Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats by Masatsugu Ohara, Shunsuke Ohnishi, Hidetaka Hosono, Koji Yamamoto, Kohei Yuyama, Hideki Nakamura, Qingjie Fu, Osamu Maehara, Goki Suda, Naoya Sakamoto

“…There are no approved drug treatments for liver fibrosis and nonalcoholic steatohepatitis (NASH), an advanced stage of fibrosis which has rapidly become a major cause of cirrhosis. Therefore, development of anti-inflammatory and antifibrotic therapies is desired. …”
Get full text

Multivalent Neuroprotective Activity of <i>Elettaria cardamomum</i> (Cardamom) and <i>Foeniculum vulgare</i> (Fennel) in H₂O₂-Induced Oxidative Stress in SH-S... by Himadri Sharma, Hyewon Yang, Niti Sharma, Seong Soo A. An

“…Results: α-Terpinyl acetate and anethol were identified as major phytocompounds in cardamom and fennel, respectively. …”
Get full text

Administration of Phyllanthus niruri to control IMNV (myonecrosis infectious virus) infection white shrimp Litopenaeus vannamei by Sukenda ., Sri Nuryati, Isni Rahmatika Sari

“… ABSTRACT Infectious myonecrosis (IMN) disease is a major disease in Indonesia shrimp farming. The disease is caused by infectious myonecrosis virus (IMNV). …”
Get full text

Predictors of failure of DISE-directed adenotonsillectomy in children with sleep disordered breathing by Noura Alsufyani, Andre Isaac, Manisha Witmans, Paul Major, Hamdy El-Hakim

Get full text

Evolution and effectiveness of bilateral and multilateral development assistance for health: a mixed-methods review of trends and strategic shifts (1990–2022) by Yan Luo, Ying Chen, Beibei Yuan, Ming Xu, Shuduo Zhou, Zhijie Zheng, Siwei Xie, Sijin Du, Yuxin Huang

“…Similarly, the overall funding for health system strengthening decreased from 19% in 1990 to 7% in 2022. Major contributors to DAH included the USA, the UK and the Bill &amp; Melinda Gates Foundation. …”
Get full text

The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007&ndash;2010 by Ding Y, Liu Y, Yu J, Cai C, Fu L, Zhu J, Yang S, Jiang Y, Wang J

“…The CALLY index was a major predictor of survival in COPD patients [fully adjusted model: in the 3rd quartile, HR = 1.61, 95% CI: 1.02– 2.52, p = 0.039; in the 2nd quartile, HR = 2.11, 95% CI: 1.22– 3.65, p = 0.008; in the 1st quartile, HR = 3.12, 95% CI: 2.00– 4.85, p < 0.001]. …”
Get full text

Parallel randomised trial testing community fibrosis assessment for suspected non-alcoholic fatty liver disease: outcomes from LOCATE-NAFLD by Sanjeewa Kularatna, James O'Beirne, Adrian Barnett, Patricia C Valery, Elizabeth Powell, Ingrid J Hickman, Ruth Tulleners, David Brain, Katherine Stuart, Carolyn McIvor, Elen Witness, Melanie Aikebuse

“…Participants had suspected NAFLD and were referred to a hepatology clinic in one of three major hospitals in South-East Queensland. Eligible consenting participants were randomised to receive usual care or the intervention (LOCATE). …”
Get full text

The StbHLH47 transcription factor negatively regulates drought tolerance in potato (Solanum tuberosum L.) by Peijie Wang, Xiaojuan Wu, Nan Li, Hushuai Nie, Yu Ma, Juan Wu, Zhicheng Zhang, Yanhong Ma

“…Abstract Background Drought stress is a major environmental constraint affecting crop yields. …”
Get full text

A deep learning model for assistive decision-making during robot-aided rehabilitation therapies based on therapists’ demonstrations by David Martínez-Pascual, José M. Catalán, Luís D. Lledó, Andrea Blanco-Ivorra, Nicolás García-Aracil

“…These robotic devices provide tools to monitor the patient’s recovery progress while providing highly standardized and intensive therapy. A major challenge in using these robotic devices is the ability to decide when to assist the user. …”
Get full text

Cyclophilin–CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8 by Gabor Tajti, Laura Gebetsberger, Gregor Pamlitschka, Katharina Aigner-Radakovics, Judith Leitner, Peter Steinberger, Hannes Stockinger, Anna Ohradanova-Repic

“…By employing THP-1 and Jurkat NF-κB::eGFP reporter cell lines expressing specific TLRs, various TLR ligands and blocking antibodies, we determined that surface TLRs, including TLR2/1, TLR2/6 and TLR4 do not play a major role in SARS-CoV-2 sensing. However, monocytes are potently activated by the replication-competent SARS-CoV-2, and the response correlates with the viral uptake that is observed only in monocytes, but not in lymphocytes. …”
Get full text

Plant growth-promoting endophytic consortium improved artemisinin biosynthesis via modulating antioxidants, gene expression, and transcriptional profile in Artemisia annua (L.) und... by Arpita Tripathi, Praveen Pandey, Shakti Nath Tripathi, Alok Kalra

“…This stimulation of artemisinin by consortia and ART7 emerged from the up-regulation of major structural genes like CYP7AV1, DXS1, HMGR, DXR1, FPS, ADS, ADH2, SQC, ALDH, HMGS, ADH1, and ISPH while down-regulation of SQS, that enabled the metabolic flux flowed toward artemisinin biosynthesis and were able to disrupt the restricted enzymatic stages in the artemisinin biosynthesis pathway; besides, TFs such as bZIP, AP2, C3H, ARF, E2F, MYB, WRKY, MYC, and ERF modulate gene expression, and these proved as possible candidates for studying adaptation to multiple stress and their mechanisms. …”
Get full text

Magnitude of consistent condom use and associated factors among people living with HIV/AIDS in Ethiopia: Implication for reducing infections and re-infection. A systematic review a... by Firomsa Bekele, Lalise Tafese, Teshome Debushe

“…<h4>Background</h4>The human immune virus or acquired immune deficiency syndrome, is a major threat to the health of millions of people worldwide. …”
Get full text

In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders by Stephen Tunmise Akanbi, Joshua Ayodele Yusuf, Thompson Oluwaferanmi Ayandele, Dayo Samson Oladipupo, Darasimi Racheal Olorunlowu, Blessing Dorcas Olawuyi, Joshua Oluwafisayo Adepoju, Dolapo Emmanuel Opasina, Elizabeth Kehinde Opoola, Uchenna Victor Ugwuanyi, Olufunto Omodele Adeleye

“…Conclusions Our findings revealed close associations between the hub genes of PD putamen and non-motor symptoms of PD such as major depressive disorder, mood disorders and schizophrenia. …”
Get full text

Transformers for Neuroimage Segmentation: Scoping Review by Maya Iratni, Amira Abdullah, Mariam Aldhaheri, Omar Elharrouss, Alaa Abd-alrazaq, Zahiriddin Rustamov, Nazar Zaki, Rafat Damseh

“…MethodsA systematic search in major databases, including Scopus, IEEE Xplore, PubMed, and ACM Digital Library, was carried out for studies applying transformers to neuroimaging segmentation problems from 2019 through 2023. …”
Get full text

The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…Furthermore, bioinformatics and network pharmacology techniques were applied to decipher the major active components and their targets of XFC. …”
Get full text

SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase by Xiaobin Wang, Shulin Li, Zichen Li, Zhuona Lin, Zhifeng Wang

“…Despite significant advances in diagnosis and treatment, the compromised therapeutic effect of chemotherapeutic agents, such as Oxaliplatin (OXA), remains a major clinical challenge. Thus, a combination therapy is required to enhance the OXA’s therapeutic effectiveness and improve patient outcomes. …”
Get full text

Health Care Professionals and Data Scientists’ Perspectives on a Machine Learning System to Anticipate and Manage the Risk of Decompensation From Patients With Heart Failure: Quali... by Joana Seringa, Anna Hirata, Ana Rita Pedro, Rui Santana, Teresa Magalhães

“…The worsening of HF, also known as HF decompensation, is a major factor behind hospitalizations, contributing to substantial health care costs related to this condition. …”
Get full text

Pulse Pressure Relationships with Demographics and Kidney Function in Ashanti, Ghana by Debasish Banerjee, Jacob Plange-Rhule, Nihil Chitalia, Kwabena Kumi, Frank B. Micah, Francesco P. Cappuccio, John B. Eastwood

“…Hypertension, particularly pulse pressure [PP] is a major risk factor for end-stage renal disease. However, the effect of individual components of hypertension namely PP, systolic [SBP] and diastolic blood pressure [DBP] on kidney function, in the general African population is unknown. …”
Get full text

Structural variability of sunflower gene for methionine-rich albumin SFA8 by I. N. Anisimova, N. V. Alpatieva, S. V. Goryunova, D. V. Goryunov, Al. V. Konarev, V. A. Gavrilova, E. E. Radchenko

“…The 2S albumins of sunflower and other oilseed plants possess a high nutritional quality, the defense activity against fungi diseases casual gents and also valuable functional properties. The major component of albumin fraction, the SFA8 protein consists of 103 amino acid residues among which methionine constitutes 15 Mole %. …”
Get full text

The impact of an integrated intervention program combining drug therapy with water, sanitation, and hygiene (WASH) education on reinfection with intestinal parasitic infections amo... by Woottichai Nachaiwieng, Sangob Sanit, Nattharinee Kongta, Jassada Saingamsook, Suwit Duangmano, Sakorn Pornprasert, Pradya Somboon, Jintana Yanola

“…Abstract Background Intestinal parasitic infections (IPIs) are a major health problem among the Karen hill tribe in Thailand. …”
Get full text