The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway by Danilo Figueiredo Soave, Marina Pacheco Miguel, Fernanda Dias Tomé, Liliana Borges de Menezes, Patrícia Resende Alo Nagib, Mara Rúbia Nunes Celes

“…Since 2000, written with elegance and accuracy, Hanahan and Weinberg have proposed six major hallmarks of cancer and, together, they provide great advances to the understanding of tumoral biology. …”
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Deep Learning Approach for Automatic Classification of Ocular and Cardiac Artifacts in MEG Data by Ahmad Hasasneh, Nikolas Kampel, Praveen Sripad, N. Jon Shah, Jürgen Dammers

“…The overall accuracy of the model was validated using a cross-validation test and revealed a median accuracy of 94.4%, indicating high reliability of the DCNN-based artifact removal in task and nontask related MEG experiments. The major advantages of the proposed method are as follows: (1) it is a fully automated and user independent workflow of artifact classification in MEG data; (2) once the model is trained there is no need for auxiliary signal recordings; (3) the flexibility in the model design and training allows for various modalities (MEG/EEG) and various sensor types.…”
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Geophysical flows over topography, a playground for laboratory experiments by Vidal, Jérémie, Noir, Jérôme, Cébron, David, Burmann, Fabian, Monville, Rémy, Giraud, Vadim, Charles, Yoann

“…Physicists face major challenges in modelling multi-scale phenomena that are observed in geophysical flows (e.g. in the Earth’s oceans and atmosphere, or liquid planetary cores). …”
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Prevalence of Hypertension, Obesity, Diabetes, and Metabolic Syndrome in Nepal by Sanjib Kumar Sharma, Anup Ghimire, Jeyasundar Radhakrishnan, Lekhjung Thapa, Nikesh Raj Shrestha, Navaraj Paudel, Keshar Gurung, Maskey R, Anjali Budathoki, Nirmal Baral, David Brodie

“…The high incidence of dyslipidemia and abdominal obesity could be the major contributors to MS in Nepal. Education also appears to be related to the prevalence of MS. …”
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Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Abstract Genotype-informed anticancer therapies such as BRAF inhibitors can show remarkable clinical efficacy in BRAF-mutant melanoma; however, drug resistance poses a major hurdle to successful cancer treatment. Many resistance events to targeted therapies have been identified, suggesting a complex path to improve therapeutics. …”
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The Evolution of Immunosuppressive Therapy in Pig-to-Nonhuman Primate Organ Transplantation by S. A. Sanatkar, K. Kinoshita, A. Maenaka, H. Hara, D. K. C. Cooper

“…Despite initial challenges, including hyperacute rejection resulting from natural (preformed) antibody binding and complement activation, significant progress has been made through gene editing of the organ-source pigs and refinement of immunosuppressive regimens. Major steps were the identification and deletion of expression of the three known glycan xenoantigens on pig vascular endothelial cells, the transgenic expression of human “protective” proteins, e.g., complement-regulatory, coagulation-regulatory, and anti-inflammatory proteins, and the administration of an immunosuppressive regimen based on blockade of the CD40/CD154 T cell co-stimulation pathway. …”
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Unlikelihood of a phonon mechanism for the high-temperature superconductivity in La3Ni2O7 by Jing-Yang You, Zien Zhu, Mauro Del Ben, Wei Chen, Zhenglu Li

“…While Coulomb interactions (via G W self-energy and Hubbard U) enhance the e-ph coupling strength, electron doping (oxygen vacancies) introduces no major changes. Additionally, different structural phases display varying characteristics near the Fermi level, but do not alter the conclusion. …”
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Two-component system GrpP/GrpQ promotes pathogenicity of uropathogenic Escherichia coli CFT073 by upregulating type 1 fimbria by Xueping Li, Yu Pang, Lingyan Jiang, Le Liu, Jiarui Zhou, Chen Jin, Qian Wang, Hongmin Sun, Qing Li, Zhen Chen, Jingliang Qin, Jianwei Mu, Bin Liu, Qiyue Zhang, Yutao Liu, Lu Feng, Lei Wang

“…Abstract Uropathogenic Escherichia coli (UPEC) is a major cause of urinary tract infections (UTIs). Invasion into bladder epithelial cells (BECs) on the bladder luminal surface via type 1 fimbria is the first critical step in UPEC infection. …”
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Effect of Alternative Wood Species and First Thinning Wood on Oriented Strand Board Performance by Fabiane Salles Ferro, Amós Magalhães Souza, Isabella Imakawa de Araujo, Milena Maria Van Der Neut de Almeida, André Luis Christoforo, Francisco Antonio Rocco Lahr

“…Physical properties such as the moisture content, thickness swelling, and water absorption, both after 2 and 24 hours of water immersion, and mechanical properties such as the modulus of elasticity and resistance in static bending, in major and minor axes, and internal bonding were investigated. …”
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Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals by Ghyda Murad Hashim, Mehdi Shahgolzari, Kathleen Hefferon, Afagh Yavari, Srividhya Venkataraman

“…In spite of significant advancements in diagnosis and treatment, cancer remains one of the major threats to human health due to its ability to cause disease with high morbidity and mortality. …”
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Snowfall in the Northwest Iberian Peninsula: Synoptic Circulation Patterns and Their Influence on Snow Day Trends by Andrés Merino, Sergio Fernández, Lucía Hermida, Laura López, José Luis Sánchez, Eduardo García-Ortega, Estíbaliz Gascón

“…In this work, we develop a classification of synoptic situations that produced important snowfalls at observation stations in the major cities of Castilla y León from 1960 to 2011. …”
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New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation by Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Mohamed A. Zaki, Enas I. A. Mohamed, Shabana I. Khan, Babu L. Tekwani, Amar G Chittiboyina, Ikhlas A Khan, Tarfah Al-Warhi, Nada Aljaeed, Ohoud J. Alotaibi, Abdulsalam A. M. Alkhaldi, Heba A. H. Elshemy

“…The molecular docking study rationalizes the relative inhibitory activity of compound 5a as an antimalarial agent with the deregulation of PfPNP activity which has emerged as a major mechanism of these targets.…”
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Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein by Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Surl-Hee Ahn, Igor Vorobyov

“…Using advanced computer modeling and simulation, we identified atomistic-level structural, dynamic, and energetic mechanisms of norepinephrine (NE) and stimulatory G protein (Gs) interactions with β-adrenergic receptors (βARs), crucial GPCRs for heart function regulation and major drug targets. Our analysis revealed distinct binding behaviors of NE within β1AR and β2AR despite identical orthosteric binding pockets. β2AR had an additional binding site, explaining variations in NE binding affinities. …”
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Endoscopic Ex Vivo Evaluation of Bile Concentrations by Narrow Band Imaging: A Pilot Study by Roberta Maselli, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Esperanza Grace Santi, Hiroki Sato, Nikolas Eleftheriadis, Shin-ei Kudo

“…Background. Bile juice plays a major role in duodenogastroesophageal reflux (DGERD). …”
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Internal Limiting Membrane Peeling for Persistent Submacular Fluid after Successful Repair of Diabetic Tractional Retinal Detachment by Byung Ju Jung, Sohee Jeon, Kook Lee, Jiwon Baek, Won Ki Lee

“…The area of ILM peeling was expanded up to the major vascular arcade. Only air tamponade was used. …”
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Removal of the Textile Dye Indanthrene Olive Green from Aqueous Solution Using Chitosan by José Alberto P. Chaves, Lane Aparecida A. Santana, Mário S. Schultz, Hildo Antônio S. Silva, Rosiane S. Penha, Adriana P. Vieira, Antônio G. de Souza, Cícero Wellington B. Bezerra

“…The adsorption followed second-order rate kinetics and the experimental equilibrium data followed the Langmuir isotherm, thereby suggesting that chemisorption might be the major adsorption mode. Such adsorption also occurred on chitosan fibres, although to a significantly lower extent than on crushed chitosan. …”
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S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells by Junyu Chi, Qitao Wang, Zhen Wang, Wenjie Zeng, Yangyang Gao, Xin Li, Wanpeng Wang, Jiali Wang, Ming Qu

“…Abstract Previous studies highlighting the pivotal function of the S100A8 protein have shown that inflammation and vascular endothelial harm play a major role in deep vein thrombosis (DVT) development, as evidenced by earlier studies highlighting the pivotal function of the S100 calcium-binding protein A8 (S100A8). …”
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Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell Profile by A. M. Koorts, P. F. Levay, P. J. Becker, M. Viljoen

“…Normal relationships between storage iron, bioavailable iron, and RBC indices were absent in the elevated CRP group—implying the role of iron as major determinant of the RBC profile to be diminished during CIS. …”
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The Flare Irradiance Spectral Model‐Version 2 (FISM2) by P. C. Chamberlin, F. G. Eparvier, V. Knoer, H. Leise, A. Pankratz, M. Snow, B. Templeman, E. M. B. Thiemann, D. L. Woodraska, T. N. Woods

“…FISM2 estimates solar ultraviolet irradiance variations due to the solar cycle, solar rotations, and solar flares. The major improvement provided by FISM2 is that it is based on multiple new, more accurate instruments that have now captured almost a full solar cycle and thousands of flares, drastically improving the accuracy of the modeled FISM2 solar irradiance spectra. …”
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Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives by Hongzhuan Zhou, Kaidi Cui, Xia Su, Huanhuan Zhang, Bing Xiao, Songping Li, Bing Yang

“…CPV-2 causes severe diseases such as hemorrhagic gastroenteritis and myocarditis, posing a major threat to canine health, particularly with a high mortality rate in puppies. …”
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