Integrin α8 is a useful cell surface marker of alveolar lipofibroblasts by Atsuki Fukada, Yasunori Enomoto, Ryo Horiguchi, Yoichiro Aoshima, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Takafumi Suda, Toshihide Iwashita

“…Methods and results Using cell surface markers applicable even into wild-type mouse lungs, we could classify PDGFRα+ total lung resident fibroblasts into at least two major distinct subpopulations: integrin α8 (ITGA8)+ and SCA-1+ fibroblasts. …”
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Factors and barriers to sulfadoxine-pyrimethamine uptake for intermittent preventive treatment during pregnancy in Ghana by Akua Kumi Yeboah, Patrick Ohemeng Gyaase, Richmond Bediako Nsiah, Regina Amoa-Tutu, Saida Abdul-Rahman Zakaria, Lynna Naa Adede Obeng, Frank Prempeh, Phenihas Kwadwo Opoku, Amos Andoono, Gilbert Elara Dagoe, Kwame Kusi Agyemang, Jonathan Mawutor Gmanyami, Dominic Nyarko, Paul Kofi Awuah, Gifty Sefaah Owusu, Solomon Anum-Doku

“…Sociodemographic factors such as age, education, and parity showed no significant associations. Major barriers included time and financial constraints related to ANC attendance. …”
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Multidrug-Resistant Tuberculosis and Its Association with Adrenal Insufficiency: Assessment with the Low-Dose ACTH Stimulation Test by René Rodríguez-Gutiérrez, Adrian Rendon, Maximiliano Barrera-Sánchez, Kevin Erick Gabriel Carlos-Reyna, Neri Alejandro Álvarez-Villalobos, Gloria González-Saldivar, José Gerardo González-González

“…Multidrug-resistant tuberculosis (MDR-TB) is a major public health care concern that affects the life of millions of people around the world. …”
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Use of Blood Lipid Indicators as a Screening Tool of Insulin Resistance among Individuals in Low-Income Country Sides of China: A Multiethnic Region Study by Yi-Zhong Yan, Jia-Ning Fan, Jia-Ming Liu, Yun-hua Hu, Jiao-Long Ma, Jia He, Heng Guo, Xiang-hui Zhang, Xin-ping Wang, Shu-gang Li, Shu-Xia Guo

“…This study is aimed at evaluating the diagnostic value of blood lipid indicators (BLIs) for insulin resistance (IR) among major ethnic groups in Xinjiang, China, to identify the most valuable indicators and appropriate cut-off points for each ethnic group and to lay the foundation for the early detection, diagnosis, and treatment of metabolic diseases in remote rural areas. …”
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A clean energy Korea by 2035: Transitioning to 80% carbon-free electricity generation by Won Young Park, Yong Hyun Song, Nikit Abhyankar, Hee Seung Moon, Umed Paliwal, Eunsung Kim, Nina Khanna, Sanghyun Hong, James Hyungkwan Kim, Kenji Shiraishi, Jiang Lin, Seung Wan Kim, Amol Phadke

“…We also introduce offshore high-voltage direct current transmission lines as a strategic network planning option to address the significant discrepancies between major load centers and high-potential renewable energy regions. …”
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Strategies to Promote ResiliencY (SPRY): a randomised embedded multifactorial adaptative platform (REMAP) clinical trial protocol to study interventions to improve recovery after s... by Derek C Angus, Jennifer Holder-Murray, Katherine Moll Reitz, Christopher W Seymour, Jennifer Vates, Melanie Quintana, Kert Viele, Michelle Detry, Michael Morowitz, Alison Morris, Barbara Methe, Jason Kennedy, Brian Zuckerbraun, Timothy D Girard, Oscar C Marroquin, Stephen Esper, Anne B Newman, Scott Berry, Matthew Neal

“…SPRY-Metformin is a placebo-controlled trial and is the first SPRY domain evaluating the effectiveness of three metformin dosages across three preoperative durations within a heterogeneous set of major surgical procedures. The primary outcome is 90-day hospital-free days. …”
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Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function by Inssaf Berkiks, Inssaf Berkiks, Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Blessing Moses, Blessing Moses, Tiroyaone Brombacher, Tiroyaone Brombacher, Frank Brombacher, Frank Brombacher

“…One of the major consequences of schistosomiasis is its impact on brain function, and despite its severity, the underlying mechanism(s) remain inadequately understood, highlighting a knowledge gap in the disease. …”
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Evolution within a given virulence phenotype (pathotype) is driven by changes in aggressiveness: a case study of French wheat leaf rust populations by Fontyn, Cécilia, Meyer, Kevin JG, Boixel, Anne-Lise, Delestre, Ghislain, Piaget, Emma, Picard, Corentin, Suffert, Frédéric, Marcel, Thierry C, Goyeau, Henriette

“…A previous study on the French population of Puccinia triticina, the causal agent of wheat leaf rust, showed that two major pathotypes — groups of isolates with a particular combination of virulences — predominated but then declined over the 2005-2016 period. …”
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Economic impact of heart failure with preserved ejection fraction: insights from the ALDO‐DHF trial by Djawid Hashemi, Ludwig Dettmann, Tobias D. Trippel, Volker Holzendorf, Johannes Petutschnigg, Rolf Wachter, Gerd Hasenfuß, Burkert Pieske, Antonia Zapf, Frank Edelmann

“…Conclusions In this relatively young, oligosymptomatic, and with regard to the protocol without major comorbidities patient cohort, the overall costs are lower than expected compared with the HFrEF population. …”
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Assessing environmental change and population declines of large wading birds in southwestern India by K.M. Aarif, Aymen Nefla, K.A. Rubeena, Yanjie Xu, Zakher Bouragaoui, M. Nasser, C.T. Shifa, T.R. Athira, K. Jishnu, Jasmine Anand, Seerangan Manokaran, P.P. Moosa, Anu Gopinath, Omer R. Reshi, K.M. Rajaneesh, H. Byju, Thadickal V. Joydas, Karuppasamy P. Manikandan, Mohd Irfan Naikoo, Christian Sonne, Sabir Bin Muzaffar

“…Anthropogenic factors are driving major changes in coastal and inland wetlands. We investigated the relationship between environmental variables, productivity, fish diversity and large waders in southwestern India. …”
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Have the COVID-19 pandemic and lockdown affected children’s mental health in the long term? A repeated cross-sectional study by Alan Johnson, Sayan Mukherjee, Sushant Mane, Manas Pustake, Ajit Bhagwat, Mohammad Arfat Ganiyani, Misba Sayed, Varada Mithbavkar, Zaid Memon, Abdus Samad Momin, Krishna Deshmukh, Ayush Chordia, Sabyasachi Parida, Sanket Warghade, Deepankar Varma

“…Demographic data and COVID-19 pandemic-related data were collected from specific parent-report and self-report questionnaires.Participants Participants included children and adolescents between ages 6 and 16 years, attending a tertiary care hospital without any diagnosed major psychiatric or chronic disorder.Analysis Data were collected at two points (before the COVID-19 pandemic and during it) and compared. …”
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A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease by Yuyang Wang, Tongtong Liu, Fang Ma, Xiaoguang Lu, Huimin Mao, Weie Zhou, Liping Yang, Ping Li, Yongli Zhan

“…Diabetic kidney disease (DKD) poses a major public-health burden globally. Tripterygium wilfordii Hook F (TwHF) is a widely employed herbal medicine in decreasing albuminuria among diabetic patients. …”
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Lidar estimates of birch pollen number, mass, and CCN-related concentrations by M. Filioglou, P. Tiitta, P. Tiitta, X. Shang, A. Leskinen, P. Ahola, S. Pätsi, A. Saarto, V. Vakkari, V. Vakkari, U. Isopahkala, M. Komppula

“…This set of conversion parameters for birch pollen is derived from in situ observations of major birch pollen events at Vehmasmäki station in eastern Finland. …”
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Opportunities, challenges, and difficulties in NMR-based metabolomics applied to neovascular age-related macular degeneration (nAMD) patient follow-up by M. Schoumacher, M. Schoumacher, V. Lambert, M. Campas, P. Blaise, B. Locht, M. Thys, E. Duchateau, E. Cavalier, E. Cavalier, J.-M. Rakic, A. Noël, P. de Tullio, P. de Tullio

“…., lactate, glucose levels, HDL/LDL cholesterol, and blood pH), and optical coherence tomography (OCT) images were collected to evaluate the progression of choroidal neovascularization. 1H-NMR metabolomic analysis led to the quantification of over 60 metabolites and of the major lipoprotein fractions. Both multivariate and univariate statistical approaches tailored for longitudinal data were employed to identify biomarkers correlating metabolomic changes with ocular alterations during disease progression.Results and DiscussionDespite a rigorous analytical workflow enabling precise quantification of over 60 metabolites and the application of advanced statistical tools for longitudinal data, achieving consistent results across the cohort proved challenging. …”
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First Experiences with Fusion of PET-CT and MRI Datasets for Navigation-Assisted Percutaneous Biopsies for Primary and Metastatic Bone Tumors by Hagen Fritzsche, Alexander Pape, Klaus-Dieter Schaser, Franziska Beyer, Verena Plodeck, Ralf-Thorsten Hoffmann, Patricia Hahlbohm, Elisabeth Mehnert, Anne Weidlich

“…In the reference group, a re-biopsy had to be performed in nine patients (diagnostic yield: 84%). A total of four major and three minor complications occurred in the reference group. …”
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Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre tr... by Burkhard Toenshoff, Martin Konrad, Steffen Luntz, Anja Sander, Peter F Hoyer, Rasmus Ehren, Marcus R Benz, Jorg Doetsch, Alexander Fichtner, Jutta Gellermann, Dieter Haffner, Britta Höcker, Bärbel Kästner, Markus J Kemper, Uwe Querfeld, Lutz T Weber

“…Our findings will be submitted to major international paediatric nephrology and general paediatric conferences and submitted for publication in a peer-reviewed, open-access journal.Trial registration number DRKS0006547; EudraCT2014-001991-76; Pre-result.Date of registration 30 October 2014; 24 February 2017.…”
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Phytochemical Profiling, GC-MS Analysis and Antibacterial Activity of Sida acuta leave Extracts Against Helicobacter pylori by Kamoldeen Ajijolakewu, Ayobami Elias Ajadi, S A Ayoola, Sheriffdeen Issa Bale, Taiwo Ayodeji Sorunke, Saheed Abayomi Onifade, Tomisin Oyawoye

“…Full Abstract: Helicobacter pylori is a major cause of ulcers, and increasing resistance to standard antibiotics underscores the need for alternative treatments.  …”
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Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis by Ninet Sinaii, Guru Sonpavde, Amin H Nassar, Min Yuen Teo, Andrea B Apolo, Jonathan E Rosenberg, Giovanni Maria Iannantuono, Elias B A Chandran, Saad O Atiq, Dilara Akbulut, Nicholas I Simon, Abdul Rouf Banday, Salah Boudjadi, Sandeep Gurram, Gisela Butera, Jonathan A Coleman

“…We searched for studies published up to 26 October 2022 in major scientific databases. We screened 1745 studies and included 110. …”
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Identification of methyltransferase and demethylase genes and their expression profiling under biotic and abiotic stress in pigeon pea (Cajanus cajan [L.] Millspaugh) by Priyanka Kumari, Priyanka Kumari, Sougata Bhattacharjee, Sougata Bhattacharjee, K. Venkat Raman, Jyotsana Tilgam, Jyotsana Tilgam, Krishnayan Paul, Krishnayan Paul, Kameshwaran Senthil, Mahi Baaniya, Mahi Baaniya, G. Rama Prashat, Rohini Sreevathsa, Debasis Pattanayak

“…The methylation- demethylation dynamics of RNA plays major roles in different biological functions, including stress responses, in plants. m6A methylation in RNA is orchestrated by a coordinated function of methyl transferases (writers) and demethylases (Erasers). …”
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Reattempt Percutaneous Coronary Intervention of Chronic Total Occlusions after Prior Failures: A Single-Center Analysis of Strategies and Outcomes by Mingqiang Fu, Shufu Chang, Lei Ge, Dong Huang, Kang Yao, Feng Zhang, Qing Qin, Jianying Ma, Juying Qian, Junbo Ge

“…Data on clinical factors (age, sex, comorbidities, left ventricular ejection fraction, history of cigarette usage, and revascularization), angiographic characteristics of CTOs (target lesion, Japanese Chronic Total Occlusion (J-CTO) score, the morphology of CTO lesions, and collateral channel scale), strategies (procedural approach and use of devices), and major adverse events were obtained and analyzed. …”
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