Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC by Kai-Xia Zhou, Shan Huang, Li-Peng Hu, Xue-Li Zhang, Wei-Ting Qin, Yan-Li Zhang, Lin-Li Yao, Yanqiu Yu, Yao-Qi Zhou, Lei Zhu, Jianguang Ji, Zhi-Gang Zhang

“…Tumor immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. …”
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Deep Reinforcement Learning for Selection of Dispatch Rules for Scheduling of Production Systems by Kosmas Alexopoulos, Panagiotis Mavrothalassitis, Emmanouil Bakopoulos, Nikolaos Nikolakis, Dimitris Mourtzis

“…Computationally expensive and time-consuming solutions have created major issues for companies trying to respect their customers’ demands. …”
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Acetylation Modification Improves Immunoregulatory Effect of Polysaccharide from Seeds of Plantago asiatica L. by Le-Ming Jiang, Shao-Ping Nie, Dan-Fei Huang, Zhi-Hong Fu, Ming-Yong Xie

“…The results showed that Ac-PLCPs with degree of substitution (DS) from 0.06 to 0.1 could not only stimulate the expression of surface molecules major histocompatibility complex class II (MHC II), cluster of differentiation 86 (CD86), and CD80 on DCs (P<0.01) but also increase the secretion of cytokine IL-12p70 (P<0.01). …”
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A chromosome-level genome assembly of the cabbage aphid Brevicoryne brassicae by Jun Wu, Guomeng Li, Zhimou Lin, Yangzhi Zhang, Wenyuan Yu, Rong Hu, Shuai Zhan, Yazhou Chen

“…Abstract The cabbage aphid, Brevicoryne brassicae, is a major pest on Brassicaceae plants, causing significant yield losses annually. …”
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Morphogenesis and Organogenesis to Hatching of the Green Octopus, <i>Octopus hubbsorum</i>: A Species That Includes a Paralarval Stage in Its Life Cycle by Maritza García-Flores, Marcial Arellano-Martínez, Carlos A. Aguilar-Cruz, M. Carmen Rodríguez-Jaramillo

“…During the paralarval phase, <i>O. hubbsorum</i> undergoes major morphological and physiological changes until it reaches the subadult phase and develops the reproductive organs. …”
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PMWFCM: A Possibility based MultiKernel Weighted Fuzzy Clustering Algorithm for classification of driving behaviors by Ning Ma, Kaijun Wu, Yubin Yuan, Jiawei Li, Xiaoqiang Wu

“…Therefore, the improved FCM algorithm proposed in this paper can accurately and comprehensively reflect changes in traffic data, providing a solid theoretical foundation for identifying and assessing major risk types among passenger drivers.…”
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Graphene Oxide-Gold Star Construct on Triangular Electrodes for Alzheimer’s Disease Identification by Wenlong Chang, Jing Zhao, Lu Liu, Xiaoming Xing, Chao Zhang, Huihong Meng, Subash C. B. Gopinath, Yonggang Liu

“…Nanotechnology is playing a major role in the field of medical diagnosis, in particular with the biosensor and bioimaging. …”
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Electronic spin susceptibility in metallic strontium titanate by A. Najev, N. Somun, M. Spaić, I. Khayr, M. Greven, A. Klein, M. N. Gastiasoro, D. Pelc

“…Abstract Metallic strontium titanate (SrTiO3) is known to have both normal-state and superconducting properties that strongly vary over a wide range of charge carrier densities, but the complex interplay between lattice and electronic degrees of freedom has hindered the development of a clear qualitative description of the observed behavior. A major challenge is to understand how the charge carriers themselves evolve with doping and temperature, with possible polaronic effects and evidence of an effective mass that strongly increases with temperature. …”
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Identification of Bioactive Compounds and Analysis of Inhibitory Potential of the Digestive Enzymes from Syzygium sp. Extracts by Tuanny Cavatão de Freitas, Ronaldo Junio de Oliveira, Ricardo José de Mendonça, Pamela Aparecida Candido, Luciana Lopes Silva Pereira, Karina Ferrazzoli Devienne, Ana Carolina da Silva, Chrystian Araújo Pereira

“…Diabetes and obesity represent major public health problems worldwide. High cost of medicines and drug treatments propose the research for less expensive alternatives, such as enzymatic inhibitors present in medicinal plants from natural sources. …”
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Uncovering Diversity within the Glomeromycota: Novel Clades, Family Distributions, and Land Use Sensitivity by Camille S. Delavaux, Alexis Aellen, Sidney L. Stürmer, Silmar Primieri, Ursel M. E. Schütte, Devin M. Drown, Robert J. Ramos, Thomas W. Crowther, James D. Bever

“…However, increasing human land use represents a major threat to native AMF globally. Characterizing the loss of AMF diversity remains challenging because many taxa are undescribed, resulting in poor documentation of their biogeography and family‐level disturbance sensitivity. …”
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Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection by Vicente P. Martins, Carina S. Pinheiro, Barbara C. P. Figueiredo, Natan R. G. Assis, Suellen B. Morais, Marcelo V. Caliari, Vasco Azevedo, William Castro-Borges, R. Alan Wilson, Sergio C. Oliveira

“…In the search for potential vaccine candidates, numerous tegument antigens have been assessed. As the major interface between parasite and mammalian host, the tegument plays crucial roles in the establishment and further course of schistosomiasis. …”
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Enhancement of state response capability and famine mitigation: a comparative analysis of two drought events in northern China during the Ming dynasty by F. Tian, F. Tian, Y. Su, Y. Su, X. Chen, X. Chen, L. Tao, L. Tao

“…<p>Studying social impacts of and responses to historical extreme climate events can offer valuable insights into coping with major disaster events and adapting to climate change better. …”
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Introducing reservoir sustainability indexing to investigate reservoir operations and piloting it at the basin of Lake Urmia with sparse data by Sina Sadeghfam, Navid Fahmfam, Rahman Khatibi, Brian Mark Crookston, Meysam Vadiati, Marjan Moazamnia

“…The capability is piloted on 9 major reservoirs with available data out of 44 in the basin of Lake Urmia for a proof-of-concept. …”
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Isolated central nervous system relapse in blast crisis of chronic myeloid leukemia: a case report by Hari Priya Raghvan, Caroline Ho Siew Ling, Wee Shiang Yui, Boo Yang Liang, Ehram Jamian, Indhira Subbiah

“…Despite aggressive treatment, CNS relapse remains a major concern due to the limited penetration of standard therapies into the CNS. …”
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Role of microRNA in the risk stratification of ischemic strokes by Hosam M. Al-Jehani, Hosam M. Al-Jehani, Hosam M. Al-Jehani, Hosam M. Al-Jehani, Ahmed Hafez Mousa, Ahmed Hafez Mousa, Ahmed Hafez Mousa, Ahmed Hafez Mousa, May Adel Alhamid, Fawaz Al-Mufti

“…BackgroundIschemic stroke is a major cause of death and morbidity, and risk classification is essential for predicting therapeutic outcomes. …”
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Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies by Blessing A. Obafemi, Isaac A. Adedara, Cássia Pereira Delgado, Olabisi T. Obafemi, Michael Aschner, Joao B.T. Rocha

“…Both in vitro and in vivo studies have demonstrated that alteration in sphingolipid metabolism is a major event in FB-induced neurotoxicity. Studies have also shown that neurotoxicity due to FB1 involves dysregulation of several biochemical events in the brain, such as induction of oxidative stress and inflammation, mitochondrial dysfunction and associated programmed cell death, inhibition of acetylcholinesterase and alteration of neurotransmitter levels, decreased activity of Na+K+ ATPase, as well as disruption of blood-brain barrier. …”
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An explainable sentiment prediction model based on the portraits of users sharing representative opinions in social sensors by Bin Wang, Enhui Wang, Zikun Zhu, Yangyang Sun, Yaodong Tao, Wei Wang

“…“Social sensors” refer to those who provide opinions through electronic communication channels such as social networks. There are two major issues in current models of sentiment analysis in social sensor networks. …”
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Oxidative Stress, Glutathione Insufficiency, and Inflammatory Pathways in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions by John Dawi, Yura Misakyan, Stephen Affa, Samuel Kades, Ananya Narasimhan, Fouad Hajjar, Max Besser, Kevin Tumanyan, Vishwanath Venketaraman

“…This imbalance contributes to insulin resistance, β-cell dysfunction, and complications in organs like the vasculature and nervous system. Glutathione (GSH), a major antioxidant, is crucial for neutralizing ROS, but GSH levels are notably low in T2DM, exacerbating oxidative stress and inflammation. …”
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In Vitro Analyses Reveal the Effect of Synthetic Cytokinin Forchlorfenuron (FCF) on a Septin-Like Protein of Taeniid Cysticerci by Diana G. Rios-Valencia, Edgar O. López-Villegas, Dylan Diaz Chiguer, Adrian Marquez Navarro, Ruben D. Díaz-Martín, Benjamin Nogueda-Torres, Javier R. Ambrosio

“…The rabbit polyclonal antibody prepared against the synthetic peptide recognized a major band of 41 kDa in both parasites. Our results establish the importance of SEPT4_Tsm in the dynamics and survival of taeniid cysticerci, as well as their susceptibility to FCF. …”
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A Pseudomonas-based bio-formulation to control bacterial blight of pomegranate caused by Xanthomonas axonopodis pv. punicae by Pavan Kumar, Giandomenico Corrado, Girigowda Manjunatha, Suma Ramegowda, Pradeep Kumar, Boris Basile, Ganadalu Puttaswamy Mutthuraju, Baggana Girish Jasmitha

“…This study investigates the potential of a Pseudomonas-based biocontrol agent to manage bacterial blight (BB) in pomegranate. This major disease is caused by Xanthomonas axonopodis pv. punicae (Xap) and it is traditionally controlled with antibiotics. …”
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