R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania by Jeziel D. Damasceno, Emma M. Briggs, Marija Krasilnikova, Catarina A. Marques, Craig Lapsley, Richard McCulloch

“…Here we show that both R-loops and RNase H1, a ribonuclease that resolves RNA-DNA hybrids, accumulate in Leishmania major chromosomes in a pattern that reflects their replication timing. …”
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Will the Increasing of Anthropogenic Pressures Reduce the Biopotential Value of Sponges? by Hedi Indra Januar, Asri Pratitis, Aditya Bramandito

“…Abiotic cover was detected as the major factor (36.19%) contributed to the differences and also the most discriminant factor distinguishing sponges spatial competition in the groups of bioactivity level (93.91%). …”
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Development and Application of Urban Landslide Vulnerability Assessment Methodology Reflecting Social and Economic Variables by Yoonkyung Park, Ananta Man Singh Pradhan, Ungtae Kim, Yun-Tae Kim, Sangdan Kim

“…An urban landslide vulnerability assessment methodology is proposed with major focus on considering urban social and economic aspects. …”
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Bile Imprint on Parietal Peritoneum of Gilthead Seabream and Red Seabream: Effects of Fasting Duration, Stress, and Ice Storage by Sofia Brinkmann Bougali, Nafsika Karakatsouli, Christos Balaskas, Konstantinos Petropoulos, Despoina Trampouli, Alkisti Batzina, Pinelopi-Paraskevi Laskari

“…Two experiments were designed, one for gilthead seabream (<i>Sparus aurata</i>) and one for red seabream (<i>Pagrus major</i>). The fish were grouped according to fasting duration (1, 2, 3 days), harvesting method (stressed, unstressed), and ice storage (0 h, 48 h). …”
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Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry for Identification of In Vitro and In Vivo Metabolites of Bornyl Gallate in Rats by Wei Lan, Liujiao Bian, Xinfeng Zhao, Pu Jia, Xue Meng, Yizhen Wu, Shixiang Wang, Sha Liao, Jie Yu, Xiaohui Zheng

“…Five compounds were identified as isomers of hydroxylated BG metabolites in vitro. The major metabolites of BG in rat urine and plasma proved to be BG-O-glucuronide and O-methyl BG-O-glucuronide. …”
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Determination of Traces of Pd(II) in Spiked Samples by Using 3,4-Dihydroxybenzaldehydeisonicotinol-hydrazone as a Chelating Agent with UV Visible Spectrophotometer by S. Lakshmi Narayana, C. Ramachandraiah, A. Varada Reddy, Dongyeun Lee, Jaesool Shim

“…The correlation coefficient and regression coefficient of the Pd(II)-3,4-DHBINH complex were 1.08 and 0.04 respectively. Major cations and anions did not show any interference. …”
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Decoupling and Collaboration: An Intelligent Gateway-Based Internet of Things System Architecture for Meat Processing by Jun Liu, Chenggang Zhou, Haoyuan Wei, Jie Pi, Daoying Wang

“…The quality and nutritional value of the final meat product are significantly influenced by each processing link. To address the major challenges in the meat processing industry, including device heterogeneity, model deficiencies, rapidly increasing demands for data analysis, and limitations of cloud computing, this study proposes an Internet of Things (IoT) architecture. …”
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High Relative Humidity‐Induced Growth of Perovskite Nanowires from Glass toward Single‐Mode Photonic Nanolasers at Sub‐100‐nm Scale by Zhiqiang Wang, Xinkuo Li, Chenduan Chen, Minhan Lou, Jiajia Wu, Kai Gao, Zengling Li, Ke Sun, Zhou Li, Zhu Xiao, Linhan Li, Pan Wang, Sai Bai, Jianrong Qiu, Dezhi Tan

“…In particular, high relative humidity (RH) commonly causes severe MHP degradation, which poses a major obstacle to long‐term device operation. Herein, high RH‐induced growth of anisotropic MHP structures on glass surfaces is reported under 25 °C and atmospheric conditions on a basis of glass corrosion by moisture. …”
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Species diversity, taxonomy, multi-gene phylogeny, and divergence times of Meruliaceae (Polyporales, Basidiomycota) by Yue Li, Yi-Feng Cao, Karen K. Nakasone, Shi-Liang Liu, Man-Rong Huang, Shuang-Hui He

“…Meruliaceae is one of the three major families of the phlebioid clade in the Polyporales that consists primarily of wood-decaying species. …”
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Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells by Atsushi Kaneko, Toru Kono, Naoko Miura, Naoko Tsuchiya, Masahiro Yamamoto

“…Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel disease (IBD), have histopathologically and immunologically different characteristics. …”
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Health-Related Quality of Life after Pediatric Liver Transplantation: A Qualitative Analysis of the Perspectives of Health Care Providers by Mar Miserachs, David B. Nicholas, Anthony R. Otley, Vicky Lee Ng

“…Data analysis via a thematic analysis approach revealed 4 major themes: “LT as a facilitator of better HRQoL,” “coping and adapting to LT,” “living with a transplanted liver,” and “the family context.” …”
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Debate effectiveness for the strengthening the university educational work from the curricular work by Julio Fragoso Fragoso, Blanca Rosa Garcés Garcés, Lian Roque Roque, Ibys Espinosa Requesens, Valia Caminero Chávez, Francisco Jacas Frada

“…Methods: Pedagogical research carried out at the University of Medical Sciences of Cienfuegos, from September 2016 to January 2017, with the Philosophy class in the first year of the Dentistry Major. The debate deliberated by the teacher was introduced on the basis of articles with impact on the current Cuban society, previously selected and student oriented. …”
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The Effect of Storage Temperature and Time on the Concentrations of Bovine Serum Amyloid A and Its Mammary Associated Isoform by Csilla Tóthová, Oskar Nagy, Herbert Seidel, Gabriel Kováč

“…The objective of this study was to evaluate the effect of storage under various conditions on the concentrations of major bovine acute phase protein—serum amyloid A, and its mammary isoform. …”
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Salvage of Failed Local and Regional Flaps with Porcine Urinary Bladder Extracellular Matrix Aided Tissue Regeneration by Gregory J. Kruper, Zachary P. VandeGriend, Ho-Sheng Lin, Giancarlo F. Zuliani

“…Local and regional flap failure can be a major complication in head and neck surgery, which continue to be prevalent for a number of reasons including poor flap design, improper surgical technique, and poor tissue vascularity. …”
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Protective Role of Platelets in Myocardial Infarction and Ischemia/Reperfusion Injury by Kornela Hałucha, Alina Rak-Pasikowska, Iwona Bil-Lula

“…Paradoxically, reperfusion may result in further tissue damage called ischemia/reperfusion injury (IRI). Platelets play a major role in the pathogenesis of MI and IRI, since they contribute to the thrombus and microthrombi formation, inflammation, release of immunomodulatory mediators, and vasoconstrictive molecules. …”
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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases by Juan Shi, Shuhong Chi, Jing Xue, Jiali Yang, Feng Li, Xiaoming Liu

“…This review summarizes currently our understanding of the pathogenic roles of Wnt signaling in several major autoimmune disorders and miRNAs, those targeting Wnt signaling in autoimmune diseases, with a focus on the implication of the Wnt signaling as potential biomarkers and therapeutic targets in immune diseases, as well as miRNA-mediated regulation of Wnt signaling activation in the development of autoimmune diseases.…”
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Case report: Rare observation of thyroid-like cholangiocarcinoma by Ekaterina Bondarenko, Dmitriy Kalinin, Liliya Urusova, Dariya Pastukhova, Rustam Salimkhanov, Natalia Mokrysheva

“…Intrahepatic cholangiocarcinoma is primarily classified into two major histologic types: small and large ductal cholangiocarcinomas. …”
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Promoter capture Hi-C identifies promoter-related loops and fountain structures in Arabidopsis by Dingyue Wang, Suxin Xiao, Jiayue Shu, Lingxiao Luo, Minqi Yang, Myriam Calonje, Hang He, Baoxing Song, Yue Zhou

“…In atxr3 mutants, which lack the major H3K4me3 methyltransferases in Arabidopsis, the number of promoter-related loops at fountains is reduced, leading to upregulation of fountain-regulated genes. …”
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Metal Sourcing For a Sustainable Future by Ortwin Renn, Richard Gloaguen, Christina Benighaus, Leila Ajjabou, Ludger Benighaus, Virginia Del Rio, Javier Gómez, Sari Kauppi, Michaela Keßelring, Moritz Kirsch, Marko Komac, Juha Kotilainen, Elena Kozlovskaya, Jari Lyytimaki, Cathryn McCallum, Tuija Mononen, Jouni Nevalainen, Lasse Peltonen, Jukka-Pekka Ranta, Stephane Ruiz, Jon Russill, Frank Wagner

“…Our analysis shows that the sustainability of mining cannot be reached without harmonized political instruments and investment policies that take the three pillars of environmental, economic, and social sustainability as a major priority.…”
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Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

“…Obesity is a major risk factor for several diseases including diabetes, heart disease, and some forms of cancer and due to its rapidly increasing prevalence it has become one of the biggest problems medicine is facing today. …”
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