Burden of chronic obstructive pulmonary disease attributable to ambient ozone pollution across China and its provinces, 1990–2021: An analysis for the Global Burden of Disease Stud... by Yixuan Jiang, Fanshu Yan, Haidong Kan, Maigeng Zhou, Peng Yin, Renjie Chen, Jing Ni

“…Ambient O3 pollution is a major contributor to the COPD burden in China. Our findings highlight the significant spatial heterogeneity across different provinces and underscore the implementation of geographically tailored policies to effectively reduce O3 pollution and alleviate the associated disease burden.…”
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Strategies to Improve Health Care Provider Prescription of and Patient Adherence to Guideline-Recommended Cardiovascular Medications for Atherosclerotic Occlusive Disease: Protocol... by Aidan M Kirkham, Dean A Fergusson, Justin Presseau, Daniel I McIsaac, Risa Shorr, Derek J Roberts

“… BackgroundIn patients with atherosclerotic occlusive diseases, systematic reviews and meta-analyses of randomized controlled trials (RCTs) report that antiplatelets, statins, and antihypertensives reduce the risk of major adverse cardiac events, need for revascularization procedures, mortality, and health care resource use. …”
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The correlation between cumulative cigarette consumption and infarction-related coronary spasm in patients with ST-segment elevation acute myocardial infarction across different ag... by Zhihui Kuang, Lin Lin, Ranran Kong, Zhonghua Wang, Xianjun Mao, Dingcheng Xiang

“…While smoking is recognized as a major risk factor for CAS, the relationship between cumulative cigarette consumption and infarction-related CAS across different age groups in STEMI patients remains unclear. …”
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Melt inclusion bubbles provide new insights into crystallisation depths and CO2 systematics at Soufrière Hills Volcano, Montserrat by TiVonne A. Howe, Thomas E. Christopher, Thomas E. Christopher, Séverine Moune, Séverine Moune, Hugh Tuffen, Federica Schiavi

“…Here, we present a new dataset of volatile (H2O and total CO2) and major element concentrations in plagioclase- and orthopyroxene-hosted SHV MI, that span almost all of the eruptive activity (Phases 1, 2, 4, and 5), and include the first measurement of bubble-hosted CO2 for SHV and indeed the Lesser Antilles Arc. …”
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Daily home monitoring of potassium, creatinine, and estimated plasma volume in heart failure post‐discharge by Patrick Rossignol, Renaud Fay, Nicolas Girerd, Faiez Zannad

“…Abstract Aims Congestive status, serum potassium, and renal function are major determinants of outcomes as well as critical elements for adjusting drug therapy in heart failure (HF) patients. …”
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Effect of JumpstartMD, a Commercial Low-Calorie Low-Carbohydrate Physician-Supervised Weight Loss Program, on 22,407 Adults by Sean Bourke, John Magaña Morton, Paul Williams

“…Frequent health coach meetings was a major determinant of weight loss, with women and men attending ≥75% of their weekly appointments losing 8.8 ± 0.04 and 11.9 ± 0.1 kg, respectively, after 3 mo, 13.1 ± 0.1 and 16.5 ± 0.3 kg after 6 mo, and 16.5 ± 0.3 and 19.4 ± 0.8 kg after 12 mo. …”
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Capital structure, profitability, and short-term solvency of nascent SMEs in Ghana: An empirical study by Karikari Amoa-Gyarteng, Shepherd Dhliwayo

“…Notably, the study finds that an appropriate balance between debt and equity financing raises the working capital ratio and thus reduces the liability of newness, which is a major challenge faced by nascent SMEs. This highlights the relevance of the trade-off theory, which recommends a combination of debt and equity financing to leverage the advantages of both sources of capital, in the context of nascent SMEs. …”
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Implementasi Kebijakan Retribusi Parkir Badan Jalan di Kota Pekanbaru by Ema Fitri Lubis, Rio Sundari, Rosmayani Rosmayani, Zilfi Purnama Rahmi

“…Parking management policies play a major role in developing strategies to improve mobility in urban areas in Indonesia. …”
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Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments by Ding B, Li M, Zhang J, Zhang X, Gao H, Gao J, Shen C, Zhou Y, Li F, Liu A

“…In addition, in vivo results indicated that Co-PHRD micelles can significantly inhibit tumor growth without causing significant damage to major organs.Conclusion: Co-delivery of DTIC and miRNA 34a via polypeptide micelles showed synergistic effects against MM, offering a new strategy for gene and chemotherapy.Keywords: nano micelle, DTIC, miRNA 34a, co-delivery, malignant melanoma…”
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A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA by Di Li, Yunhua Chen, Xingyu Zhu, Yanlei Yang, Hongling Li, Robert Chunhua Zhao

“…Abstract Background Obesity is becoming one of the major non-communicable diseases with increasing incidence and risks that cannot be ignored. …”
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Effectiveness and Side Effect Incidence in a Real-World Digital Weight-Loss Service Using Compounded Semaglutide: A Retrospective Comparative Study by Louis Talay, Matt Vickers

“…Although compounding has been relatively common over the past century, prominent medical bodies have argued that compounding a relatively novel medication such as Semaglutide represents a major safety risk. This study retrospectively compared the weight and side effect outcomes of patients from a large Australian DWLS whose lifestyle coaching was supplemented with either compounded or pure Semaglutide (both groups following the same titration schedule). …”
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Accurate phenotype-to-genotype mapping of high-diversity yeast libraries by heat-shock-electroporation (HEEL) by Marcus Wäneskog, Emma Elise Hoch-Schneider, Shilpa Garg, Christian Kronborg Cantalapiedra, Elena Schäfer, Michael Krogh Jensen, Emil Damgaard Jensen

“…This advancement holds significant promise for the fields of molecular biology and protein engineering.IMPORTANCEWith the recent expansion of artificial intelligence in the field of synthetic biology, there has never been a greater need for high-quality data and reliable measurements of phenotype-to-genotype relationships. However, one major obstacle to creating accurate computer-based models is the current abundance of low-quality phenotypic measurements originating from numerous high-throughput but low-resolution assays. …”
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Peroral Endoscopic myotomy (POEM) in pediatric achalasia: a retrospective cohort on institutional experience and quality of life by Thijs Kuipers, Carlijn Mussies, Aaltje Lei, Gwen M.C. Masclee, Marc A. Benninga, Paul Fockens, Barbara A.J. Bastiaansen, Albert J. Bredenoord, Michiel P. van Wijk

“…POEM was technically successful in all patients and no major complications occurred. Mean follow-up duration was 33 (± 25) months. …”
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Association of lower-limb strength with different fall histories or prospective falls in community-dwelling older people: a systematic review and meta-analysis by Ringo Tang-Long Zhu, Jenny Jing-Jing Zuo, Ke-Jing Li, Freddy Man Hin Lam, Arnold Yu Lok Wong, Lin Yang, Xue Bai, Man Sau Wong, Timothy Kwok, Yong-Ping Zheng, Christina Zong-Hao Ma

“…Abstract Background Fall is a major health threat to older people. The lower-limb power and rate of torque or force development (RTD or RFD) are prominently affected by aging and are crucial for maintaining postural balance. …”
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Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 by Qi Zhang, Lan Luo, Lai-lai Yan, Lai-lai Yan, Jing Guo, Hui-jun Wu, Zi-wei Zhang, Yu-hua Zhu, Rui Qiao, Rui Qiao

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Genotype by environment interactions and phenotypic traits stability of the EUCLEG faba bean collection by Dejan Sokolović, Snežana Babić, Mirjana Petrović, Ignacio Solís, Mathias Cougnon, Natalia Gutierrez, Pertti Pärssinen, Dirk Reheul, Jasmina Radović, Ana M. Torres

“…Significant differences among genotypes and environments were detected, being the genotype x environment interaction (GEI) the major source of variation in five of the nine evaluated traits. …”
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Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

“…However, CD11b can bind to multiple different ligands, leading to various myeloid cell functions such as adhesion, migration, phagocytosis, and proliferation. This has created a major challenge in understanding how CD11b converts the differences in the receptor-ligand binding into subsequent signaling responses and using this information for therapeutic development.Methods This study aimed to investigate the antitumor effect of a carbohydrate ligand, named BG34-200, which modulates the CD11b+ cells. …”
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Diagnostic criteria for asthenic accommodative asthenopia in patients with computer vision syndrome by I.G. Ovechkin, I.S. Gadzhiev, Kozhukhov A.A, E.I. Belikova

“…</i> </p> <p> <i><b>Patients and Methods: </b>86 men (172 eyes) aged 24–36 years (mean age 28.6±1.4 years) were examined. Major inclusion criteria were occupational daily activities (at least 2 years) regarded as a visually intensive work related to electronic chart displays (at least 8 hours daily) with a high level of responsibility for a final result; complaints which are typical of accommodative asthenopia and evident of its subcompensation or decompensation; low myopia (SE &lt;3.0 diopters) or emmetropia; no ocular disorders (excepting refractive errors).…”
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ANALISIS PERANCANGAN STRUKTUR BETON BERTULANG UNTUK FUNGSI RENTAL OFFICE 30 LANTAI DENGAN PENEKANAN SISTEM RIGID FRAME BERKANTILEVER by Reinhart Bunadi, Nasruddin Junus, Imriyanti Imriyanti

“…Abstract_ Makassar City is increasingly characterized by a large number of multi-storey buildings, including office functions and building architectural design ideas that tend to vary the structure as an attractive design, the building structure is a major concern. reinforced concrete. The analysis aims to determine the exact structure details for the building with the SAP2000 program v.14. …”
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Nisin A-producing Lactococcus cremoris formulations for pre- and post-milking teat disinfection modulate the bovine milk microbiota by Alessandra Gazzola, Camilla Ceccarani, Bianca Castiglioni, Filippo Biscarini, Stefano Morandi, Tiziana Silvetti, Renata Piccinini, Milena Brasca, Paola Cremonesi

“…Abstract Background Bovine mastitis is a major challenge in dairy farms. Since the agents commonly used for pre- and post-dipping can affect the udder health by modifying milk microbiota, alternative products are needed. …”
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