The differentiation state of small intestinal organoid models influences prediction of drug-induced toxicity by Jessica A. Klein, Julia D. Heidmann, Tomomi Kiyota, Aaron Fullerton, Kimberly A. Homan, Julia Y. Co

“…Primary tissue-derived intestinal organoids, on the other hand, are a scalable Complex in vitro Model (CIVM) that recapitulates major intestinal cell lineages and function. Intestinal organoid toxicity assays have been shown to correlate with clinical incidence of drug-induced diarrhea, however existing studies do not consider how differentiation state of the organoids impacts assay readouts and predictivity. …”
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Litchi chinensis: nutritional, functional, and nutraceutical properties by Guillermo Castillo-Olvera, José Sandoval-Cortes, Juan A. Ascacio-Valdes, Jorge E. Wong-Paz, Olga B. Álvarez-Pérez, María L. FloresLópez, Cristóbal N. Aguilar

“…Rapid browning of the pericarp is a major problem resulting in considerable product loss. …”
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Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms by Xiaozheng Liu, Jiuzun Chen, Bangli Shen, Gang Wang, Jiapeng Li, Hongtao Hou, Xingli Chen, Zhongwei Guo, Chuanwan Mao

“…Neuroimaging studies have demonstrated that major depressive disorder increases the risk of dementia in older individuals with mild cognitive impairment. …”
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Mesenchymal Stem Cells Ameliorate Hepatic Ischemia/Reperfusion Injury via Inhibition of Neutrophil Recruitment by Shihui Li, Xu Zheng, Hui Li, Jun Zheng, Xiaolong Chen, Wei Liu, Yan Tai, Yingcai Zhang, Genshu Wang, Yang Yang

“…Ischemia/reperfusion injury (IRI) remains a major problem in organ transplantation, which represents the main cause of graft dysfunction posttransplantation. …”
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Schwann cells in regeneration and cancer by Lan Zhang, Jiale Xie, Wenyu Dai, Bing Lu, Sheng Yi

“…Schwann cells are the major cellular component of neurofibromatosis type 1 and the sole cell type in neurofibromatosis type 2 and schwannomatosis. …”
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Antegrade Therapy for Management of Choledocholithiasis through Endoscopic Ultrasound-Guided Hepaticogastrostomy in a Patient with Surgically Altered Gastrointestinal Anatomy by Robert Dorrell, Katelyn Madigan, Swati Pawa, Rishi Pawa

“…He underwent two endoscopic retrograde cholangiopancreatography (ERCP) procedures at an outside hospital which were unsuccessful due to an inaccessible major papilla in the setting of the patient’s surgically altered anatomy. …”
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Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity by Akadiri Yessoufou, Magloire P. Nekoua, Adam Gbankoto, Yohana Mashalla, Kabirou Moutairou

“…In this paper, we report data on the observed effects of omega-3 PUFA on major metabolic disorders and immune system disruption during gestational diabetes and their consequences on macrosomia. …”
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Hepatocellular Carcinoma: Current Management and Future Development—Improved Outcomes with Surgical Resection by Yoji Kishi, Kiyoshi Hasegawa, Yasuhiko Sugawara, Norihiro Kokudo

“…Especially for advanced HCC, surgical resection is the only strategy that is potentially curative, and the indications for surgical resection have expanded concomitantly with the technical advances in hepatectomy. A major problem is the high recurrence rate even after curative resection, especially in the remnant liver. …”
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Two Small Peptides from <i>Buthus martensii</i> Hydrolysates Exhibit Antitumor Activity Through Inhibition of TNF-α-Mediated Signal Transduction Pathways by Mengshuang Zhu, Shanshan Zhang, Jiyang Tang, Hairong Hou, Lizhen Wang, Houwen Lin, Xuanming Zhang, Meng Jin

“…EGFR, TP53, MYC, PTEN, and STAT3 were also identified as major functional targets of the peptides. Mechanistically, AK and GK inactivated the TNF-α/EGFR/STAT3-signaling pathway, decreased c-myc protein expression levels, and upregulated p53 and PTEN expression, thereby preventing TNF-α-induced tumor growth. …”
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Clinical Guide Adaptation for Amalgam Waste Management in Dental Settings in Iran by Mahsa Eshrati, Fatemeh Momeniha, Nafiseh Momeni, Elham Ahmadi, Atieh Hashemian, Homa Kashani, Mojgan Alaeddini

“… Objectives: Dental clinics are one of the major producers of mercury-containing waste due to the use of dental amalgam.  …”
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Serious issues with cryo-EM structures of human prothrombinase by James A. Huntington, Alexandre Faille, Fatma Isik Ustok

“…(Ruben et al. 2022 Blood 139, 3463–3473 (doi:10.1182/blood.2022015807)) reported a major breakthrough in the field: the cryogenic electron microscopy structures of human prothrombinase on nanodiscs at 5.5 Å resolution (7TPQ) and of a catalytically inert human prothrombinase with its substrate prothrombin in the absence of any membrane at 4.1 Å resolution (7TPP). …”
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New Approach of the Oxidant Peroxo Method (OPM) Route to Obtain Ti(OH)4 Nanoparticles with High Photocatalytic Activity under Visible Radiation by André E. Nogueira, Lucas S. Ribeiro, Luiz F. Gorup, Gelson T. S. T. Silva, Fernando F. B. Silva, Caue Ribeiro, Emerson R. Camargo

“…Environmental problems related to the generation of wastewater contaminated with organic compounds and the emissions of pollutants from fuel burning have become major global problems. Thus, there is a need for the development of alternative and economically viable technologies for the remediation of the affected ecosystems. …”
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Inhibitory Effect of Matrine on Blood-Brain Barrier Disruption for the Treatment of Experimental Autoimmune Encephalomyelitis by Su Zhang, Quan-Cheng Kan, Yuming Xu, Guang-Xian Zhang, Lin Zhu

“…In the present study, we show that MAT treatment had a therapeutic effect comparable to dexamethasone (DEX) in EAE rats, with reduced Evans Blue extravasation, increased expression of collagen IV, the major component of the basement membrane, and the structure of tight junction (TJ) adaptor protein Zonula occludens-1 (ZO-1). …”
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HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure by Runkuan Yang, Xiaoping Zou, Jyrki Tenhunen, Tor Inge Tønnessen

“…ALF patients/animals also have high levels of circulating histones, which might be the major mediators of systemic inflammation in patients with ALF. …”
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Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells by Yu Zhang, Dilaware Khan, Julia Delling, Edda Tobiasch

“…Adipogenic differentiation is another interesting lineage, because fat tissue is considered to be a major factor triggering atherosclerosis that ultimately leads to cardiovascular diseases, the main cause of death in industrialized countries. …”
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An Intelligent Heuristic Manta-Ray Foraging Optimization and Adaptive Extreme Learning Machine for Hand Gesture Image Recognition by Seetharam Khetavath, Navalpur Chinnappan Sendhilkumar, Pandurangan Mukunthan, Selvaganesan Jana, Lakshmanan Malliga, Subburayalu Gopalakrishnan, Sankuru Ravi Chand, Yousef Farhaoui

“…In conventional works, various image processing techniques like segmentation, optimization, and classification are deployed for hand gesture recognition. Still, it limits the major problems of inefficient handling of large dimensional datasets and requires more time consumption, increased false positives, error rate, and misclassification outputs. …”
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Brain CT image classification based on mask RCNN and attention mechanism by Shoulin Yin, Hang Li, Lin Teng, Asif Ali Laghari, Ahmad Almadhor, Michal Gregus, Gabriel Avelino Sampedro

“…Brain tumor is one of the major diseases threatening human life. The number of deaths caused by these diseases is increasing dramatically every year in the world. …”
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Studies of the Interaction between Isoimperatorin and Human Serum Albumin by Multispectroscopic Method: Identification of Possible Binding Site of the Compound Using Esterase Activ... by Samira Ranjbar, Yalda Shokoohinia, Sirous Ghobadi, Nooshin Bijari, Saeed Gholamzadeh, Nastaran Moradi, Mohammad Reza Ashrafi-Kooshk, Abbas Aghaei, Reza Khodarahmi

“…Fluorescence data indicated that isoimperatorin quenches the intrinsic fluorescence of the HSA via a static mechanism and hydrophobic interaction play the major role in the drug binding. The binding average distance between isoimperatorin and Trp 214 of HSA was estimated on the basis of the theory of Förster energy transfer. …”
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Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy by Hanyu Zhu, Moyan Liu, Hanjie Yu, Xiawei Liu, Yaogang Zhong, Jian Shu, Xinle Fu, Guangyan Cai, Xiangmei Chen, Wenjia Geng, Xiaoli Yang, Minghui Wu, Zheng Li, Dong Zhang

“…Diabetic nephropathy is a major cause of chronic kidney disease and end-stage kidney disease. …”
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A Study of Lithosphere–Ionosphere Seismic Precursors from Detecting Gamma-Ray and Total Electron Content Anomalies Prior to the 2018 M_L6.2 Hualien Earthquake in Eastern... by Ching-Chou Fu, Hau-Kun Jhuang, Yi-Ying Ho, Tsung-Che Tsai, Lou-Chuang Lee, Cheng-Horng Lin, Ching-Ren Lin, Vivek Walia, I-Te Lee

“…Prior research has shown that significant gamma-ray enhancements are frequently detected at the YMSG (Yangmingshan gamma-ray) station prior to major earthquakes in eastern and northeastern Taiwan, suggesting that gamma-ray anomalies may serve as reliable indicators for identifying seismic precursors in this area. …”
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