PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1 by Fei Xie, Han Zhang, Kongkai Zhu, Cheng‐Shi Jiang, Xiaoya Zhang, Hongkai Chang, Yaya Qiao, Mingming Sun, Jiyan Wang, Mukuo Wang, Junzhen Tan, Tao Wang, Lianmei Zhao, Yuan Zhang, Jianping Lin, Chunze Zhang, Shuangping Liu, Jianguo Zhao, Cheng Luo, Shuai Zhang, Changliang Shan

“…Abstract Protein arginine methyltransferase 5 (PRMT5) is a major type II enzyme responsible for symmetric dimethylation of arginine (SDMA), and plays predominantly roles in human cancers, including in ovarian cancer. …”
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Depression in Parkinson’s Disease: The Contribution from Animal Studies by Jéssica Lopes Fontoura, Camila Baptista, Flávia de Brito Pedroso, José Augusto Pochapski, Edmar Miyoshi, Marcelo Machado Ferro

“…The dopaminergic role could be more significant, since it can modulate the release of the others, and its depletion is progressive, due to the degenerative feature of PD. Highly regarded in major depression, serotonin can be depleted in rats after nigrostriatal damage, but data from human patients are more conflicting. …”
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Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity by Ponraj Prabakaran, Abhinav Gupta, Sambasiva P. Rao, Deepak Rajpal, Maria Wendt, Yu Qiu, Partha S. Chowdhury

“…Abstract Antibodies, essential components of adaptive immunity, derive their remarkable diversity primarily from V(D)J gene rearrangements, particularly within the heavy chain complementarity-determining region 3 (CDR-H3) where D genes play a major role. Traditionally, D genes were thought to recombine only in the forward direction, despite having identical recombination signal sequences (12 base pair spacers) at both ends. …”
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Health effects of fruit juices and beverages with varying degrees of processing by Xinyue Zhang, Xiaojun Liao, Yongtao Wang, Lei Rao, Liang Zhao

“…In this study, we first integrated 4 systems used to classify the degree of food processing and then classified FJBs into three major categories, low (minimal), moderate and high. …”
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In vitro inhibition mechanisms of Trichoderma yunnanense TM10 against Pyricularia oryzae and Rhizoctonia solani causing blast and sheath blight diseases in rice (Oryza sativa L.) by Dedat Prismantoro, Thomas Argyarich Jefferson, Sulistya Ika Akbari, Mia Miranti, Muhamad Shakirin Mispan, Febri Doni

“…Blast and sheath blight diseases, caused by Pyricularia oryzae and Rhizoctonia solani, respectively, are major threats to rice production worldwide. Efforts should be made to limit the spread of these phytopathogens, preferably through sustainable methods. …”
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Nutritional optimization of fecal microbiota transplantation in humans: a scoping review by Levi M Teigen, Austin Hoeg, Hijab Zehra, Priyali Shah, Remy Johnson, Kristen Hutchison, Megan Kocher, Annie W Lin, Abigail J Johnson, Byron P Vaughn

“…Diet constitutes a major source of nutrient flow to the gut microbes. …”
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Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo by Yilai Shu, Yong Tao, Wenyan Li, Jun Shen, Zhengmin Wang, Zheng-Yi Chen

“…Adenovirus is one of the major vectors to deliver genes into the inner ear for functional studies and hair cell regeneration. …”
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Mesenchymal Stem Cells in Oriented PLGA/ACECM Composite Scaffolds Enhance Structure-Specific Regeneration of Hyaline Cartilage in a Rabbit Model by Weimin Guo, Xifu Zheng, Weiguo Zhang, Mingxue Chen, Zhenyong Wang, Chunxiang Hao, Jingxiang Huang, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Shuyun Liu, Shibi Lu, Quanyi Guo

“…Hence, articular cartilage regeneration remains a major challenge in orthopedics. Decellularized extracellular matrix- (ECM-) based strategies have recently received particular attention. …”
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Cyber Security and Key Management Issues for Internet of Things: Techniques, Requirements, and Challenges by Mohammad Faisal, Ikram Ali, Muhammad Sajjad Khan, Junsu Kim, Su Min Kim

“…Internet of Things-based environments pose various challenges due to their anytime/anywhere computing, and the efficient cryptographic based key management is one of the major challenges in Internet of Things. The key management life cycle consists of initialization, key generation, key registration, key backup, key update, key recovery, and key revocation. …”
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<i>Pseudomonas simiae</i> WCS417 Strain Enhances Tomato (<i>Solanum lycopersicum</i> L.) Plant Growth Under Alkaline Conditions by Miguel A. Aparicio, Francisco J. Ruiz-Castilla, José Ramos, Francisco J. Romera, Carlos Lucena

“…Current production systems are based on the use of high-yielding varieties and the application of large quantities of agrochemicals, which can cause major environmental problems. The use of beneficial rhizosphere microorganisms is considered a relevant sustainable alternative to synthetic fertilizers. …”
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Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways by Ersilia Nigro, Fabio Perrotta, Rita Polito, Vito D’Agnano, Filippo Scialò, Andrea Bianco, Aurora Daniele

“…The impact of metabolic disorders on the prognosis of COVID-19 has major implications in public health especially for countries affected by a high incidence of metabolic diseases.…”
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Circulating Tumor DNA in a Breast Cancer Patient's Plasma Represents Driver Alterations in the Tumor Tissue by Jieun Lee, Sung-Min Cho, Min Sung Kim, Sug Hyung Lee, Yeun-Jun Chung, Seung-Hyun Jung

“…Tumor tissues from biopsies or surgery are major sources for the next generation sequencing (NGS) study, but these procedures are invasive and have limitation to overcome intratumor heterogeneity. …”
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Hydrochemistry and Entropy-Based Groundwater Quality Assessment in the Suining Area, Southwestern China by Yunhui Zhang, Xiao Li, Ming Luo, Changli Wei, Xun Huang, Yong Xiao, Limao Qin, Qiuming Pei

“…Correlations of ions and geomodelling revealed the concentrations of major ions were mainly determined by carbonate dissolution and ion exchange process, and NO3− concentrations were controlled by agriculture activities. …”
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Impact of Mouthwash-Induced Oral Microbiome Disruption on Alzheimer's Disease Risk: A Perspective Review by Ayoub Boulares, Hela Jdidi, Nicola Luigi Bragazzi

“…This disruption can lead to increased blood pressure, a major risk factor for AD. Given the established connection between hypertension and AD, the long-term use of CHX mouthwash may indirectly contribute to the onset of AD. …”
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A novel buffering fault‐tolerance approach for network on chip (NoC) by Nima Jafarzadeh, Ahmad Jalili, Jafar A. Alzubi, Khosro Rezaee, Yang Liu, Mehdi Gheisari, Bahram Sadeghi Bigham, Amir Javadpour

“…Hence, in this research, it is tried first to investigate the scale of fault tolerance effect on the mechanism in the router on the network by injecting simulated errors, and then these errors are prevented. As the major novelty, the authors implemented a router on a synchronised network and calculated the network buffering fault tolerance by injecting error in the buffer. …”
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Magnesium-based nanocomposites for orthopedic applications: A review by Meng Cheng, Xigang Liang, Lihua Cui, Dongyan Guan, Yang Qu, Jianwu Zhao, Kai Guan

“…However, during the early application process, their major drawback was rapid degradation rate, which limited their clinical application. …”
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Guy’s Stone Score (GSS) Based on Intravenous Pyelogram (IVP) Findings Predicting Upper Pole Access Percutaneous Nephrolithotomy (PCNL) Outcomes by Bannakij Lojanapiwat, Pattara Rod-Ong, Pruit Kitirattrakarn, Wilaiwan Chongruksut

“…There were statistically significant differences between the groups in stone size, overall immediate success rate, operative time, number of access tracts, and frequency of tubeless PCNL. Major complications (a Clavien score of 3–5) were significantly higher in the cases with a higher GSS. …”
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Assessment of Underground Water Contamination and Effect of Textile Effluents on Noyyal River Basin In and Around Tiruppur Town, Tamilnadu by A. Geetha, P. N. Palanisamy, P. Sivakumar, P. Ganesh Kumar, M. Sujatha

“…The samples were analyzed for major physical and chemical water quality parameters like pH, alkalinity, electrical conductivity (EC), total dissolved solids (TDS), total hardness (TH), Ca, Mg, Na, K, Cl & SO42-. …”
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Determinants of adoption of quality protein maize varieties in Misrak Badewacho District, Southern Ethiopia: policy implications by Yilma Jambo, Alemu Daka, Berhanu Nega

“…A binary logit model was used to identify major determinants. The results indicated that access to QPM seed, land size, on-farm income, involvement in off/non-farm activities, frequency of contact with development agents (Das), educational level of the household head, and participation of farmers on field days were statistically significant determinants of QPM variety adoption. …”
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Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus by Lucie Caillon, Anais R. F. Hoffmann, Alexandra Botz, Lucie Khemtemourian

“…Human islet amyloid polypeptide (hIAPP) is the major component of the amyloid deposits found in the pancreatic islets of patients with type 2 diabetes mellitus (T2DM). …”
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