Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes by Ambre Bertrand, Andrew Lewis, Julia Camps, Vicente Grau, Blanca Rodriguez

“…Abstract Background Type 2 diabetes mellitus (T2DM) is a major risk factor for heart failure with preserved ejection fraction and cardiac arrhythmias. …”
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A Risk Management Approach to Global Pandemics of Infectious Disease and Anti-Microbial Resistance by Annie Sparrow, Meghan Smith-Torino, Samuel M. Shamamba, Bisimwa Chirakarhula, Maranatha A. Lwaboshi, Christine Stabell Benn, Konstantin Chumakov

“…Pandemics of infectious disease and growing anti-microbial resistance (AMR) pose major threats to global health, trade, and security. …”
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Observations on old Serbian terminology for iron mining and processing: Želězo and gvozdje by Loma Aleksandar B.

“…Otherwise, since at least the 14th century, želězo has been an archaism surviving in the toponymy across the major part of Serbian lands. Some toponymic instances, however, are assumed to have been imported from other Slavic lands, such as Železnik, a medieval mine near Belgrade, attested since 1358; it may be interpreted as having arisen through univerbation from a descriptive denomination *želězьnъjь potokъ ‘iron stream’, but also from a possessive noun phrase *potokъ želěznikь ‘ironsmiths’ stream’, i.e., the one by which their hammer mills were situated, where the second element is the old genitive plural of *želěznikъ ‘ironsmith’, which is homophonous with its nominative singular form. …”
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Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C... by Raphael Cinotti, Yvan Derouin, Amandine Chenet, Lydia Oujamaa, Bertrand Glize, Yoann Launey, Claire Dahyot-Fizelier, Emmanuelle Cartron, Melodie Renvoise, Benedicte Sautenet, Veronique Sebille

“… Background: With more than 60 million new cases around the world each year, traumatic brain injury (TBI) causes substantial mortality and morbidity. Managing TBI is a major human, social, and economic concern. In the last 20 years, there has been an increase in clinical trials in neurocritical care, leading mostly to negative results. …”
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Clinical and cost-effectiveness of a guided internet-based Acceptance and Commitment Therapy to improve chronic pain–related disability in green professions (PACT-A): study protoco... by Claudia Buntrock, Harald Baumeister, Yannik Terhorst, Lina Braun, Ingrid Titzler, Johanna Freund, Janika Thielecke, David Ebert

“…Secondary outcomes are depression severity (Quick Inventory Depressive Symptomology; QIDS-SR16), incidence of major depressive disorder, quality of life (Assessment of Quality of Life; AQoL-8D) and possible side effects associated with the treatment (Inventory for the Assessment of Negative Effects of Psychotherapy; INEP). …”
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Do Nonsuicidal Severely Depressed Individuals with Diabetes Profit from Internet-Based Guided Self-Help? Secondary Analyses of a Pragmatic Randomized Trial by Sandra Schlicker, Kiona K. Weisel, Claudia Buntrock, Matthias Berking, Stephanie Nobis, Dirk Lehr, Harald Baumeister, Frank J. Snoek, Heleen Riper, David D. Ebert

“…Changes in depressive symptom severity and treatment response were examined in a nonsuicidal severely depressed subgroup (CES−D>40; N=40). Results. Major depressive disorder diagnosis at the baseline (pprf6=0.01), higher levels of depression (Beck Depression Inventory II; pprpo=0.00; pprf6=0.00), and lower HbA1c (pprpo=0.04) predicted changes in depressive symptoms. …”
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Optimised extraction of antioxidant components from Calophyllum inophyllum L. seeds using response surface methodology by L. Fitriyana, M.D. Supardan, Y. Aisyah, Irfan .

“…Characterisation with gas chromatography-mass spectroscopy revealed ten compounds with major percentage values, among them 2''-(trimethylsilyl)oxy-3,4,4'',5- tetramethoxychalcone (49.70 per cent). …”
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Kinesiophobia and associated factors among people with musculoskeletal disorders in Ethiopia: a multicenter cross-sectional study by Yazachew Mekonnen, Moges Gashaw, Yohannes Abich, Mihret Dejen Takele, Samuel Teferi Chanie, Dechasa Imiru Wayessa, Sisay Deme, Alemu Kassaw Kibret

“…Abstract Introduction Kinesiophobia has a major health impact on patients with Musculoskeletal disorders (MSDs) in their functional and physical activities, which leads to poor outcomes, loss of motivation, loss of mobility, and decreased quality of life. …”
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PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus by Li Zheng, Wei Zhang, Aimei Li, Yan Liu, Bin Yi, Farid Nakhoul, Hao Zhang

“…Objective. Inflammation plays a major role in albuminuria in type 2 diabetes mellitus (T2DM). …”
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Efficacy and safety of super selective bronchial artery coil embolisation for haemoptysis: a single-centre retrospective observational study by Daijiro Kabata, Ayumi Shintani, Masanori Akira, Masahiko Hara, Hideo Ishikawa, Misaki Ryuge, Jun Takafuji, Mihoko Youmoto, Yukio Nagasaka, Kouji Yamamoto

“…The total number of target vessels was 4 (quartile 2–7), and the procedural success rate was 93.4%. There were 8 (1.6%) major complications: 1 aortic dissection, 2 symptomatic cerebellar infarctions and 5 mediastinal haematoma cases. …”
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ϵ-Confidence Approximately Correct (ϵ-CoAC) Learnability and Hyperparameter Selection in Linear Regression Modeling by Soosan Beheshti, Mahdi Shamsi

“…The practical uncertainty of the label samples in the training data set has a major effect in the generalization ability of the learned model. …”
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Pola Infeksi Oportunistik yang Menyebabkan Kematian pada Penyandang AIDS di RS Dr. M. Djamil Padang Tahun 2010-2012 by Aghnia Jolanda Putri, Eryati Darwin, Efrida .

“…This study observed that the major opportunistic infection in people with AIDS as leading cause of death is bron-chopneumonia (9 patients) and the least are meningitis (1 patient) and chronic bronchitis (1 patient). …”
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Systematic analysis and prediction of the burden of Alzheimer’s disease and other dementias caused by hyperglycemia by Dongying He, Dongying He, Manting Liu, Yujin Tang, Xiaona Tian, Lisi Zhou, Yizhen Chen, Xiaoxia Liu, Xiaoxia Liu

“…Emerging evidence has identified high fasting plasma glucose (HFPG) as a major modifiable risk factor for ADOD, linking impaired glucose metabolism to cognitive decline and neurodegeneration. …”
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Microplastics contamination in two peripheral fish species harvested from a downstream river by M.R. Maulana, S. Saiful, Z.A. Muchlisin

“…BACKGROUND AND OBJECTIVE: The occurrence of plastic waste pollution in waters has become a major issue globally. One of the waters which tend to be polluted with plastic waste such as bags, food wrappers, and unused fishing nets, is the Krueng Aceh River, which is located in the center of Banda Aceh city, Indonesia. …”
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In Vitro and In Vivo Evaluation of Sorghum (Sorghum bicolor L. Moench) Genotypes for Pre- and Post-attachment Resistance against Witchweed (Striga asiatica L. Kuntze) by V. O. Gwatidzo, J. T. Rugare, S. Mabasa, R. Mandumbu, J. Chipomho, S. Chikuta

“….), a noxious parasitic weed causing major damage in cereal crops, such as sorghum. However, resistance through reduced germination stimulant production or altered germination stimulant composition provides a sustainable and most effective way for managing the parasitic weeds. …”
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Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation by Tristan Whitmarsh, Wei Cope, Julia Carmona-Bozo, Roido Manavaki, Stephen-John Sammut, Ramona Woitek, Elena Provenzano, Emma L. Brown, Sarah E. Bohndiek, Ferdia A. Gallagher, Carlos Caldas, Fiona J. Gilbert, Florian Markowetz

“…A significant relationship between the major/minor axis ratio, a measure of elongation, and the tumour grade was found. …”
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Using OCO-2 Observations to Constrain Regional CO₂ Fluxes Estimated with the Vegetation, Photosynthesis and Respiration Model by Igor B. Konovalov, Nikolai A. Golovushkin, Evgeny A. Mareev

“…The inversion of the OCO-2 observations resulted in a major (more than threefold) reduction of the prior uncertainty in the regional NEE estimate. …”
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Parametric Study of the Borehole Drilling in Jointed Rock Mass by Yanan Gao, Yudong Zhang, Zetian Zhang, Minghui Li, Yingfeng Sun, Donghao Lan, Feng Gao

“…Gas is associated with coal mining; it commonly exists in the coal seam. It is one of the major dangers during the production because its reaction between the coal masses may induce the gas-coal outburst as well as it being an expositive matter. …”
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Implementasi Algoritma Genetika dalam optimasi Performa Truk Sampah Menggunakan Aplikasi Trash Queen by Arief Kelik Nugroho, Muhammad Naufal Faza

“…That is why a design optimization where it only accounts for the easier to find parts of a vehicle’s specification is needed, the wheel size and the weight of the vehcile which can be represented by two major factors: cargo capacity and fuel capacity. …”
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Sibling Species Composition and Susceptibility Status of Anopheles gambiae s.l. to Insecticides Used for Indoor Residual Spraying in Eastern Uganda by Julius Iga, Stephen Ochaya, Richard Echodu, Elizabeth A. Opiyo, Alex K. Musiime, Angella Nakamaanya, Geoffrey M. Malinga

“…These findings indicate that bendiocarb and pirimiphos-methyl are still effective against the major malaria vector, A. arabiensis in Nsinze sub-county, Namutumba district, Uganda and can be effectively used for IRS. …”
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