Paving the Way for Speech: Voice-Training-Induced Plasticity in Chronic Aphasia and Apraxia of Speech—Three Single Cases by Monika Jungblut, Walter Huber, Christiane Mais, Ralph Schnitker

“…Difficulties with temporal coordination or sequencing of speech movements are frequently reported in aphasia patients with concomitant apraxia of speech (AOS). Our major objective was to investigate the effects of specific rhythmic-melodic voice training on brain activation of those patients. …”
Get full text

Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats by Ibrahim Abubakar, Mu'azu Abubakar Gusau, Jabir Aliyu Danyaya, Shehu Ibrahim, Zayyanu Abdullahi, Abdulhakim Zubairu, Abdulsalam Umar Sahabi

“…Pain remains a major health, social, and economic problem worldwide. …”
Get full text

Study on the synergistic effect of NOx and CO2 emission reduction in the industrial sector of Guangzhou by Xingcun Qin, Xingcun Qin, Pengcheng Xie, Cuiping Liao, Cuiping Liao

“…IntroductionAs a major source of pollutant and CO2 emissions, the industrial sector faces the dual challenge of pollution control and carbon reduction. …”
Get full text

A Study on Parameterization of the Beijing Winter Heavy Haze Events Associated with Height of Pollution Mixing Layer by Tao Niu, Jizhi Wang, Yuanqin Yang, Yaqiang Wang, Cheng Chen

“…North China Plain, Beijing, Tianjin, and Hebei province are the major areas facing the decreasing air quality and frequent pollution events in the recent years. …”
Get full text

HIFU-CCL19/21 Axis Enhances Dendritic Cell Vaccine Efficacy in the Tumor Microenvironment by Bum-Seo Baek, Hyunmi Park, Ji-Woong Choi, Eun-Young Lee, Seung-Yong Seong

“…Background/Objectives: Effectively targeting treatment-resistant tumor cells, particularly cancer stem cells (CSCs) involved in tumor recurrence, remains a major challenge in immunotherapy. This study examines the potential of combining mechanical high-intensity focused ultrasound (M-HIFU) with dendritic cell (DC) vaccines to enhance immune responses against OLFM4-expressing tumors, a CSC marker linked to immune evasion and tumor growth. …”
Get full text

Gap Junctions Are Involved in the Rescue of CFTR-Dependent Chloride Efflux by Amniotic Mesenchymal Stem Cells in Coculture with Cystic Fibrosis CFBE41o- Cells by Annalucia Carbone, Roberto Zefferino, Elisa Beccia, Valeria Casavola, Stefano Castellani, Sante Di Gioia, Valentina Giannone, Manuela Seia, Antonella Angiolillo, Carla Colombo, Maria Favia, Massimo Conese

“…In order to explore the role of gap junction- (GJ-) mediated intercellular communication (GJIC) in this rescue, cocultures (hAMSC : CFBE, 1 : 5 ratio) were studied for the formation of GJIC, before and after silencing connexin 43 (Cx43), a major component of GJs. Functional GJs in cocultures were inhibited when the expression of the Cx43 protein was downregulated. …”
Get full text

Short‐term load forecasting at electric vehicle charging sites using a multivariate multi‐step long short‐term memory: A case study from Finland by Tim Unterluggauer, Kalle Rauma, Pertti Järventausta, Christian Rehtanz

“…Abstract This study assesses the performance of a multivariate multi‐step charging load prediction approach based on the long short‐term memory (LSTM) and commercial charging data. The major contribution of this study is to provide a comparison of load prediction between various types of charging sites. …”
Get full text

Modeling the endocrine control of vitellogenin production in female rainbow trout by Kaitlin Sundling, Gheorghe Craciun, Irvin Schultz, Sharon Hook, James Nagler, Tim Cavileer, Joseph Verducci, Yushi Liu, Jonghan Kim, William Hayton

“…This study focuses on the endocrine regulation of vitellogenin (Vg) protein synthesis, which is the major egg yolk precursor in this fish species.We present a model of Vg production in female rainbowtrout which incorporates a biological pathway beginningwith sex steroid estradiol-17β levels in the plasma andconcluding with Vg secretion by the liver and sequestration in theoocytes. …”
Get full text

Qualitative study on nurse preceptors’ preparedness, roles and familiarity with the basic principles of teaching and learning in a district hospital in Ghana by Dorothy Serwaa Boakye, Vida Maame Kissiwaa Amoah, Edward Appiah Boateng, John Antwi, Joyce Yeboah, Jennifer Owusu

“…Objective This qualitative study explored the experiences, preparedness, instructional practices and roles of preceptors supervising nursing students in a clinical setting.Design Exploratory descriptive study employing semi-structured interviews.Setting A district hospital in the Kumasi Metropolis accredited for training nursing students in clinical practice.Participants 12 nurse preceptors, each holding at least a Bachelor of Science in Nursing.Major findings Findings revealed gaps in the preparation of preceptors and a lack of a clear definition of preceptors’ roles and responsibilities from the outset, contributing to feelings of under-preparedness. …”
Get full text

Production of Palmitoleic and Linoleic Acid in Oleaginous and Nonoleaginous Yeast Biomass by Irena Kolouchová, Olga Maťátková, Karel Sigler, Jan Masák, Tomáš Řezanka

“…We investigated the possibility of utilizing both oleaginous yeast species accumulating large amounts of lipids (Yarrowia lipolytica, Rhodotorula glutinis, Trichosporon cutaneum, and Candida sp.) and traditional biotechnological nonoleaginous ones (Kluyveromyces polysporus, Torulaspora delbrueckii, and Saccharomyces cerevisiae) as potential producers of dietetically important major fatty acids. The main objective was to examine the cultivation conditions that would induce a high ratio of dietary fatty acids and biomass. …”
Get full text

Gene drive-based population suppression in the malaria vector Anopheles stephensi by Xuejiao Xu, Jingheng Chen, You Wang, Yiran Liu, Yongjie Zhang, Jie Yang, Xiaozhen Yang, Bin Chen, Zhengbo He, Jackson Champer

“…Here, we construct a homing suppression drive in the major urban malaria vector Anopheles stephensi targeting the female-specific exon of doublesex, incorporating two gRNAs and a nanos-Cas9 to reduce functional resistance and improve female heterozygote fitness. …”
Get full text

Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies by Tilahun Alelign, Momina M. Ahmed, Kidist Bobosha, Yewondwossen Tadesse, Rawleigh Howe, Beyene Petros

“…As part of the host immune defense mechanism, human leukocyte antigen (HLA) is a major challenge for graft rejection in transplantation therapy. …”
Get full text

Massively Parallel Screening of Toll/Interleukin‐1 Receptor (TIR)‐Derived Peptides Reveals Multiple Toll‐Like Receptors (TLRs)‐Targeting Immunomodulatory Peptides by Yun Lim, Tae Kyeom Kang, Meong Il Kim, Dohyeon Kim, Ji Yul Kim, Sang Hoon Jung, Keunwan Park, Wook‐Bin Lee, Moon‐Hyeong Seo

“…A large peptide library is constructed, named TIR surfacesome, by tiling surface sequences of the large TIR domain family and screening against MALTIR and MyD88TIR, TIRs of two major TLR adaptor proteins, resulting in the discovery of hundreds of TIR‐binding peptides. …”
Get full text

The Missing Heritability in T1D and Potential New Targets for Prevention by Brian G. Pierce, Ryan Eberwine, Janelle A. Noble, Michael Habib, Hennady P. Shulha, Zhiping Weng, Elizabeth P. Blankenhorn, John P. Mordes

“…It is strongly associated with susceptibility haplotypes within the major histocompatibility complex, but this association accounts for an estimated 50% of susceptibility. …”
Get full text

Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies by Venkata Lokesh Battula, Abhishek Maiti, Adishwar Rao, Akriti Agrawal, Gautam Borthakur

“…These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. …”
Get full text

State of the Art Review of Wearable Devices for Respiratory Monitoring by Zhiyu Jia, Hannah Huth, Wen Qi Teoh, Sheng Xu, Bradford Wood, Zion Tsz Ho Tse

“…This review identifies major challenges, including power efficiency, ergonomic design, data accuracy, and data privacy concerns. …”
Get full text

Novel cis-Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action by Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Аlexey A. Logvinov, Viktor V. Temnov, Nataliya E. Borisova, Tatiana A. Podrugina, Lenka Markova, Pavel Starha, Alexey. A. Nazarov, Viktor Brabec

“…Further results focused on the mechanism of action of the studied complexes and showed that in contrast to cisplatin and several platinum-based antitumor drugs, DNA damage by the investigated Pt(II)-alkylpyrazole complexes does not play a major role in their mechanism of action. Our findings demonstrate that inhibition of the tubulin kinesin Eg5, which is essential for forming a functional mitotic spindle, plays an important role in their mechanism of antiproliferative action.…”
Get full text

Language and Culture in Health Literacy for People Living with HIV: Perspectives of Health Care Providers and Professional Care Team Members by Keitshokile Dintle Mogobe, Sheila Shaibu, Ellah Matshediso, Motshedisi Sabone, Esther Ntsayagae, Patrice K. Nicholas, Carmen J. Portillo, Inge B. Corless, Carol Dawson Rose, Mallory O. Johnson, Allison Webel, Yvette Cuca, Marta Rivero-Méndez, Solymar S. Solís Báez, Kathleen Nokes, Darcel Reyes, Jeanne Kemppainen, Paula Reid, Lucille Sanzero Eller, Teri Lindgren, William L. Holzemer, Dean Wantland

“…Thus, this study suggests that language and culture have a major role in health literacy for PLHIV.…”
Get full text

Assessing the Potential of Brewer’s Spent Grain to Enhance Cookie Physicochemical and Nutritional Profiles by Marisa Nicolai, Maria Lídia Palma, Ricardo Reis, Rúben Amaro, Jaime Fernandes, Elsa M. Gonçalves, Mafalda Silva, Manuela Lageiro, Adília Charmier, Elisabete Maurício, Patrícia Branco, Carla Palma, Joaquim Silva, Maria Cristiana Nunes, Pedro C. B. Fernandes, Paula Pereira

“…Brewers’ spent grain (BSG), the major by-product of the brewery industry, has high nutritional value, making it suitable for upcycling into products such as healthy, and sustainable cookies. …”
Get full text

Economic consequences of the First World War by Nikolić Srboljub, Mihajlović Milan, Epler Igor, Milanović Nikola

“…This paper analyzes the economic consequences of the war, focusing on the costs, both material and in terms of human losses, the major economic crisis, as well as the mortgage and agricultural crises. …”
Get full text