Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs by Jinshuang Bo, Shiya Xie, Yi Guo, Chunli Zhang, Yanming Guan, Chunmei Li, Jianxin Lu, Qing H. Meng

“…Methylglyoxal (MG) is a highly reactive glucose metabolic intermediate and a major precursor of advanced glycation end products. …”
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Sidewall Roughness Measurement and Bearing Performance Simulation of Rock-Socketed Piles Based on Laser Scanning Point Cloud by Junbao Zhang, Yule Hu, Yiteng Wang, Di Zhang

“…The results show that, although the working load is carried by both the side and base resistances, the former plays a major role. The slow-varying load-settlement curve indicates that the pile has a superior load–bearing capacity, and the maximum allowable settlement should be considered in the application. …”
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Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition by Yu Fu, Xin Hao, Jingru Nie, Peng Shang, Xinxing Dong, Bo Zhang, Dawei Yan, Hao Zhang

“…Transient receptor potential channel 1 (TRPC1), an ion transporter, is adipocytes’ major Ca2+ entry channel. However, its function in fat deposition is poorly understood, particularly in pigs, which are both an ideal model for human obesity research and a primary meat source for human diets. …”
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Intrathecal Immunoglobulin A Synthesis in Multiple Sclerosis: From Biological Aspects to Clinical Relevance by Dariia Kliushnikova, Ferdinand Otto, Georg Pilz, Peter Wipfler, Andrea Harrer

“…In this review, we summarize current evidence on the occurrence and immunopathology of intrathecal IgA synthesis in MS, explore its biological implications, and address methodological challenges regarding the detection of IgA as a major limitation and possible source of inconsistencies in clinical studies. …”
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Nondestructive Testing on Ancient Wooden Components Based on Shapley Value by Li-hong Chang, Xiao-hong Chang, Hao Chang, Wei Qian, Li-ting Cheng, Xiao-li Han

“…Internal defects data for major wooden components of an ancient building in China and reverse laboratory test data on matching tree species indicated various degrees of damage on the pavilion wood structure surface and internal defects in certain pillars. …”
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Köppen–Geiger climate classification across France based on an ensemble of high-resolution climate projections by Strohmenger, Laurent, Collet, Lila, Andréassian, Vazken, Corre, Lola, Rousset, Fabienne, Thirel, Guillaume

“…Moderate changes in climate types are expected in 2035 for approximately 20% of France, regardless of the emission scenario. However, major changes are expected after 2040 under RCP 8.5 for 86% of France, with a massive expansion of the temperate, hot summer with or without dry season, as well as the expansion of temperate climate in mountainous regions. …”
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Postural correlates of pleasant landscapes visual perception by Mbarka Akounach, Thierry Lelard, Harold Mouras

“…Notably, significant differences in approach-avoidance behavior were observed approximately 7 s after the onset of stimulus viewing.DiscussionThe findings are discussed in relation to major theories in environmental psychology, highlighting the central role of emotional and embodiment processes in appreciating pleasant environmental scenes and related motor behaviors.…”
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Solving an enigma in the tree of life, at the origins of teleost fishes by Parey, Elise, Berthelot, Camille, Roest Crollius, Hugues, Guiguen, Yann

“…Specifically, the relationships at the origins of teleost fishes have been the subject of extensive debate over the last 50 years. This question has major implications for various research fields: there are almost 30,000 species in the teleost group, which includes invaluable model organisms for biomedical, evolutionary and ecological studies. …”
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Design of a release-free piezo-optomechanical quantum transducer by Paul Burger, Joey Frey, Johan Kolvik, David Hambraeus, Raphaël Van Laer

“…Traditionally, these transducers are suspended to confine mechanical fields, but this complicates manufacturing and comes with the major challenge of poor thermal anchoring and a trade-off between noise and efficiency. …”
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Digestive cancers: mechanisms, therapeutics and management by Tianzuo Zhan, Johannes Betge, Nadine Schulte, Lena Dreikhausen, Michael Hirth, Moying Li, Philip Weidner, Antonia Leipertz, Andreas Teufel, Matthias P. Ebert

“…Abstract Cancers of the digestive system are major contributors to global cancer-associated morbidity and mortality, accounting for 35% of annual cases of cancer deaths. …”
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Micropollutants Identification Affecting the Nearby Environment from Highway Runoff: The Case Study of Cyprus Highway by Antonis A. Zorpas, Lampis A. Ilia, Irene Voukkali, Vassilis Inglezakis

“…The results indicated that the first flush consists of major pollution due to the fact that all parameters are in high levels. …”
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Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status by Nelo Eidy Zanchi, Felipe Natali Almeida, Fábio Santos Lira, José César Rosa Neto, Humberto Nicastro, Claudia Ribeiro da Luz, Mário Alves de Siqueira Filho, Vitor Felitti, Mariz Vainzof, Marilia Seelaender, Jacques R. Poortmans, Antonio Herbert Lancha

“…The so called “acute exercise threshold”, the complex mixture of several variables involved in exercise, such as type, volume, frequency, and intensity range is capable of inducing positive physiological adaptations and has been specifically addressed in the recent literature. The major concern is related to the level of the threshold: “exercise training shifts from a therapeutic adaptive intervention to one with potential pathological consequences”. …”
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Solar Origins of August 26, 2018 Geomagnetic Storm: Responses of the Interplanetary Medium and Equatorial/Low‐Latitude Ionosphere to the Storm by A. O. Akala, O. J. Oyedokun, P. O. Amaechi, K. G. Simi, A. Ogwala, O. A. Arowolo

“…There was a clear hemispherical asymmetry, with higher Total Electron Content (TEC) in the northern hemisphere. The major determining factors of the ionospheric responses during the various phases of this storm were the local time of the storm's onset, local time of storm's minimum SYM‐H, and changes in thermospheric O/N2.…”
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Analysis of Some Heavy Metals and Organic Acids in Ficus carica Growing Adjacent in the Serpentine Soil in Sulaimani/Kurdistan, Iraq by Othman Abdulrahman Mohammed, Mohammed Rawf Hussain, Osama Hamid Shareef, Abdullah Ahmed Hama, Sardar Mohammed Weli, Fatimah Mohammed Ali, Sabiha Sharif Salih

“…Fig (Ficus carica) is a plant of major importance in the world. It is a nourishing food and is used in industrial productions. …”
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Impact of Dried Stems on the Chemical Profile of Passito Wines: A Case Study of Four Veneto Varieties by Giovanni Luzzini, Loris Colognato, Leonardo Vanzo, Jessica Anahi Samaniego Solis, Naíssa Prévide Bernardo, Rosario Pascale, Beatrice Perina, Giacomo Cristanelli, Maurizio Ugliano, Davide Slaghenaufi

“…Grapes were fermented with and without withered stems. A major impact on enological parameters, in particular pH and total polyphenols, was observed. …”
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JointTracker: Real-time inertial kinematic chain tracking with joint position estimation [version 2; peer review: 1 approved, 2 approved with reservations] by Michael Lorenz, Didier Stricker, Markus Miezal, Gabriele Bleser-Taetz, Bertram Taetz

“…In contrast, inertial motion capture does not suffer from occlusions, thus being a promising approach for capturing motion outside the laboratory. However, one major challenge of such methods is the necessity of spatial registration. …”
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Unveiling the molecular and cellular links between obstructive sleep apnea-hypopnea syndrome and vascular aging by Wei Liu, Le Zhang, Wenhui Liao, Huiguo Liu, Wukaiyang Liang, Jinhua Yan, Yi Huang, Tao Jiang, Qian Wang, Cuntai Zhang, Peifang Wei

“…Vascular aging (VA) is a common etiology of various chronic diseases and represents a major public health concern. Intermittent hypoxia (IH) associated with obstructive sleep apnea-hypopnea syndrome (OSAHS) is a primary pathological and physiological driver of OSAHS-induced systemic complications. …”
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With big data comes big responsibility: Strategies for utilizing aggregated, standardized, de‐identified electronic health record data for research by Veronica R. Olaker, Sarah Fry, Pauline Terebuh, Pamela B. Davis, Daniel J. Tisch, Rong Xu, Margaret G. Miller, Ian Dorney, Matvey B. Palchuk, David C. Kaelber

“…This article describes 26 topics broken into three major areas: (1) 14 topics related to design issues for observational study using EHR data, (2) 7 topics related to analysis issues when analyzing EHR data, and (3) 5 topics related to reporting studies using EHR data.…”
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Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis? by Kanchana Bandara, Chinthika Gunasekara, Manjula Weerasekera, Chamil Marasinghe, Nilantha Ranasinghe, Neluka Fernando

“…Elevation of serum IL-10 and IL-17A levels and significant elevation of serum IL-21 (p=0.002), IL-23 (p=0.002), and TNF-α (p=0.039) were observed among leptospirosis patients compared to the healthy control group. The two major complications observed among these patients were renal failure and liver involvement. …”
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Mechanisms and environmental factors shaping the ecosystem of brain macrophages by Silvia Penati, Simone Brioschi, Zhangying Cai, Claudia Z. Han, Claudia Z. Han, Marco Colonna, Marco Colonna

“…Brain macrophages encompass two major populations: microglia in the parenchyma and border-associated macrophages (BAMs) in the extra-parenchymal compartments. …”
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