort to prevent new infections. …”
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Utilizing Indonesian Empty Palm Fruit Bunches: Biochar Synthesis via Temperatures Dependent Pyrolysis by Fairuz Gianirfan Nugroho, Abu Saad Ansari, Nurul Taufiqu Rochman, Shubhangi Satish Khadtare, Vijaya Gopalan Sree, Nabeen K. Shrestha, Afina Faza Hafiyyan, Hyunsik Im, Abu Talha Aqueel Ahmed

“…Biomass, though a major energy source, remains underutilized. Biochar from biomass pyrolysis, with its high porosity and surface area, is especially useful as catalyst support, enhancing catalytic activity and reducing electron recombination in photocatalysis. …”
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NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts by Selim Terhzaz, David Kerrigan, Floriane Almire, Agnieszka M. Szemiel, Joseph Hughes, Jean-Philippe Parvy, Massimo Palmarini, Alain Kohl, Xiaohong Shi, Emilie Pondeville

“…Some bunyaviruses are transmitted between vertebrate hosts by blood-sucking arthropods and cause major diseases in humans and animals. It is not understood why only some bunyaviruses have evolved the capacity to be transmitted by arthropod vectors. …”
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Pivotal Cytoprotective Mediators and Promising Therapeutic Strategies for Endothelial Progenitor Cell-Based Cardiovascular Regeneration by Hyunyun Kim, Sujin Kim, Sang Hong Baek, Sang-Mo Kwon

“…Cardiovascular diseases (CVDs), including atherosclerosis, stroke, and myocardial infarction, is a major cause of death worldwide. In aspects of cell therapy against CVD, it is generally accepted that endothelial progenitor cells (EPCs) are potent neovascular modulators in ischemic tissues. …”
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PREDICTION OF MEGATHRUST IMPACT ON SEISMIC RESPONSE IN SELEBAR DISTRICT OF BENGKULU CITY by Zhehan Fahrezi, Rena Misliniyati, Khairul Amri, Lindung Zalbuin Mase, Hardiansyah

“… Bengkulu City was hit by major earthquakes in 2000 and 2007 with magnitudes of 7.9 Mw and 8.6 Mw. …”
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Comparison of earthquake emergency management system in China and Japan by Zhongzhi Min, Xiaojun Li, Mianshui Rong

“…This paper discussed the emergency management system in China and Japan, involving emergency plan and emergency management system, and showed the necessity of centralized administrative power to deal with the major earthquakes, and highlighted the characteristics of concentrating resources to do key things. …”
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Modeling the Effect of Plants and Peat on Evapotranspiration in Constructed Wetlands by Florent Chazarenc, Simon Naylor, Yves Comeau, Gérard Merlin, Jacques Brisson

“…Evapotranspiration (ET) in constructed wetlands (CWs) represents a major factor affecting hydrodynamics and treatment performances. …”
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Application of therapeutical nanoparticles with neutrophil membrane camouflaging for inflammatory plaques targeting against atherosclerosis by Ningnannan Zhang, Tianzhu Zhang, Jintang Feng, Jian Shang, Beibei Zhang, Qingyang Dong, Zhang Zhang, Chunyang Sun

“…Precise and effective plaque targeting is a major objective for therapeutic outcomes throughout various stages of atherosclerosis. …”
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Preclinical assessment of splicing modulation therapy for ABCA4 variant c.768G>T in Stargardt disease by Dyah W. Karjosukarso, Femke Bukkems, Lonneke Duijkers, Tomasz Z. Tomkiewicz, Julia Kiefmann, Andrei Sarlea, Sander Bervoets, Irene Vázquez-Domínguez, Laurie L. Molday, Robert S. Molday, Mihai G. Netea, Carel B. Hoyng, Alejandro Garanto, Rob W. J. Collin

“…In situ hybridization and probe-based ELISA demonstrate its distribution and stability in vitro and in vivo. No major safety concerns regarding off-targets, immunostimulation and toxicity are observed in transcriptomics analysis, cytokine stimulation assays in human primary immune cells, and cytotoxicity assays. …”
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Maternal–Foetal Effects of Exposure to Bisphenol A: Outcomes and Long-Term Consequences by Henrique Eloi Costa, Ines Medeiros, Melissa Mariana, Elisa Cairrao

“…Exposure to bisphenol A (BPA), one of the most widely produced plasticisers, can have a major effect on the growing embryo and the mother during pregnancy; as this is the most vulnerable period, the cutoff established in the legislation does not take this factor into account. …”
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Decoding vascular aging: implications for atherosclerosis progression and clinical intervention by Silumbwe Ceaser Wankumbu, Xiao-Man Ji, Ming Xu

“…Atherosclerosis remains the major cause of various cardiovascular diseases. Hence, this review focused on the interaction between known mechanisms of vascular aging, disease manifestation, and progression during atherosclerosis. …”
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The Role of Nutrition Across Production Stages to Improve Sow Longevity by Matheus Saliba Monteiro, Rafaella Fernandes Carnevale, Bruno Bracco Donatelli Muro, Ana Lígia Braga Mezzina, Bruno Braga Carnino, André Pegoraro Poor, Carlos Emilio Cabrera Matajira, Cesar Augusto Pospissil Garbossa

“…Collectively, these strategies address major health challenges, enhancing welfare and promoting sow’s longevity.…”
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