Grain Yield Stability Analysis of Lentil Genotypes by AMMI Indices by Payam Pezeshkpour, Reza Amiri, Iraj Karami, Amir Mirzaei

“…Therefore, the identification of high-yield genotypes with adaptation to a wide range of environments is one of the major goals in crop breeding programs. In multi-environment experiments, lentil yield is influenced by the genetic structure, environment, and genotype × environment interaction. …”
Get full text

La datation des aqueducs lyonnais : un état des lieux by Aldo Borlenghi, Catherine Coquidé

“…However, the main focus of research has been the Gier aqueduct, with little attention paid to the three other major Roman aqueducts –Brévenne, Yzeron and Mont d'Or. …”
Get full text

A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Forty-five percent of patients receiving VPA-Li completed the trial, whereas only 22.22% of patients in the placebo group attended the final visit 18 months later (P = 0.09). Major changes in the ALSFRS-R score were observed, including a decrease of 1.195 points/month in the placebo group (95% CI: 0.7869–1.6031) and of 0.5085 under VPA-Li treatment (95% CI: 0.2288–0.7882) between months 6 and 14. …”
Get full text

Estimating Suitable Areas for Dry Almond (Amygdalus communis L.) Cultivation Development in Fars Province using Geographic Information System (GIS) by Ayatollah Karami, Alireza Salehi, Vida Aliyari

“…IntroductionDrought stress is one of the major environmental stresses affecting more than 60% of Iran's area. …”
Get full text

Perbedaan Rerata Kadar Soluble Fms-Like Tyrosine Kinase-1 (Sflt-1) Serum pada Penderita Early Onset, Late Onset Preeklampsia Berat / Eklampsia dan Kehamilan Normal by Laila Rahmi, Rahmatina B. Herman, Yusrawati .

“…<strong></strong></p><p><strong>Kata kunci:</strong> sFlt-1, antiangiogenik, preeklampsia berat/ eklampsia, kehamilan normal</p><p> </p><p><strong><em>Abstract</em></strong><strong><em></em></strong></p><p><em>Preeclampsia is a major cause maternal morbidity and mortality in the world. …”
Get full text

In vitro functional validation of anti-CD19 chimeric antigen receptor T cells expressing lysine-specific demethylase 1 short hairpin RNA for the treatment of diffuse large B cell l... by Zhi Guo, Zhi Guo, Mingxin He, Ning Liu, Yiqing Yang, Rui Sun, Jianxun Wang, Qiang Wang

“…CAR-T cell exhaustion is a major cause of relapse. Epigenetic modifications can regulate T cell activation, maturation and depletion; they can be applied to reduce T cell depletion, improve infiltration, and promote memory phenotype formation to reduce relapse after CAR-T cell therapy.PurposeWe propose to develop and validate in vitro the function of novel CAR-T cells for the treatment of DLBCL, which simultaneously express an anti-CD19 CAR with lysine-specific demethylase 1 (LSD1) short hairpin (sh)RNA to prevent depletion and prolong the survival of CAR-T cells.MethodsWe designed an shRNA sequence targeting LSD1 mRNA, and created a vector with the following elements: the U6 promoter driving expression of the LSD1 shRNA sequence, the EF1a promoter driving a second-generation anti-CD19 CAR sequence encoding an anti-CD19 single-chain variable fragment (FMC63), the CD8 hinge and transmembrane structural domains, the CD28 co-stimulatory structural domain, and the CD3ζ-activating structural domain. …”
Get full text

A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Forty-five percent of patients receiving VPA-Li completed the trial, whereas only 22.22% of patients in the placebo group attended the final visit 18 months later (P = 0.09). Major changes in the ALSFRS-R score were observed, including a decrease of 1.195 points/month in the placebo group (95% CI: 0.7869–1.6031) and of 0.5085 under VPA-Li treatment (95% CI: 0.2288–0.7882) between months 6 and 14. …”
Get full text

Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…Should the current inhabitants of the major emitter countries compensate the victims of their ancestors’ emissions of greenhouse gases? …”
Get full text

Antimicrobial resistance (AMR) and spread of New Delhi Metallo-β-Lactamase (NDM) in Italy: A call for policymakers by Gabriella Nucera

“…According to the European Centre for Disease Prevention and Control (ECDC) country visit to Italy in 2017, the Antimicrobial resistance (AMR) situation in Italian hospitals and regions poses a major public health threat to the country. The levels of carbapenem-resistant Enterobacteriaceae (CRE) and Acinetobacter baumannii have now reached hyper-endemic levels and, together with meticillin-resistant Staphylococcus aureus (MRSA), this situation causes Italy to be one of the Member States with the highest level of resistance in Europe [5, 6]. …”

Efficacy of Streptococcus agalactiae vaccine strains N3M and N4M in fry tilapia infected by different strains of S. agalactiae by Sukenda, Sukenda, Arif Lukman Firmansyah, Rahman, Rahman, Sri Nuryati, Dendi Hidayatullah

“…ABSTRACT     Streptococcus agalactiae is a major bacterial streptococcosis disease that infects tilapia. …”
Get full text

Çin Siyasi Düşüncesi ve Siyasi Tarihi Bağlamında Çinli Siyasi Elitler by Tuğrul Keskin

“…By analyzing 1 key moments like the Self-Strengthening Movement, the 1911 Revolution, and the Cultural Revolution, Ulusoy vividly portrays the conflicts, strategies, and ideologies that shaped the political elite's decisions and survival. A major contribution of the work is its comparative analysis between Chinese and Turkish political modernizations. …”
Get full text

Case Reports: The core of practice-based evidence by Antonio Villa

“…It provides a 13-item checklist as a framework to publish case reports, by balancing adequate detail and concise writing that is one of the major characteristics of a case report (see more at: http://www.equator-network.org/reporting-guidelines/care/). …”
Get full text

Using the HBSC Symptom Checklist to measure junior secondary school students’ psychosomatic complaints in the Chinese Mainland: Rasch-based validation, population-based norm, and n... by Yuhang Zhu, Xianzhu Cong, Zhenliang Qiu, Ricky Jeffrey, Ranran Li, Li Jing, Gaopei Zhu, Xi Yang, Shuang Li, Jinling Wang, Xu Xu, Hongliu Zhu, Xinjian Wang, Ling Huang, Xueqin Sun, Di Wu, Kai Zhang, Xunhong Miao, Rui Wen, Qinglang Huang, Zhuang He, Juan Li, Alina Cosma, Fuyan Shi, Suzhen Wang, the PROSQoL-JSSS research group

Get full text

T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis by Yang X, Zhou Y, Zhou F, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S, Ma D

“…Xiaoshan Yang,1– 3,&ast; Yang Zhou,2,3,&ast; Fuxing Zhou,4,&ast; Lili Bao,2,3 Zhengyan Wang,5 Zihan Li,2,3 Feng Ding,2,3 Huijuan Kuang,6,7 Huan Liu,8 Shenglong Tan,1 Xinyuan Qiu,1 Huan Jing,9 Shiyu Liu,2,3 Dandan Ma1 1Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, People’s Republic of China; 2State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi’an, 710032, People’s Republic of China; 3State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, 710032, People’s Republic of China; 4Department of Gynecology and Obstetrics, Xijing Hospital, The Fourth Military Medical University, Xi’an, 710032, People’s Republic of China; 5Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, People’s Republic of China; 6Department of Orthopaedics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China; 7State Key Laboratory for Manufacturing System Engineering, Xi’an Jiaotong University, Xi’an, 710054, People’s Republic of China; 8Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, 100871, People’s Republic of China; 9Department of Endodontics, Guangdong Provincial High-level Clinical Key Specialty, Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dandan Ma, Stomatological Hospital, Southern Medical University, S366 Jiangnan Boulevard, Guangzhou, Guangdong, 510280, People’s Republic of China, Tel +86-20-34152996, Email mdd@smu.edu.cn Shiyu Liu, School of Stomatology, The Fourth Military Medical University, No. 145, West Changle Road, Xi’an, Shaanxi, 710032, People’s Republic of China, Tel +86-29-84772645, Email liushiyu@vip.163.comBackground: Osteoporosis is a major public health concern characterized by decreased bone density. …”
Get full text

Fálétí’s Philosophical Sensibility by Adeshina Afolayan

“… Let us begin with an unfortunate fact: Adébáyọ̀ Fálétí is one major writer that is hardly anthologized. The problem could not have been that he wrote in Yorùbá because Fágúnwà is far more anthologized than he is. …”
Get full text

Rome à la campagne : les décors en pierre de la villa de la Grande Boussue à Nouvelles (Mons, Belgique) by Catherine Coquelet, Roland Dreesen, Éric Goemaere, Éric Leblois, Marie-Thérèse Raepsaet-Charlier

“…Sawn slabs in Gris des Ardennes and Rance red marble form the major tones of the decoration. They are combined with complex geometric patterns, such as circular shapes in Trier diabase and Rance red marble, and rhombuses in Fior di Pesco and white marble. …”
Get full text

The high-resolution global shipping emission inventory by the Shipping Emission Inventory Model (SEIM) by W. Yi, X. Wang, T. He, H. Liu, Z. Luo, Z. Lv, K. He

“…In 2021, the ship activity dataset established based on AIS data covered 109 300 vessels globally (101 400 vessels reported by the United Nations Conference on Trade and Development). Concerning the major air pollutants and greenhouse gases, global ships emitted <span class="inline-formula">847.2×10⁶</span> t of CO<span class="inline-formula">₂</span>, <span class="inline-formula">2.3×10⁶</span> t of SO<span class="inline-formula">₂</span>, <span class="inline-formula">16.1×10⁶</span> t of NO<span class="inline-formula">_<i>x</i></span>, 791.2 kt of CO, 737.3 kt of HC (hydrocarbon), 415.5 kt of primary PM<span class="inline-formula">_2.5</span>, 61.6 kt of BC (black carbon), 210.3 kt of CH<span class="inline-formula">₄</span>, and 45.1 kt of N<span class="inline-formula">₂</span>O in 2021, accounting for 3.2 % of SO<span class="inline-formula">₂</span>, 14.2 % of NO<span class="inline-formula">_<i>x</i></span>, and 2.3 % of CO<span class="inline-formula">₂</span> emissions from all global anthropogenic sources, based on the Community Emissions Data System (CEDS). …”
Get full text

Révision de l’espèce Homo erectus (Dubois, 1893) by Valéry Zeitoun

“…When the phylogenetic pattern is reconsidered in a chronostratigraphic frame, it seems that a “boom” of speciation is happened in east Africa triggered by major climato-tectonic shift around 2,8 Ma. to 2,4 Ma. …”
Get full text

Global, regional, and national trends in drug use disorder mortality rates across 73 countries from 1990 to 2021, with projections up to 2040: a global time-series analysis and mod... by Soeun Kim, Hayeon Lee, Selin Woo, Hyeri Lee, Jaeyu Park, Tae Kim, Guillaume Fond, Laurent Boyer, Masoud Rahmati, Lee Smith, Guillermo F. López Sánchez, Elena Dragioti, Christa J. Nehs, Jinseok Lee, Hyeon Jin Kim, Jiseung Kang, Dong Keon Yon

“…Summary: Background: Drug use disorder (DUD) poses a major public health crisis globally, necessitating immediate attention to global trends and future projections to develop effective health policies and interventions. …”
Get full text

FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregn... by Kerry Woolfall, Jamie J Kirkham, Jane Sandall, Mariana Popa, Enrico Lopriore, Mark Turner, Shakila Thangaratinam, Aris T Papageorghiou, Andrew Sharp, Lawrence Impey, Andy Healey, Jessica Mendoza, Asma Khalil, Dharmintra Pasupathy, Brigitte Vollmer, Zarko Alfirevic, Rajeswari Parasuraman, Jan Deprest, Richard Edmund Ashcroft, Kurt Hecher, Smriti Prasad, Baskaran Thilaganathan, Richard J Jackson, Tracy Karen Mitchell, Natasha Fenwick, Monique C Haak, Liesbeth Lewi, Shauna Leven, Fabricio Da Silva Costa, Odai Yaghi, Tracey Ricketts, George Attilakos, Carolyn Bailie, Christine Cornforth, Mark Denbow, Louise Hardman, Jane Harrold, Joel Marsden, Tommy Mousa, Surabhi Nanda, Michelle Watson, Karen Wilding, Dilly Anumba, Edward D Johnstone, Yoav Yinon, Ahmet Baschat

“…For WP2, interviews will be conducted until data saturation and sample variance are achieved, that is, when no new major themes are being discovered. Based on previous similar pilot studies, this is anticipated to be approximately 15–25 interviews in both the parent and clinician groups. …”
Get full text