On the representation and evolution of Australian English and New Zealand English by Anne Przewozny, Cécile Viollain

“…With a view to contribute to the definition of AusE and NZE as linguistic objects in motion and to promote a dynamic portrait of each variety, we then provide contemporary oral data from the PAC programme as well as comparative analyses in favour of two major arguments for distinctiveness between AusE and NZE: rhoticity in NZE as well as the short front vowel shift in both AusE and NZE.…”
Get full text

Exploring the link between Multimorbidity and direct healthcare costs in Ireland: A cross-sectional study by Sharon Walsh, Paddy Gillespie

“…Background Multimorbidity has emerged as a major challenge facing health services globally, which will place a substantial burden on health systems going forward. …”
Get full text

Physiologically-based pharmacokinetic modeling of enantioselective hydroxychloroquine kinetics and impact of genetic polymorphisms by Gabriella de Souza Gomes Ribeiro, Leandro Francisco Pippa, Fernanda de Lima Moreira, Natália Valadares de Moraes

“…This work aimed to build physiologically-based pharmacokinetic (PBPK) models to predict the pharmacokinetics (PK) of R-and S-HCQ and assess the impact of major genetic polymorphisms on PK. Whole-body PBPK models accounting for first-order absorption, Rodgers and Rowland distribution method, and enzyme kinetics data were built for R-and S-HCQ. …”
Get full text

The Effect of Urban Macroform on Urban Resilience: The Case of Düzce by Ecrin Kar, Selim Altuntaş, Hicran Hamza Çelikyay

“…Düzce, located on the North Anatolian Fault line in the north-west of Türkiye, was shaken by two major earthquakes on August 17 and November 12, 1999. …”
Get full text

In Vitro Assay of Lytic Bacteriophage to Suppress the Growth of Ralstonia syzygii subsp. indonesiensis, the Causal Pathogen of Potato Wilt Disease by Nur Azizah, Irda Safni

“… Bacterial wilt disease, the one of the major diseases of potatoes, caused by Ralstonia syzygii subsp. indonesiensis (Rsi). …”
Get full text

How do smoking, vaping, and nicotine affect people with epilepsy and seizures? A scoping review protocol. by Jackson A Narrett, Waleed Khan, Melissa C Funaro, Jeremy J Moeller

“…<h4>Background</h4>Epilepsy is a prevalent disease that requires personalized care to control seizures, reduce side effects, and ameliorate the burden of comorbidities. Smoking is a major cause of preventable death and disease. There is evidence that patients with epilepsy smoke at high rates and that smoking may increase seizure frequency. …”
Get full text

Implementation of digital health in rural populations with chronic musculoskeletal conditions: A scoping review protocol. by Lara Campos, Daniela Costa, Helena Donato, Baltazar Nunes, Eduardo B Cruz

“…Musculoskeletal conditions are a major source of disability worldwide, and its burden have been rising in the last decades. …”
Get full text

Residential Property Value and Security Features in Gated Communities by J.U OSAGIE, V.U ILECHUKWU

“…A total of 124 questionnaires were administered on the resident households. Major finding showed that high security arrangements/features are ranked first & second as the determinant of the rental value paid in both gated communities observed. …”
Get full text

SEDIMENT RUNOFF AND WATER TURBIDITY OF THE MAIN TRIBUTARIES OF THE LAKE LADOGA by Marina V. Shmakova, Sergey A. Kondratyev

“…The main sources of sediment are three major tributaries of the Lake Ladoga – the Svir, Volkhov and Vuoksa rivers, which account for 253 thousand t/year or 59 % of the total amount of sediment received in the lake. …”

ILLEGAL APPENDAGES TO RESIDENTIAL BUILDINGS IN KUMASI, GHANA A CASE STUDY OF NORTH SUNTRESO by E Adinyira, P Anokye

“…The study confirmed ‘population growth’, ‘inadequate space’, ‘commercialisation of facilities’ and ‘inadequate knowledge of the Building Regulations’ as the major causes of this phenomenon. Findings from the study points to ‘effect on the value of such properties’, ‘effect on spatial planning’, ‘effect on indoor conditions such as lighting and ventilation’ and ‘structural effects’ as the most significant effects of such additions to buildings. …”
Get full text

The use of paracetamol during pregnancy: A qualitative study and possible strategies for a clinical trial. by Cathrine Vedel, Ditte Staub Jørgensen, David Møbjerg Kristensen, Olav Bjørn Petersen, Gorm Greisen

“…As a negative attitude among users has been considered the major hindrance for such a study, we cannot see hindrances for performing an RCT.…”
Get full text

Geology of the Pleistocene volcano of Monte Amiata (Southern Tuscany, Italy) by Claudia Principe, Luigina Vezzoli, Sonia La Felice

“…Based on the occurrence of a first-order geological unconformity representing a paleo-weathering surface of paleoclimatic significance, two major volcanic stratigraphic units and seven phases of activity are recognized.Highlights Monte Amiata is a volcano with the rare peculiarity of being completely silicic and effusiveThe produced, detailed, geological map has been the primary tool for the comprehension of the history of the volcano and will be the primary tool for land managementUsing of the Unconformity Bounded Stratigraphic Units hallowed us to reconsider Monte Amiata not as an isolated volcanic body but as a part of the geology of this portion of Southern Tuscany.At Monte Amiata, where the second largest Italian geothermal field is located, a complete geological picture means giving substantial help to geothermal resource development…”
Get full text

Induction of Cell Activation Processes by Low Frequency Electromagnetic Fields by Myrtill Simkó

“…To demonstrate a possible interaction between EMF and cellular systems, we present a mechanistic model describing cell activation as a major importance for cellular response.…”
Get full text

Altered ERK1/2 Signaling in the Brain of Learned Helpless Rats: Relevance in Vulnerability to Developing Stress-Induced Depression by Yogesh Dwivedi, Hui Zhang

“…Extracellular signal-regulated kinase 1/2- (ERK1/2-) mediated cellular signaling plays a major role in synaptic and structural plasticity. …”
Get full text

CD47/SIRPα axis: bridging innate and adaptive immunity by Sjoerd H van der Burg, Anneloes van Duijn, Ferenc A Scheeren

“…Furthermore, we discuss the interconnection between the myeloid CD47/SIRPα axis and adaptive T cell responses as well as the potential therapeutic role of the CD47/SIRPα axis in tumors with acquired resistance to the classic immunotherapy through major histocompatibility complex downregulation. …”
Get full text

Circulating Endothelial Microparticles: A Key Hallmark of Atherosclerosis Progression by Keshav Raj Paudel, Nisha Panth, Dong-Wook Kim

“…Atheroemboli, resulting from ruptured carotid plaques, is a major cause of stroke. Increasing evidence suggests that EMPs play an important role in the pathogenesis of cardiovascular disease, acting as a marker of damage, either exacerbating disease progression or triggering a repair response. …”
Get full text

FINANCIAL INCLUSION AS A PARADOX FOR ECONOMIC GROWTH IN NIGERIA by Majeed Ajibola IBRAHIM, Olawale DADA, Kayode Abdul-Ganiyu AKANBI, Lateef Kayode JAJI

“… Access to financial services at affordable rate is one of the major concerns of financial inclusion in both advanced and developing nation around the globe since the subject matter is considered as a key driver for economic growth acceleration. …”
Get full text

THE EFFECTS OF ENVIRONMENTAL PECULIARITIES ON TRANSPORTATION INFRASTRUCTURE PERFORMANCE IN LAGOS METROPOLIS, NIGERIA: RESIDENTS' EXPERIENCES by Ayobami Ademola AKANMU, Umar Obafemi SALISU

“…A combination of descriptive (percentage and mean-weighted analysis) and inferential (Fisher’s exact test and Phi Cramer's V Test) statistics was adopted for data analysis. Major findings revealed that the environmental peculiarities in Lagos foster the use of multimodal infrastructure options and concurrently exert adverse effects on various facets of transportation infrastructure performance, including travel cost, commuting time, fare charges, wear and tear of infrastructure, and the overall cost of maintenance and repairs. …”
Get full text

«BRAIN DRAIN» FROM RUSSIA AS PROBLEM OF POLITICAL GOVERNANCE by A. A. Kazantsev, K. P. Borishpolets

“…When the status of the federal state at the international arena is in major defined by its scientific and technological potential, migration of the highly trained professional from or to Russia acquires a strategic status. …”
Get full text

Miserable victims or Troublesome delinquents? A Critical perspective on the news media coverage of Chinese rural left-behind children by Ruixia Sun, Wei Han

“…We employed the discourse-historical approach and the concept of agency to analyze the data and found that China Daily has constructed three major images of LBC: victims, problem-plagued group, beneficiaries. …”
Get full text