Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field ¹H NMR Investigation by Kayleigh Hunwin, Georgina Page, Mark Edgar, Mohammed Bhogadia, Martin Grootveld

“…However, at higher Ni(II) concentrations (140–670 µmol/L), weaker carboxylate O-donor ligands such as lactate, formate, succinate, and acetate were featured as major Ni(II) ligands, a consequence of their much higher WMSS concentrations, which were sufficient for them to compete for these higher Ni(II) availabilities. …”
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Inappropriate medication prescribing, polypharmacy, potential drug-drug interactions and medication regimen complexity in older adults attending three referral hospitals in Asmara,... by Nuru Abdu, Saleh Idrisnur, Hanae Said, Lude Kifle, Natnael Habte, Semira Ghirmai, Tomas Tewelde, Senai Mihreteab Siele, Eyasu H. Tesfamariam

“…The mean (SD) of the overall MRCI score was 9.1 (3.7), with dose frequency being the major contributor. The number of drugs prescribed was a determinant of MRCI score (r = 0.625, p < 0.001). …”
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Association between insulin resistance indices and outcomes in patients with heart failure with preserved ejection fraction by Weicheng Ni, Ruihao Jiang, Di Xu, Jianhan Zhu, Jing Chen, Yuanzhen Lin, Hao Zhou

“…The outcome was defined as major adverse cardiovascular event (MACE), encompassing all-cause mortality and rehospitalization for heart failure. …”
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Study protocol for key interventions to improve the follow-up adherence postcervical precancerous lesion treatment in Ethiopia: a pragmatic randomised controlled trial by Adamu Addissie, Eva Johanna Kantelhardt, Eric Sven Kroeber, Sefonias Getachew, Muluken Gizaw, Abel Shita, Alemnew Destaw, Eyerusalem Getachew, Miresa Midaksa, Sophie Rossner

“…Introduction The follow-up adherence after treatment for a positive screening test is critical for preventing the development of screen‐detected abnormalities in cervical cancer. Yet, this poses a major challenge in developing countries like Ethiopia, emphasising the urgency for intervention strategies. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…The average tumor size in groups treated with 131I-HLX58-Der and HLX58-Der was reduced by factors of 12.15 and 4.80, respectively, compared to the control group. 131I-HLX58-Der demonstrated no toxic effects on hepatorenal function, routine blood tests, or major organs in mice when compared to the control group.Conclusion: These findings validate the potential of RADCs targeting CLDN18.2 in treating CLDN18.2-expressing solid tumors. …”
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L’enterrement d’une triade divine féminine à Lugdunum : étude du dépôt de la place d’Albon à Lyon (Métropole de Lyon) by Lucas Guillaud, Emmanuel Bernot, Aline Colombier-Gougouzian, Amaury Gilles, Nicolas Garnier

“…The cult was organised in curiae and revered in major temples. As tutelary goddesses, they usually appeared in threes and were often associated with a particular geographical area or ethnic group, as evidenced by the Celtic or Germanic epithets that accompanied them. …”
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Gender differences in associations between obesity and hypertension, diabetes, dyslipidemia: evidence from electronic health records of 3.5 million Chinese senior population by Xuewen Jiang, Yanrong Zhao, Qing Yang, Wei Wang, Tianxiang Lin, Yinwei Qiu

“…There were risks for having dyslipidemia or abnormal lipid-related indices even in senior population without obesity. TC and TG were major indicators of discovering disease and preventing senior population from dyslipidemia.…”
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Vertical bacterial variability in oxidation ponds in the tropical zone by C. Tudsanaton, T. Pattamapitoon, O. Phewnil, W. Wararam, K. Chunkao, P. Maskulrath, M. Srichomphu

“…Next-generation sequencing techniques were used to identify bacterial diversity, and the water quality at each depth was applied as an indicator of bacterial degradation activities.FINDINGS: Community domestic wastewater contained 10 major bacterial phyla that differed at different depths. …”
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Prediksi Bidang Penelitian dan Rekomendasi Dosen Pembimbing Skripsi Berdasarkan Konten Latar Belakang pada Naskah Proposal Menggunakan Metode Multi-Class Support Vector Machine dan... by Yustinus Radityo Pradana, Ahmad Afif Supianto, Yusi Tyroni Mursityo

“…The data that was obtained from unit PSIK FILKOM are supervisor’s majors, remaining quota for supervising, degree level, and work load. …”
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The evaluation of pharmacokinetic parameters of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide and its metabolites in rat plasma by Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov, Alena N. Tyushina, Olga E. Lasaryanz

“…The activesubstance has a high relative bioavailability after instillation into eyes. M1 is a major metabolite, and M2 is a minormetabolite. The studied compounds had a long half-life.…”
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Colgajo fasciocutáneo tipo lengüeta medial como alternativa para el manejo de defectos de tejidos blandos en la pierna by X. Ríos Garrido, A. De la Rosa, L. Arzuza Ortega, G. Vargas Lievano, J. Molina Gándara, D.A. Tellez Gamarra, C. Medina Monje

“…Conclusion: The findings suggest that the medial tab flap technique is as effective as the conventional flap technique, with complete flap survival and healing, and without any major complications in this studied group.…”
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Annual Changes in the Ecological Environment and Microbial Community Structure and Their Correlation Analyses in the Core Area of Dalian National Sea Cucumber Stock Field of China by Xiaotong ZHU, Xiaojun RONG, Bin LI, Yingeng WANG, Jianlong GE, Meijie LIAO, Jinjin WANG, Yanqiang WU, Xintao ZHAO, Guojun SHI

“…The correlation analysis between environmental factors and microbial community structure showed that temperature, pH, and salinity were the major environmental factors affecting the microbial community structure in the water body, whereas organic carbon, sulfide, heavy metal copper, and lead were the chief environmental factors affecting the microbial community structure in the sediments. …”
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Antibiotic resistance genotype, phenotype, and clinical outcomes in patients with Gram-negative infections at Rabin Medical Center in Israel by Rachelle E. Koch, Jackson Barth, Andrew E. Clark, Dhara Desai, Jiwoong Kim, Christine A. Pybus, Xiaowei Zhan, Leonard Leibovici, Dafna Yahav, David E. Greenberg

“…ABSTRACT Antibiotic resistance is a major cause of morbidity and mortality. However, a better understanding of the relationship between bacterial genetic markers, phenotypic resistance, and clinical outcomes is needed. …”
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Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome by Min Du, Xinran Liu, Xu Ji, Yue Wang, Xiaodan Liu, Chunfang Zhao, Chunfang Zhao, Erhui Jin, Erhui Jin, Youfang Gu, Youfang Gu, Hongyu Wang, Feng Zhang, Feng Zhang

“…This disease can lead to substantial morbidity and mortality and is a major global health concern. Managing ETEC infections is challenging owing to the increasing prevalence of antibiotic resistance. …”
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Bibliometric analysis of laryngeal cancer treatment literature (2003–2023) by Yan Zhao, Jiancheng Xue

“…The Head and Neck Science Journal was the most frequently co-cited publication. Major research themes encompassed morphological aspects, chemotherapy, and molecular pathway mechanisms in laryngeal cancer treatment. …”
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Immune responses and resistance of white shrimp (Litopenaeus vannamei) fed Probiotic Bacillus sp NP5 and prebiotic honey against White Spot Syndrome Virus infection by Widanarni Widanarni, Dewi Rahmi, Muhamad Gustilatov, Sukenda Sukenda, Diah Ayu Satyari Utami

“… ABSTRACT   White spot disease caused by White Spot Syndrome Virus (WSSV) is the most serious viral disease and has a major impact on the decline in production of white shrimp farm. …”
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Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation by Lingyu Song, Yali Huang, Lu Liu, Xuebing Chang, Laying Hu, Guifang Wang, Lifen Xu, Tian Zhang, Yuanyuan Wang, Ying Xiao, Hong Yang, Suye Ran, Qing Shi, Tuanlao Wang, Mingjun Shi, Yuxia Zhou, Bing Guo

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Mechanism study of KCMF1 promoting proliferation and NF-κB signaling transduction in colorectal cancer cells by WU Zhibai, XU Guiqin, ZHANG Li, YANG Zhaojuan, LIU Yun, JIAO Kun, CHEN Zehong, XU Chen, ZUO You, ZHENG Ningqian, YE Zhiqian, LIU Yongzhong

“…Background and purpose: Colorectal cancer (CRC) is one of the major malignant tumors threatening human health worldwide, with long-term high incidence and mortality rate. …”
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USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer by Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang

“…Background: Radiotherapy is a major modality for esophageal cancer (ESCA) treatment, yet radioresistance severely hampers its therapeutic efficacy. …”
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Kajian patogenisitas bakteri Edwardsiella ictaluri pada ikan patin Pangasionodon hypophthalmus by Wiwik Susanti, Agustin Indrawati, Fachriyan H Pasaribu

“…ABSTRACT   One of major problem of striped catfish Pangasionodon hypophthalmus culture is enteric septicemia of catfish (ESC), bacterial disease of Edwardsiella ictaluri, caused of more than 50% of mortalities. …”
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